CN105004872A - Full-automatic immuno-quantitation analyzer - Google Patents

Full-automatic immuno-quantitation analyzer Download PDF

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Publication number
CN105004872A
CN105004872A CN201510425061.7A CN201510425061A CN105004872A CN 105004872 A CN105004872 A CN 105004872A CN 201510425061 A CN201510425061 A CN 201510425061A CN 105004872 A CN105004872 A CN 105004872A
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movable plate
centrifugal
lower floor
scanning
full
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CN105004872B (en
Inventor
黄晓俊
王颖
席再军
何军军
向小飞
张旭
王玉平
张必武
徐正霞
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WUHAN EASYDIAGNOSIS BIOMEDICAINE CO Ltd
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WUHAN EASYDIAGNOSIS BIOMEDICAINE CO Ltd
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Abstract

The invention discloses a full-automatic immuno-quantitation analyzer, which comprises a centrifugal rotary disk mechanism, a moving needle insertion mechanism, a sample moving mechanism, a detection card moving mechanism, a scanning mechanism, a needle washing mechanism and a fluid path control mechanism. The centrifugal rotary disk mechanism is used for fixing blood collection tubes and centrifuging samples in the blood collection tubes. The moving needle insertion mechanism is used for drawing and dripping the centrifuged samples in the blood collection tubes. The sample moving mechanism is used for moving the moving needle insertion mechanism with the drawn samples to be above the detection card moving mechanism. The detection card moving mechanism is used for placing detection cards and moving the detection cards with the samples dripped therein to a detection station. The scanning mechanism is used for scanning the detection cards on the detection station and then outputting a scanning result. The needle washing mechanism is used for washing the sampling needles of the moving needle insertion mechanism. The fluid path control mechanism is used for controlling the fluid flowing condition of the entire analyzer. The full-automatic immuno-quantitation analyzer can be used for detecting biological samples.

Description

Full-automatic immune quantitative analyser
Technical field
The present invention relates to a kind of automatic clinical chemistry analyzer, particularly relate to a kind of full-automatic immune quantitative analyser.
Background technology
At present, instant detect (POCT) because it is easy, feature fast, be widely used in domestic and international reagent detection technique field.Wherein, full-automatic immune quantitative analyser is the most frequently used a kind of instant detector based on using flat scanning to detect, and existing full-automatic immune quantitative analyser exists following problem when reality uses:
1, first need carry out centrifugal blood with the corresponding sample of extra hydro-extractor, and then take on existing full-automatic immune quantitative analyser and carry out immune quantitative analysis, operate more loaded down with trivial details;
2, during sampling, the inside due to heparin tube is seal cavity, so can not penetrate sampling (in sampling process by direct sampling needle, the inside of heparin tube can form negative pressure, thus impact sampling), first the gland bonnet on heparin tube must be pulled out, then just can sample;
3, artificial sample is needed, more consuming time, effort;
4, once can only carry out the detection of three projects, the high flux cross detection of multiple sample cannot be met;
5, discarded test card need manually artificially collect, and operating process is more loaded down with trivial details.
Summary of the invention
The object of the invention is the deficiency in order to overcome above-mentioned background technology, providing a kind of and be integrated with centrifugal and sampling and meet the full-automatic immune quantitative analyser of the high flux cross detection of multiple sample.
In order to realize above object, the full-automatic immune quantitative analyser of one provided by the invention, comprises centrifugal turntable mechanism, for fixing heparin tube, the sample in described heparin tube is carried out centrifugally operated; Motion acupuncture treatment mechanism, for taking out, dripping in described heparin tube and has completed centrifugal sample; Move model machine structure, for moving to above test card travel mechanism by the described motion acupuncture treatment mechanism pumping sample; Described test card travel mechanism, for putting test card, and has the described test card of sample to move to detection station by dripping; Scanning mechanism, for scanning the test card that is positioned on described detection station and being exported by scanning result; Xi Zhen mechanism, for cleaning the sampling needle of described motion acupuncture treatment mechanism; Fluid path control gear, for controlling the liquid flow of complete machine.
First achieve sample by centrifugal turntable mechanism completes centrifugal in this instrument, then the automatic precision determined amounts sampling of sample is achieved by motion acupuncture treatment mechanism, the quantitative sample obtained sampling by moving model machine structure again moves to above test card and by the sample of accurate quantification and drips in test card, then the test card of sample is had to move to below scanning mechanism by test card travel mechanism by dripping, complete scanning and Output rusults after, the test card de-card automatically that test card travel mechanism will detect, finally by the sampling needle of washing motion acupuncture treatment mechanism of Xi Zhen mechanism, thus complete whole action, whole action is without the need to manual intervention, achieve full-automatic operation, thus greatly increase efficiency.
In such scheme, described centrifugal turntable mechanism comprises centrifugal motor, rotating shaft one end of described centrifugal motor is connected with the Block Cartridge for plug-in mounting heparin tube, described Block Cartridge is provided with the fixed cap for being fixed on by described heparin tube in described Block Cartridge, the rotating shaft other end of described centrifugal motor is provided with the heparin tube pick-up unit for detecting heparin tube position in described Block Cartridge, and described heparin tube is vertically inserted in described Block Cartridge.
By heparin tube is vertically arranged, so just can realize the automatic sampling of sampling needle, thus improve efficiency, decrease human cost.
In such scheme, described heparin tube pick-up unit is scrambler; The rotating shaft of described centrifugal motor is fixedly connected with described Block Cartridge by connecting shaft part.
Connected rotating shaft and the Block Cartridge of centrifugal motor by the transition of connecting shaft part, like this, facilitate the assembling of each parts, also for the maintenance in later stage provides conveniently.
In such scheme, described fixed cap is disk-like structure, and described fixed cap is along the circumferential direction provided with the through hole matched with the port bore of described heparin tube, and described fixed cap is arranged on the end face of described Block Cartridge by the lock-screw being vertically arranged in center; The insertion station fixing longer heparin tube for plug-in mounting is provided with between described fixed cap and described Block Cartridge, described insertion station is cylindrical-shaped structure, described insertion station is along the circumferential direction provided with the vertical plug-in opening arranged, the internal diameter of this plug-in opening matches with the external diameter of described longer heparin tube.
By adopting the lock-screw vertically arranged to realize the fixing of fixed cap, this fixed form is simple and firmly, cost is low and reliability is high; The plug-in mounting being achieved longer heparin tube by the insertion station added is fixed, thus without the need to changing whole Block Cartridge, reduces cost and simple to operation.Certainly, also insertion station and fixed cap can be designed to one-piece construction, like this, when needing the longer heparin tube of plug-in mounting, select the fixed cap of band insertion station, when the shorter heparin tube of plug-in mounting, selecting the fixed cap not with insertion station.
In such scheme; the outer protective cover being arranged with one end band opening of described centrifugal motor and Block Cartridge; the base plate of described protective cover is slidably fitted with centrifugal pedestal; described centrifugal motor is fixedly mounted on centrifugal pedestal by fixed installation shell, and on the top board of described protective cover, the position of corresponding described Block Cartridge is provided with the blood sampling hole of inserting for sampling needle.
Potential safety hazard existing when effectively can avoid high speed centrifugation by the protective cover added, improves the safe class of mechanism.
In such scheme; on the top board of described protective cover, the position of corresponding described fixed cap is provided with the screw escape groove dodging described lock-screw; the base plate of described protective cover is provided with the pick-up unit escape groove for dodging described heparin tube pick-up unit, and the rotating shaft of described centrifugal motor runs through described centrifugal pedestal and is connected with described heparin tube pick-up unit after stretching out described protective cover.
In such scheme, on described protective cover, the position of corresponding described centrifugal pedestal termination is provided with the accurate fixed electromagnet for fixing described centrifugal pedestal.
Can effectively be prevented in high speed centrifugation process by the accurate fixed electromagnet added, centrifugal pedestal is moved, rocks, thus improves the reliability of mechanism, is also conducive to the noise reducing mechanism.
In such scheme, be slidably connected by accurate slide rail between the base plate of described centrifugal pedestal and the base plate of described protective cover, between the both sides correspondence of described centrifugal pedestal and the both sides of described protective cover, be respectively equipped with directive slide track.
By the slide rail between the base plate of centrifugal pedestal and the base plate of protective cover is designed to accurate slide rail, effectively can improves the accuracy that centrifugal pedestal slides like this, thus improve the accuracy of detection of instrument; Meanwhile, by adding directive slide track respectively between and the both sides of protective cover corresponding in the both sides of centrifugal pedestal, which enhancing the stationarity that centrifugal pedestal slides, being also conducive to the noise reducing mechanism.
In such scheme, on described centrifugal pedestal, the openend of corresponding described protective cover is provided with handle, and described protective cover both sides are respectively equipped with the centrifugal heat conduction fan for dispelling the heat.
Facilitated the operation of operating personnel by the handle added, promptly the heat that centrifugal motor produces can be left by the centrifugal heat conduction fan added, thus improve the serviceable life of centrifugal motor.
In such scheme, described test card travel mechanism comprises bracing frame, closed assembly that support frame as described above slides respectively has upper strata movable plate and lower floor's movable plate, described lower floor movable plate is positioned at below the movable plate of described upper strata, described upper strata movable plate is provided with the small opening matched with the outer profile size of described test card, described small opening and described lower floor movable plate form the holding tank for holding described test card, and support frame as described above is provided with the falling hole dropped for described test card.
Be stacked by adopting and the upper strata movable plate of relative sliding and the structure of lower floor's movable plate can achieve the putting of test card, mobile and de-card, structure is simple, easy to operate, efficiency is high and cost is low.
In such scheme, described upper strata movable plate is slidably mounted on bracing frame by upper strata slide rail, described lower floor movable plate is slidably mounted on bracing frame by lower floor's slide rail, and the difference in height of described upper strata slide rail and described lower floor slide rail is equal to or greater than the thickness of lower floor's movable plate.
By the difference in height of upper strata slide rail and lower floor's slide rail is designed to the thickness being equal to or greater than lower floor's movable plate, can avoid like this interfering between upper strata movable plate and lower floor's movable plate.
In such scheme, support frame as described above one end is provided with the upper mobile motor for driving described upper strata movable plate to slide, the support frame as described above other end is provided with the upper belt-wheel matched with described upper mobile motor, the output terminal of described upper mobile motor is in transmission connection by upper driving band and described upper belt-wheel, and described upper driving band is fixedly connected with described upper strata movable plate; Support frame as described above one end is provided with the lower mobile motor for driving described lower floor movable plate to slide, the support frame as described above other end is provided with the lower belt wheel matched with described lower mobile motor, the output terminal of described lower mobile motor is connected with described lower belt wheel transmission by lower drive belts, and described lower drive belts is fixedly connected with described lower floor movable plate.
In such scheme, described upper mobile motor and described upper belt-wheel are all positioned at above the movable plate of described upper strata, and described lower mobile motor and described lower belt wheel are all positioned at below described lower floor movable plate; The width of movable plate one end, described upper strata is greater than the width of described lower floor movable plate corresponding end, and described upper mobile motor and described upper belt-wheel are arranged in side movable plate corresponding Width in described upper strata exceeding described lower floor movable plate.
By becoming to be greater than the width of lower floor's movable plate corresponding end by the width design of movable plate one end, upper strata, be convenient to layout and the installation of mobile motor and upper belt-wheel like this, be also conducive to the maintenance in later stage.
In such scheme, two described upper strata slide rails are arranged in the position of both sides, movable plate bottom surface, corresponding described upper strata on support frame as described above, two described lower floor slide rails are arranged in the position of both sides, corresponding described lower floor's movable plate bottom surface on support frame as described above, and two described lower floor slide rails are between two described upper strata slide rails.
By two upper strata slide rails being arranged in the position of both sides, movable plate bottom surface, corresponding upper strata on bracing frame, and Liang Gen lower floor slide rail is arranged in the position of both sides, corresponding lower floor's movable plate bottom surface on bracing frame, again Liang Gen lower floor slide rail is arranged between two upper strata slide rails, be convenient to the installation of upper strata slide rail and lower floor's slide rail like this, be also conducive to the maintenance in later stage.
In such scheme, the width being provided with one end of described small opening of described upper strata movable plate is consistent with the width of described lower floor movable plate, the width of the described upper strata movable plate other end is greater than the width of described lower floor movable plate, and described lower floor movable plate is the consistent square plate of two ends width.
By the width design being provided with one end of small opening of upper strata movable plate is become consistent with the width of lower floor movable plate, and become to be greater than the width of lower floor's movable plate by the width design of the upper strata movable plate other end, like this, while being convenient to upper strata slide rail and lower floor's slide rail installation, the size of upper strata movable plate can be reduced as far as possible, thus reduce the size that upper strata movable plate and lower floor's movable plate stretch out supporting frame part, reduce upper strata movable plate and lower floor's movable plate stretches out taking up room of instrument, facilitate the operation of operating personnel.
In such scheme, the quantity of described holding tank is at least 2, and multiple described holding tank is at least put in an arrangement; Described upper strata slide rail and described lower floor slide rail are accurate slide rail.
By being arranged in rows by holding tank, so once can meeting the high flux cross detection of multiple sample, improve detection efficiency; By upper strata slide rail and lower floor's slide rail are designed to accurate slide rail, which enhance the mobile accuracy of upper strata slide rail and lower floor's slide rail, thus improve the accuracy of detection of instrument.
In such scheme, described scanning mechanism comprises scanning pedestal, described scanning pedestal is slidably fitted with scan components, the sweep test of described scan components down, described scanning pedestal one end is provided with the scanning mobile motor for driving described scan components to slide, the described scanning pedestal other end is provided with the scanning belt wheel matched with described scanning mobile motor, the output terminal of described scanning mobile motor is in transmission connection by scanning driving-belt and described scanning belt wheel, and described scanning driving-belt is fixedly connected with described scan components.
Achieved the movement of scan components by scanning mobile motor and the transmission of scanning belt wheel, thus the high flux cross detection that once can meet multiple sample can be realized, improve detection efficiency.
In such scheme, described scanning pedestal is arranged on support frame as described above by supporting leg, and the sweep test of described scan components is positioned at above the movable plate of described upper strata.
In such scheme, described Xi Zhen mechanism comprises housing, be provided with in described housing quantity consistent with described sampling needle quantity wash pin chamber, the described inwall washing the pin mouth inclined-plane towards described sampling needle in pin chamber is arcuate structure, also be provided with in described housing and wash with described the waste liquid exhaust chamber matched in pin chamber, the sidewall of described waste liquid exhaust chamber is communicated with the described sidewall washing pin chamber, the bottom of described waste liquid exhaust chamber is communicated with the delivery outlet of described housing, described in wash the upper port in pin chamber side be communicated with the input port of described housing.
By the inwall on the pin mouth inclined-plane towards described sampling needle washing pin chamber is designed to arcuate structure, like this, the cleaning fluid having cleaned sampling needle inwall upwards can backwash at this arcuate structure place, thus also can clean the outer wall of sampling needle, and then add the number of times of sampling needle outer wall flushing, the working time of saving instrument that simultaneously can be suitable, save cleaning fluid liquid measure; Meanwhile, add waste liquid exhaust chamber by employing and substitute directly washing the scheme offering waste liquor stream outlet bottom pin chamber, make the better effects if that cleaning fluid upwards backwashes.
In such scheme, described motion acupuncture treatment mechanism comprises acupuncture treatment pedestal, described acupuncture treatment pedestal is slidably fitted with at least one sampling needle, described acupuncture treatment pedestal is provided with the acupuncture treatment drive motor driving described sampling needle vertically to move up and down, negative pressure cover is set with outside described sampling needle, the described upper end going negative pressure to overlap is communicated with air, described in go negative pressure to overlap lower end be pin mouth structure.
Automatic sampling is achieved by the acupuncture treatment drive motor added; Meanwhile, by adding negative pressure cover outside sampling needle, solving heparin tube inside in sampling process and can form the problem of negative pressure, thus achieving without the need to pulling out the object covered and can sample smoothly.
In such scheme, described sampling needle is slidably mounted on described acupuncture treatment pedestal by feed screw nut, and the output terminal of described acupuncture treatment drive motor is connected with the screw mandrel matched with described feed screw nut, and described screw mandrel is inserted in described feed screw nut.
By the structure adopting acupuncture treatment drive motor to coordinate screw mandrel and feed screw nut, achieve automatic sampling functions, structure is simple, easy to operate and cost is low.
In such scheme, this instrument also comprises for installing described centrifugal turntable mechanism, motion acupuncture treatment mechanism, move model machine structure, test card travel mechanism, scanning mechanism, the instrument stand of Xi Zhen mechanism and fluid path control gear, describedly wash the side of pin arrangement of mechanism at described instrument stand, described test card travel mechanism is arranged in the opposite side of instrument stand, described centrifugal turntable arrangement of mechanism is between described Xi Zhen mechanism and described test card travel mechanism, that moves described in described motion acupuncture treatment mechanism passes through that model machine structure can move horizontally is arranged on described instrument stand, during initial position, described motion acupuncture treatment mechanism is positioned at above described Xi Zhen mechanism, and described Xi Zhen mechanism and described centrifugal turntable mechanism are located along the same line, described scanning mechanism is positioned at above described test card travel mechanism.
In such scheme, described move model machine structure comprise cooperatively interact move sample motor and move belt transect wheel, describedly move one end that sample motor is arranged on described instrument stand top, the described belt transect that moves takes turns the other end being arranged on described instrument stand top, the described output terminal moving sample motor is by moving sample belt and the described belt transect that moves is taken turns and is in transmission connection, the described sample belt that moves is fixedly connected with described acupuncture treatment pedestal, described acupuncture treatment pedestal is provided with linear bearing, described instrument stand upper level is provided with the linear guide matched with described linear bearing, described linear bearing is sleeved on described linear guide, described acupuncture treatment pedestal is also provided with accurate guide support slide block, described instrument stand top is also horizontally installed with the accurate line slide rail matched with described accurate guide support slide block, described accurate guide support skid is arranged on described accurate line slide rail.
By the unitized construction adopting guide rod to coordinate slide rail, like this, in reality acupuncture treatment loading process, linear bearing and linear guide form the torsion pulling force of whole an of circumference, are convenient to the steady and well stressed of mechanism; Meanwhile, accurate line slide rail, makes acupuncture treatment whole mechanism easy for installation, and forms one and reverse and the anchorage force of vertical direction, is convenient to operating steadily and increasing serviceable life of acupuncture treatment mechanism of heavy duty acupuncture treatment mechanism, increases reliability and the running quality of mechanism.
In such scheme, described fluid path control gear comprises wash liquor vessel, sampling pump, sampling valve, washes pin pump and waste fluid container, described wash liquor vessel is communicated with the input port of described sampling pump, the delivery outlet of described sampling pump is communicated with described sampling needle by described sampling valve, described wash liquor vessel is also communicated with the described input port washing pin pump, the described delivery outlet washing pin pump is communicated with the input port of described Xi Zhen mechanism, and the delivery outlet of described Xi Zhen mechanism is communicated with described waste fluid container.
By cooperatively interacting between sampling pump and sampling valve, achieve the automatic collection of sample, thus improve efficiency; Meanwhile, the automatic cleaning of sampling needle inwall can also be realized by cooperatively interacting between sampling pump and sampling valve; And, coordinate by what wash pin pump and Xi Zhen mechanism the automatic cleaning achieving sampling needle outer wall.
In such scheme, between described wash liquor vessel and described sampling pump, be provided with drawing liquid pump.
The beneficial effect that technical scheme provided by the invention is brought is:
1, first achieve sample by centrifugal turntable mechanism completes centrifugal in this instrument, then the automatic precision determined amounts sampling of sample is achieved by motion acupuncture treatment mechanism, the quantitative sample obtained sampling by moving model machine structure again moves to above test card and by the sample of accurate quantification and drips in test card, then the test card of sample is had to move to below scanning mechanism by test card travel mechanism by dripping, complete scanning and Output rusults after, the test card de-card automatically that test card travel mechanism will detect, finally by the sampling needle of washing motion acupuncture treatment mechanism of Xi Zhen mechanism, thus complete whole action, whole action is without the need to manual intervention, achieve full-automatic operation, thus greatly increase efficiency,
2, by heparin tube is vertically arranged, so just can realize the automatic sampling of sampling needle, thus improve efficiency, decrease human cost;
3, connected rotating shaft and the Block Cartridge of centrifugal motor by the transition of connecting shaft part, like this, facilitate the assembling of each parts, also for the maintenance in later stage provides conveniently;
4, by adopting the lock-screw vertically arranged to realize the fixing of fixed cap, this fixed form is simple and firmly, cost is low and reliability is high;
5, the plug-in mounting that the insertion station by adding achieves longer heparin tube is fixed, thus without the need to changing whole Block Cartridge, reduces cost and simple to operation;
6, potential safety hazard existing when the protective cover by adding can avoid high speed centrifugation effectively, improves the safe class of mechanism;
7, the accurate fixed electromagnet by adding can prevent effectively in high speed centrifugation process, and centrifugal pedestal is moved, rocks, thus improves the reliability of mechanism, is also conducive to the noise reducing mechanism;
8, by the slide rail between the base plate of centrifugal pedestal and the base plate of protective cover is designed to accurate slide rail, effectively can improve the accuracy that centrifugal pedestal slides like this, thus improve the accuracy of detection of instrument;
9, by adding directive slide track respectively between and the both sides of protective cover corresponding in the both sides of centrifugal pedestal, which enhancing the stationarity that centrifugal pedestal slides, being also conducive to the noise reducing mechanism;
10, the handle by adding facilitates the operation of operating personnel, promptly can be left by the heat that centrifugal motor produces, thus improve the serviceable life of centrifugal motor by the centrifugal heat conduction fan added;
11, once the quantity of heparin tube of plug-in mounting 2 can be at least in described Block Cartridge, like this, centrifugal while once can realizing multiple sample, provide condition for multiple sample once completes high flux cross detection;
12, be stacked by adopting and the upper strata movable plate of relative sliding and the structure of lower floor's movable plate can achieve the putting of test card, mobile and de-card, structure is simple, easy to operate, efficiency is high and cost is low;
13, by the difference in height of upper strata slide rail and lower floor's slide rail is designed to the thickness being equal to or greater than lower floor's movable plate, can avoid like this interfering between upper strata movable plate and lower floor's movable plate;
14, by becoming to be greater than the width of lower floor's movable plate corresponding end by the width design of movable plate one end, upper strata, be convenient to layout and the installation of mobile motor and upper belt-wheel like this, be also conducive to the maintenance in later stage;
15, by two upper strata slide rails being arranged in the position of both sides, movable plate bottom surface, corresponding upper strata on bracing frame, and Liang Gen lower floor slide rail is arranged in the position of both sides, corresponding lower floor's movable plate bottom surface on bracing frame, again Liang Gen lower floor slide rail is arranged between two upper strata slide rails, be convenient to the installation of upper strata slide rail and lower floor's slide rail like this, be also conducive to the maintenance in later stage;
16, by the width design being provided with one end of small opening of upper strata movable plate is become consistent with the width of lower floor movable plate, and become to be greater than the width of lower floor's movable plate by the width design of the upper strata movable plate other end, like this, while being convenient to upper strata slide rail and lower floor's slide rail installation, the size of upper strata movable plate can be reduced as far as possible, thus reduce the size that upper strata movable plate and lower floor's movable plate stretch out supporting frame part, reduce upper strata movable plate and lower floor's movable plate stretches out taking up room of instrument, facilitate the operation of operating personnel;
17, by being arranged in rows by holding tank, so once can meet the high flux cross detection of multiple sample, improve detection efficiency;
18, by upper strata slide rail and lower floor's slide rail are designed to accurate slide rail, which enhance the mobile accuracy of upper strata slide rail and lower floor's slide rail, thus improve the accuracy of detection of instrument;
19, achieved the movement of scan components by scanning mobile motor and the transmission of scanning belt wheel, thus the high flux cross detection that once can meet multiple sample can be realized, improve detection efficiency;
20, by the inwall on the pin mouth inclined-plane towards described sampling needle washing pin chamber is designed to arcuate structure, like this, the cleaning fluid having cleaned sampling needle inwall upwards can backwash at this arcuate structure place, thus also can clean the outer wall of sampling needle, and then add the number of times of sampling needle outer wall flushing, the working time of saving instrument that simultaneously can be suitable, save cleaning fluid liquid measure;
21, adding waste liquid exhaust chamber by employing to substitute directly washing the scheme offering waste liquor stream outlet bottom pin chamber, making the better effects if that cleaning fluid upwards backwashes;
22, the acupuncture treatment drive motor by adding achieves automatic sampling; Meanwhile, by adding negative pressure cover outside sampling needle, solving heparin tube inside in sampling process and can form the problem of negative pressure, thus achieving without the need to pulling out the object covered and can sample smoothly;
23, the structure by adopting acupuncture treatment drive motor to coordinate screw mandrel and feed screw nut, achieve automatic sampling functions, structure is simple, easy to operate and cost is low;
24, by cooperatively interacting between sampling pump and sampling valve, achieve the automatic collection of sample, thus improve efficiency; Meanwhile, the automatic cleaning of sampling needle inwall can also be realized by cooperatively interacting between sampling pump and sampling valve; And, coordinate by what wash pin pump and Xi Zhen mechanism the automatic cleaning achieving sampling needle outer wall;
25, the unitized construction by adopting guide rod to coordinate slide rail, like this, in reality acupuncture treatment loading process, linear bearing and linear guide form the torsion pulling force of whole an of circumference, are convenient to the steady and well stressed of mechanism; Meanwhile, accurate line slide rail, makes acupuncture treatment whole mechanism easy for installation, and forms one and reverse and the anchorage force of vertical direction, is convenient to operating steadily and increasing serviceable life of acupuncture treatment mechanism of heavy duty acupuncture treatment mechanism, increases reliability and the running quality of mechanism.
The present invention is compared with the prior art, and fully its superiority of display is: achieve full-automation, structure is simple, easy to operate, efficiency is high, cost is low and once can the high flux cross detection etc. of multiple sample.
Accompanying drawing explanation
Fig. 1 is the stravismus structural representation of embodiment;
Fig. 2 is another stravismus structural representation of embodiment;
Fig. 3 is the centrifugal turntable mechanism of embodiment and test card travel mechanism plan structure schematic diagram when stretching;
Fig. 4 is the stravismus structural representation of centrifugal turntable mechanism;
Fig. 5 is the structural representation of Fig. 4 when stretching out;
Fig. 6 is the cross-sectional view of Fig. 4;
Fig. 7 is the structural representation after Fig. 4 removes the top board of protective cover;
Fig. 8 is the structural representation after Fig. 7 removes fixed cap;
Fig. 9 is the structural representation after Fig. 8 removes protective cover and handle;
Figure 10 is the wiring layout of fixed cap and insertion station;
Figure 11 is the structural representation of fixed cap;
Figure 12 is the structural representation of insertion station;
Figure 13 is the structural representation of motion acupuncture treatment mechanism;
Figure 14 is the structural representation of motion acupuncture treatment mechanism when stretching out;
Figure 15 is the side-looking structural representation of Figure 13;
Figure 16 is the side-looking structural representation of Figure 14;
Figure 17 is the cross-sectional view of Figure 13;
Figure 18 is the wiring layout of test card travel mechanism and scanning mechanism;
Figure 19 is another viewing angle constructions schematic diagram of Figure 18;
Figure 20 is the plan structure schematic diagram of Figure 18;
Figure 21 is the cross-sectional view along A-A line in Figure 20;
Figure 22 is the structural representation of Figure 20 when stretching out and load test card;
Figure 23 is the structural representation of Figure 22 when retracting;
Structural representation when Figure 24 is the scanning of first row test card;
Figure 25 is the structural representation of first row test card when taking off card;
Figure 26 is the stravismus structural representation of scanning mechanism;
Figure 27 is another stravismus structural representation of scanning mechanism;
Figure 28 is the stravismus structural representation of Xi Zhen mechanism;
Figure 29 is another stravismus structural representation of Xi Zhen mechanism;
Figure 30 is the cross-sectional view of Xi Zhen mechanism;
Figure 31 is another cross-sectional view of Xi Zhen mechanism;
Figure 32 is the liquid-way system theory diagram of instrument.
In figure: centrifugal turntable mechanism 1, centrifugal motor 1a, Block Cartridge 1b, fixed cap 1c, heparin tube pick-up unit 1d, connecting shaft part 1e, lock-screw 1f, insertion station 1g, protective cover 1h, centrifugal pedestal 1i, fixed installation shell 1j, accurate fixed electromagnet 1k, accurate slide rail 1m, directive slide track 1n, handle 1p, centrifugal heat conduction fan 1q, motion acupuncture treatment mechanism 2, acupuncture treatment pedestal 2a, sampling needle 2b, acupuncture treatment drive motor 2c, negative pressure is gone to overlap 2d, feed screw nut 2e, screw mandrel 2f, move model machine structure 3, move sample motor 3a, move belt transect wheel 3b, move sample belt 3c, linear bearing 3d, linear guide 3e, accurate guide support slide block 3f, accurate line slide rail 3g, test card travel mechanism 4, bracing frame 4a, upper strata movable plate 4b, lower floor movable plate 4c, holding tank 4d, upper strata slide rail 4e, lower floor slide rail 4f, upper mobile motor 4g, lower mobile motor 4h, upper belt-wheel 4j, lower belt wheel 4k, upper driving band 4m, lower drive belts 4n, falling hole 4p, scanning mechanism 5, scanning pedestal 5a, scan components 5b, scanning mobile motor 5c, scanning belt wheel 5d, scanning driving-belt 5e, supporting leg 5f, Xi Zhen mechanism 6, housing 6a, wash pin chamber 6b, waste liquid exhaust chamber 6c, fluid path control gear 7, wash liquor vessel 7a, drawing liquid pump 7b, sampling pump 7c, sampling valve 7d, wash pin pump 7e, waste fluid container 7f, instrument stand 8.
Embodiment
Below in conjunction with drawings and Examples, the present invention is described in further detail, but this embodiment should not be construed as limitation of the present invention.
As shown in Figure 1: the present embodiment provides a kind of full-automatic immune quantitative analyser, comprises centrifugal turntable mechanism 1, for fixing heparin tube, the sample in described heparin tube is carried out centrifugally operated; Motion acupuncture treatment mechanism 2, for taking out, dripping in described heparin tube and has completed centrifugal sample; Move model machine structure 3, for moving to above test card travel mechanism 4 by the described motion acupuncture treatment mechanism 2 pumping sample; Described test card travel mechanism 4, for putting test card, and has the described test card of sample to move to detection station by dripping; Scanning mechanism 5, for scanning the test card that is positioned on described detection station and being exported by scanning result; Xi Zhen mechanism 6, for cleaning the sampling needle of described motion acupuncture treatment mechanism 2; Fluid path control gear 7, for controlling the liquid flow of complete machine.
First achieve sample by centrifugal turntable mechanism 1 completes centrifugal in this instrument, then the automatic precision determined amounts sampling of sample is achieved by motion acupuncture treatment mechanism 2, the quantitative sample obtained sampling by moving model machine structure 3 again moves to above test card and by the sample of accurate quantification and drips in test card, then the test card of sample is had to move to below scanning mechanism 5 by test card travel mechanism 4 by dripping, complete scanning and Output rusults after, the test card de-card automatically that test card travel mechanism 4 will detect, finally by the sampling needle of washing motion acupuncture treatment mechanism 2 of Xi Zhen mechanism 6, thus complete whole action, whole action is without the need to manual intervention, achieve full-automatic operation, thus greatly increase efficiency.Certainly, if sample is without the need to centrifugal, then after sample plug-in mounting being entered centrifugal turntable mechanism 1, without the need to centrifugally operated, directly utilize motion acupuncture treatment mechanism 2 to carry out sampling.
Above-mentioned centrifugal turntable mechanism 1 comprises centrifugal motor 1a, rotating shaft one end of described centrifugal motor 1a is connected with the Block Cartridge 1b for plug-in mounting heparin tube, described Block Cartridge 1b is provided with the fixed cap 1c for being fixed on by described heparin tube in described Block Cartridge 1b, the rotating shaft other end of described centrifugal motor 1a is provided with the heparin tube pick-up unit 1d for detecting heparin tube position in described Block Cartridge 1b, and described heparin tube is vertically inserted in described Block Cartridge 1b.By heparin tube is vertically arranged, so just can realize the automatic sampling of sampling needle, thus improve efficiency, decrease human cost.
Above-mentioned heparin tube pick-up unit 1d is scrambler; The rotating shaft of described centrifugal motor 1a is fixedly connected with described Block Cartridge 1b by connecting shaft part 1e.Connected rotating shaft and the Block Cartridge 1b of centrifugal motor 1a by connecting shaft part 1e transition, like this, facilitate the assembling of each parts, also for the maintenance in later stage provides conveniently.
Above-mentioned fixed cap 1c is disk-like structure, and described fixed cap 1c is along the circumferential direction provided with the through hole matched with the port bore of described heparin tube, and described fixed cap 1c is arranged on the end face of described Block Cartridge 1b by the lock-screw 1f being vertically arranged in center; The insertion station 1g fixing longer heparin tube for plug-in mounting is provided with between described fixed cap 1c and described Block Cartridge 1b, described insertion station 1g is cylindrical-shaped structure, described insertion station 1g is along the circumferential direction provided with the vertical plug-in opening arranged, the internal diameter of this plug-in opening matches with the external diameter of described longer heparin tube.By adopting the lock-screw 1f vertically arranged to realize the fixing of fixed cap 1c, this fixed form is simple and firmly, cost is low and reliability is high; The plug-in mounting being achieved longer heparin tube by the insertion station 1g added is fixed, thus without the need to changing whole Block Cartridge 1b, reduces cost and simple to operation.Certainly, also insertion station 1g and fixed cap 1c can be designed to one-piece construction, like this, when needing the longer heparin tube of plug-in mounting, select the fixed cap 1c of band insertion station 1g, when the shorter heparin tube of plug-in mounting, selecting the fixed cap 1c not with insertion station 1g.
The outer protective cover 1h being arranged with one end band opening of above-mentioned centrifugal motor 1a and Block Cartridge 1b; the base plate of described protective cover 1h is slidably fitted with centrifugal pedestal 1i; described centrifugal motor 1a is fixedly mounted on centrifugal pedestal 1i by fixed installation shell 1j, and on the top board of described protective cover 1h, the position of corresponding described Block Cartridge 1b is provided with the blood sampling hole of inserting for sampling needle.Potential safety hazard existing when effectively can avoid high speed centrifugation by the protective cover 1h added, improves the safe class of mechanism.
On the top board of above-mentioned protective cover 1h, the position of corresponding described fixed cap 1c is provided with the screw escape groove dodging described lock-screw 1f; the base plate of described protective cover 1h is provided with the pick-up unit escape groove for dodging described heparin tube pick-up unit 1d, and the rotating shaft of described centrifugal motor 1a runs through described centrifugal pedestal 1i and is connected with described heparin tube pick-up unit 1d after stretching out described protective cover 1h.On described protective cover 1h, the position of corresponding described centrifugal pedestal 1i termination is provided with the accurate fixed electromagnet 1k for fixing described centrifugal pedestal 1i.Can effectively be prevented in high speed centrifugation process by the accurate fixed electromagnet 1k added, centrifugal pedestal 1i is moved, rocks, thus improves the reliability of mechanism, is also conducive to the noise reducing mechanism.
Be slidably connected by accurate slide rail 1m between the base plate of above-mentioned centrifugal pedestal 1i and the base plate of described protective cover 1h, between the both sides correspondence of described centrifugal pedestal 1i and the both sides of described protective cover 1h, be respectively equipped with directive slide track 1n.By the slide rail between the base plate of centrifugal pedestal 1i and the base plate of protective cover 1h is designed to accurate slide rail 1m, effectively can improves the accuracy that centrifugal pedestal 1i slides like this, thus improve the accuracy of detection of instrument; Meanwhile, by adding directive slide track 1n respectively between and the both sides of protective cover 1h corresponding in the both sides of centrifugal pedestal 1i, which enhancing the stationarity that centrifugal pedestal 1i slides, being also conducive to the noise reducing mechanism.On described centrifugal pedestal 1i, the openend of corresponding described protective cover 1h is provided with handle 1p, and described protective cover 1h both sides are respectively equipped with the centrifugal heat conduction fan 1q for dispelling the heat.Facilitated the operation of operating personnel by the handle 1p added, promptly the heat that centrifugal motor 1a produces can be left by the centrifugal heat conduction fan 1q added, thus improve the serviceable life of centrifugal motor 1a.
Once the quantity of heparin tube of plug-in mounting 2 can be at least in above-mentioned Block Cartridge 1b, like this, centrifugal while once can realizing multiple sample, provide condition for multiple sample once completes high flux cross detection.
Above-mentioned test card travel mechanism 4 comprises bracing frame 4a, closed assembly that support frame as described above 4a slides respectively has upper strata movable plate 4b and lower floor movable plate 4c, described lower floor movable plate 4c is positioned at below described upper strata movable plate 4b, described upper strata movable plate 4b is provided with the small opening matched with the outer profile size of described test card, described small opening and described lower floor movable plate 4c form the holding tank 4d for holding described test card, and support frame as described above 4a is provided with the falling hole 4p dropped for described test card.Be stacked by adopting and the upper strata movable plate 4b of relative sliding and the structure of lower floor movable plate 4c can achieve the putting of test card, mobile and de-card, structure is simple, easy to operate, efficiency is high and cost is low.
Above-mentioned upper strata movable plate 4b is slidably mounted on bracing frame 4a by upper strata slide rail 4e, described lower floor movable plate 4c is slidably mounted on bracing frame 4a by lower floor slide rail 4f, and the difference in height of described upper strata slide rail 4e and described lower floor slide rail 4f is equal to or greater than the thickness of lower floor movable plate 4c.By the difference in height of upper strata slide rail 4e and lower floor slide rail 4f is designed to the thickness being equal to or greater than lower floor movable plate 4c, can avoid like this interfering between upper strata movable plate 4b and lower floor movable plate 4c.
Above-mentioned bracing frame 4a one end is provided with the upper mobile motor 4g for driving described upper strata movable plate 4b to slide, the support frame as described above 4a other end is provided with the upper belt-wheel 4j matched with described upper mobile motor 4g, the output terminal of described upper mobile motor 4g is in transmission connection by upper driving band 4m and described upper belt-wheel 4j, and described upper driving band 4m is fixedly connected with described upper strata movable plate 4b; Support frame as described above 4a one end is provided with the lower mobile motor 4h for driving described lower floor movable plate 4c to slide, the support frame as described above 4a other end is provided with the lower belt wheel 4k matched with described lower mobile motor 4h, the output terminal of described lower mobile motor 4h is in transmission connection by lower drive belts 4n and described lower belt wheel 4k, and described lower drive belts 4n is fixedly connected with described lower floor movable plate 4c.
Above-mentioned upper mobile motor 4g and described upper belt-wheel 4j is all positioned at above described upper strata movable plate 4b, and described lower mobile motor 4h and described lower belt wheel 4k is all positioned at below described lower floor movable plate 4c; The width of movable plate 4b one end, described upper strata is greater than the width of described lower floor movable plate 4c corresponding end, and described upper mobile motor 4g and described upper belt-wheel 4j is arranged in the side corresponding Width of described upper strata movable plate 4b exceeding described lower floor movable plate 4c.By becoming to be greater than the width of lower floor movable plate 4c corresponding end by the width design of movable plate 4b one end, upper strata, be convenient to layout and the installation of mobile motor 4g and upper belt-wheel 4j like this, be also conducive to the maintenance in later stage.
Two described upper strata slide rail 4e are arranged in the position of both sides, movable plate 4b bottom surface, corresponding described upper strata on support frame as described above 4a, two described lower floor slide rail 4f are arranged in the position of both sides, corresponding described lower floor movable plate 4c bottom surface on support frame as described above 4a, and two described lower floor slide rail 4f are between two described upper strata slide rail 4e.By two upper strata slide rail 4e being arranged in the position of both sides, movable plate 4b bottom surface, corresponding upper strata on bracing frame 4a, and Liang Gen lower floor slide rail 4f is arranged in the position of both sides, corresponding lower floor movable plate 4c bottom surface on bracing frame 4a, again Liang Gen lower floor slide rail 4f is arranged between two upper strata slide rail 4e, be convenient to the installation of upper strata slide rail 4e and lower floor slide rail 4f like this, be also conducive to the maintenance in later stage.
The width being provided with one end of described small opening of above-mentioned upper strata movable plate 4b is consistent with the width of described lower floor movable plate 4c, the width of the described upper strata movable plate 4b other end is greater than the width of described lower floor movable plate 4c, and described lower floor movable plate 4c is the consistent square plate of two ends width.By the width design being provided with one end of small opening of upper strata movable plate 4b is become consistent with the width of lower floor movable plate 4c, and become to be greater than the width of lower floor movable plate 4c by the width design of the upper strata movable plate 4b other end, like this, while being convenient to upper strata slide rail 4e and lower floor slide rail 4f installation, the size of upper strata movable plate 4b can be reduced as far as possible, thus reduce the size that upper strata movable plate 4b and lower floor movable plate 4c stretches out bracing frame 4a part, reduce upper strata movable plate 4b and lower floor movable plate 4c stretches out taking up room of instrument, facilitate the operation of operating personnel.
The quantity of above-mentioned holding tank 4d is at least 2, and multiple described holding tank 4d at least puts in an arrangement; Described upper strata slide rail 4e and described lower floor slide rail 4f is accurate slide rail.By being arranged in rows by holding tank 4d, so once can meeting the high flux cross detection of multiple sample, improve detection efficiency.By upper strata slide rail 4e and lower floor slide rail 4f is designed to accurate slide rail, which enhances the mobile accuracy of upper strata slide rail 4e and lower floor slide rail 4f, thus improve the accuracy of detection of instrument.
Above-mentioned scanning mechanism 5 comprises scanning pedestal 5a, described scanning pedestal 5a is slidably fitted with scan components 5b, the sweep test of described scan components 5b down, described scanning pedestal 5a one end is provided with the scanning mobile motor 5c for driving described scan components 5b to slide, the described scanning pedestal 5a other end is provided with the scanning belt wheel 5d matched with described scanning mobile motor 5c, the output terminal of described scanning mobile motor 5c is in transmission connection by scanning driving-belt 5e and described scanning belt wheel 5d, and described scanning driving-belt 5e is fixedly connected with described scan components 5b.Achieved the movement of scan components 5b by the transmission of scanning mobile motor 5c and scanning belt wheel 5d, thus the high flux cross detection that once can meet multiple sample can be realized, improve detection efficiency.Described scanning pedestal 5a is arranged on support frame as described above 4a by supporting leg 5f, and the sweep test of described scan components 5b is positioned at above described upper strata movable plate 4b.
By the cooperatively interact movement of test card travel mechanism 4 with scanning mechanism 5, achieve the disposable detection of 3*6=18 test item, efficiency is very high, and the image detected can not exist the problem of marginal distortion.And existing single-point CCD imaging mode, there is the problem that sense channel is too small, if adopt single pass detection, then its detection efficiency is lower again; Meanwhile, though can one-time imaging, there is the problem of image border distortion in an existing 3*6=18 test item.
Above-mentioned Xi Zhen mechanism 6 comprises housing 6a, be provided with in described housing 6a quantity consistent with described sampling needle 2b quantity wash pin chamber 6b, the described inwall washing the pin mouth inclined-plane towards described sampling needle 2b of pin chamber 6b is arcuate structure, also be provided with in described housing 6a and the described waste liquid exhaust chamber 6c washing pin chamber 6b and match, the sidewall of described waste liquid exhaust chamber 6c is communicated with the described sidewall washing pin chamber 6b, the bottom of described waste liquid exhaust chamber 6c is communicated with the delivery outlet of described housing 6a, described in wash the upper port of pin chamber 6b side be communicated with the input port of described housing 6a.By the inwall on the pin mouth inclined-plane towards described sampling needle 2b washing pin chamber 6b is designed to arcuate structure, like this, the cleaning fluid having cleaned sampling needle 2b inwall upwards can backwash at this arcuate structure place, thus also can clean the outer wall of sampling needle 2b, and then add the number of times of sampling needle 2b outer wall flushing, the working time of saving instrument that simultaneously can be suitable, save cleaning fluid liquid measure; Meanwhile, add waste liquid exhaust chamber 6c by employing and substitute directly washing the scheme offering waste liquor stream outlet bottom the 6b of pin chamber, make the better effects if that cleaning fluid upwards backwashes.
Above-mentioned motion acupuncture treatment mechanism 2 comprises acupuncture treatment pedestal 2a, described acupuncture treatment pedestal 2a is slidably fitted with at least one sampling needle 2b, described acupuncture treatment pedestal 2a is provided with the acupuncture treatment drive motor 2c driving described sampling needle 2b vertically to move up and down, negative pressure cover 2d is set with outside described sampling needle 2b, describedly go negative pressure to overlap the upper end of 2d to be communicated with air, described in go to the lower end of negative pressure cover 2d to be pin mouth structure.Automatic sampling is achieved by the acupuncture treatment drive motor 2c added; Meanwhile, by adding negative pressure cover 2d outside sampling needle 2b, solving heparin tube inside in sampling process and can form the problem of negative pressure, thus achieving without the need to pulling out the object covered and can sample smoothly.Described sampling needle 2b is slidably mounted on described acupuncture treatment pedestal 2a by feed screw nut 2e, and the output terminal of described acupuncture treatment drive motor 2c is connected with the screw mandrel 2f matched with described feed screw nut 2e, and described screw mandrel 2f is inserted in described feed screw nut 2e.By the structure adopting acupuncture treatment drive motor 2c to coordinate screw mandrel 2f and feed screw nut 2e, achieve automatic sampling functions, structure is simple, easy to operate and cost is low.
This instrument also comprises for installing described centrifugal turntable mechanism 1, motion acupuncture treatment mechanism 2, move model machine structure 3, test card travel mechanism 4, scanning mechanism 5, the instrument stand 8 of Xi Zhen mechanism 6 and fluid path control gear 7, described Xi Zhen mechanism 6 is arranged in the side of described instrument stand 8, described test card travel mechanism 4 is arranged in the opposite side of instrument stand 8, described centrifugal turntable mechanism 1 is arranged between described Xi Zhen mechanism 6 and described test card travel mechanism 4, that moves described in described motion acupuncture treatment mechanism 2 passes through that model machine structure 3 can move horizontally is arranged on described instrument stand 8, during initial position, described motion acupuncture treatment mechanism 2 is positioned at above described Xi Zhen mechanism 6, and described Xi Zhen mechanism 6 is located along the same line with described centrifugal turntable mechanism 1, described scanning mechanism 5 is positioned at above described test card travel mechanism 4.Described move model machine structure 3 comprise cooperatively interact move sample motor 3a and move belt transect wheel 3b, describedly move one end that sample motor 3a is arranged on described instrument stand 8 top, the described belt transect that moves takes turns the other end that 3b is arranged on described instrument stand 8 top, the described output terminal moving sample motor 3a is by moving sample belt 3c and the described belt transect that moves is taken turns 3b and is in transmission connection, the described sample belt 3c that moves is fixedly connected with described acupuncture treatment pedestal 2a, described acupuncture treatment pedestal 2a is provided with linear bearing 3d, described instrument stand 8 upper level is provided with the linear guide 3e matched with described linear bearing 3d, described linear bearing 3d is sleeved on described linear guide 3e, described acupuncture treatment pedestal 2a is also provided with accurate guide support slide block 3f, described instrument stand 8 top is also horizontally installed with the accurate line slide rail 3g matched with described accurate guide support slide block 3f, described accurate guide support slide block 3f is slidably mounted on described accurate line slide rail 3g.
By the unitized construction adopting guide rod to coordinate slide rail, like this, in reality acupuncture treatment loading process, linear bearing and linear guide form the torsion pulling force of whole an of circumference, are convenient to the steady and well stressed of mechanism; Meanwhile, accurate line slide rail, makes acupuncture treatment whole mechanism easy for installation, and forms one and reverse and the anchorage force of vertical direction, is convenient to operating steadily and increasing serviceable life of acupuncture treatment mechanism of heavy duty acupuncture treatment mechanism, increases reliability and the running quality of mechanism.
Above-mentioned fluid path control gear 7 comprises wash liquor vessel 7a, sampling pump 7c, sampling valve 7d, washes pin pump 7e and waste fluid container 7f, described wash liquor vessel 7a is communicated with the input port of described sampling pump 7c, the delivery outlet of described sampling pump 7c is communicated with described sampling needle 2b by described sampling valve 7d, described wash liquor vessel 7a is also communicated with the described input port washing pin pump 7e, the described delivery outlet washing pin pump 7e is communicated with the input port of described Xi Zhen mechanism 6, and the delivery outlet of described Xi Zhen mechanism 6 is communicated with described waste fluid container 7f.By cooperatively interacting between sampling pump 7c and sampling valve 7d, achieve the automatic collection of sample, thus improve efficiency; Meanwhile, the automatic cleaning of sampling needle 2b inwall can also be realized by cooperatively interacting between sampling pump 7c and sampling valve 7d; And, coordinate by what wash pin pump 7e and Xi Zhen mechanism 6 the automatic cleaning achieving sampling needle 2b outer wall.Drawing liquid pump 7b is provided with between described wash liquor vessel 7a and described sampling pump 7c.
Certainly, in wash liquor vessel 7a and waste fluid container 7f, level sensing valve can be set, by the sequential control of circuit and software, realize pointing out supplementing and the replacing of waste fluid container 7f of wash liquor vessel 7a cleaning liquid inside; Above-mentioned all liquid-way system mechanisms all need to carry out pipeline pouring liquid by certain sequential, compressing sample, the flowing of liquid and the collection of accurate quantification and get liquid.
The course of work of this instrument is as follows:
First, operating personnel select the fixed cap 1c of different model according to the length of heparin tube, after choosing, are extracted out by centrifugal pedestal 1i, and are inserted in Block Cartridge 1b by heparin tube, then fix with fixed cap 1c, after fixing, by centrifugal pedestal 1i pushed home by handle 1p; Then, control test card travel mechanism 4 and upper strata movable plate 4b and lower floor movable plate 4c is stretched out simultaneously, and in holding tank 4d, put into corresponding test card, put rear upper strata movable plate 4b and lower floor movable plate 4c return simultaneously well; Now, just can open this instrument, after this instrument is opened, first control centrifugal motor 1a and rotate beginning centrifugally operated, after centrifugally operated, move model machine structure 3 and motion acupuncture treatment mechanism 2 is moved to directly over heparin tube; After motion acupuncture treatment mechanism 2 moves into place, by scrambler, heparin tube is located, then control corresponding acupuncture treatment drive motor 2c and drive the descending heparin tube penetrating correspondence of corresponding sampling needle 2b, and extract quantitative sample by sampling pump 7c, after sample extracts, sampling needle 2b return back to original position, then starts the sampling of next heparin tube, circulation like this, until all sampling needle 2b extract complete; Then, move the position that motion acupuncture treatment mechanism 2 is moved to again test card by model machine structure 3, and each sample in sampling needle 2b is dropped in first row test card; After dripping sample, upper strata movable plate 4b and lower floor movable plate 4c moves simultaneously inwards, has the first row test card of sample to move to detection station by dripping; And then, scanning mechanism 5 just starts to scan respectively each test card in first row test card, and is shown on display screen by result; While dripping after sample, motion acupuncture treatment mechanism 2 return back to initial position, then control all sampling needle 2b and insert corresponding washing in the 6b of pin chamber respectively, cleaning fluid just pumps in sampling pump 7c by drawing liquid pump 7b, then pumps in each sampling needle 2b by sampling pump 7c by cleaning fluid, complete the cleaning of each sampling needle 2b inwall, meanwhile, wash pin pump 7e and also cleaning fluid is pumped into and respectively wash in the 6b of pin chamber, complete the cleaning of each sampling needle 2b outer wall, after cleaning, each sampling needle 2b return back to initial position; So far, first row test card detects complete, the testing process of second row test card and the 3rd row's test card so circulates, after all test card detect complete (sample in the heparin tube in Block Cartridge 1b also all detects complete accordingly), the first return of lower floor movable plate 4c, first row test card, second row test card and the 3rd are listed and indexed to survey to block and are completed de-card motion automatically under gravity successively, thus achieve the automatic recovery of discarded test card; Finally, upper strata movable plate 4b return.
First the present invention achieves sample by centrifugal turntable mechanism 1 and completes centrifugal in this instrument, then the automatic precision determined amounts sampling of sample is achieved by motion acupuncture treatment mechanism 2, the quantitative sample obtained sampling by moving model machine structure 3 again moves to above test card and by the sample of accurate quantification and drips in test card, then the test card of sample is had to move to below scanning mechanism 5 by test card travel mechanism 4 by dripping, complete scanning and Output rusults after, the test card de-card automatically that test card travel mechanism 4 will detect, finally by the sampling needle of washing motion acupuncture treatment mechanism 2 of Xi Zhen mechanism 6, thus complete whole action, whole action is without the need to manual intervention, achieve full-automatic operation, thus greatly increase efficiency,
By heparin tube is vertically arranged, so just can realize the automatic sampling of sampling needle, thus improve efficiency, decrease human cost; Connected rotating shaft and the Block Cartridge 1b of centrifugal motor 1a by connecting shaft part 1e transition, like this, facilitate the assembling of each parts, also for the maintenance in later stage provides conveniently; By adopting the lock-screw 1f vertically arranged to realize the fixing of fixed cap 1c, this fixed form is simple and firmly, cost is low and reliability is high; The plug-in mounting being achieved longer heparin tube by the insertion station 1g added is fixed, thus without the need to changing whole Block Cartridge 1b, reduces cost and simple to operation; Potential safety hazard existing when effectively can avoid high speed centrifugation by the protective cover 1h added, improves the safe class of mechanism; Can effectively be prevented in high speed centrifugation process by the accurate fixed electromagnet 1k added, centrifugal pedestal 1i is moved, rocks, thus improves the reliability of mechanism, is also conducive to the noise reducing mechanism; By the slide rail between the base plate of centrifugal pedestal 1i and the base plate of protective cover 1h is designed to accurate slide rail 1m, effectively can improves the accuracy that centrifugal pedestal 1i slides like this, thus improve the accuracy of detection of instrument; By adding directive slide track 1n respectively between and the both sides of protective cover 1h corresponding in the both sides of centrifugal pedestal 1i, which enhancing the stationarity that centrifugal pedestal 1i slides, being also conducive to the noise reducing mechanism; Facilitated the operation of operating personnel by the handle 1p added, promptly the heat that centrifugal motor 1a produces can be left by the centrifugal heat conduction fan 1q added, thus improve the serviceable life of centrifugal motor 1a; Once the quantity of heparin tube of plug-in mounting 2 can be at least in described Block Cartridge 1b, like this, centrifugal while once can realizing multiple sample, provide condition for multiple sample once completes high flux cross detection;
Be stacked by adopting and the upper strata movable plate 4b of relative sliding and the structure of lower floor movable plate 4c can achieve the putting of test card, mobile and de-card, structure is simple, easy to operate, efficiency is high and cost is low; By the difference in height of upper strata slide rail 4e and lower floor slide rail 4f is designed to the thickness being equal to or greater than lower floor movable plate 4c, can avoid like this interfering between upper strata movable plate 4b and lower floor movable plate 4c; By becoming to be greater than the width of lower floor movable plate 4c corresponding end by the width design of movable plate 4b one end, upper strata, be convenient to layout and the installation of mobile motor 4g and upper belt-wheel 4j like this, be also conducive to the maintenance in later stage; By two upper strata slide rail 4e being arranged in the position of both sides, movable plate 4b bottom surface, corresponding upper strata on bracing frame 4a, and Liang Gen lower floor slide rail 4f is arranged in the position of both sides, corresponding lower floor movable plate 4c bottom surface on bracing frame 4a, again Liang Gen lower floor slide rail 4f is arranged between two upper strata slide rail 4e, be convenient to the installation of upper strata slide rail 4e and lower floor slide rail 4f like this, be also conducive to the maintenance in later stage; By the width design being provided with one end of small opening of upper strata movable plate 4b is become consistent with the width of lower floor movable plate 4c, and become to be greater than the width of lower floor movable plate 4c by the width design of the upper strata movable plate 4b other end, like this, while being convenient to upper strata slide rail 4e and lower floor slide rail 4f installation, the size of upper strata movable plate 4b can be reduced as far as possible, thus reduce the size that upper strata movable plate 4b and lower floor movable plate 4c stretches out bracing frame 4a part, reduce upper strata movable plate 4b and lower floor movable plate 4c stretches out taking up room of instrument, facilitate the operation of operating personnel; By being arranged in rows by holding tank 4d, so once can meeting the high flux cross detection of multiple sample, improve detection efficiency; By upper strata slide rail 4e and lower floor slide rail 4f is designed to accurate slide rail, which enhances the mobile accuracy of upper strata slide rail 4e and lower floor slide rail 4f, thus improve the accuracy of detection of instrument;
Achieved the movement of scan components 5b by the transmission of scanning mobile motor 5c and scanning belt wheel 5d, thus the high flux cross detection that once can meet multiple sample can be realized, improve detection efficiency;
By the inwall on the pin mouth inclined-plane towards described sampling needle 2b washing pin chamber 6b is designed to arcuate structure, like this, the cleaning fluid having cleaned sampling needle 2b inwall upwards can backwash at this arcuate structure place, thus also can clean the outer wall of sampling needle 2b, and then add the number of times of sampling needle 2b outer wall flushing, the working time of saving instrument that simultaneously can be suitable, save cleaning fluid liquid measure; Adding waste liquid exhaust chamber 6c by employing to substitute directly washing the scheme offering waste liquor stream outlet bottom the 6b of pin chamber, making the better effects if that cleaning fluid upwards backwashes;
Automatic sampling is achieved by the acupuncture treatment drive motor 2c added; Meanwhile, by adding negative pressure cover 2d outside sampling needle 2b, solving heparin tube inside in sampling process and can form the problem of negative pressure, thus achieving without the need to pulling out the object covered and can sample smoothly; By the structure adopting acupuncture treatment drive motor 2c to coordinate screw mandrel 2f and feed screw nut 2e, achieve automatic sampling functions, structure is simple, easy to operate and cost is low;
By the unitized construction adopting guide rod to coordinate slide rail, like this, in reality acupuncture treatment loading process, linear bearing and linear guide form the torsion pulling force of whole an of circumference, are convenient to the steady and well stressed of mechanism; Meanwhile, accurate line slide rail, makes acupuncture treatment whole mechanism easy for installation, and forms one and reverse and the anchorage force of vertical direction, is convenient to operating steadily and increasing serviceable life of acupuncture treatment mechanism of heavy duty acupuncture treatment mechanism, increases reliability and the running quality of mechanism;
By cooperatively interacting between sampling pump 7c and sampling valve 7d, achieve the automatic collection of sample, thus improve efficiency; Meanwhile, the automatic cleaning of sampling needle 2b inwall can also be realized by cooperatively interacting between sampling pump 7c and sampling valve 7d; And, coordinate by what wash pin pump 7e and Xi Zhen mechanism 6 the automatic cleaning achieving sampling needle 2b outer wall.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (24)

1. a full-automatic immune quantitative analyser, is characterized in that: comprise
Centrifugal turntable mechanism (1), carries out centrifugally operated for fixing heparin tube by the sample in described heparin tube;
Motion acupuncture treatment mechanism (2), for taking out, dripping in described heparin tube and has completed centrifugal sample;
Move model machine structure (3), for described motion acupuncture treatment mechanism (2) pumping sample is moved to test card travel mechanism (4) top;
Described test card travel mechanism (4), for putting test card, and has the described test card of sample to move to detection station by dripping;
Scanning mechanism (5), for scanning the test card that is positioned on described detection station and being exported by scanning result;
Xi Zhen mechanism (6), for cleaning the sampling needle of described motion acupuncture treatment mechanism (2);
Fluid path control gear (7), for controlling the liquid flow of complete machine.
2. full-automatic immune quantitative analyser as claimed in claim 1, it is characterized in that: described centrifugal turntable mechanism (1) comprises centrifugal motor (1a), rotating shaft one end of described centrifugal motor (1a) is connected with the Block Cartridge (1b) for plug-in mounting heparin tube, described Block Cartridge (1b) is provided with the fixed cap (1c) for being fixed on by described heparin tube in described Block Cartridge (1b), the rotating shaft other end of described centrifugal motor (1a) is provided with the heparin tube pick-up unit (1d) for detecting the interior heparin tube position of described Block Cartridge (1b), described heparin tube is vertically inserted in described Block Cartridge (1b).
3. full-automatic immune quantitative analyser as claimed in claim 2, is characterized in that: described heparin tube pick-up unit (1d) is scrambler; The rotating shaft of described centrifugal motor (1a) is fixedly connected with described Block Cartridge (1b) by connecting shaft part (1e).
4. full-automatic immune quantitative analyser as claimed in claim 2, it is characterized in that: described fixed cap (1c) is disk-like structure, described fixed cap (1c) is along the circumferential direction provided with the through hole matched with the port bore of described heparin tube, and described fixed cap (1c) is arranged on the end face of described Block Cartridge (1b) by the lock-screw (1f) being vertically arranged in center; The insertion station (1g) fixing longer heparin tube for plug-in mounting is provided with between described fixed cap (1c) and described Block Cartridge (1b), described insertion station (1g) is cylindrical-shaped structure, described insertion station (1g) is along the circumferential direction provided with the vertical plug-in opening arranged, the internal diameter of this plug-in opening matches with the external diameter of described longer heparin tube.
5. full-automatic immune quantitative analyser as claimed in claim 4; it is characterized in that: the outer protective cover (1h) being arranged with one end band opening of described centrifugal motor (1a) and Block Cartridge (1b); the base plate of described protective cover (1h) is slidably fitted with centrifugal pedestal (1i); described centrifugal motor (1a) is fixedly mounted on centrifugal pedestal (1i) by fixed installation shell (1j), and on the top board of described protective cover (1h), the position of corresponding described Block Cartridge (1b) is provided with the blood sampling hole of inserting for sampling needle.
6. full-automatic immune quantitative analyser as claimed in claim 5; it is characterized in that: on the top board of described protective cover (1h), the position of corresponding described fixed cap (1c) is provided with the screw escape groove dodging described lock-screw (1f); the base plate of described protective cover (1h) is provided with the pick-up unit escape groove for dodging described heparin tube pick-up unit (1d), and the rotating shaft of described centrifugal motor (1a) runs through described centrifugal pedestal (1i) and stretches out described protective cover (1h) and is connected with described heparin tube pick-up unit (1d) afterwards.
7. full-automatic immune quantitative analyser as claimed in claim 5, is characterized in that: the position of upper corresponding described centrifugal pedestal (1i) termination of described protective cover (1h) is provided with the accurate fixed electromagnet (1k) for fixing described centrifugal pedestal (1i).
8. full-automatic immune quantitative analyser as claimed in claim 5; it is characterized in that: be slidably connected by accurate slide rail (1m) between the base plate of described centrifugal pedestal (1i) and the base plate of described protective cover (1h), between the both sides correspondence of described centrifugal pedestal (1i) and the both sides of described protective cover (1h), be respectively equipped with directive slide track (1n).
9. full-automatic immune quantitative analyser as claimed in claim 5; it is characterized in that: the openend of the upper corresponding described protective cover (1h) of described centrifugal pedestal (1i) is provided with handle (1p), and described protective cover (1h) both sides are respectively equipped with the centrifugal heat conduction fan (1q) for dispelling the heat.
10. full-automatic immune quantitative analyser as claimed in claim 1, it is characterized in that: described test card travel mechanism (4) comprises bracing frame (4a), closed assembly that support frame as described above (4a) slides respectively has upper strata movable plate (4b) and lower floor's movable plate (4c), described lower floor movable plate (4c) is positioned at below, described upper strata movable plate (4b), described upper strata movable plate (4b) is provided with the small opening matched with the outer profile size of described test card, described small opening and described lower floor movable plate (4c) form the holding tank (4d) for holding described test card, support frame as described above (4a) is provided with the falling hole (4p) dropped for described test card.
11. full-automatic immune quantitative analysers as claimed in claim 10, it is characterized in that: described upper strata movable plate (4b) is slidably mounted on bracing frame (4a) by upper strata slide rail (4e), described lower floor movable plate (4c) is slidably mounted on bracing frame (4a) by lower floor's slide rail (4f), and described upper strata slide rail (4e) is equal to or greater than the thickness of lower floor's movable plate (4c) with the difference in height of described lower floor slide rail (4f).
12. full-automatic immune quantitative analysers as claimed in claim 11, it is characterized in that: support frame as described above (4a) one end is provided with the upper mobile motor (4g) for driving described upper strata movable plate (4b) to slide, support frame as described above (4a) other end is provided with the upper belt-wheel (4j) matched with described upper mobile motor (4g), the output terminal of described upper mobile motor (4g) is in transmission connection by upper driving band (4m) and described upper belt-wheel (4j), and described upper driving band (4m) is fixedly connected with described upper strata movable plate (4b); Support frame as described above (4a) one end is provided with the lower mobile motor (4h) for driving described lower floor movable plate (4c) to slide, support frame as described above (4a) other end is provided with the lower belt wheel (4k) matched with described lower mobile motor (4h), the output terminal of described lower mobile motor (4h) is in transmission connection by lower drive belts (4n) and described lower belt wheel (4k), and described lower drive belts (4n) is fixedly connected with described lower floor movable plate (4c).
13. full-automatic immune quantitative analysers as claimed in claim 12, it is characterized in that: described upper mobile motor (4g) and described upper belt-wheel (4j) are all positioned at top, described upper strata movable plate (4b), described lower mobile motor (4h) and described lower belt wheel (4k) are all positioned at described lower floor movable plate (4c) below; The width of described upper strata movable plate (4b) one end is greater than the width of described lower floor movable plate (4c) corresponding end, and described upper mobile motor (4g) and described upper belt-wheel (4j) are arranged in the side described upper strata movable plate (4b) corresponding Width exceeding described lower floor movable plate (4c).
14. full-automatic immune quantitative analysers as claimed in claim 12, it is characterized in that: two described upper stratas slide rail (4e) are arranged in the position of upper movable plate (4b) both sides, bottom surface, corresponding described upper strata of support frame as described above (4a), two described lower floors slide rail (4f) are arranged in the position of support frame as described above (4a) upper corresponding described lower floor movable plate (4c) both sides, bottom surface, and two described lower floors slide rail (4f) are positioned between two described upper stratas slide rail (4e).
15. full-automatic immune quantitative analysers as claimed in claim 12, it is characterized in that: the width being provided with one end of described small opening on described upper strata movable plate (4b) is consistent with the width of described lower floor movable plate (4c), the width of described upper strata movable plate (4b) other end is greater than the width of described lower floor movable plate (4c), and described lower floor movable plate (4c) is the consistent square plate of two ends width.
16. full-automatic immune quantitative analysers as claimed in claim 12, it is characterized in that: the quantity of described holding tank (4d) is at least 2, multiple described holding tank (4d) is at least put in an arrangement; Described upper strata slide rail (4e) and described lower floor slide rail (4f) are accurate slide rail.
17. full-automatic immune quantitative analysers as claimed in claim 12, it is characterized in that: described scanning mechanism (5) comprises scanning pedestal (5a), described scanning pedestal (5a) is slidably fitted with scan components (5b), the sweep test of described scan components (5b) down, described scanning pedestal (5a) one end is provided with the scanning mobile motor (5c) for driving described scan components (5b) to slide, described scanning pedestal (5a) other end is provided with the scanning belt wheel (5d) matched with described scanning mobile motor (5c), the output terminal of described scanning mobile motor (5c) is in transmission connection by scanning driving-belt (5e) and described scanning belt wheel (5d), described scanning driving-belt (5e) is fixedly connected with described scan components (5b).
18. full-automatic immune quantitative analysers as claimed in claim 17, it is characterized in that: described scanning pedestal (5a) is arranged on support frame as described above (4a) by supporting leg (5f), the sweep test of described scan components (5b) is positioned at top, described upper strata movable plate (4b).
19. full-automatic immune quantitative analysers as claimed in claim 1, it is characterized in that: described Xi Zhen mechanism (6) comprises housing (6a), be provided with in described housing (6a) quantity consistent with described sampling needle (2b) quantity wash pin chamber (6b), the described inwall washing the pin mouth inclined-plane towards described sampling needle (2b) in pin chamber (6b) is arcuate structure, also be provided with in described housing (6a) and wash with described the waste liquid exhaust chamber (6c) matched in pin chamber (6b), the sidewall of described waste liquid exhaust chamber (6c) is communicated with the described sidewall washing pin chamber (6b), the bottom of described waste liquid exhaust chamber (6c) is communicated with the delivery outlet of described housing (6a), the described side washing the upper port in pin chamber (6b) is communicated with the input port of described housing (6a).
20. full-automatic immune quantitative analysers as claimed in claim 1, it is characterized in that: described motion acupuncture treatment mechanism (2) comprises acupuncture treatment pedestal (2a), described acupuncture treatment pedestal (2a) is slidably fitted with at least one sampling needle (2b), described acupuncture treatment pedestal (2a) is provided with the acupuncture treatment drive motor (2c) driving described sampling needle (2b) vertically to move up and down, negative pressure cover (2d) is set with outside described sampling needle (2b), the described upper end of negative pressure cover (2d) of going is communicated with air, the described lower end of negative pressure cover (2d) of going is pin mouth structure.
21. full-automatic immune quantitative analysers as claimed in claim 20, it is characterized in that: described sampling needle (2b) is slidably mounted on described acupuncture treatment pedestal (2a) by feed screw nut (2e), the output terminal of described acupuncture treatment drive motor (2c) is connected with the screw mandrel (2f) matched with described feed screw nut (2e), and described screw mandrel (2f) is inserted in described feed screw nut (2e).
22. full-automatic immune quantitative analysers as claimed in claim 20, it is characterized in that: also comprise for installing described centrifugal turntable mechanism (1), motion acupuncture treatment mechanism (2), move model machine structure (3), test card travel mechanism (4), scanning mechanism (5), the instrument stand (8) of Xi Zhen mechanism (6) and fluid path control gear (7), described Xi Zhen mechanism (6) is arranged in the side of described instrument stand (8), described test card travel mechanism (4) is arranged in the opposite side of instrument stand (8), described centrifugal turntable mechanism (1) is arranged between described Xi Zhen mechanism (6) and described test card travel mechanism (4), described motion acupuncture treatment mechanism (2) pass through described in move that model machine structure (3) can move horizontally be arranged on described instrument stand (8), during initial position, described motion acupuncture treatment mechanism (2) is positioned at described Xi Zhen mechanism (6) top, and described Xi Zhen mechanism (6) and described centrifugal turntable mechanism (1) are located along the same line, described scanning mechanism (5) is positioned at described test card travel mechanism (4) top.
23. full-automatic immune quantitative analysers as claimed in claim 22, it is characterized in that: described in move model machine structure (3) comprise cooperatively interact move sample motor (3a) and move belt transect wheel (3b), describedly move one end that sample motor (3a) is arranged on described instrument stand (8) top, the described belt transect that moves takes turns the other end that (3b) is arranged on described instrument stand (8) top, the described output terminal moving sample motor (3a) is taken turns (3b) by moving sample belt (3c) be in transmission connection with the described belt transect that moves, the described sample belt (3c) that moves is fixedly connected with described acupuncture treatment pedestal (2a), described acupuncture treatment pedestal (2a) is provided with linear bearing (3d), described instrument stand (8) upper level is provided with the linear guide (3e) matched with described linear bearing (3d), described linear bearing (3d) is sleeved on described linear guide (3e), described acupuncture treatment pedestal (2a) is also provided with accurate guide support slide block (3f), described instrument stand (8) top is also horizontally installed with the accurate line slide rail (3g) matched with described accurate guide support slide block (3f), described accurate guide support slide block (3f) is slidably mounted on described accurate line slide rail (3g).
24. full-automatic immune quantitative analysers as claimed in claim 1, it is characterized in that: described fluid path control gear (7) comprises wash liquor vessel (7a), sampling pump (7c), sampling valve (7d), wash pin pump (7e) and waste fluid container (7f), described wash liquor vessel (7a) is communicated with the input port of described sampling pump (7c), the delivery outlet of described sampling pump (7c) is communicated with described sampling needle (2b) by described sampling valve (7d), described wash liquor vessel (7a) is also communicated with the described input port washing pin pump (7e), the described delivery outlet washing pin pump (7e) is communicated with the input port of described Xi Zhen mechanism (6), the delivery outlet of described Xi Zhen mechanism (6) is communicated with described waste fluid container (7f).
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