CN109715653A - 肿瘤浸润调节性t细胞中被选择性地去调节的标志物 - Google Patents

肿瘤浸润调节性t细胞中被选择性地去调节的标志物 Download PDF

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CN109715653A
CN109715653A CN201780043484.XA CN201780043484A CN109715653A CN 109715653 A CN109715653 A CN 109715653A CN 201780043484 A CN201780043484 A CN 201780043484A CN 109715653 A CN109715653 A CN 109715653A
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seq
cell
tumour
marker
tumor
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塞尔吉奥·阿布里尼亚尼
马西米利亚诺·帕加尼
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Chico Maibo LLC
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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CN201780043484.XA 2016-05-16 2017-05-15 肿瘤浸润调节性t细胞中被选择性地去调节的标志物 Pending CN109715653A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP16169791.7 2016-05-16
EP16169791 2016-05-16
EP16198724.3 2016-11-14
EP16198724 2016-11-14
PCT/EP2017/061642 WO2017198631A1 (en) 2016-05-16 2017-05-15 Markers selectively deregulated in tumor-infiltrating regulatory t cells

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CN109715653A true CN109715653A (zh) 2019-05-03

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US (3) US20190391152A1 (https=)
EP (2) EP4092045A1 (https=)
JP (3) JP7358047B2 (https=)
KR (1) KR102623927B1 (https=)
CN (1) CN109715653A (https=)
AU (1) AU2017266686B2 (https=)
ES (1) ES2922525T3 (https=)
MX (2) MX395142B (https=)
WO (1) WO2017198631A1 (https=)

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CN114381528A (zh) * 2022-02-14 2022-04-22 天津市泌尿外科研究所 Mettl7a基因及其表达产物在诊断和治疗肿瘤中的用途
CN116496417A (zh) * 2023-06-27 2023-07-28 北京市肿瘤防治研究所 含有膜型il7的融合蛋白及t细胞

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ES2863412T3 (es) 2017-03-29 2021-10-11 Shionogi & Co Composición farmacéutica para el tratamiento del cáncer
JP2021534196A (ja) 2018-08-23 2021-12-09 シージェン インコーポレイテッド 抗ｔｉｇｉｔ抗体
US20220002370A1 (en) 2018-09-27 2022-01-06 Xilio Development, Inc. Masked cytokine polypeptides
IL263394A (en) * 2018-11-29 2020-05-31 Amit Ido Methods of activating dysfunctional immune cells and treatment of cancer
WO2020138489A1 (ja) * 2018-12-27 2020-07-02 塩野義製薬株式会社 新規抗ｃｃｒ８抗体
WO2020163876A1 (en) * 2019-02-08 2020-08-13 The Regents Of The University Of California Compositions and methods involving layilin
CN110187107A (zh) * 2019-04-26 2019-08-30 温州医科大学 一种基于肿瘤组织浸润免疫细胞特征建立的结直肠癌预后评估装置及方法
KR20220154126A (ko) * 2020-02-20 2022-11-21 엥스띠뛰 퀴리 기능성 질병 특이적 조절 t 세포를 식별하는 방법
US20230097988A1 (en) * 2020-02-26 2023-03-30 Pam Theragnostics Gmbh Methods for determining peptidylglycine alpha-amidating monooxygenase (pam) and its use for diagnostic purpose
JP7771076B2 (ja) * 2020-04-01 2025-11-17 エクシリオ デベロップメント， インコーポレイテッド マスクされたｉｌ－１２サイトカイン及びその切断産物
TW202216771A (zh) 2020-06-26 2022-05-01 德商拜耳廠股份有限公司 用於治療應用之ccr8抗體
CN113933508A (zh) * 2020-07-13 2022-01-14 上海吉凯基因医学科技股份有限公司 人batf基因的用途及相关产品
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
WO2022115865A2 (en) 2020-11-25 2022-06-02 Xilio Development, Inc. Tumor-specific cleavable linkers
US12240910B2 (en) 2021-07-14 2025-03-04 Genentech, Inc. Anti-C-C motif chemokine receptor 8 (CCR8) antibodies and methods of use
FI4214240T3 (fi) 2021-07-27 2024-11-14 Abbvie Inc Ccr8-vasta-aineita
KR102492241B1 (ko) * 2022-02-25 2023-01-30 전남대학교산학협력단 Kitenin의 이량체 형성을 저해하는 펩타이드 및 이의 용도
WO2024151091A1 (ko) * 2023-01-11 2024-07-18 한국과학기술원 종양 내 treg의 바이오마커를 포함하는 진단용 조성물 및 약학 조성물
CN117079710B (zh) * 2023-08-18 2024-05-31 上海爱谱蒂康生物科技有限公司 生物标志物及其在预测和/或诊断utuc肌肉浸润中的应用
CN117587014B (zh) * 2023-11-24 2025-01-24 上海恩凯细胞技术有限公司 多功能基因修饰载体及其制备的多功能基因修饰免疫细胞和它们的应用
TW202540200A (zh) 2023-12-01 2025-10-16 美商基利科學股份有限公司 抗ｆａｐ－ｌｉｇｈｔ融合蛋白及其用途
WO2025145207A1 (en) 2023-12-29 2025-07-03 Bristol-Myers Squibb Company Combination therapy of kras inhibitor and treg-depleting agent
CN117625792B (zh) * 2024-01-23 2024-04-16 杭州华得森生物技术有限公司 用于胃癌诊断和预后判断的生物标志物及其应用
CN118064595B (zh) * 2024-04-17 2024-08-02 中山大学附属第六医院 一种预测结直肠癌肝转移的生物标志物及其应用
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