JP7358047B2 - 腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー - Google Patents

腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー Download PDF

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JP7358047B2
JP7358047B2 JP2018560847A JP2018560847A JP7358047B2 JP 7358047 B2 JP7358047 B2 JP 7358047B2 JP 2018560847 A JP2018560847 A JP 2018560847A JP 2018560847 A JP2018560847 A JP 2018560847A JP 7358047 B2 JP7358047 B2 JP 7358047B2
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アブリグナニ，セルジオ
パガーニ，マッシミリアーノ
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チェックマブ エス．アール．エル．
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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JP2018560847A 2016-05-16 2017-05-15 腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー Active JP7358047B2 (ja)

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JP2023096086A JP2023113918A (ja) 2016-05-16 2023-06-12 腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー
JP2025132766A JP2025172069A (ja) 2016-05-16 2025-08-07 腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー

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EP16169791.7 2016-05-16
EP16169791 2016-05-16
EP16198724.3 2016-11-14
EP16198724 2016-11-14
PCT/EP2017/061642 WO2017198631A1 (en) 2016-05-16 2017-05-15 Markers selectively deregulated in tumor-infiltrating regulatory t cells

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JP2019518452A JP2019518452A (ja) 2019-07-04
JP2019518452A5 JP2019518452A5 (https=) 2020-06-25
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JP2023096086A Pending JP2023113918A (ja) 2016-05-16 2023-06-12 腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー
JP2025132766A Pending JP2025172069A (ja) 2016-05-16 2025-08-07 腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー

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JP2025132766A Pending JP2025172069A (ja) 2016-05-16 2025-08-07 腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー

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US (3) US20190391152A1 (https=)
EP (2) EP4092045A1 (https=)
JP (3) JP7358047B2 (https=)
KR (1) KR102623927B1 (https=)
CN (1) CN109715653A (https=)
AU (1) AU2017266686B2 (https=)
ES (1) ES2922525T3 (https=)
MX (2) MX395142B (https=)
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KR102492241B1 (ko) * 2022-02-25 2023-01-30 전남대학교산학협력단 Kitenin의 이량체 형성을 저해하는 펩타이드 및 이의 용도
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CN116496417B (zh) * 2023-06-27 2023-10-10 北京市肿瘤防治研究所 含有膜型il7的融合蛋白及t细胞
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CN117587014B (zh) * 2023-11-24 2025-01-24 上海恩凯细胞技术有限公司 多功能基因修饰载体及其制备的多功能基因修饰免疫细胞和它们的应用
TW202540200A (zh) 2023-12-01 2025-10-16 美商基利科學股份有限公司 抗ｆａｐ－ｌｉｇｈｔ融合蛋白及其用途
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