CN109641891B - 新化合物和方法 - Google Patents

新化合物和方法 Download PDF

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Publication number
CN109641891B
CN109641891B CN201780046788.1A CN201780046788A CN109641891B CN 109641891 B CN109641891 B CN 109641891B CN 201780046788 A CN201780046788 A CN 201780046788A CN 109641891 B CN109641891 B CN 109641891B
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compound
formula
reaction
solvent
carbonate
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Chinese (zh)
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CN109641891A (zh
Inventor
彼得·莱昂内尔·斯帕戈
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Verona Pharma Ltd
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Verona Pharma Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN201780046788.1A 2016-07-28 2017-07-27 新化合物和方法 Active CN109641891B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1613054.4A GB201613054D0 (en) 2016-07-28 2016-07-28 New compound and process
GB1613054.4 2016-07-28
PCT/GB2017/052190 WO2018020249A1 (en) 2016-07-28 2017-07-27 New compound and process

Publications (2)

Publication Number Publication Date
CN109641891A CN109641891A (zh) 2019-04-16
CN109641891B true CN109641891B (zh) 2021-05-04

Family

ID=56936838

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CN201780046788.1A Active CN109641891B (zh) 2016-07-28 2017-07-27 新化合物和方法

Country Status (19)

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US (1) US10710998B2 (https=)
EP (1) EP3490988B1 (https=)
JP (1) JP6985367B2 (https=)
KR (1) KR102396059B1 (https=)
CN (1) CN109641891B (https=)
CY (1) CY1122138T1 (https=)
DK (1) DK3490988T3 (https=)
ES (1) ES2751948T3 (https=)
GB (1) GB201613054D0 (https=)
HR (1) HRP20192109T1 (https=)
HU (1) HUE046509T2 (https=)
LT (1) LT3490988T (https=)
PL (1) PL3490988T3 (https=)
PT (1) PT3490988T (https=)
RS (1) RS59566B1 (https=)
SI (1) SI3490988T1 (https=)
SM (1) SMT201900582T1 (https=)
TW (1) TWI739871B (https=)
WO (1) WO2018020249A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3142701T3 (en) 2014-05-12 2018-08-13 Verona Pharma Plc New treatment
GB201502260D0 (en) 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
PT4090654T (pt) * 2020-01-17 2025-10-07 Lupin Ltd Métodos, processos e intermediários para a preparação de compostos de cromano
CN116917287A (zh) 2021-04-29 2023-10-20 苏州盛迪亚生物医药有限公司 异喹啉酮类化合物及其用途
JP2024545189A (ja) * 2021-12-14 2024-12-05 シーツァン ハイスコ ファーマスーティカル カンパニー リミテッド 三環式縮合複素環系ｐｄｅ３／４二重阻害剤及びその用途
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
EP4378942A1 (en) 2022-12-02 2024-06-05 Sandoz AG Crystal form of a pde3/4 inhibitor
WO2025003643A1 (en) 2023-06-26 2025-01-02 Verona Pharma Plc Particulate composition comprising ensifetrine
CN121620356A (zh) 2023-06-26 2026-03-06 维罗纳制药公司 包含恩塞芬汀的颗粒组合物
US20250073240A1 (en) 2023-09-06 2025-03-06 Verona Pharma Plc New treatment
US20250249007A1 (en) 2024-02-07 2025-08-07 Verona Pharma Plc Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease
WO2025168708A1 (en) 2024-02-07 2025-08-14 Verona Pharma Plc Pharmaceutical compositions of ensifentrine for chronic obstructive pulmonary disease
WO2025176871A1 (en) 2024-02-23 2025-08-28 Inke, S.A. Process for preparing pyrimido[6,1-a]isoquinoline-4-ones

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1348453A (zh) * 1999-03-31 2002-05-08 韦尔纳利斯有限公司 嘧啶并[6,1－a] 异喹啉－4－酮衍生物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ185900A (en) 1976-12-10 1981-04-24 Hoechst Ag Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines
FI64370C (fi) 1977-05-05 1983-11-10 Hoechst Ag Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
DE3135831A1 (de) 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1237429A (en) 1983-05-05 1988-05-31 Frank Kienzle Pyrimidone derivatives
PH12013500261A1 (en) 2010-08-09 2013-03-04 Verona Pharma Plc Crystalline form of pyrimidio[6,1-a]isoquinolin-4-one compound
EP2968313B1 (en) 2013-03-15 2018-01-31 Verona Pharma PLC Drug combination
DK3142701T3 (en) 2014-05-12 2018-08-13 Verona Pharma Plc New treatment
CN110051627A (zh) 2014-09-15 2019-07-26 维罗纳制药公司 包含rpl554的液体吸入制剂
GB201502260D0 (en) 2015-02-11 2015-04-01 Verona Pharma Plc Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1348453A (zh) * 1999-03-31 2002-05-08 韦尔纳利斯有限公司 嘧啶并[6,1－a] 异喹啉－4－酮衍生物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Trequinsin, a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones;BANSI LAL ET AL,;《JOURNAL OF MEDICINAL CHEMISTRY》;19841231;第27卷(第11期);1470-1480 *

Also Published As

Publication number Publication date
SMT201900582T1 (it) 2019-11-13
CY1122138T1 (el) 2020-11-25
JP2019527228A (ja) 2019-09-26
TWI739871B (zh) 2021-09-21
SI3490988T1 (sl) 2019-11-29
KR20190034231A (ko) 2019-04-01
PL3490988T3 (pl) 2020-02-28
EP3490988A1 (en) 2019-06-05
US10710998B2 (en) 2020-07-14
HRP20192109T1 (hr) 2020-02-21
US20190330206A1 (en) 2019-10-31
HUE046509T2 (hu) 2020-03-30
JP6985367B2 (ja) 2021-12-22
DK3490988T3 (da) 2019-10-28
GB201613054D0 (en) 2016-09-14
KR102396059B1 (ko) 2022-05-10
WO2018020249A1 (en) 2018-02-01
RS59566B1 (sr) 2019-12-31
EP3490988B1 (en) 2019-08-28
LT3490988T (lt) 2019-10-10
PT3490988T (pt) 2019-10-28
CN109641891A (zh) 2019-04-16
ES2751948T3 (es) 2020-04-02
TW201806951A (zh) 2018-03-01

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