CN109620748A - A kind of anti-wrinkle essence and preparation method thereof - Google Patents

Abstract

The present invention discloses a kind of anti-wrinkle essence and preparation method thereof, raw material including following mass percent: combination extracting solution 5-15%, active factors 12-22%, propylene glycol 0.5-1.3%, butanediol 0.3-1.2%, diglycerol 0.7-1.5%, acetyl chitosamine 0.2-0.8%, glycine betaine 0.5-1.5%, carbomer 0.3-1.1%, glycerol 0.6-2.3%, ammonium acryloyl taurate/VP copolymer 0.6-3.2%, hydroxyethyl cellulose 0.5-2.3%, Sodium Hyaluronate 0.4-3.2%, niacinamide 0.3-2.1%, panthenol 0.2-1.5%, dipropylene glycol 1.2-8.5%, -20 0.5-2.3% of polysorbate, EDETATE SODIUM 0.6 - 1.2%, dipotassium glycyrrhizinate 0.5-1.2%, 1,2- hexylene glycol 0.3-1.2%, remaining component is deionized water, by the way that active factors and combination extracting solution are prepared into nano-solution, nano-solution is wrapped up with gel with liquid crystal structure system, so that human body is easier to absorb, while nano-solution can be prevented to be oxidized, the slow-releasing system of gel with liquid crystal structure is easier to promote absorption of human body, enhances anti-wrinkle effect.

Description

A kind of anti-wrinkle essence and preparation method thereof

Technical field

The invention belongs to cosmetic fields, and in particular to a kind of anti-wrinkle essence and preparation method thereof.

Background technique

Puberty is people's most pretty beautiful period in life, at this time skin slip, gloss, plentiful, high resilience, Bai Li It is thoroughly red.To after 25 years old, metabolism starts to slow down, and moisture and subcutaneous fat are reduced, and elastomer is gradually thicker, and skin becomes Wrinkle, gloss subside.After 40 years old, hormone in vivo dysequilibrium, keratin reduce, elastic fibers break, cutis laxa, it is coarse, Wrinkle increases, and progresses into aging period.Skin aging is the outstanding behaviours of entire body aging, and wherein facial skin aging is especially Obviously, fibroblastic quantity gradually decreases in human body, and the collagen and elastic fibers albumen of secretion are also because by oxygen Change gradually decrease, be broken, just disappear to the supporting role of epidermis, cause it is inhomogenous collapse, skin corium starts thinning, skin bullet Property be deteriorated, wrinkle also starts gradually to generate, and wrinkle is one of mark of skin aging, is since human body is by endogenous and outer After the influence of source sexual factor, lead to the variation of skin support tissue and skin texture, causes the forfeiture of skin moisturizing ability, elastic force Thus the variation that fiber and collagen put in order leads to the mechanical force and flexibility decrease of skin, recess is formed, to form wrinkle Line.

The mechanism that wrinkle generates is sufficiently complex, one of them is exactly that cell caused by each factor including ultraviolet light damages Wound and by the increased Apoptosis of the damage, protease such as matrix metalloproteinase (matrix metalloprotease, MMPs) fibre bundle watt caused by the hydrolysis of fibre composition such as collagen and the increase of cell factor caused by the increase expressed Solution.Wherein MMPs plays critical effect in this process, and it with multiple functions, such as degradation is by collagen, egg The protein etc. that the extracellular matrix of the formation such as white polysaccharide, elastin laminin and degradation are expressed on cell surface.And these are degraded Effect leads to the reduction and denaturation of extracellular matrix, is the key factor that skin forms wrinkle, relaxation etc..In addition, due to inflammation The inflammatory cytokines such as TNF-α, IL-1 and the IL-6 for causing cell to generate can lead to wrinkle of skin by the generation of induction MMPs With loose formation.

Skin aging by objective factors such as age, heredity other than being influenced, also by many factors such as daylight, environment, health It influences.Excessive solarization is exposed to the sun, and is not only speeded up skin aging, is also also easy to produce pigmented spots；Seriously polluted environment is lived in for a long time In or excessive contact to the harmful chemical substance of skin, can all make skin damage, accelerated ageing；Malnutrition, lassitude, disease Disease is burdened with, and skin is easier to premature aging.Especially modern life pressure is big, overtime work stays up late, for a long time to computer, smoke, sleep Sleep it is insufficient, stay in air-conditioned room for a long time, drink, excess eye-using etc. becomes life normality.According to the beautiful scientific center of Dior Christian Dior U.S. Research, daily, each layer of skin can accumulate the largely cellular elements toxin as caused by inherent or external factor, and it is thin to will lead to skin Born of the same parents' asphyxia, and the toxin Scavenging activity of skin itself is affected, to just produce, the colour of skin is obscure, lack gloss, tired state is showed fully Etc. worries；The burden of skin has been aggravated, skin aging is accelerated.

Although skin aging is irreversible physiological phenomenon, its process can delay or slow down.For face wrinkles, Common anti-wrinkle method is operation smoothing wrinkle, injection anti-wrinkle and anti-wrinkle cosmetic.The treatment cost height of smoothing wrinkle of performing the operation and injection anti-wrinkle, Risk is big, is not that each consumer can bear, and anti-wrinkle cosmetic is a selection well.Anti-wrinkle cosmetic is again Be divided into anti-wrinkle face mask, mildy wash, crease-resistant toner, face cream, Essence etc. are a variety of, anti-wrinkle face mask, mildy wash face stop Time is short, and effect is unobvious, needs to be used for a long time, and use process is also inconvenient；Active constituent in crease-resistant toner, face cream Content is relatively low, and anti-wrinkle effect is also unobvious, and nutriment and active constituent that Essence contains are compared with toner, face cream Want high more, effect is powerful, and anti-wrinkle effect is significant, and anti-wrinkle product currently on the market is mainly for moisturizing and anti-freedom Base has a single function, cannot take into account wrinkle generation composite factor, and it is easy to oxidize lose effect, good crease-resistant effect is not achieved Fruit.

Such as application No. is the patent of CN201510731589.7 disclose it is a kind of have effects that the Essence of skin wrinkle resisting, It is characterized in that: being made of following parts by weight of component: functional component: 0.01~20 part of cyperus alternifolius extract, Roselle flower extract 0.01~20 part, 0.001~10 part of gumbo extract, fuller olefinic carbon 60 .0001~10 part, 0.1~20 part of micromolecule hyaluronic acid； Carrier: 0.1~10 part of 1,3-BDO, 1~10 part of glycerol, 0.05~0.5 part of Phenoxyethanol, 60~90 parts of deionized water.Its The a variety of mechanism generated for wrinkle of skin are compounded, and are innovated to compounding ingredient, are obtained with synergistic function Formula combination, although its crease-resistant factor for having taken into account various aspects makes it can not since functional component is oxidized easily Preferably enter skin corium, reaches the crease-resistant of profound level, can only largely be absorbed by skin surface, so that crease-resistant effect Fruit substantially reduces.

Summary of the invention

In response to the problems existing in the prior art, the purpose of the present invention is to provide a kind of anti-wrinkle essences and preparation method thereof.

To achieve the above object, the technical solution adopted by the present invention is that:

A kind of anti-wrinkle essence, the raw material including following mass percent: combination extracting solution 5-15%, active factors 12- 22%, propylene glycol 0.5-1.3%, butanediol 0.3-1.2%, diglycerol 0.7-1.5%, acetyl chitosamine 0.2-0.8%, beet Alkali 0.5-1.5%, carbomer 0.3-1.1%, glycerol 0.6-2.3%, ammonium acryloyl taurate/VP copolymer 0.6- 3.2%, hydroxyethyl cellulose 0.5-2.3%, Sodium Hyaluronate 0.4-3.2%, niacinamide 0.3-2.1%, panthenol 0.2- 1.5%, dipropylene glycol 1.2-8.5%, -20 0.5-2.3% of polysorbate, EDETATE SODIUM 0.6-1.2%, dipotassium glycyrrhizinate 0.5-1.2%, 1,2- hexylene glycol 0.3-1.2%, remaining component are deionized water.

Further, the combination extracting solution includes that the centella asiatica extract that is added of equivalent, chlorella extract, light fruit are sweet Grass roots extracting solution, Selaginella tamariscina extracting solution and white willow bark extracting solution.

Further, the centella asiatica extract, chlorella extract, glycyrrhiza glabra root extracting solution, Selaginella tamariscina extracting solution and The preparation process of white willow bark extracting solution: centella, chlorella, glycyrrhiza glabra root, Selaginella tamariscina, white willow bark are subjected to boiling water respectively Simultaneously cold water is cooling for sterilization processing, the boiling 1-2h that is added to the water is shredded after cooling treatment, under conditions of 12-16KHz, 21-31W Concentration is evaporated in vacuo in ultrasonic-leaching at 60-80 DEG C after extraction.

Further, the active factors include the Argireline being added by 1:1:1:1:1-5 mass percent, second Acyl group octapeptide -3, palmityl tripeptides -1, palmityl tetrapeptide -7 and dipeptides diaminobutyryl benzyl amide diacetin.

Further, a kind of preparation method of anti-wrinkle essence, comprising the following steps:

(1) by propylene glycol, butanediol, diglycerol, glycerol, panthenol, dipropylene glycol, 1,2- hexylene glycol and polysorbate- Be heated to 100 DEG C in 20 addition kettles, stir and evenly mix rear cooling water temperature to 70 DEG C, be added while stirring Sodium Hyaluronate, EDETATE SODIUM, dipotassium glycyrrhizinate stirring continue cool to 40 DEG C, acetyl chitosamine, glycine betaine, card wave are added up to being completely dissolved Nurse, ammonium acryloyl taurate/VP copolymer, hydroxyethyl cellulose, niacinamide heating melting are vortexed, and are sufficiently mixed It is even, it stands obtain gel with liquid crystal structure solution at room temperature；

(2) the combination extracting solution and active factors are mixed to join in deionized water and are stirred evenly, after ultrasonic disperse It carries out again high-pressure homogeneous, obtains nano-solution；

(3) nano-solution obtained in gel with liquid crystal structure solution obtained in step (1) and step (2) is mixed and heated to 30 DEG C, it is slowly stirred and uniformly obtains anti-wrinkle essence.

Further, the power of ultrasonic disperse is 750-1000W, ultrasonic time 25-50min, homogeneous in the step (2) Pressure 800-1300bar, cycle-index are 3-10 times.

Argireline: competition SNAP-25 is participated in the site for melting bubble complex, to influence the formation of complex. When melting, bubble complex is slightly unstable, and vesica cannot be released effectively neurotransmitter, so that contraction of muscle be caused to weaken, prevent wrinkle Formation.

Acetyl group octapeptide -3: can effectively prevent catecholamine excessively to discharge, and reduction is shunk by facial expression muscle and generated And the wrinkle generated.

Palmityl tripeptides -1: can largely promote the generation of collagen, substantially reduce face wrinkle, enhance face elasticity, Promote cell activity, improve skin water content, improves the colour of skin.

Palmityl tetrapeptide -7: have effects that the draining of strength, excessive moisture is discharged rapidly, effectively beat back skin facial edema Edema can also accelerate eye circumference skin cell to activate while tightening eye skin, accelerate metabolism Vitamin K, resist eye Skin relaxation, so that the smoothly solid high resilience of eye circumference skin.

Dipeptides diaminobutyryl benzyl amide diacetin: can reduce the generation of wrinkle by inhibition contraction of muscle, With outstanding smooth and rapid anti-wrinkle performance.

By by propylene glycol, butanediol, diglycerol, glycerol, panthenol, dipropylene glycol, 1,2- hexylene glycol and polysorbate- 20, Sodium Hyaluronate, EDETATE SODIUM, dipotassium glycyrrhizinate, acetyl chitosamine, glycine betaine, carbomer, acryloyldimethyl taurine Ammonium/VP copolymer hydroxyethyl cellulose, niacinamide heating melting, is vortexed, is sufficiently mixed uniformly, prepares liquid crystal gel solution, will Combination extracting solution and active factors carry out ultrasonic disperse and prepare nano-solution, and gel with liquid crystal structure solution and nano-solution are mixed, made It obtains nano-solution to be wrapped in liquid crystal gel, and the biological compatibility of liquid crystal gel is preferable, is convenient for absorption of human body, receives simultaneously Rice solution, which is wrapped in liquid crystal gel, to be not easy to be aoxidized by the external world, so that effect is more longlasting；Argireline, acetyl group eight Peptide -3, dipeptides diaminobutyryl benzyl amide diacetin inhibit to reduce the generation that contraction of muscle reduces wrinkle, while dipeptides two The further wrinkle reduction of aminobutyryl benzyl amide diacetin, improves the smoothness of skin, so that anti-wrinkle effect is more preferable, palm Acyl tripeptides -1 promotes the generation of collagen, promotes cell activity, improves skin water content, the discharge rapidly of palmityl tetrapeptide -7 Extra moisture beats back skin facial edema edema, and each other by synergistic effect, so that anti-wrinkle effect greatly enhances.

Centella asiatica extract can promote blood circulation, and promote the generation of collagen, at the same to ultraviolet light irradiation after After-sun recovery have remarkable result, and enzyme type and non-enzyme type polyphenoils discrimination in newly-generated tissue can be improved in Gotu Kola P.E Change the content of enzyme, hydrogen peroxide, Agifutol peroxidase, vitamin C and ascorbic acid usp/bp, while centella is extracted The bioactive substance that liquid contains can inhibit and remove free radical to the oxidative damage of skin；Chlorella extract can play Toxin expelling, function that is anti-oxidant, repairing damaged cell；The deep enough skin inside of glycyrrhiza glabra root extracting solution energy simultaneously keeps high activity, The effect of capable of preventing pachylosis and anti-inflammatory, antibacterial；Selaginella tamariscina extracting solution is able to suppress the release of inflammatory factor, has anti-inflammatory anti-ageing Old effect.

Compared with prior art, the beneficial effects of the present invention are:

1, subtracted using Argireline, acetyl group octapeptide -3, the inhibition of dipeptides diaminobutyryl benzyl amide diacetin Few contraction of muscle reduces the generation of wrinkle, and palmityl tripeptides -1 promote the generation of collagen, promote cell activity, improves skin Extra moisture is discharged rapidly in water content, palmityl tetrapeptide -7, beats back skin facial edema edema, and pass through association each other Same-action, so that anti-wrinkle effect greatly enhances.

2, pass through centella asiatica extract, chlorella extract, glycyrrhiza glabra root extracting solution, Selaginella tamariscina extracting solution and white willow bark Synergistic effect between extracting solution carrys out replenishing collagen, removes and inhibits free radical to the oxidative damage of skin, plays simultaneously The effect of anti-inflammatory, antibacterial.

3, it is prepared into nano-solution by the way that extracting solution and active factors will be combined, while is wrapped up using liquid crystal gel, liquid The biological compatibility of brilliant gelinite is preferable, can promote absorption of human body, while playing the role of slow release active factors, one Determine to avoid active factors in degree by external world's oxidation, enhances anti-wrinkle effect.

Specific embodiment

Below in conjunction with the embodiment in the present invention, technical solution of the present invention is clearly and completely described, is shown So, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based on the reality in the present invention Example is applied, those of ordinary skill in the art's all other embodiment obtained under the conditions of not making creative work all belongs to In the scope of protection of the invention.

Re-surface intensive wrinkle correct formula of liquid in embodiment 1-5 is shown in Table one:

Table one: each group test recipe

The preparation method is as follows:

(1) by propylene glycol, butanediol, diglycerol, glycerol, panthenol, dipropylene glycol, 1,2- hexylene glycol and polysorbate- Be heated to 100 DEG C in 20 addition kettles, stir and evenly mix rear cooling water temperature to 70 DEG C, be added while stirring Sodium Hyaluronate, EDETATE SODIUM, dipotassium glycyrrhizinate stirring continue cool to 40 DEG C, acetyl chitosamine, glycine betaine, card wave are added up to being completely dissolved Nurse, ammonium acryloyl taurate/VP copolymer, hydroxyethyl cellulose, niacinamide heating melting are vortexed, and are sufficiently mixed It is even, it stands obtain gel with liquid crystal structure solution at room temperature；

(2) the combination extracting solution and active factors are mixed to join in deionized water and are stirred evenly, after ultrasonic disperse It carries out again high-pressure homogeneous, obtains nano-solution, the power of ultrasonic disperse is 750-1000W, ultrasonic time 25-50min, homogeneous pressure Power 800-1300bar, cycle-index are 3-10 times.

(3) nano-solution obtained in gel with liquid crystal structure solution obtained in step (1) and step (2) is mixed and heated to 30 DEG C, it is slowly stirred and uniformly obtains anti-wrinkle essence.

Wherein: centella asiatica extract, chlorella extract, glycyrrhiza glabra root extracting solution, Selaginella tamariscina extracting solution and white willow bark The preparation process of extracting solution: centella, chlorella, glycyrrhiza glabra root, Selaginella tamariscina, white willow bark are subjected to boiling water sterilization processing respectively And cold water is cooling, and the boiling 1-2h that is added to the water is shredded after cooling treatment, ultrasonic wave soaks under conditions of 12-16KHz, 21-31W It mentions, concentration is evaporated in vacuo after extraction at 60-80 DEG C.

Comparative example 1:

The difference from embodiment 1 is that Argireline, acetyl group octapeptide -3, other preparation conditions and method are not added It is same as Example 1.

Comparative example 2:

The difference from embodiment 1 is that palmityl tripeptides -1 are not added, other preparation conditions and method and 1 phase of embodiment Together.

Comparative example 3:

The difference from embodiment 1 is that combination extracting solution and the nanometer factor do not carry out ultrasonic disperse and high pressure after being stirred Homogeneous, other preparation conditions and method are same as Example 1.

Comparative example 4:

The difference from embodiment 1 is that each component of step (1) is only that heating stirring dissolves to form mixed liquor, other systems Standby condition and method are same as Example 1.

Efficacy validation:

The evaluation of atraumatic human body is carried out to anti-wrinkle essence prepared by embodiment 1-5 and comparative example 1-5, test object: Each group is 20 women (35-45 years old), and test zone: crows feet area uses: it is secondary daily, continue one month；Test refers to Mark: the soft degree of skin, wrinkle depth, result on trial such as table two:

Table two: test result

Thus table results are it is found that Argireline, acetyl group octapeptide -3 and dipeptides diaminobutyryl benzyl amide two There is synergistic function between acetate, there is synergistic effect, while liquid between palmityl tripeptides -1 and palmityl tetrapeptide -7 Brilliant gel rubber system anti-wrinkle effect does not use the Essence of gel with liquid crystal structure system good than, and active factors are prepared into nano-solution and are obtained To the anti-wrinkle effect of Essence be also better than and be not prepared into the Essence of nano-solution.

It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (6)

1. a kind of anti-wrinkle essence, which is characterized in that the raw material including following mass percent: combination extracting solution 5-15%, work Sex factor 12-22%, propylene glycol 0.5-1.3%, butanediol 0.3-1.2%, diglycerol 0.7-1.5%, acetyl chitosamine 0.2- 0.8%, glycine betaine 0.5-1.5%, carbomer 0.3-1.1%, glycerol 0.6-2.3%, ammonium acryloyldime-thyltaurate/VP are total Polymers 0.6-3.2%, hydroxyethyl cellulose 0.5-2.3%, Sodium Hyaluronate 0.4-3.2%, niacinamide 0.3-2.1%, panthenol 0.2-1.5%, dipropylene glycol 1.2-8.5%, -20 0.5-2.3% of polysorbate, EDETATE SODIUM 0.6-1.2%, glycyrrhizic acid Dipotassium 0.5-1.2%, 1,2- hexylene glycol 0.3-1.2%, remaining component are deionized water.

2. a kind of anti-wrinkle essence as described in claim 1, which is characterized in that the combination extracting solution includes what equivalent was added Centella asiatica extract, chlorella extract, glycyrrhiza glabra root extracting solution, Selaginella tamariscina extracting solution and white willow bark extracting solution.

3. a kind of anti-wrinkle essence as claimed in claim 2, which is characterized in that the centella asiatica extract, chlorella are extracted The preparation process of liquid, glycyrrhiza glabra root extracting solution, Selaginella tamariscina extracting solution and white willow bark extracting solution: respectively by centella, chlorella, Glycyrrhiza glabra root, Selaginella tamariscina, white willow bark carry out boiling water sterilization processing and cold water is cooling, and the steaming that is added to the water is shredded after cooling treatment 1-2h is boiled, concentration is evaporated in vacuo in ultrasonic-leaching under conditions of 12-16KHz, 21-31W at 60-80 DEG C after extraction.

4. a kind of anti-wrinkle essence as described in claim 1, which is characterized in that the active factors include pressing 1:1:1:1:1- Argireline, acetyl group octapeptide -3, palmityl tripeptides -1, palmityl tetrapeptide -7 and the dipeptides two that 5 mass percents are added Aminobutyryl benzyl amide diacetin.

5. a kind of preparation method of anti-wrinkle essence, which comprises the following steps:

(1) propylene glycol, butanediol, diglycerol, glycerol, panthenol, dipropylene glycol, 1,2- hexylene glycol and polysorbate -20 are added Enter and be heated to 100 DEG C in kettle, stirs and evenly mixs rear cooling water temperature to 70 DEG C, Sodium Hyaluronate, EDTA bis- are added while stirring Sodium, dipotassium glycyrrhizinate stirring continue cool to 40 DEG C, acetyl chitosamine, glycine betaine, carbomer, third are added up to being completely dissolved Alkene acyl dimethyltaurine ammonium/VP copolymer, hydroxyethyl cellulose, niacinamide heating melting are vortexed, and are sufficiently mixed uniformly, room Lower stand of temperature obtains gel with liquid crystal structure solution；

(2) the combination extracting solution and active factors are mixed to join in deionized water and are stirred evenly, after ultrasonic disperse again into Horizontal high voltage homogeneous, obtains nano-solution；

(3) nano-solution obtained in gel with liquid crystal structure solution obtained in step (1) and step (2) is mixed and heated to 30 DEG C, It is slowly stirred and uniformly obtains anti-wrinkle essence.

6. a kind of preparation method of anti-wrinkle essence as claimed in claim 5, which is characterized in that ultrasonic in the step (2) The power of dispersion is 750-1000W, ultrasonic time 25-50min, homogenization pressure 800-1300bar, and cycle-index is 3-10 times.