CN103006512B - Hirudin anti-winkle face-softening conditioning cream and production process thereof - Google Patents
Hirudin anti-winkle face-softening conditioning cream and production process thereof Download PDFInfo
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Abstract
The invention belongs to the field of cosmetics and particularly relates to hirudin anti-winkle face-softening conditioning cream and a production process thereof. The conditioning cream is prepared by oil phase raw materials such as squalane, hexadecyl alcohol/hexadecyl glucoside, jojoba oil, glyceryl monostearate/PEG (polyethylene glycol)-100 stearate and dimethyl silicon oil, and water phase raw materials such as hirudin, oat polypeptide, oat beta-glucan, D panthenol, collagen polypeptide, a saffron crocus extracting solution and a ginseng extract. The production process comprises the steps of heating, sterilization, stirring, dissolving, emulsifying, homogenizing, cooling, discharging, sampling, detecting, filling, and packaging to obtain the conditioning cream. The conditioning cream can directly permeate into a corium layer of skin autonomously, can be easily absorbed by the skin, can solve the problems such as presenility of the skin and wrinkles of eyes caused by unsmooth blood circulation, is very good in wrinkle-removing effect, improves facial microcirculation, and has a function of improving the skin quality; as multiple moisture-keeping, skin-moisturizing and oxidation-resisting raw materials are added, the conditioning cream has very good whitening and nourishing effects; and the production process is simple and easy to operate.
Description
Technical field
The invention belongs to cosmetic field, specifically the crease-resistant soft face conditioning frost of a kind of hirudin and production technology thereof.
Background technology
Scientific research shows: human skin cell can only absorb the daltonian material in molecular weight≤8000 under normal circumstances.Natural materials in the cosmetics of selling on market is as hyaluronic acid, SOD and collagen protein etc., its molecular weight is mostly several ten thousand hundreds of thousands dalton even, thereby be difficult to by the fully effective absorption of skin the deep layer that all needs the assosting effect that relies on other permeation-promoter to penetrate to the skin.
Natural hirudin (Hirudin) is a kind of material of Hirudo salivary gland secretion, and the single chain polypeptide being made up of 65～66 amino acid residues, containing arginine, methionine and tryptophan.Hirudin molecular weight is only 7000 dalton, does not need the auxiliary deep layer that just can directly independently penetrate to the skin of other permeation-promoter, is easily absorbed by Skin Cell.Hirudin independently penetrates into facial blood capillary: reduce the blood viscosity of facial vessels, accelerate face blood flowing velocity, dredge facial blood capillary.Improve facial microcirculation, promoted to reduce cuticle thickness after skin of face metabolism, make cell obtain sufficient nutrient.Improve the self-repairing capability of cell, the growth of check melanin cell, disappear facial sunburn and pigmentation, make skin exquisiteness, fair and clear.Hirudin is a kind of polypeptides matter; Be by Amino acid profile but be different from the intermediate material of protein.It has the characteristic of protein, but simpler than protein, molecular weight is few, is easily absorbed by body.
Sun Zhiyong, Wang Gang etc. are in " experimentation of natural hirudin on the impact of pig random pattern skin flap venous congestion " (Chinese Reconstructive surgery magazine, 2008; 22,11), in, Chen Weihua etc. are in " control of topical application hirudin to Cure of Expanded Flap Venous Congestion " (Chinese practical drainer for plastic surgery magazine, 2005; 16,5) in, all mention, the generation of flap venous congestion is from human body blood coagulation mechanism, thrombin plays very important effect in wound process, hirudin is as the special effect inhibitor of thrombin, all multiactions that can Trombin inhibiting, and aggregate performance is for promoting congestion diffusion, can effectively prevent and treat Cure of Expanded Flap Venous Congestion by hirudin interventional therapy, alleviate the venous congestion after random pattern skin flap is transplanted.
Yuan Xiaohui, Wang Wanjie etc. are in " preliminary observation of preventive function of hirudin against proliferative viteoretinopathy " (Recent Advances in Ophthalmology, 2000; 20,4), in, Yang Ying, Zheng Yanlin etc. are in " impact that hirudin is grown up on the fibroblast of In vitro culture " (ophthalmology, 2004; 13,5) mention, by to injecting hirudin in the vitreous chamber of experimental external coat animal model, and set up external fibroblasts model etc., observe its turbidity and optical fundus propagation film formational situation, and the fibroblast growth situation of In vitro culture, conclusion is that hirudin can obviously suppress external fibroblastic growth and differentiation, to comprising that the position proliferative diseases such as eye, cornea, bulbar conjunctiva polyp are deformed into and have in early days good preventive effect, thereby can be used as the external raw material of the above-mentioned position for the treatment of proliferative lesion.
Li Xuan, Liu Daen etc. are in " hirudin suppresses the experimentation of in-vitro simulated scar model " (Chinese Chinese medicine magazine, 2009; 24,7) one the article pointed out, hypertrophic cicatrix is the common disease of burn plastic surgery, and fibroblast can cause at the abnormality proliferation of different tissue sites and the extracellular matrix excessive secretion causing the disease that various hypertrophy are abnormal.Experimental result shows, hirudin can produce to be suppressed to the functions such as fibrocellular propagation, secretion, contraction by reducing collagen, thereby suppresses generation and the development of hypertrophic cicatrix, thereby can be used for treating hypertrophic cicatrix class disease.And " structure observation of hirudin on proliferative vitreoretinopathy impact " (Chinese TCM Ophthalmology magazine, 2000; 01), " inhibitory action of hirudin to the Cultured Rabbit Smooth Muscle Cells of cultivating " (Chinese circulation magazine, 1996; 02, Zhou little Ming etc.), Ogichit, " Tissue factor and cancer procoagulantexpressed by gliom a cells participate in their throm binmediated proliferation " (Neurooncol, 2000 of Hirashima etc.; 46,1) experiment report etc. has also fully confirmed this point.
Natural hirudin energy and thrombin carry out specific binding, hinder the carrying out of coagulation process, from this angle, natural hirudin has anticoagulation, thrombus, antiinflammatory and reduction blood fat, reduces the effects such as blood viscosity, at present the research of natural hirudin is also concentrated on to this both at home and abroad, but be used for from improving tissue blood microcirculation, expansion local organization blood vessel etc., natural hirudin improving flap venous congestion, be suppressed to that fibrocyte is grown up and development, suppress and removing hypertrophic cicatrix and epidermis fat the aspect such as silt up and has good effect.
Conventional crease-resistant product is various at present, and effect is variant greatly, conventionally cannot improve skin metabolism, promotes cutaneous circulation, increase skin-nourishing, cannot fundamentally remove wrinkle and mottle that skin occurs.And most products are containing heavy metal, and safety and sequela be difficult prediction still, if improper use, may after cause the damage of skin.And natural hirudin is a kind of low molecular polypeptide, molecular weight is little, the auxiliary deep layer that just can directly independently penetrate to the skin that does not need other permeation-promoter, dredging blood capillary, reduces blood viscosity, accelerate blood flow rate, improve facial microcirculation, promoted to reduce cuticle thickness after skin of face metabolism, make cell obtain sufficient nutrient, the self-repairing capability that improves cell, fundamentally improves skin.So hirudin anti-wrinkle cosmetic be a kind ofly integrate anti-, control, the new type ideal skin care good product of adornment.
Summary of the invention
The object of this invention is to provide the crease-resistant soft face conditioning frost of a kind of hirudin, skin corium can independently directly penetrate to the skin, be easy to be absorbed by the skin, can solve the skin freely not causing due to blood and cross the problem such as presenility and eye wrinkle-removing, the effect of wrinkle removing stricture of vagina is very good, improve facial microcirculation, there is the effect that improves skin quality; The present invention also provides production technology, simple to operation.
The crease-resistant soft face conditioning frost of hirudin of the present invention, made by the raw material of following percentage by weight:
Oil phase raw material: squalane 4-6%, cetyl alcohol/cetyl glucoside 1-3%, Jojoba oil 2-4%, tristerin/PEG-100 stearate 2-4%, dimethicone 0.3-0.7%, caprylic/capric glyceride 0.5-1.5%, cetearyl alcohol 0.5-1.5%, Vitamin E acetate 0.5-1.5%, isopropyl myristate 0.5-1.5% and white oil 0.5-1.5%;
Water raw material: glycerol 4-6%, oat polypeptide 4-6%, avenabeta glucosan 2-4%, 1,3 propylene glycol 2-4%, chitosan 2-4%, D pantothenylol 0.5-1.5%, collagen protein polypeptide 0.5-1.5%, crocus sativus 0.5-1.5%, glycyrrhizic acid dipotassium 0.3-0.7%, Radix Ginseng extract 0.2-0.4%, diazolidinyl urea 0.2-0.4%, daily essence 0.1-0.2%, HV1-3% and deionized water 53.8-58.8%.
The crease-resistant soft face conditioning frost of hirudin is preferably made up of the raw material of following percentage by weight:
Oil phase raw material: squalane 5%, cetyl alcohol/cetyl glucoside 2%, Jojoba oil 3%, tristerin/PEG-100 stearate 3%, dimethicone 0.5%, caprylic/capric glyceride 1%, cetearyl alcohol 1%, Vitamin E acetate 1%, isopropyl myristate 1% and white oil 1%;
Water raw material: glycerol 5%, oat polypeptide 5%, avenabeta glucosan 3%, 1,3 propylene glycol 3%, chitosan 3%, D pantothenylol 1%, collagen protein polypeptide 1%, crocus sativus 1%, glycyrrhizic acid dipotassium 0.5%, Radix Ginseng extract 0.3%, diazolidinyl urea 0.3%, daily essence 0.1%, hirudin 2% and deionized water 56.3%.
Wherein the effect of each raw material is as follows:
Squalane: can suppress the peroxidating of skin lipid, can effectively infiltrate through skin, and promote the propagation of skin base cell, to delay skin aging, improving and eliminating chloasma all has obvious physiologic effect.
Cetyl alcohol/cetyl glucoside: emulsifying agent.
Jojoba oil: there is the effect of nourishing softening skin.
Tristerin/PEG-100 stearate: emulsifying agent.
Dimethicone: skin moistening.
Caprylic/capric glyceride: skin moistening.
Vitamin E acetate: antioxidation.
Isopropyl myristate: skin moistening.
White oil: prevent moisture of skin excessive vaporization.
Glycerol: moisturizing.
Oat polypeptide: strengthen skin elasticity, tighten up and softening tiny wrinkle.
1,3 propylene glycol: moisturizing.
Chitosan: the immunity that improves skin.
D pantothenylol: the deeply wetting agent of infiltration, irritate epithelial growth, promote wound healing, play antiinflammation.
Collagen protein polypeptide: supplement the collagen protein that skin runs off, improve the density of skin, increase the elasticity of skin.
Crocus sativus: activation skin, delay skin aging.
Glycyrrhizic acid dipotassium: prevent skin allergy.
Radix Ginseng extract: the metabolism, delaying cell aging, the removing free radical that regulate human body.
Diazolidinyl urea: anticorrosion.
Daily essence: covering agent.
Hirudin: have effect of blood circulation promoting and blood stasis dispelling, putrefaction removing and tissue regeneration promoting, the skin corium that can independently directly penetrate to the skin, is easy to be absorbed by the skin.On the other hand due to the effect of antithrombase, the microcirculation of the blood capillary to epidermis and face, good assosting effect has enhanced metabolism.Fundamentally solve because pore stops up the comedo that causes, acne and the skin that freely do not cause due to blood is crossed presenility and eye wrinkle-removing, chloasma, freckle, red blood streak etc.
Deionized water: solvent.
The crease-resistant soft face of hirudin of the present invention is nursed one's health white production technology, carries out according to the following steps:
(1) agitated kettle, oil phase pot and water pot are cleaned by purified water, with ethanol disinfection;
(2) taking deionized water adds in water pot, add glycerol, oat polypeptide, avenabeta glucosan, 1 in water, 3 propylene glycol, chitosan and crocus sativus are heated to 90-100 ℃ of sterilizing 18-22 minute, then add the collagen protein polypeptide stirring and dissolving in water;
(3) homogenizing pot is heated to 80-90 ℃ for subsequent use;
(4) all oil phase raw materials are added in oil phase pot and are heated to 80-90 ℃, then by oil phase suction homogenizing pot;
(5) product step (2) being obtained slowly stirs in suction homogenizing pot, keeps vacuum state, adds Radix Ginseng extract, D pantothenylol and glycyrrhizic acid dipotassium in water, stirring and emulsifying;
(6) homogenizing;
(7) while being slowly cooled to 38-42 ℃ under stirring, add diazolidinyl urea, daily essence and the hirudin in water, stir;
(8) be down to discharging after room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing, obtain product.
Wherein:
Preparation before production is: take respectively oil phase with plastic containers; Hold the glycerol in water, oat polypeptide, avenabeta glucosan, 1,3 propylene glycol, chitosan, D pantothenylol, collagen protein polypeptide and crocus sativus with plastics, for subsequent use; Take respectively glycyrrhizic acid dipotassium, Radix Ginseng extract, diazolidinyl urea, daily essence and the hirudin in water with beaker, for subsequent use; Take each material, container tool and instrument are special, must not obscure, and weigh completely on material package, to indicate, stand-by.Must be strictly when weighing by claiming, the requirement such as multiple, note, mark carries out.
The ethanol that in step (1), ethanol is 75%.
In step (4), the rotating speed of homogenizing pot remains on 38-42r/min.
In step (5), the stirring and emulsifying time is 28-32 minute.
In step (6), processing condition is: temperature is 73-77 ℃, and the time is 8-12 minute, and speed controlling is at 2900-3100r/min.
In step (7), speed of agitator is 50-60r/min,, the time is 13-17 minute.
The present invention has the following advantages:
(1) skin corium that can independently directly penetrate to the skin, be easy to be absorbed by the skin, can solve the skin freely not causing due to blood and cross the problem such as presenility and eye wrinkle-removing, the effect of wrinkle removing stricture of vagina is very good, improve facial microcirculation simultaneously, there is the effect that improves skin quality;
(2) add multiple skin-moisturizing, skin antioxidative raw material, the crease-resistant microgroove effect of going is very good;
(3) production technology is simple to operation.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
(1) agitated kettle, oil phase pot and water pot are cleaned by purified water, used 75% ethanol disinfection;
(2) taking 56.3kg deionized water adds in water pot, add 5kg glycerol, 5kg oat polypeptide, 3kg avenabeta glucosan, 3kg1,3 propylene glycol, 3kg chitosan and 1kg crocus sativus are heated to 95 ℃ of sterilizings 20 minutes, then add 1kg collagen protein polypeptide stirring and dissolving;
(3) homogenizing pot is heated to 85 ℃ for subsequent use;
(4) all oil phase raw materials are added in oil phase pot and are heated to 85 ℃, then, by oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 40r/min;
(5) product step (2) being obtained slowly stirs in suction homogenizing pot, keeps vacuum state, adds 0.3kg Radix Ginseng extract, 1kgD pantothenylol and 0.5kg glycyrrhizic acid dipotassium, stirring and emulsifying 30 minutes;
(6) temperature is 75 ℃, and speed controlling is at 3000r/min, homogenizing 10 minutes.
(7) while being slowly cooled to 40 ℃ under stirring, add 0.3kg diazolidinyl urea, 0.1kg daily essence and 2kg hirudin, stir 15 minutes, speed of agitator is 50r/min;
(8) be down to discharging after room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing, obtain product.
Embodiment 2
(1) agitated kettle, oil phase pot and water pot are cleaned by purified water, used 75% ethanol disinfection;
(2) taking 53.8kg deionized water adds in water pot, add 6kg glycerol, 6kg oat polypeptide, 2kg avenabeta glucosan, 2kg1,3 propylene glycol, 4kg chitosan and 1.5kg crocus sativus are heated to 90 ℃ of sterilizings 22 minutes, then add 0.5kg collagen protein polypeptide stirring and dissolving;
(3) homogenizing pot is heated to 90 ℃ for subsequent use;
(4) all oil phase raw materials are added in oil phase pot and are heated to 80 ℃, then, by oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 40r/min;
(5) product step (2) being obtained slowly stirs in suction homogenizing pot, keeps vacuum state, adds 0.2kg Radix Ginseng extract, 0.5kgD pantothenylol and 0.7kg glycyrrhizic acid dipotassium, stirring and emulsifying 32 minutes;
(6) temperature is 73 ℃, and speed controlling is at 3100r/min, homogenizing 8 minutes.
(7) while being slowly cooled to 42 ℃ under stirring, add 0.4kg diazolidinyl urea, 0.2kg daily essence and 1kg hirudin, stir 17 minutes, speed of agitator is 50r/min;
(8) be down to discharging after room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing, obtain product.
Embodiment 3
(1) agitated kettle, oil phase pot and water pot are cleaned by purified water, used 75% ethanol disinfection;
(2) taking 58.8kg deionized water adds in water pot, add 4kg glycerol, 4kg oat polypeptide, 4kg avenabeta glucosan, 4kg1,3 propylene glycol, 2kg chitosan and 0.5kg crocus sativus are heated to 100 ℃ of sterilizings 18 minutes, then add 1.5kg collagen protein polypeptide stirring and dissolving;
(3) homogenizing pot is heated to 80 ℃ for subsequent use;
(4) all oil phase raw materials are added in oil phase pot and are heated to 90 ℃, then, by oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 40r/min;
(5) product step (2) being obtained slowly stirs in suction homogenizing pot, keeps vacuum state, adds 0.4kg Radix Ginseng extract, 1.5kgD pantothenylol and 0.3kg glycyrrhizic acid dipotassium, stirring and emulsifying 28 minutes;
(6) temperature is 77 ℃, and speed controlling is at 2900r/min, homogenizing 12 minutes.
(7) while being slowly cooled to 38 ℃ under stirring, add 0.2kg diazolidinyl urea, 0.1kg daily essence and 3kg hirudin, stir 13 minutes, speed of agitator is 60r/min;
(8) be down to discharging after room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing, obtain product.
Claims (7)
1. the crease-resistant soft face conditioning frost of hirudin, is characterized in that: the raw material by following percentage by weight is made:
Oil phase raw material: squalane 4-6%, cetyl alcohol/cetyl glucoside 1-3%, Jojoba oil 2-4%, tristerin/PEG-100 stearate 2-4%, dimethicone 0.3-0.7%, caprylic/capric glyceride 0.5-1.5%, cetearyl alcohol 0.5-1.5%, Vitamin E acetate 0.5-1.5%, isopropyl myristate 0.5-1.5% and white oil 0.5-1.5%;
Water raw material: glycerol 4-6%, oat polypeptide 4-6%, avenabeta glucosan 2-4%, 1,3 propylene glycol 2-4%, chitosan 2-4%, D pantothenylol 0.5-1.5%, collagen protein polypeptide 0.5-1.5%, crocus sativus 0.5-1.5%, glycyrrhizic acid dipotassium 0.3-0.7%, Radix Ginseng extract 0.2-0.4%, diazolidinyl urea 0.2-0.4%, daily essence 0.1-0.2%, HV1-3% and deionized water 53.8-58.8%.
2. the crease-resistant soft face conditioning frost of hirudin according to claim 1, is characterized in that: the raw material by following percentage by weight is made:
Oil phase raw material: squalane 5%, cetyl alcohol/cetyl glucoside 2%, Jojoba oil 3%, tristerin/PEG-100 stearate 3%, dimethicone 0.5%, caprylic/capric glyceride 1%, cetearyl alcohol 1%, Vitamin E acetate 1%, isopropyl myristate 1% and white oil 1%;
Water raw material: glycerol 5%, oat polypeptide 5%, avenabeta glucosan 3%, 1,3 propylene glycol 3%, chitosan 3%, D pantothenylol 1%, collagen protein polypeptide 1%, crocus sativus 1%, glycyrrhizic acid dipotassium 0.5%, Radix Ginseng extract 0.3%, diazolidinyl urea 0.3%, daily essence 0.1%, hirudin 2% and deionized water 56.3%.
3. the crease-resistant soft face of the hirudin described in claim 1 or 2 is nursed one's health a white production technology, it is characterized in that: carry out according to the following steps:
(1) agitated kettle, oil phase pot and water pot are cleaned by purified water, with ethanol disinfection;
(2) taking deionized water adds in water pot, add glycerol, oat polypeptide, avenabeta glucosan, 1 in water, 3 propylene glycol, chitosan and crocus sativus are heated to 90-100 ℃ of sterilizing 18-22 minute, then add the collagen protein polypeptide stirring and dissolving in water;
(3) homogenizing pot is heated to 80-90 ℃ for subsequent use;
(4) all oil phase raw materials are added in oil phase pot and are heated to 80-90 ℃, then by oil phase suction homogenizing pot;
(5) product step (2) being obtained slowly stirs in suction homogenizing pot, keeps vacuum state, adds Radix Ginseng extract, D pantothenylol and glycyrrhizic acid dipotassium in water, stirring and emulsifying;
(6) homogenizing;
(7) while being slowly cooled to 38-42 ℃ under stirring, add diazolidinyl urea, daily essence and the hirudin in water, stir;
(8) be down to discharging after room temperature, the record of weighing;
(9) sampling detection, fill, outsourcing, obtain product.
4. the crease-resistant soft face of hirudin according to claim 3 is nursed one's health white production technology, it is characterized in that: in step (4), the rotating speed of homogenizing pot remains on 38-42r/min.
5. the crease-resistant soft face of hirudin according to claim 3 is nursed one's health white production technology, it is characterized in that: in step (5), the stirring and emulsifying time is 28-32 minute.
6. the crease-resistant soft face of hirudin according to claim 3 is nursed one's health white production technology, it is characterized in that: in step (6), processing condition is: temperature is 73-77 ℃, and the time is 8-12 minute, and speed controlling is at 2900-3100r/min.
7. the crease-resistant soft face of hirudin according to claim 3 is nursed one's health white production technology, it is characterized in that: in step (7), speed of agitator is 50-60r/min, and the time is 13-17 minute.
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| CN107519037A (en) * | 2017-09-06 | 2017-12-29 | 深圳肽之妃科技有限公司 | A kind of liquid facial mask containing polypeptide and preparation method thereof and application method |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
| CN109453059B (en) * | 2018-12-26 | 2022-03-11 | 广州市科能化妆品科研有限公司 | Whitening cosmetic additive, whitening sleep mask and preparation method of whitening cosmetic additive |
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Effective date of registration: 20190611 Address after: 256300 No. 2 Gaoyuan East Road, Gaoqing County, Zibo City, Shandong Province Patentee after: Zibo overseas medical supplies Limited by Share Ltd Address before: 256300 No. 13 Qinghe Road, Gaoqing County, Zibo City, Shandong Province Patentee before: Shandong Qiaopai Group Co., Ltd. |