CN103006511B - Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof - Google Patents
Hirudin skin-whitening moisture-keeping conditioning cream and production process thereof Download PDFInfo
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Abstract
The invention belongs to the field of cosmetics and particular relates to hirudin skin-whitening moisture-keeping conditioning cream and a production process thereof. The conditioning cream is prepared by oil phase raw materials such as squalane, polyoxyethylene stearyl alcohol ether, jojoba oil, white oil, ferulic acid derivative, cetostearyl alcohol and evening primrose oil, and water phase raw materials such as hirudin, oat polypeptide, a saffron crocus extracting solution, collagen polypeptide, caffeine derivative and an epidermal growth factor. The production process comprises the steps of heating, sterilization, stirring, dissolving, emulsifying, homogenizing, cooling, discharging, sampling, detection, filling, and packaging to obtain the conditioning cream. The conditioning cream can permeate into a corium layer of skin autonomously and directly, can be easily absorbed by the skin, can solve the problems such as the lusterless skin caused by pore blockage, has a better skin-whitening, moisture-keeping and skin-softening effect, and can promote regeneration of the skin and improve the skin quality; as multiple skin-whitening, moisture-keeping and skin-tone-improving raw materials are added, the conditioning cream can improve blood circulation and the skin elasticity, and has very good skin-whitening, moisture-keeping and skin-softening effects; and the production process is simple and easy to operate.
Description
Technical field
The invention belongs to cosmetic field, specifically a kind of hirudin whitening skin and preserving moisture conditioning frost and production technology thereof.
Background technology
Scientific research shows: human skin cell can only absorb the daltonian material in molecular weight≤8000 under normal circumstances.Natural materials in the cosmetics that market is sold is as hyaluronic acid, SOD and collagen protein etc., its molecular weight is mostly several ten thousand even hundreds of thousands dalton, thus be difficult to by the fully effective absorption of skin, all need the deep layer relying on the assosting effect of other permeation-promoter to penetrate to the skin.
Natural hirudin (Hirudin) is a kind of material of Hirudo salivary gland secretion, the single chain polypeptide be made up of 65 ~ 66 amino acid residues, not containing arginine, methionine and tryptophan.Hirudin molecular weight is only 7000 dalton, does not need the auxiliary deep layer that just can directly independently penetrate to the skin of other permeation-promoter, is easily absorbed by Skin Cell.Hirudin independently penetrates into facial blood capillary: the blood viscosity reducing facial vessels, accelerates facial blood flow speed, dredges facial blood capillary.Improve facial microcirculation, after facilitating skin of face metabolism, reduce cuticle thickness, make cell obtain sufficient nutrient.Improve the self-repairing capability of cell, the growth of check melanin cell, disappear facial sunburn and pigmentation, makes skin fine and smooth, fair and clear.Hirudin is a kind of polypeptides matter; Be by Amino acid profile but be different from the intermediate material of protein.It has the characteristic of protein, but simpler than protein, and molecular weight is few, is easily absorbed by body.
Sun Zhiyong, Wang Gang etc. are in " experimentation that natural hirudin affects pig random pattern skin flap venous congestion " (Chinese Reconstructive surgery magazine, 2008; 22,11), in, Chen Weihua etc. are in " topical application hirudin is to the control of Cure of Expanded Flap Venous Congestion " (Chinese practical drainer for plastic surgery magazine, 2005; 16,5) all mention in, the generation of flap venous congestion is from human body blood coagulation mechanism, thrombin plays very important effect in wound process, hirudin, can all multiactions of Trombin inhibiting as the special effect inhibitor of thrombin, and aggregate performance is for promoting congestion diffusion, effectively can prevent and treat Cure of Expanded Flap Venous Congestion by hirudin interventional therapy, alleviate the venous congestion after random pattern skin flap transplanting.
Yuan Xiaohui, Wang Wanjie etc. are in " preliminary observation of preventive function of hirudin against proliferative viteoretinopathy " (Recent Advances in Ophthalmology, 2000; 20,4), in, Yang Ying, Zheng Yanlin etc. are in " impact that hirudin is grown up on the fibroblast of In vitro culture " (ophthalmology, 2004; 13,5) mention, by injecting hirudin in the vitreous chamber to experimental external coat animal model, and set up vitro in fibroblast model etc., observe its turbidity and optical fundus propagation film formational situation, and the fibroblast growth situation of In vitro culture, conclusion is growth and the differentiation that hirudin obviously can suppress vitro in fibroblast, position proliferative diseases such as comprising eye, cornea, bulbar conjunctiva polyp is deformed into there is good preventive effect in early days, thus can be used as the external raw material for the treatment of above-mentioned position proliferative lesion.
Li Xuan, Liu Daen etc. are in " hirudin suppresses the experimentation of in-vitro simulated scar model " (Chinese Chinese medicine magazine, 2009; 24,7) one the article pointed out, hypertrophic cicatrix is the common disease of burn plastic surgery, and fibroblast can cause the disease of various hypertrophy exception at the abnormality proliferation of different tissue sites and the extracellular matrix excessive secretion that causes.Experimental result shows, hirudin is suppressed to the functions such as fibrocellular propagation, secretion, contraction by reducing collagen generation, thus the emergence and development of Inhibiting proliferation cicatrix, thus can be used for treatment hypertrophic cicatrix class disease.And " structure observation that hirudin affects proliferative vitreoretinopathy " (Chinese TCM Ophthalmology magazine, 2000; 01), " hirudin is to the inhibitory action of the Cultured Rabbit Smooth Muscle Cells cultivated " (Chinese circulation magazine, 1996; 02, Zhou little Ming etc.), Ogichit, " Tissue factorand cancer procoagulantexpressed by gliom a cells participate in their throm binmediatedproliferation " (Neurooncol, 2000 of Hirashima etc.; 46,1) Experimental report etc. also fully confirms this point.
Natural hirudin energy and thrombin carry out specific binding, hinder the carrying out of coagulation process, from this angle, natural hirudin has anticoagulation, thrombus, antiinflammatory and reduction blood fat, reduces the effects such as blood viscosity, the domestic and international research to natural hirudin at present also concentrates on this, but be used for from improving tissue blood microcirculation, expansion local organization blood vessel etc., natural hirudin improving flap venous congestion, be suppressed to fibrocyte grow up and development, suppress and removing hypertrophic cicatrix and epidermis fat to silt up etc. in there is good effect.
Whitening skin and preserving moisture product conventional is at present various, and effect is variant greatly, mostly take effect slow, and whitening effect is also unstable, and a lot of whitening product is containing heavy metal, the still difficult prediction of safety and sequela.If improper use, may after cause the damage of skin.And natural hirudin is a kind of low molecular polypeptide, molecular weight is little, do not need the auxiliary deep layer that just can directly independently penetrate to the skin of other permeation-promoter, dredging blood capillary, reduces blood viscosity, accelerate blood flow rate, improve facial microcirculation, suppress and reduce melanic formation, improve the self-repairing capability of cell, disappear facial sunburn and pigmentation, makes skin fine and smooth, fair and clear.So hirudin whitening skin and preserving moisture cosmetics be a kind ofly integrate anti-, control, the new type ideal skin care good product of adornment.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of hirudin whitening skin and preserving moisture conditioning frost, independently directly can be penetrated to the skin skin corium, be easy to be absorbed by the skin, can solve because the problem such as the colour of skin that causes of clogging of pores is obscure, there is good whitening skin and preserving moisture skin care effect, can skin regeneration be promoted and improve skin quality; The present invention also provides production technology, simple to operation.
Hirudin whitening skin and preserving moisture conditioning frost of the present invention, be made up of the raw material of following percentage by weight:
Oil phase raw material: squalane 4-6%, polyoxyethylene stearyl alcohol ether 2-4%, Jojoba oil 1-3%, white oil 0.5-1.5%, dimethicone 0.5-1.5%, ferulic acid derivative 1-3%, cetearyl alcohol 0.3-0.7% and Radix Oenotherae erythrosepalae oil 0.5-1.5%;
Aqueous Phase Raw Material: glycerol 4-6%, oat polypeptide 4-6%, crocus sativus 2-4%, 1,3 propylene glycol 2-4%, Licorice flavanone 0.5-1.5%, acrylic copolymer 0.1-0.3%, collagen protein polypeptide 0.5-1.5%, caffeine derivative 0.5-1.5%, glycyrrhizic acid dipotassium 0.3-0.7%, triethanolamine 0.1-0.3%, diazolidinyl urea 0.2-0.4%, daily essence 0.04-0.06%, HV1-3%, epidermal growth factor 0.01-0.02% and deionized water 60-64%.
Hirudin whitening skin and preserving moisture conditioning frost is preferably made up of the raw material of following percentage by weight:
Oil phase raw material: squalane 5%, polyoxyethylene stearyl alcohol ether 3%, Jojoba oil 2%, white oil 1%, dimethicone 1%, ferulic acid derivative 2%, cetearyl alcohol 0.5% and Radix Oenotherae erythrosepalae oil 1%;
Aqueous Phase Raw Material: glycerol 5%, oat polypeptide 5%, crocus sativus 3%, 1,3 propylene glycol 3%, Licorice flavanone 1%, acrylic copolymer 0.2%, collagen protein polypeptide 1%, caffeine derivative 1%, glycyrrhizic acid dipotassium 0.5%, triethanolamine 0.2%, diazolidinyl urea 0.3%, daily essence 0.05%, hirudin 2%, epidermal growth factor 0.01% and deionized water 62.24%.
Wherein the effect of each raw material is as follows:
Squalane: the peroxidating that can suppress skin lipid, effectively can infiltrate through skin, and promotes the propagation of skin base cell, and to delay skin aging, improving and eliminating chloasma all has obvious physiologic effect.
Polyoxyethylene stearyl alcohol ether: emulsifying agent.
Jojoba oil: there is the effect of nourishing softening skin.
White oil: prevent moisture from evaporating.
Dimethicone: skin moistening.
Ferulic acid derivative: the activity suppressing TYR enzyme.
Cetearyl alcohol: thickening agent.
Radix Oenotherae erythrosepalae oil: improve blood circulation.
Glycerol: moisturizing.
Oat polypeptide: strengthen skin elasticity, tighten up and softening fine wrinkles.
Crocus sativus: activating skin.
1.3 propylene glycol: moisturizing.
Licorice flavanone: whitening and speckle dispelling.
Acrylic copolymer: thickening.
Collagen protein polypeptide: the collagen protein supplementing skin losses, improves the density of skin, increases the elasticity of skin.
Caffeine derivative: improve the low and deep colour of skin.
Glycyrrhizic acid dipotassium: hypo-allergenic.
Triethanolamine: pH value regulates.
Diazolidinyl urea: anticorrosion.
Daily essence: covering agent.
Hirudin: the effect having blood circulation promoting and blood stasis dispelling, putrefaction removing and tissue regeneration promoting, can independently directly penetrate to the skin skin corium, is easy to be absorbed by the skin.On the other hand due to the effect of antithrombase, to the microcirculation of the blood capillary of epidermis and face, enhanced metabolism good assosting effect.Fundamentally solve because comedo, acne and the skin that freely do not cause due to blood that clogging of pores causes cross presenility and eye wrinkle-removing, chloasma, freckle, red blood streak etc.
Epidermal growth factor: promote reepithelialization.
Deionized water: solvent.
The production technology of hirudin whitening skin and preserving moisture conditioning frost of the present invention, carry out according to the following steps:
(1) agitated kettle, oil phase pot and aqueous phase pot purified water are cleaned, with ethanol disinfection;
(2) take deionized water to add in aqueous phase pot, add the glycerol in aqueous phase and 1,3 propylene glycol are heated to 90-100 DEG C of sterilizing 18-22 minute, then add the acrylic copolymer stirring and dissolving in aqueous phase; Temperature controls at 85-95 DEG C, then in aqueous phase, add oat polypeptide, crocus sativus, Licorice flavanone, collagen protein polypeptide, caffeine derivative;
(3) homogenizing pot is heated to 80-90 DEG C for subsequent use;
(4) all oil phase raw materials are added in oil phase pot be heated to 80-90 DEG C, then by oil phase suction homogenizing pot;
(5) product step (2) obtained is stirring and emulsifying in suction homogenizing pot slowly;
(6) keep vacuum state, add the triethanolamine in aqueous phase, stirring and emulsifying;
(7) homogenizing;
(8) add glycyrrhizic acid dipotassium, diazolidinyl urea, daily essence, hirudin and the epidermal growth factor element in aqueous phase when being slowly cooled to 43-47 DEG C under stirring, stir;
(9) discharging after room temperature is down to, record of weighing;
(10) sample detection, fill, outsourcing, obtain product.
Wherein:
In step (1), ethanol is the ethanol of 75%.
In step (4), the rotating speed of homogenizing pot remains on 38-42r/min.
In step (5), the stirring and emulsifying time is 18-22 minute.
In step (6), the stirring and emulsifying time is 8-12 minute.
In step (7), processing condition is: temperature is 73-77 DEG C, and the time is 8-12 minute, and speed controlling is at 2900-3100r/min.
In step (8), speed of agitator is 50-60r/min, and the time is 13-17 minute.
The present invention has the following advantages:
(1) can independently directly penetrate to the skin skin corium, is easy to be absorbed by the skin, and can solve because the problem such as the colour of skin that causes of clogging of pores is obscure, have good whitening skin and preserving moisture skin care effect, can promote skin regeneration and improve skin quality;
(2) add multiple whitening, moisturizing, improve the raw material of the colour of skin, blood circulation can be improved and strengthen skin elasticity, having good whitening skin and preserving moisture skin care effect;
(3) production technology is simple to operation.
Detailed description of the invention
Below in conjunction with embodiment, the present invention will be further described.
Embodiment 1
(1) agitated kettle, oil phase pot and aqueous phase pot purified water are cleaned, with the ethanol disinfection of 75%;
(2) take 62.24kg ionized water to add in aqueous phase pot, add 5kg glycerol and 3kg1,3 propylene glycol are heated to 95 DEG C of sterilizings 20 minutes, then add 0.2kg acrylic copolymer stirring and dissolving; Temperature controls at 90 DEG C, adds 5kg oat polypeptide, 3kg crocus sativus, 1kg Licorice flavanone, 1kg collagen protein polypeptide, 1kg caffeine derivative in aqueous phase;
(3) homogenizing pot is heated to 85 DEG C for subsequent use;
(4) added in oil phase pot by all oil phase raw materials and be heated to 85 DEG C, then by oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 40r/min;
(5) product step (2) obtained is stirring and emulsifying 20 minutes in suction homogenizing pot slowly;
(6) keep vacuum state, add 0.2kg triethanolamine, stirring and emulsifying 10 minutes;
(7) temperature is 75 DEG C, speed controlling at 3000r/min, homogenizing 10 minutes;
(8) add 0.5kg glycyrrhizic acid dipotassium, 0.3kg diazolidinyl urea, 0.05kg daily essence, 2kg hirudin and 0.01kg epidermal growth factor element when being slowly cooled to 45 DEG C under stirring, stir 15 minutes, rotating speed is 50r/min;
(9) discharging after room temperature is down to, record of weighing;
(10) sample detection, fill, outsourcing, obtain product.
Embodiment 2
(1) agitated kettle, oil phase pot and aqueous phase pot purified water are cleaned, with the ethanol disinfection of 75%;
(2) take 60kg ionized water to add in aqueous phase pot, add 4kg glycerol and 2kg1,3 propylene glycol are heated to 90 DEG C of sterilizings 22 minutes, then add 0.3kg acrylic copolymer stirring and dissolving; Temperature controls at 85 DEG C, adds 6kg oat polypeptide, 2kg crocus sativus, 0.5kg Licorice flavanone, 1.5kg collagen protein polypeptide, 0.5kg caffeine derivative in aqueous phase;
(3) homogenizing pot is heated to 80 DEG C for subsequent use;
(4) added in oil phase pot by all oil phase raw materials and be heated to 90 DEG C, then by oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 38r/min;
(5) product step (2) obtained is stirring and emulsifying 22 minutes in suction homogenizing pot slowly;
(6) keep vacuum state, add 0.3kg triethanolamine, stirring and emulsifying 8 minutes;
(7) temperature is 73 DEG C, speed controlling at 3100r/min, homogenizing 12 minutes;
(8) add 0.7kg glycyrrhizic acid dipotassium, 0.2kg diazolidinyl urea, 0.06kg daily essence, 3kg hirudin and 0.01kg epidermal growth factor element when being slowly cooled to 47 DEG C under stirring, stir 13 minutes, rotating speed is 55r/min;
(9) discharging after room temperature is down to, record of weighing;
(10) sample detection, fill, outsourcing, obtain product.
Embodiment 3
(1) agitated kettle, oil phase pot and aqueous phase pot purified water are cleaned, with the ethanol disinfection of 75%;
(2) take 64kg ionized water to add in aqueous phase pot, add 6kg glycerol and 4kg1,3 propylene glycol are heated to 100 DEG C of sterilizings 18 minutes, then add 0.1kg acrylic copolymer stirring and dissolving; Temperature controls at 95 DEG C, adds 4kg oat polypeptide, 4kg crocus sativus, 1.5kg Licorice flavanone, 0.5kg collagen protein polypeptide, 1.5kg caffeine derivative in aqueous phase;
(3) homogenizing pot is heated to 90 DEG C for subsequent use;
(4) added in oil phase pot by all oil phase raw materials and be heated to 80 DEG C, then by oil phase suction homogenizing pot, the rotating speed of homogenizing pot remains on 42r/min;
(5) product step (2) obtained is stirring and emulsifying 18 minutes in suction homogenizing pot slowly;
(6) keep vacuum state, add 0.1kg triethanolamine, stirring and emulsifying 12 minutes;
(7) temperature is 77 DEG C, speed controlling at 2900r/min, homogenizing 8 minutes;
(8) add 0.3kg glycyrrhizic acid dipotassium, 0.4kg diazolidinyl urea, 0.04kg daily essence, 1kg hirudin and 0.02kg epidermal growth factor element when being slowly cooled to 43 DEG C under stirring, stir 17 minutes, rotating speed is 60r/min;
(9) discharging after room temperature is down to, record of weighing;
(10) sample detection, fill, outsourcing, obtain product.
Claims (7)
1. a hirudin whitening skin and preserving moisture conditioning frost, is characterized in that: be made up of the raw material of following percentage by weight:
Oil phase raw material: squalane 4-6%, polyoxyethylene stearyl alcohol ether 2-4%, Jojoba oil 1-3%, white oil 0.5-1.5%, dimethicone 0.5-1.5%, ferulic acid derivative 1-3%, cetearyl alcohol 0.3-0.7% and Radix Oenotherae erythrosepalae oil 0.5-1.5%;
Aqueous Phase Raw Material: glycerol 4-6%, oat polypeptide 4-6%, crocus sativus 2-4%, 1,3 propylene glycol 2-4%, Licorice flavanone 0.5-1.5%, acrylic copolymer 0.1-0.3%, collagen protein polypeptide 0.5-1.5%, caffeine derivative 0.5-1.5%, glycyrrhizic acid dipotassium 0.3-0.7%, triethanolamine 0.1-0.3%, diazolidinyl urea 0.2-0.4%, daily essence 0.04-0.06%, HV1-3%, epidermal growth factor 0.01-0.02% and deionized water 60-64%;
The production technology of described hirudin whitening skin and preserving moisture conditioning frost, carry out according to the following steps:
(1) agitated kettle, oil phase pot and aqueous phase pot purified water are cleaned, with ethanol disinfection;
(2) take deionized water to add in aqueous phase pot, add the glycerol in aqueous phase and 1,3 propylene glycol are heated to 90-100 DEG C of sterilizing 18-22 minute, then add the acrylic copolymer stirring and dissolving in aqueous phase; Temperature controls at 85-95 DEG C, then in aqueous phase, add oat polypeptide, crocus sativus, Licorice flavanone, collagen protein polypeptide, caffeine derivative;
(3) homogenizing pot is heated to 80-90 DEG C for subsequent use;
(4) all oil phase raw materials are added in oil phase pot be heated to 80-90 DEG C, then by oil phase suction homogenizing pot;
(5) product step (2) obtained is stirring and emulsifying in suction homogenizing pot slowly;
(6) keep vacuum state, add the triethanolamine in aqueous phase, stirring and emulsifying;
(7) homogenizing;
(8) add glycyrrhizic acid dipotassium, diazolidinyl urea, daily essence, hirudin and the epidermal growth factor element in aqueous phase when being slowly cooled to 43-47 DEG C under stirring, stir;
(9) discharging after room temperature is down to, record of weighing;
(10) sample detection, fill, outsourcing, obtain product.
2. hirudin whitening skin and preserving moisture conditioning frost according to claim 1, is characterized in that: be made up of the raw material of following percentage by weight:
Oil phase raw material: squalane 5%, polyoxyethylene stearyl alcohol ether 3%, Jojoba oil 2%, white oil 1%, dimethicone 1%, ferulic acid derivative 2%, cetearyl alcohol 0.5% and Radix Oenotherae erythrosepalae oil 1%;
Aqueous Phase Raw Material: glycerol 5%, oat polypeptide 5%, crocus sativus 3%, 1,3 propylene glycol 3%, Licorice flavanone 1%, acrylic copolymer 0.2%, collagen protein polypeptide 1%, caffeine derivative 1%, glycyrrhizic acid dipotassium 0.5%, triethanolamine 0.2%, diazolidinyl urea 0.3%, daily essence 0.05%, hirudin 2%, epidermal growth factor 0.01% and deionized water 62.24%.
3. hirudin whitening skin and preserving moisture conditioning frost according to claim 1, is characterized in that: in step (4), the rotating speed of homogenizing pot remains on 38-42r/min.
4. hirudin whitening skin and preserving moisture conditioning frost according to claim 1, is characterized in that: in step (5), the stirring and emulsifying time is 18-22 minute.
5. hirudin whitening skin and preserving moisture conditioning frost according to claim 1, is characterized in that: in step (6), the stirring and emulsifying time is 8-12 minute.
6. hirudin whitening skin and preserving moisture conditioning frost according to claim 1, is characterized in that: in step (7), processing condition is: temperature is 73-77 DEG C, and the time is 8-12 minute, and speed controlling is at 2900-3100r/min.
7. hirudin whitening skin and preserving moisture conditioning frost according to claim 1, is characterized in that: in step (8), speed of agitator is 50-60r/min, and the time is 13-17 minute.
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| CN105342966B (en) * | 2015-12-05 | 2018-05-18 | 重庆市中药研究院 | Skin care moisturiser containing Hirudo japonica and preparation method thereof |
| CN105662944B (en) * | 2016-01-16 | 2018-12-28 | 深圳安济堂医药科技有限公司 | Tender skin whitening lotion of anti-wrinkle and preparation method thereof |
| CN107519037A (en) * | 2017-09-06 | 2017-12-29 | 深圳肽之妃科技有限公司 | A kind of liquid facial mask containing polypeptide and preparation method thereof and application method |
| CN107510619B (en) * | 2017-09-06 | 2020-11-24 | 深圳肽之妃科技有限公司 | Composite polypeptide mask and preparation method thereof |
| CN107854326A (en) * | 2017-12-19 | 2018-03-30 | 乳山寰海生物科技有限公司 | A kind of hirudin moistens face moisturizing maintenance Essence |
| CN109771324B (en) * | 2019-03-29 | 2021-12-10 | 华熙生物科技股份有限公司 | An eye skin care composition containing hirudin and hyaluronic acid |
| CN113520898B (en) * | 2021-09-17 | 2021-12-21 | 汇泰渤海水产有限责任公司 | Application of hirulog HE-D in skin care and whitening |
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| CN1522689A (en) * | 2003-09-12 | 2004-08-25 | 周维海 | Leech extract cosmetics and method for making same |
| CN1660041A (en) * | 2004-02-24 | 2005-08-31 | 刘凤鸣 | Application of hirudinoid protease chalone incosmetic |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1522689A (en) * | 2003-09-12 | 2004-08-25 | 周维海 | Leech extract cosmetics and method for making same |
| CN1660041A (en) * | 2004-02-24 | 2005-08-31 | 刘凤鸣 | Application of hirudinoid protease chalone incosmetic |
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