CN109600989B - 2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的改性的释放制剂 - Google Patents

2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的改性的释放制剂 Download PDF

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CN109600989B
CN109600989B CN201780049475.1A CN201780049475A CN109600989B CN 109600989 B CN109600989 B CN 109600989B CN 201780049475 A CN201780049475 A CN 201780049475A CN 109600989 B CN109600989 B CN 109600989B
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oral dosage
dosage form
modified release
solid oral
compound
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CN109600989A (zh
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A·J·费尔多斯
M·R·马斯杰迪扎德
W·林
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Principia Biopharma Inc
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CN201780049475.1A 2016-06-29 2017-06-29 2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁烷-3-基)哌嗪-1-基]戊-2-烯腈的改性的释放制剂 Active CN109600989B (zh)

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US201662356345P 2016-06-29 2016-06-29
US62/356,345 2016-06-29
PCT/US2017/040075 WO2018005849A1 (en) 2016-06-29 2017-06-29 Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

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MA42242A (fr) 2015-06-24 2018-05-02 Principia Biopharma Inc Inhibiteurs de la tyrosine kinase
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CN112424207B (zh) 2018-07-25 2024-03-19 诺华股份有限公司 Nlrp3炎性小体抑制剂
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UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
BR112022005575A2 (pt) 2019-10-09 2022-06-21 Principia Biopharma Inc Métodos de tratar pênfigo por administração de (r)-2-[3-[4-amino-3-(2-fluoro-4-fenóxi-fenil)pirazolo[3,4-d]pirimidin-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enonitrila
MX2022004427A (es) 2019-10-14 2022-07-12 Principia Biopharma Inc Metodos para el tratamiento de la trombocitopenia inmunitaria mediante la administracion de (r)-2-[3-[4-amino-3-(2-fluoro-4-feno xi-fenil)pirazolo[3,4-d]pirimidin-1-il]piperidino-1-carbonil]-4-m etil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enonitrilo.
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US11583533B2 (en) * 2020-01-08 2023-02-21 Principia Biopharma Inc. Topical pharmaceutical compositions comprising 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4,4-dimethylpent-2-enenitrile
KR20220130184A (ko) 2020-01-22 2022-09-26 프린시피아 바이오파마, 인코퍼레이티드 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)-1H-피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 결정질 형태
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KR20230051227A (ko) 2020-08-14 2023-04-17 노파르티스 아게 헤테로아릴 치환된 스피로피페리디닐 유도체 및 이의 제약 용도
CN117279641A (zh) 2021-04-16 2023-12-22 普林斯匹亚生物制药公司 通过施用特定化合物治疗药物和疫苗诱导的免疫性血小板减少症的方法
AR128269A1 (es) * 2022-01-13 2024-04-10 Amryt Endo Inc Formas de dosificación orales
UY40374A (es) 2022-08-03 2024-02-15 Novartis Ag Inhibidores de inflamasoma nlrp3
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SG11201811255WA (en) 2019-01-30
IL293621B1 (en) 2023-05-01
MX2018016056A (es) 2019-07-04
KR102391693B1 (ko) 2022-04-29
US20240207275A1 (en) 2024-06-27
EP3478273A1 (en) 2019-05-08
JP2019519581A (ja) 2019-07-11
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AU2017290354A1 (en) 2019-01-24
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JP7129704B2 (ja) 2022-09-02
CN115054586A (zh) 2022-09-16
MA45547A (fr) 2019-05-08
US12336999B2 (en) 2025-06-24
IL263815A (en) 2019-01-31
US20210113567A1 (en) 2021-04-22
KR102515813B1 (ko) 2023-03-30
IL293621A (en) 2022-08-01
BR112018077503A2 (pt) 2019-04-09
CN115054586B (zh) 2024-08-02
AU2017290354C1 (en) 2023-07-06
CA3028169A1 (en) 2018-01-04
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KR20190025947A (ko) 2019-03-12
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