BRPI0709916B8 - drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas - Google Patents

drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas

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Publication number
BRPI0709916B8
BRPI0709916B8 BRPI0709916A BRPI0709916A BRPI0709916B8 BR PI0709916 B8 BRPI0709916 B8 BR PI0709916B8 BR PI0709916 A BRPI0709916 A BR PI0709916A BR PI0709916 A BRPI0709916 A BR PI0709916A BR PI0709916 B8 BRPI0709916 B8 BR PI0709916B8
Authority
BR
Brazil
Prior art keywords
drugs
caffeic acid
orally bioavailable
anticancer drugs
anticancer
Prior art date
Application number
BRPI0709916A
Other languages
English (en)
Inventor
Conrad Charles
Fokt Izabela
Myers Jeffrey
Szymanski Slawomir
Madden Timothy
Priebe Waldemar
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of BRPI0709916A2 publication Critical patent/BRPI0709916A2/pt
Publication of BRPI0709916B1 publication Critical patent/BRPI0709916B1/pt
Publication of BRPI0709916B8 publication Critical patent/BRPI0709916B8/pt

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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Abstract

drogas anticancer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas. a presente invenção refere-se a compostos e seu uso para tratar doenças proliferativas celulares tais como câncer. os compostos da presente invenção apresentam potência significativa como inibidores das vias de jak2/stat3 e alvos a jusante e inibem o crescimento e a sobrevivência de linhagens de células cancerosas.
BRPI0709916A 2006-03-31 2007-04-02 drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas BRPI0709916B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74410506P 2006-03-31 2006-03-31
US60/744,105 2006-03-31
PCT/US2007/065805 WO2007115269A2 (en) 2006-03-31 2007-04-02 Orally bioavailable caffeic acid related anticancer drugs

Publications (3)

Publication Number Publication Date
BRPI0709916A2 BRPI0709916A2 (pt) 2011-07-26
BRPI0709916B1 BRPI0709916B1 (pt) 2020-09-29
BRPI0709916B8 true BRPI0709916B8 (pt) 2021-05-25

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BRPI0709916A BRPI0709916B8 (pt) 2006-03-31 2007-04-02 drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas

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US (2) US8779151B2 (pt)
EP (2) EP2514742B1 (pt)
JP (2) JP5654233B2 (pt)
CN (1) CN101454275B (pt)
AU (1) AU2007234455B2 (pt)
BR (1) BRPI0709916B8 (pt)
CA (1) CA2648003C (pt)
ES (1) ES2533383T3 (pt)
HK (1) HK1134072A1 (pt)
MX (1) MX2008012612A (pt)
PL (1) PL2514742T3 (pt)
RU (1) RU2456265C2 (pt)
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ES2533383T3 (es) 2015-04-09
CN101454275B (zh) 2014-07-23
US8779151B2 (en) 2014-07-15
AU2007234455B2 (en) 2012-10-04
HK1134072A1 (en) 2010-04-16
AU2007234455A1 (en) 2007-10-11
JP2009532387A (ja) 2009-09-10
WO2007115269A2 (en) 2007-10-11
EP2514742B1 (en) 2014-12-31
JP5654233B2 (ja) 2015-01-14
RU2008143237A (ru) 2010-05-10
CN101454275A (zh) 2009-06-10
WO2007115269A3 (en) 2007-12-21
EP2514742A2 (en) 2012-10-24
BRPI0709916B1 (pt) 2020-09-29
CA2648003C (en) 2014-07-08
CA2648003A1 (en) 2007-10-11
PL2514742T3 (pl) 2015-07-31
BRPI0709916A2 (pt) 2011-07-26
MX2008012612A (es) 2008-12-12
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EP2007714A2 (en) 2008-12-31
EP2514742A3 (en) 2013-01-09

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