BRPI0709916B8 - drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas - Google Patents

drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas

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Publication number
BRPI0709916B8
BRPI0709916B8 BRPI0709916A BRPI0709916A BRPI0709916B8 BR PI0709916 B8 BRPI0709916 B8 BR PI0709916B8 BR PI0709916 A BRPI0709916 A BR PI0709916A BR PI0709916 A BRPI0709916 A BR PI0709916A BR PI0709916 B8 BRPI0709916 B8 BR PI0709916B8
Authority
BR
Brazil
Prior art keywords
drugs
caffeic acid
orally bioavailable
anticancer drugs
anticancer
Prior art date
Application number
BRPI0709916A
Other languages
English (en)
Inventor
Conrad Charles
Fokt Izabela
Myers Jeffrey
Szymanski Slawomir
Madden Timothy
Priebe Waldemar
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of BRPI0709916A2 publication Critical patent/BRPI0709916A2/pt
Publication of BRPI0709916B1 publication Critical patent/BRPI0709916B1/pt
Publication of BRPI0709916B8 publication Critical patent/BRPI0709916B8/pt

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P15/04Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
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    • C07C233/29Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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Abstract

drogas anticancer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas. a presente invenção refere-se a compostos e seu uso para tratar doenças proliferativas celulares tais como câncer. os compostos da presente invenção apresentam potência significativa como inibidores das vias de jak2/stat3 e alvos a jusante e inibem o crescimento e a sobrevivência de linhagens de células cancerosas.
BRPI0709916A 2006-03-31 2007-04-02 drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas BRPI0709916B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74410506P 2006-03-31 2006-03-31
US60/744,105 2006-03-31
PCT/US2007/065805 WO2007115269A2 (en) 2006-03-31 2007-04-02 Orally bioavailable caffeic acid related anticancer drugs

Publications (3)

Publication Number Publication Date
BRPI0709916A2 BRPI0709916A2 (pt) 2011-07-26
BRPI0709916B1 BRPI0709916B1 (pt) 2020-09-29
BRPI0709916B8 true BRPI0709916B8 (pt) 2021-05-25

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BRPI0709916A BRPI0709916B8 (pt) 2006-03-31 2007-04-02 drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas

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Country Link
US (2) US8779151B2 (pt)
EP (2) EP2514742B1 (pt)
JP (2) JP5654233B2 (pt)
CN (1) CN101454275B (pt)
AU (1) AU2007234455B2 (pt)
BR (1) BRPI0709916B8 (pt)
CA (1) CA2648003C (pt)
ES (1) ES2533383T3 (pt)
HK (1) HK1134072A1 (pt)
MX (1) MX2008012612A (pt)
PL (1) PL2514742T3 (pt)
RU (1) RU2456265C2 (pt)
WO (1) WO2007115269A2 (pt)

Families Citing this family (34)

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EP1701941B1 (en) * 2003-12-11 2012-05-30 Board of Regents, The University of Texas System Compounds for treatment of cell proliferative diseases
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