BRPI0709916B8 - drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas - Google Patents

drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas

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Publication number
BRPI0709916B8
BRPI0709916B8 BRPI0709916A BRPI0709916A BRPI0709916B8 BR PI0709916 B8 BRPI0709916 B8 BR PI0709916B8 BR PI0709916 A BRPI0709916 A BR PI0709916A BR PI0709916 A BRPI0709916 A BR PI0709916A BR PI0709916 B8 BRPI0709916 B8 BR PI0709916B8
Authority
BR
Brazil
Prior art keywords
drugs
caffeic acid
orally bioavailable
anticancer drugs
anticancer
Prior art date
Application number
BRPI0709916A
Other languages
English (en)
Inventor
Conrad Charles
Fokt Izabela
Myers Jeffrey
Szymanski Slawomir
Madden Timothy
Priebe Waldemar
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of BRPI0709916A2 publication Critical patent/BRPI0709916A2/pt
Publication of BRPI0709916B1 publication Critical patent/BRPI0709916B1/pt
Publication of BRPI0709916B8 publication Critical patent/BRPI0709916B8/pt

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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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Abstract

drogas anticancer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas. a presente invenção refere-se a compostos e seu uso para tratar doenças proliferativas celulares tais como câncer. os compostos da presente invenção apresentam potência significativa como inibidores das vias de jak2/stat3 e alvos a jusante e inibem o crescimento e a sobrevivência de linhagens de células cancerosas.
BRPI0709916A 2006-03-31 2007-04-02 drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas BRPI0709916B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74410506P 2006-03-31 2006-03-31
US60/744,105 2006-03-31
PCT/US2007/065805 WO2007115269A2 (en) 2006-03-31 2007-04-02 Orally bioavailable caffeic acid related anticancer drugs

Publications (3)

Publication Number Publication Date
BRPI0709916A2 BRPI0709916A2 (pt) 2011-07-26
BRPI0709916B1 BRPI0709916B1 (pt) 2020-09-29
BRPI0709916B8 true BRPI0709916B8 (pt) 2021-05-25

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BRPI0709916A BRPI0709916B8 (pt) 2006-03-31 2007-04-02 drogas anticâncer associadas ao ácido caféico biodisponível por via oral e uso das referidas drogas

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US (2) US8779151B2 (pt)
EP (2) EP2007714A2 (pt)
JP (2) JP5654233B2 (pt)
CN (1) CN101454275B (pt)
AU (1) AU2007234455B2 (pt)
BR (1) BRPI0709916B8 (pt)
CA (1) CA2648003C (pt)
ES (1) ES2533383T3 (pt)
HK (1) HK1134072A1 (pt)
MX (1) MX2008012612A (pt)
PL (1) PL2514742T3 (pt)
RU (1) RU2456265C2 (pt)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745468B2 (en) * 2003-12-11 2010-06-29 Board of Regents, University of Texas Systems The Compounds for treatment of cell proliferative diseases
CN101454275B (zh) * 2006-03-31 2014-07-23 得克萨斯大学体系董事会 口服生物可利用的咖啡酸相关的抗癌药
ES2569215T3 (es) * 2007-09-10 2016-05-09 Boston Biomedical, Inc. Un nuevo grupo de inhibidores de la ruta de Stat3 e inhibidores de la ruta de las células madre del cáncer
KR20110033922A (ko) 2008-07-08 2011-04-01 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 전사의 신호 변환자 및 활성제（ｓｔａｔｓ）의 증식 및 활성화의 신규한 억제제
US8450337B2 (en) * 2008-09-30 2013-05-28 Moleculin, Llc Methods of treating skin disorders with caffeic acid analogs
MX2009008889A (es) * 2009-08-20 2009-10-15 Biokab S A De C V Composiciones fitoceuticas para mascotas.
CA2781056A1 (en) 2009-11-16 2011-05-19 Rebecca Maglathlin Kinase inhibitors
US20130129675A1 (en) 2009-12-04 2013-05-23 Board Of Regents, The University Of Texas System Interferon therapies in combination with blockade of stat3 activation
US20110275577A1 (en) * 2010-01-08 2011-11-10 Moleculin, Llc Methods of treating dermatologic, gynecologic, and genital disorders with caffeic acid analogs
US9730909B2 (en) 2010-03-19 2017-08-15 Boston Biomedical, Inc Methods for targeting cancer stem cells
US8809377B2 (en) 2010-09-24 2014-08-19 The Regents Of The University Of Michigan Deubiquitinase inhibitors and methods for use of the same
EP2629766B1 (en) * 2010-10-18 2017-02-22 Chemigen Combination therapy
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
PL2710005T3 (pl) 2011-05-17 2017-07-31 Principia Biopharma Inc. Inhibitory kinazy tyrozynowej
EP2723892A2 (en) * 2011-06-27 2014-04-30 Galderma Research & Development New th-17 differentiation markers for rosacea and uses thereof
RU2641903C2 (ru) * 2012-05-25 2018-01-23 Дзе Гавернинг Каунсил Оф Дзе Юниверсити Оф Торонто Новые производные салициловой кислоты, их фармацевтически приемлемая соль, композиции и способ применения
CN102911916A (zh) * 2012-08-24 2013-02-06 东莞中山大学研究院 一种中国人舌部鳞状上皮细胞癌细胞系ctsc-2及其建立方法
RS58956B1 (sr) 2012-09-10 2019-08-30 Principia Biopharma Inc Jedinjenja pirazolopirimidina kao inhibitori kinaze
WO2014138727A1 (en) * 2013-03-08 2014-09-12 Board Of Regents, The University Of Texas System Suppression of malignant mesothelioma by overexpression or stimulation of endothelial protein c receptors (epcr)
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
CA2908380A1 (en) 2013-04-09 2014-10-16 Boston Biomedical, Inc. Methods for treating cancer
US20160367627A1 (en) 2013-07-02 2016-12-22 Nikolai Khodarev Anti-tumor therapy
ES2841248T3 (es) 2014-02-21 2021-07-07 Principia Biopharma Inc Sales y forma sólida de un inhibidor de BTK
MX359974B (es) * 2014-04-01 2018-10-05 Univ Mexico Nac Autonoma Compuestos analogos del ester fenetilico del acido cafeico y uso de los mismos para preparacion de composiciones farmaceuticas para prevencion y tratamiento de cancer.
PT3233103T (pt) 2014-12-18 2021-01-18 Principia Biopharma Inc Tratamento de pênfigo
MA42242A (fr) 2015-06-24 2018-05-02 Principia Biopharma Inc Inhibiteurs de la tyrosine kinase
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
KR102515813B1 (ko) 2016-06-29 2023-03-30 프린시피아 바이오파마, 인코퍼레이티드 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제
US11299469B2 (en) 2016-11-29 2022-04-12 Sumitomo Dainippon Pharma Oncology, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
JP2020520923A (ja) 2017-05-17 2020-07-16 ボストン バイオメディカル， インコーポレイテッド がんを処置するための方法
TW201922707A (zh) 2017-11-10 2019-06-16 美國德州系統大學評議委員會 咖啡酸衍生物及其用途
CN108324713B (zh) * 2018-01-25 2020-09-01 三峡大学 一种烷基吲哚酮衍生物的应用及抗甲状腺肿瘤药物
AU2020252372A1 (en) * 2019-04-02 2021-10-28 Board Of Regents, The University Of Texas System Combinations of transcription inhibitors and immune checkpoint inhibitors for treatment of disease
CN116407527A (zh) * 2023-01-04 2023-07-11 河南科技大学第一附属医院 咖啡酸的应用以及用于预防和治疗口腔鳞癌的药物

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3001A (en) * 1843-03-10 Method of coupling straps as a substitute for a buckle
FR2629455B1 (fr) * 1988-03-29 1991-09-27 Rhone Poulenc Agrochimie Derives de 2-(3-pyridinyl)3-(phenoxy) propanenitrile
WO1991016305A1 (en) 1990-04-16 1991-10-31 Rhone-Poulenc Rorer International (Holdings), Inc. Heterocyclicethenediyl compounds which inhibit egf receptor tyrosine kinase
US5196446A (en) * 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
US5981569A (en) * 1992-11-13 1999-11-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease
IL107736A (en) 1993-11-24 2001-01-11 Yissum Res Dev Co Pharmaceutical composition for the prevention of septic shock and for the treatment of chronic inflammatory diseases
IL112205A0 (en) * 1994-01-06 1995-03-15 Res Dev Foundation Curcumin, analogues of curcumin and novel uses thereof
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
AU2096895A (en) * 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
US6331555B1 (en) * 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
IL119069A0 (en) 1996-08-14 1996-11-14 Mor Research Applic Ltd Pharmaceutical composition comprising tyrphostins
US5854285A (en) * 1997-04-03 1998-12-29 Natpro, Inc. Protein kinase inhibitor
US6420338B1 (en) 1997-06-13 2002-07-16 New York University Medical Center Inhibition of the Src kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma
US6225346B1 (en) * 1997-10-24 2001-05-01 Sugen, Inc. Tyrphostin like compounds
KR100674760B1 (ko) * 1999-03-04 2007-01-25 리가가쿠 겐큐쇼 촉매 조성물
US20020045191A1 (en) * 2000-09-15 2002-04-18 Schneider Robert J. Inhibition of the SRC kinase family pathway as a method of treating HBV infection and hepatocellular carcinoma
JP2003119169A (ja) 2001-07-30 2003-04-23 Shigetoshi Kadota 細胞毒性活性を有する化合物およびそれを有効成分とする医薬組成物
US6433018B1 (en) * 2001-08-31 2002-08-13 The Research Foundation Of State University Of New York Method for reducing hypertrophy and ischemia
SE0201937D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab Therapeutic agents
WO2004047743A2 (en) * 2002-11-22 2004-06-10 Bristol-Myers Squibb Company 1-aryl-2-hydroxyethyl amides as potassium channel openers
KR20050055479A (ko) 2003-12-08 2005-06-13 김철호 카페인산 또는 카페인산 페네틸에스테르를 유효성분으로하는 ｍｍｐ-9 억제제
US7745468B2 (en) * 2003-12-11 2010-06-29 Board of Regents, University of Texas Systems The Compounds for treatment of cell proliferative diseases
CN101454275B (zh) * 2006-03-31 2014-07-23 得克萨斯大学体系董事会 口服生物可利用的咖啡酸相关的抗癌药

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CA2648003C (en) 2014-07-08
MX2008012612A (es) 2008-12-12
RU2008143237A (ru) 2010-05-10
US8779151B2 (en) 2014-07-15
HK1134072A1 (en) 2010-04-16
ES2533383T3 (es) 2015-04-09
US20070232668A1 (en) 2007-10-04
BRPI0709916A2 (pt) 2011-07-26
RU2456265C2 (ru) 2012-07-20
AU2007234455A1 (en) 2007-10-11
WO2007115269A3 (en) 2007-12-21
JP5654233B2 (ja) 2015-01-14
EP2007714A2 (en) 2008-12-31
CN101454275B (zh) 2014-07-23
CN101454275A (zh) 2009-06-10
EP2514742B1 (en) 2014-12-31
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AU2007234455B2 (en) 2012-10-04
US20150094343A1 (en) 2015-04-02
CA2648003A1 (en) 2007-10-11
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