CN109563100B - 三唑并嘧啶化合物的晶体形式 - Google Patents

三唑并嘧啶化合物的晶体形式 Download PDF

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CN109563100B
CN109563100B CN201780050951.1A CN201780050951A CN109563100B CN 109563100 B CN109563100 B CN 109563100B CN 201780050951 A CN201780050951 A CN 201780050951A CN 109563100 B CN109563100 B CN 109563100B
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compound
cancer
organic solvent
dihydrobenzofuran
triazolo
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CN109563100A (zh
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刘波
黄颖
毛亮
王龙
L·M·维科尔
张丽珺
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Novartis AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201780050951.1A 2016-06-20 2017-06-19 三唑并嘧啶化合物的晶体形式 Active CN109563100B (zh)

Applications Claiming Priority (3)

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CN2016086350 2016-06-20
CNPCT/CN2016/086350 2016-06-20
PCT/CN2017/089003 WO2017219948A1 (en) 2016-06-20 2017-06-19 Crystalline forms of triazolopyrimidine compound

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IL291471B2 (en) 2019-09-30 2025-04-01 Incyte Corp Pyrimido[3,2–D]pyrimidine compounds as immunomodulators
CN110796297B (zh) * 2019-10-21 2020-11-10 浙江大学 一种基于平衡度方差和可靠度的电力系统结构优化方法
AU2020374041B2 (en) * 2019-11-01 2024-02-08 Jing Medicine Technology (Shanghai) Ltd. EED inhibitor, and preparation method therefor and use thereof
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CA3185154A1 (en) * 2020-05-28 2021-12-02 Novartis Ag Dosing regimens for n-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, or a pharmaceutically acceptable salt thereof, for use in treating prc2-mediated diseases or disorders
CN114426541B (zh) * 2020-10-29 2023-06-30 成都先导药物开发股份有限公司 氮杂芳基化合物及其用途
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CA3027246A1 (en) 2017-12-28
EP3472168A1 (en) 2019-04-24
MX2018016331A (es) 2019-05-20
MX388824B (es) 2025-03-20
EP3472168A4 (en) 2019-12-11
KR20190020753A (ko) 2019-03-04
EP3472168B1 (en) 2024-01-10
US11091489B2 (en) 2021-08-17
IL263429A (en) 2018-12-31
RU2019101220A (ru) 2020-07-21
ES2975263T3 (es) 2024-07-04
CL2020002277A1 (es) 2021-02-12
RU2754856C2 (ru) 2021-09-08
JP2019522051A (ja) 2019-08-08
RU2019101220A3 (enExample) 2020-10-28
AU2017282871A1 (en) 2018-12-20
IL263429B (en) 2022-08-01
BR112018076443A2 (pt) 2019-04-09
US20210340152A1 (en) 2021-11-04
AU2017282871B2 (en) 2020-03-05
CN109563100A (zh) 2019-04-02
US11548897B2 (en) 2023-01-10
SA518400704B1 (ar) 2022-11-03
KR102519922B1 (ko) 2023-04-11
US20190211022A1 (en) 2019-07-11
CL2018003734A1 (es) 2019-02-15
JP7042812B2 (ja) 2022-03-28
WO2017219948A1 (en) 2017-12-28

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