CN109504731B - 一种羊胎盘活性肽的制备方法 - Google Patents
一种羊胎盘活性肽的制备方法 Download PDFInfo
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- CN109504731B CN109504731B CN201811570910.8A CN201811570910A CN109504731B CN 109504731 B CN109504731 B CN 109504731B CN 201811570910 A CN201811570910 A CN 201811570910A CN 109504731 B CN109504731 B CN 109504731B
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- placenta
- active peptide
- sheep placenta
- sheep
- enzymolysis
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- 210000002826 placenta Anatomy 0.000 title claims abstract description 71
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 69
- 241001494479 Pecora Species 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000004365 Protease Substances 0.000 claims abstract description 29
- 108090000270 Ficain Proteins 0.000 claims abstract description 16
- POTUGHMKJGOKRI-UHFFFAOYSA-N ficin Chemical compound FI=CI=N POTUGHMKJGOKRI-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000019836 ficin Nutrition 0.000 claims abstract description 16
- 239000000796 flavoring agent Substances 0.000 claims abstract description 15
- 235000019634 flavors Nutrition 0.000 claims abstract description 15
- 239000004367 Lipase Substances 0.000 claims abstract description 14
- 102000004882 Lipase Human genes 0.000 claims abstract description 14
- 108090001060 Lipase Proteins 0.000 claims abstract description 14
- 150000001875 compounds Chemical class 0.000 claims abstract description 14
- 235000019421 lipase Nutrition 0.000 claims abstract description 14
- 108091005804 Peptidases Proteins 0.000 claims abstract description 12
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract description 12
- 235000019419 proteases Nutrition 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 7
- 238000005238 degreasing Methods 0.000 claims abstract description 6
- 238000004108 freeze drying Methods 0.000 claims abstract description 6
- 210000004911 serous fluid Anatomy 0.000 claims abstract description 6
- 238000001728 nano-filtration Methods 0.000 claims description 17
- 238000001035 drying Methods 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 238000010612 desalination reaction Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000000746 purification Methods 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 5
- 108090000790 Enzymes Proteins 0.000 claims description 5
- 230000002779 inactivation Effects 0.000 claims description 5
- 239000012466 permeate Substances 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 239000002002 slurry Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000003795 desorption Methods 0.000 claims description 3
- 238000000859 sublimation Methods 0.000 claims description 3
- 230000008022 sublimation Effects 0.000 claims description 3
- 108010007119 flavourzyme Proteins 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 3
- 241000283898 Ovis Species 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 239000000413 hydrolysate Substances 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 20
- 229920001184 polypeptide Polymers 0.000 abstract description 17
- 230000007062 hydrolysis Effects 0.000 abstract description 12
- 238000006460 hydrolysis reaction Methods 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 8
- 230000000975 bioactive effect Effects 0.000 abstract description 6
- 238000011033 desalting Methods 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
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- 239000013543 active substance Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000001976 enzyme digestion Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000007710 freezing Methods 0.000 description 3
- 230000008014 freezing Effects 0.000 description 3
- 235000013372 meat Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 108010024636 Glutathione Proteins 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 239000002054 inoculum Substances 0.000 description 2
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- 102000004400 Aminopeptidases Human genes 0.000 description 1
- 108090000915 Aminopeptidases Proteins 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 240000006439 Aspergillus oryzae Species 0.000 description 1
- 235000002247 Aspergillus oryzae Nutrition 0.000 description 1
- 108090000145 Bacillolysin Proteins 0.000 description 1
- 102000005367 Carboxypeptidases Human genes 0.000 description 1
- 108010006303 Carboxypeptidases Proteins 0.000 description 1
- 102400000321 Glucagon Human genes 0.000 description 1
- 108060003199 Glucagon Proteins 0.000 description 1
- 102000035092 Neutral proteases Human genes 0.000 description 1
- 108091005507 Neutral proteases Proteins 0.000 description 1
- 102400000050 Oxytocin Human genes 0.000 description 1
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 description 1
- 101800000989 Oxytocin Proteins 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
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- 230000004071 biological effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
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- 230000029087 digestion Effects 0.000 description 1
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- 239000002158 endotoxin Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Water Supply & Treatment (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (5)
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CN201811570910.8A CN109504731B (zh) | 2018-12-21 | 2018-12-21 | 一种羊胎盘活性肽的制备方法 |
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CN201811570910.8A CN109504731B (zh) | 2018-12-21 | 2018-12-21 | 一种羊胎盘活性肽的制备方法 |
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CN109504731A CN109504731A (zh) | 2019-03-22 |
CN109504731B true CN109504731B (zh) | 2021-05-28 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109943614A (zh) * | 2019-04-02 | 2019-06-28 | 河北康进生物科技有限公司 | 一种羊胎盘活性肽的制备方法及其应用 |
CN111850076A (zh) * | 2020-07-29 | 2020-10-30 | 中国人民解放军联勤保障部队第九二〇医院 | 一种干细胞蛋白活性肽的制备方法 |
CN117925570A (zh) * | 2023-12-18 | 2024-04-26 | 蚌埠学院 | 从羊胎盘中提取生物活性物质的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103330048A (zh) * | 2013-07-19 | 2013-10-02 | 内蒙古迦妮生物科技开发有限公司 | 一种羊胎盘多肽粉的制备方法及其可溶性颗粒的制备方法 |
CN105341948A (zh) * | 2015-09-29 | 2016-02-24 | 北京御肽堂生物科技有限公司 | 一种牡蛎肽制备方法 |
CN108308620A (zh) * | 2018-03-27 | 2018-07-24 | 张至德 | 食用蛋白酶酶解动物器官和骨骼制备功能性肽食品的方法 |
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2018
- 2018-12-21 CN CN201811570910.8A patent/CN109504731B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103330048A (zh) * | 2013-07-19 | 2013-10-02 | 内蒙古迦妮生物科技开发有限公司 | 一种羊胎盘多肽粉的制备方法及其可溶性颗粒的制备方法 |
CN105341948A (zh) * | 2015-09-29 | 2016-02-24 | 北京御肽堂生物科技有限公司 | 一种牡蛎肽制备方法 |
CN108308620A (zh) * | 2018-03-27 | 2018-07-24 | 张至德 | 食用蛋白酶酶解动物器官和骨骼制备功能性肽食品的方法 |
Non-Patent Citations (2)
Title |
---|
Occurrence of a growth hormone-releasing hormone-like messenger ribonucleic acid and immunoreactive peptide in the sheep placenta;Lacroix MC,et al;《Reprod Fertil Dev》;19961231;第8卷(第3期);全文 * |
无花果蛋白酶的研究进展;郭冬青等;《北方园艺》;20100415;第211页左栏第2段 * |
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Publication number | Publication date |
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CN109504731A (zh) | 2019-03-22 |
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Address after: 056900 in the economic development zone of Daming County, Handan City, Hebei Province Applicant after: Hebei peptide Biotechnology Group Co.,Ltd. Address before: 056900 in the economic development zone of Daming County, Handan City, Hebei Province Applicant before: HEBEI TAIDU BIOTECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20210510 Address after: 056900 in Jingfu industrial city, Daming County, Handan City, Hebei Province (west side of 215 provincial road, Fuqiao village, Daming town) Applicant after: Hebei Peifeng Biotechnology Co.,Ltd. Address before: 056900 in the economic development zone of Daming County, Handan City, Hebei Province Applicant before: Hebei peptide Biotechnology Group Co.,Ltd. |
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Effective date of registration: 20240904 Address after: 056900 in the economic development zone of Daming County, Handan City, Hebei Province Patentee after: Hebei peptide Biotechnology Group Co.,Ltd. Country or region after: China Address before: 056900 in Jingfu industrial city, Daming County, Handan City, Hebei Province (west side of 215 provincial road, Fuqiao village, Daming town) Patentee before: Hebei Peifeng Biotechnology Co.,Ltd. Country or region before: China |