CN109464308B - Essential oil composition with blue light resisting and skin caring effects and application thereof - Google Patents
Essential oil composition with blue light resisting and skin caring effects and application thereof Download PDFInfo
- Publication number
- CN109464308B CN109464308B CN201811360637.6A CN201811360637A CN109464308B CN 109464308 B CN109464308 B CN 109464308B CN 201811360637 A CN201811360637 A CN 201811360637A CN 109464308 B CN109464308 B CN 109464308B
- Authority
- CN
- China
- Prior art keywords
- essential oil
- blue light
- skin
- oil composition
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Birds (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an essential oil composition with blue light resisting and skin caring effects and application thereof, and belongs to the field of cosmetics. The essential oil composition is prepared from the following components in percentage by weight: 0.05-10.0% of orange flower essential oil; 0.05-6.0% of pomegranate essential oil; 0.1-5.0% of ginger essential oil; 0.1-10.0% of lavender essential oil; the balance of base oil. The essential oil composition disclosed by the invention is prepared by matching various components according to a specific proportion, so that the synergistic effect is achieved, the blue light absorption effect of the essential oil composition is utilized to avoid the damage of the blue light to the skin, the skin darkness caused by the blue light is eliminated by utilizing the effects of promoting blood circulation, whitening and removing freckles of the essential oil composition, the skin damage and skin aging caused by the blue light are eliminated by utilizing the effects of promoting cell growth, promoting blood circulation to remove blood stasis and resisting free radicals of the essential oil composition, and the skin dryness problem caused by the blue light is solved by utilizing the moisturizing effect of the essential oil composition, so that the aim of comprehensively.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to an essential oil composition with blue light resisting and skin care effects and application thereof.
Background
With the continuous improvement of the living standard and the living quality of people, the requirements of consumers on the beauty and skin care products necessary for daily life are higher and higher, and the influence of the plant skin care concept of returning to nature is emphasized more and more.
Compared with ultraviolet rays, visible light has stronger penetrating power and can reach the dermis of human skin directly, so that the visible light can cause deeper damage to the skin and even genes. The visible light is composed of seven colors of light such as purple, blue, cyan, green, yellow, orange, red and the like, wherein the energy of the blue light wave band with the wavelength of 400-500 nm is the highest, and the harm to human bodies is the greatest. Blue light can penetrate into the dermis of skin, under the irradiation of the blue light, mitochondria in cells can generate active oxygen free radicals, and the active oxygen free radicals can generate oxidation reaction with the mitochondria, DNA and cell structures containing lipid, such as cell membranes, mitochondrial membranes, lysosomes and the like, so that the mitochondria and the DNA are damaged, the cell membrane dysfunction is caused to influence the growth and development of the cells, the cell structures are damaged, and the cells are damaged to cause apoptosis. Apparently, blue light induces the production of free radicals by cells, causing the fibroblasts of the dermal layer of the skin to be damaged and the extracellular matrix to be reduced, thereby causing premature aging of the skin.
The influence of blue light on human body draws more and more attention, and people begin to consciously carry out relevant blue light protection research, such as blue light prevention glasses, blue light prevention cosmetics and the like. Once cosmetics mainly pushing the concept of resisting blue light are introduced in the market, the cosmetics are pursued by a large number of consumers, and the consumers are gradually aware of the importance of resisting blue light. Under the background of the large environment, the anti-blue light product becomes another research hotspot of the photoprotective cosmetics.
CN2016112330321 discloses a blue light protection composition, which comprises the following raw materials by weight: the composition comprises lutein, cocoa seed extract, black rose extract, rose hip oil and xylitol, and has very strong blue light absorption, oxidation resistance and skin repair effects.
CN2018103006455 discloses a cosmetic raw material with blue light resistance and ultraviolet resistance, and a preparation method and application thereof. The raw material components of the cosmetic comprise jasmine extract, butterflybush flower extract, bisabolol, glycerin, water, propylene glycol, titanium dioxide, cyclopentadimethylsiloxane, isohexadecane, polydimethylsiloxane, petrolatum, 1, 2-hexanediol, butyl methoxy dibenzoyl methane, xanthan gum and the like.
CN2017109855422 discloses a traditional Chinese medicine composition with ultraviolet and blue light protection effects, which is prepared by pulverizing turmeric, butterflybush flower, marigold, ginkgo leaf and cabbage, sieving, mixing, adding an extraction solvent, and extracting with a continuous low-temperature micro-jet wall-breaking extractor.
CN2017109855418 discloses a plant extract composition capable of absorbing ultraviolet light and blue light in all bands, which comprises spinach extract, corn stigma extract, orange peel extract, calendula extract and tomato extract.
Scientific blue light resistance starts from dredging and absorbing blue light, and comprehensively treats skin problems caused by blue light, such as dark color, skin injury and the like from the aspects of promoting blood circulation, resisting free radicals, promoting cell growth, whitening, moisturizing and the like.
Disclosure of Invention
In order to overcome the defects and shortcomings of the prior art, the invention mainly aims to provide an essential oil composition with blue light resisting and skin caring effects. The invention provides an essential oil composition with blue light absorption, whitening, anti-aging and moisturizing effects based on the monarch, minister, assistant and guide theory of traditional Chinese medicine.
The invention also aims to provide application of the essential oil composition with the blue light resisting and skin caring effects.
The purpose of the invention is realized by the following technical scheme:
an essential oil composition with blue light resisting and skin caring effects is prepared from the following components in percentage by weight: 0.05-10.0% of orange flower essential oil; 0.05-6.0% of pomegranate essential oil; 0.1-5.0% of ginger essential oil; 0.1-10.0% of lavender essential oil; the balance of base oil.
Preferably, the essential oil composition with the blue light resisting and skin care effects is prepared from the following components in percentage by weight: 0.1-8.0% of orange flower essential oil; 0.1-5.0% of pomegranate essential oil; 0.1-3.0% of ginger essential oil; 0.1-8.0% of lavender; the balance of base oil.
Further preferably, the essential oil composition with the blue light resisting and skin care effects is prepared from the following components in percentage by weight: 1.8-2.8% of orange flower essential oil; 0.7-1.0% of pomegranate essential oil; 0.4-0.7% of ginger essential oil;
1.1-1.5% of lavender; the balance of base oil.
Preferably, the essential oil composition with the blue light resisting and skin care effects is prepared from the following components in percentage by weight: orange flower essential oil 2.0%; 1.0% of pomegranate essential oil; ginger essential oil 0.6%; 1.4% of lavender essential oil; the balance of base oil.
Preferably, the essential oil composition with the blue light resisting and skin care effects is prepared from the following components in percentage by weight: orange flower essential oil 2.5%; 0.8% of pomegranate essential oil; ginger essential oil 0.5%; 1.2% of lavender essential oil; the balance of base oil.
Preferably, the essential oil composition with the blue light resisting and skin care effects is prepared from the following components in percentage by weight: 1.8% of orange flower essential oil; 0.8% of pomegranate essential oil; ginger essential oil 0.7%; 1.5% of lavender essential oil; the balance of base oil.
Preferably, the essential oil composition with the blue light resisting and skin care effects is prepared from the following components in percentage by weight: orange flower essential oil 2.8%; 0.7% of pomegranate essential oil; ginger essential oil 0.4%; 1.1% of lavender essential oil; the balance of base oil.
The base oil is one or more of seabuckthorn fruit oil, grape seed oil, wheat germ oil, olive oil and jojoba oil.
The invention further aims to provide application of the essential oil composition with the blue light resisting and skin caring effects in cosmetics.
In order to achieve the purpose of the invention, the invention adopts the following technical scheme:
the application of the essential oil composition with the blue light resisting and skin caring effects in preparing cosmetics comprises the essential oil composition with the blue light resisting and skin caring effects, wherein the addition amount of the essential oil composition in the cosmetics is 0.1-50% (preferably 1-20%) by mass fraction.
The invention also provides a cosmetic with blue light resisting and skin caring effects, which contains the essential oil composition with blue light resisting and skin caring effects.
Preferably, the cosmetic contains 0.1-50% (preferably 1-20%) by mass of the essential oil composition with the blue light resisting and skin care effects.
The cosmetic is as follows: essential oils, aqueous solutions, emulsions, creams, sprays, essences, soaps, lotions.
Specifically, the invention provides anti-blue-light skin-care essence oil which comprises the following components in parts by mass:
specifically, the invention provides an anti-blue-light skin care emulsion which comprises the following components in parts by mass:
| name of substance | Mass fraction/% |
| Dimethylsiloxane | 6 |
| Caprylic/capric triglyceride | 6 |
| Palmitic acid isopropyl ester | 4 |
| Monoglyceride | 0.5 |
| Stearic acid | 2 |
| Glycerol | 6 |
| Butanediol | 4 |
| The essential oil composition of the invention | 2 |
| Aminomethyl propanol | 0.7 |
| Deionized water | Balance of |
Specifically, the invention provides blue-light-resistant skin lotion which comprises the following components in parts by mass:
| name of substance | Mass fraction/% |
| Water (W) | Balance of |
| EDTA-2Na | 0.05 |
| Glycerol | 6 |
| Butanediol | 5 |
| Xanthan gum | 0.05 |
| 1% sodium hyaluronate solution | 1 |
| Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer | 0.5 |
| The essential oil composition of the invention | 1 |
| Polydimethylsiloxane | 1 |
The basis of the invention is as follows:
the essential oil composition with the blue light resisting and skin protecting effects is obtained by taking the monarch, minister, assistant and guide traditional Chinese medicine composition theory as guidance and carrying out a large number of experimental researches by the inventor, and is an optimal composition obtained by selecting orange flower essential oil, pomegranate essential oil, ginger essential oil and lavender essential oil to carry out compatibility experiments according to a specific proportion. The orange flower essential oil in the essential oil composition is a monarch drug, and has the effects of strongly absorbing blue light and whitening, moisturizing, resisting wrinkles and lightening spots; the pomegranate essential oil is a ministerial drug, and has the blue light absorption effect and the excellent free radical scavenging effect; the ginger essential oil is an adjuvant drug, has good blue light absorption effect, and also has the effects of promoting blood circulation, removing blood stasis and promoting cell growth; the lavender essential oil is a messenger drug, has the effects of soothing nerves, promoting sleep and regulating biological rhythm, and has excellent effects of controlling oil, removing acnes, removing freckles, whitening, removing wrinkles and tendering skin.
Compared with the prior art, the invention has the following advantages and effects:
the essential oil composition disclosed by the invention is prepared by matching various components according to a specific proportion, so that the synergistic effect is achieved, the blue light absorption effect of the essential oil composition is utilized to avoid the damage of the blue light to the skin, the skin darkness caused by the blue light is eliminated by utilizing the effects of promoting blood circulation, whitening and removing freckles of the essential oil composition, the skin damage and skin aging caused by the blue light are eliminated by utilizing the effects of promoting cell growth, promoting blood circulation to remove blood stasis and resisting free radicals of the essential oil composition, and the skin dryness problem caused by the blue light is solved by utilizing the moisturizing effect of the essential oil composition, so that the aim of comprehensively.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
The test methods in the following examples, in which specific experimental conditions are not specified, are generally performed according to conventional experimental conditions or according to the experimental conditions recommended by the manufacturer.
EXAMPLE 1 an essential oil composition (I) having skin care effect against blue light
An essential oil composition with blue light resisting and skin caring effects is prepared from the following components in percentage by weight: orange flower essential oil 2.0%; 1.0% of pomegranate essential oil; ginger essential oil 0.6%; 1.4% of lavender essential oil; the balance of seabuckthorn fruit oil.
EXAMPLE 2 an essential oil composition (II) having skin care effect against blue light
An essential oil composition with blue light resisting and skin caring effects is prepared from the following components in percentage by weight: orange flower essential oil 2.5%; 0.8% of pomegranate essential oil; ginger essential oil 0.5%; 1.2% of lavender essential oil; jojoba oil as the balance.
EXAMPLE 3 an essential oil composition (III) having skin-protecting effect against blue light
An essential oil composition with blue light resisting and skin caring effects is prepared from the following components in percentage by weight: 1.8% of orange flower essential oil; 0.8% of pomegranate essential oil; ginger essential oil 0.7%; 1.5% of lavender essential oil; the rest is olive oil.
EXAMPLE 4 an essential oil composition (IV) having skin care effect against blue light
An essential oil composition with blue light resisting and skin caring effects is prepared from the following components in percentage by weight: orange flower essential oil 2.8%; 0.7% of pomegranate essential oil; ginger essential oil 0.4%; 1.1% of lavender essential oil; the rest is wheat germ oil.
Comparative examples 1-5 compositions of a Single essential oil and base oil
The specific combination is shown in table 1.
TABLE 1
| Composition (I) | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| Orange flower essential oil | 5％ | 0 | 0 | 0 | 0 |
| Lavender essential oil | 0 | 5％ | 0 | 0 | 0 |
| Pomegranate essential oil | 0 | 0 | 5％ | 0 | 0 |
| Ginger essential oil | 0 | 0 | 0 | 5％ | 0 |
| Sea buckthorn fruit oil | 95％ | 95％ | 95％ | 95％ | 100％ |
Test example 1 blue light absorption test
The products prepared in the above example 1 and comparative examples 1 to 5 were dissolved and diluted with absolute ethanol to a mass fraction of 0.1%, and diluted samples were prepared. And (3) carrying out a waveband scanning test at 400-500 nm by using a spectrophotometer.
The result shows that the sample prepared in the example 1 has stronger absorption at each wavelength within the range of 400-500 nm, while the samples prepared in the comparative examples 1-5 have no absorption or poor absorption effect at certain wave bands, and the absorbance of the sample prepared in the example 1 is obviously higher than that of the samples prepared in the comparative examples 1-5. The essential oil composition has the effect of strongly absorbing blue light, and particularly has a synergistic effect among components after the essential oil is scientifically compounded.
Test example 2 melanin inhibition test
1. Preparation of the test specimens
The sample prepared in example 1 and the samples prepared in comparative examples 1 to 5 were dissolved in dimethyl sulfoxide to prepare a sample solution having a concentration of 1%.
2. Tyrosinase inhibitory activity effect evaluation test
Accurately sucking a sample solution, a Phosphate Buffer Solution (PBS) with the pH value of 6.8 and a dopa solution with the mass fraction of 0.1% according to the table 2, fully mixing, incubating at 30 ℃ for 5min, adding a tyrosinase solution with the activity of 110U/mL, incubating at 30 ℃ for 10min, quickly transferring to a cuvette, and measuring the absorbance at 475 nm.
TABLE 2
| Components of reaction solution | Group 1 | 2 groups of | Group 3 | 4 groups of |
| Sample solution/mL | 0 | 0 | 1 | 1 |
| Phosphate buffer solution/mL | 2 | 2.5 | 1 | 1.5 |
| Dopa solution/mL | 1 | 1 | 1 | 1 |
| Tyrosinase solution/mL | 0.5 | 0 | 0.5 | 0 |
| Total volume/mL | 3.5 | 3.5 | 3.5 | 3.5 |
The relative inhibition rate (I, inhibition rate for short, the same below) of the sample on tyrosinase was calculated according to the formula (1).
In the formula: a. the1、A2、A3、A4The absorbance of each of the solutions was 1 to 4.
3. Test for inhibiting melanin synthesis in melanocytes
B16 melanoma cells (mouse melanoma cells, Shanghai cell bank of Chinese academy of sciences, model TCM2) were cultured at 1X 105one/mL of the cells were seeded in 96-well plates at 90. mu.L/well in CO2After incubation in the incubator for 24 hours, the sample solution was added to each well. A blank control group of medium and cells was set up simultaneously.
After the plates were incubated in an incubator for 72 hours, the supernatant was discarded, washed twice with PBS, and then 0.5mL of trypsinized cells were added to each well for 3min, and 2mL of maintenance solution was added to each well to stop digestion. After mixing, 0.5mL of each concentration was taken out and counted. Centrifuging the rest cell suspension at 2500r/min for 5min, discarding supernatant, adding NaOH solution into the precipitate, heating to dissolve melanin, and measuring absorbance at 490nm under enzyme-linked immunosorbent assay. The melanin synthesis inhibition ratio (I') of the sample was calculated according to the formula (2).
In the formula: a. the5Is the absorbance value of the sample solution hole; p1Cell density of the sample solution well; a. the6Absorbance values for control wells; p2Control wells are used for cell density.
4. Test results
The test results are shown in Table 3.
TABLE 3
The experimental results in table 3 show that the essential oil composition of the present invention can significantly inhibit tyrosinase activity and melanin synthesis, and under the condition of no change in total usage amount, the effect of the essential oil composition of the present invention is significantly improved compared with the effect of a single essential oil and base oil composition and pure base oil, which indicates that synergistic interaction is exerted among different essential oils.
Test example 3 radical scavenging test
1. Preparation of the test specimens
The products prepared in example 1 and comparative examples 1 to 5 were prepared into 1% ethanol solutions, and the following experiments were performed.
2. Evaluation of superoxide anion radical scavenging ability
4.5mL of Tris-HCl buffer (0.05 mol/L, pH 8.2) was preheated in a water bath at 25 ℃ for 20 min. Then adding 1mL of sample ethanol solution and 0.4mL of 25mmol/L pyrogallol solution, mixing uniformly, reacting for 5min in a water bath at 25 ℃, and adding 1.0mL of 8mol/L HCl to terminate the reaction. Absorbance values were measured at 299nm with Tris-HCl buffer as a reference. Blank control the sample was replaced with 1mL of solvent of the sample ethanol solution.
Superoxide anion radical scavenging rate (%) [ 1- (A2/A1) ] x 100%
Wherein A1 is the absorbance value of the blank control; a2 is the absorbance value of the sample.
3. Evaluation of hydroxyl radical scavenging ability
Sequentially adding 2mmol/L FeSO into a 25mL colorimetric tube4 3mL，1mmol/L H2O23mL, shaking up, then adding 3mL of salicylic acid with the concentration of 6mmol/L, shaking up, heating in a water bath at 37 ℃ for 15min, taking out, and measuring the absorbance; adding the solutions to be tested with certain concentrations, shaking, heating in water bath for 15min, and taking out to test their absorbance. The following formula is the clearance rate of hydroxyl radical (. OH) by the liquid to be tested:
hydroxyl radical clearance (%) ([ A3-A4- (A3-A5) ]/A3X 100%
Wherein A3 is the absorbance value of the reaction system before adding the sample; a4 is the absorbance value of the system after removing OH from the sample; a5 is the absorbance value of the system after blank control elimination of OH.
4. Comparative testing of samples against free radicals
TABLE 4 evaluation results of radical scavenging function
Experimental results show that the essential oil composition in the embodiment 1 has a removal rate of superoxide anions of more than 83% and a removal rate of hydroxyl radicals of about 88%, and the essential oil composition has an obvious effect of removing free radicals, has a much better effect on the removal rate of the free radicals than samples in a comparison ratio of 1-5, and has a synergistic effect after scientific compounding.
Test example 4 skin moisturizing effect test
Experimental materials: the product of example 1 and comparative examples 1-5 is diluted to 5 times with olive oil to be used as a sample, and the change of the moisture content of the skin of a test person after the sample is used is compared.
In the test, moisturizing efficacy tests are performed on example 1 and comparative examples 1 to 5 according to the evaluation guidelines of moisturizing efficacy of cosmetics in the light industry standard. The principle of the method is as follows: the capacitance method is used for measuring the moisture content of the human skin stratum corneum, and is based on the obvious difference of dielectric constants of water and other substances, the capacitance values of the measured skin are different according to the moisture content of the skin stratum corneum, and the parameters can represent the moisture content of the skin.
40 subjects, half of both male and female, were selected. The whole testing process is carried out in a constant temperature and humidity laboratory, the room temperature is 20-22 ℃, and the humidity is 40-60%. The testee should wash the forearm, sit at a set humidity for 30min, and then mark 3 × 3cm on the left and right forearms2The square experiment area of the size takes the left arm as the test area of the moisturizing product, the corresponding symmetrical area of the right arm is blank control, the moisture content of each experiment part is tested and detected by using a Corneometer CM825, the test is repeated for 5 times respectively, and the average value of each test is obtained, and the result is shown in Table 5.
TABLE 5
As can be seen from Table 5, the skin of the sample of example 1 of the present invention still has a higher moisture content 2 hours after use, indicating that the essential oil composition prepared by the present invention has a better moisturizing effect. The samples of comparative examples 1 to 5, however, had lower hydration rates per time period than the samples of example 1 of the present invention. Therefore, after the essential oils are scientifically combined, the moisturizing effect is improved under the condition of consistent dosage, and the essential oils have good synergistic moisturizing and synergistic effects.
Test example 5 skin irritation test
Experimental materials: the product of example 1 and comparative examples 1-5 was diluted 5 times with olive oil and used as a sample.
Subject: a total of 30 volunteers, of which women: 20 men and 10 men, the age is 20-40 years old.
The test method comprises the following steps: 0.03mL of the sample was taken by a syringe and placed in a chamber of a spot test tape, and the spot test tape with the sample was immediately stuck to the normal skin of the left forearm from the lower part in the longitudinal direction while gently pressing the chamber one by one to expel air and uniformly distribute the test substance. The test site is marked for easy observation. Every 24 hours, and half an hour after the patch was removed, the examination was performed according to the terms of the CTFA guidelines (1981). The patch test was performed 6 times in total, and on day 6 after completion of the skin application, additional examination was performed to observe delayed reactions. The data is compared using the last examination. The identification was carried out using the following table 6 as a standard:
TABLE 6 skin irritation assay standards
| Grade | (symbol) | Identification criteria |
| 0 | - | Negative reaction: has no irritation and erythema |
| 1 | ± | And (3) suspicious reaction: mild erythema |
| 2 | + | Weak positive reaction: erythema |
| 3 | ++ | Strong positive reaction: erythema, papules, blisters |
| 4 | +++ | Extremely strong positive reaction: severe edema and bulla |
And (3) test results: as shown in table 7.
Table 7 skin irritation test results
| Number of times of skin sticking | Example 1 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 |
| 1 | 0 | 1 time +/-) | 1 time +/-) | 1 time +/-) | 1 time +/-) | 0 |
| 2 | 0 | 0 | 0 | 0 | 1 time of | 0 |
| 3 | 0 | 0 | 1 time +/-) | 0 | 0 | 0 |
| 4 | 0 | 0 | 0 | 1 time +/-) | 1 time of | 0 |
| 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 6 | 0 | 0 | 0 | 0 | 0 | 0 |
| Total up to | 0 | 1 time +/-) | 2 times +/-) | 2 times +/-) | 1 time plus or minus and 2 times plus | 0 |
The results in Table 7 show that the essential oil composition sample of example 1 of the invention is equivalent to the base oil sample of comparative example 5 in irritation, no irritation is found in volunteers, and the irritation is much lower than that of the samples of comparative examples 1-4. Therefore, the essential oil is milder than that used alone under the condition of consistent dosage after being scientifically combined.
Application example 1 anti-blue light skin care essence oil
The blue light resisting skin care essence oil containing the essential oil composition with the blue light resisting skin care effect has the specific formula shown in the table 8:
TABLE 8 anti-blue light skin care essential oil formula
| Component name | Mass fraction (%) |
| Squalane | 38 |
| Caprylic/capric triglyceride | 22 |
| Isononyl isononanoate | 14 |
| Jojoba oil | 5 |
| Olive oil | 1 |
| Essential oil composition (I) prepared in example 1 | 20 |
The preparation method comprises the following steps: the raw materials of each component are weighed according to the formula proportion in sequence and stirred and mixed evenly at normal temperature.
Application comparative example 1 general skin care essential oil
Except that the essential oil composition (I) of the present invention was not contained, the same was conducted as in application example 1.
Application example 2 anti-blue light skin care emulsion
The blue light resisting skin care emulsion containing the essential oil composition with the blue light resisting skin care effect has the specific formula shown in the table 9:
TABLE 9 anti-blue light skin care emulsion formulation
| Name of substance | Mass fraction (%) |
| Dimethylsiloxane | 6 |
| Caprylic/capric triglyceride | 6 |
| Palmitic acid isopropyl ester | 4 |
| Monoglyceride | 0.5 |
| Stearic acid | 2 |
| Glycerol | 6 |
| Butanediol | 4 |
| The essential oil composition (I) of the invention | 2 |
| Aminomethyl propanol | 0.7 |
| Deionized water | Balance of |
The preparation method comprises the following steps: mixing dimethyl siloxane, isopropyl palmitate, caprylic/capric triglyceride, monoglyceride and stearic acid in a formula table, heating to 80 ℃, and melting and uniformly stirring to obtain an oil phase; mixing glycerol, butanediol, essential oil composition, aminomethyl propanol, and deionized water, heating to 85 deg.C, stirring, and dissolving to obtain water phase. Adding the oil phase and the water phase into an emulsifying pot, stirring uniformly, emulsifying and homogenizing for 6 minutes, and stirring and cooling to 38 ℃.
Application example 3 anti-blue light skin lotion
The blue light resisting skin lotion containing the essential oil composition with the blue light resisting skin care effect has the specific formula shown in the table 10:
TABLE 10 anti-blue-light skin lotion formulation
| Name of substance | Mass fraction (%) |
| Water (W) | Balance of |
| EDTA-2Na | 0.05 |
| Glycerol | 6 |
| Butanediol | 5 |
| Xanthan gum | 0.05 |
| 1% sodium hyaluronate solution | 1 |
| Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer | 0.5 |
| The essential oil composition (I) of the invention | 1 |
| Polydimethylsiloxane | 1 |
The preparation method comprises the following steps: dissolving water, EDTA-2Na, glycerol, butanediol, xanthan gum and 1% sodium hyaluronate aqueous solution completely, heating to 80 deg.C, keeping the temperature for 20min, stirring uniformly, cooling to 60 deg.C, adding hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, essential oil composition (I) and polydimethylsiloxane, homogenizing for 5min, stirring, cooling to 50 deg.C, stirring uniformly, and cooling to 38 deg.C.
Effect example 1 evaluation of blue light resistance effect
1. Test method
The essential oils prepared in application example 1 and application comparative example 1 were subjected to human trial evaluation, respectively. Selecting 40 volunteers who like to watch videos by using the mobile phone, wherein the volunteers are 20-45 years old and half male and half female. The blue light resisting skin care essential oil of application example 1 is used on the left side, the common skin care essential oil of application example 1 is used on the right side, the skin care essential oil is used once every day in the morning, the noon and the evening, 2g of the product is smeared on the face each time, the face is massaged for 2 minutes and is continuously used for 30 days, and the skin colors of the left face and the right face after two months of use are observed.
In the using process, the using effect of the product, such as improvement conditions of skin whiteness, glossiness, moisture retention and firmness, is evaluated, wherein the highest score is 5, and the lowest score is 1.
2. Test results
Filling out a trial evaluation table according to the sensory evaluation. And collecting a half-face test trial evaluation table, and showing the statistical result in table 11.
TABLE 11 average values of human trial results
| Evaluation results | Application example 1 | Application comparative example 1 |
| Whiteness degree | 4.3 | 2.5 |
| Moisture retention | 4.2 | 3.3 |
| Degree of gloss | 4.5 | 2.1 |
| Compactness degree | 3.9 | 2.4 |
The results in table 11 show that the user thinks that the skin whiteness, glossiness, moisture retention and firmness are significantly improved after using the essential oil of application example 1 of the present invention, and the effects are much more obvious than those of using the essential oil of application example 1, which indicates that the essential oil composition of the present invention has significant comprehensive blue light resistance effects of whitening, anti-aging, moisture retention, etc. when applied to cosmetics.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (10)
1. An essential oil composition with blue light resisting and skin caring effects is characterized in that: the composition is prepared from the following components in percentage by weight: 1.8-2.8% of orange flower essential oil; 0.7-1.0% of pomegranate essential oil; 0.4-0.7% of ginger essential oil; 1.1-1.5% of lavender; the balance of base oil;
the base oil is one or more of fructus Hippophae oil, wheat germ oil, oleum Olivarum, and jojoba oil.
2. Use of the essential oil composition having skin care effects against blue light according to claim 1 for the preparation of cosmetics.
3. Use according to claim 2, characterized in that:
the addition amount of the essential oil composition with the blue light resisting and skin care effects in the cosmetics is 0.1-50% by mass.
4. A cosmetic with blue light resisting and skin caring effects is characterized in that: the essential oil composition having skin care effects against blue light according to claim 1.
5. The cosmetic with anti-blue light skin care efficacy according to claim 4, characterized in that:
the cosmetic contains 0.1-50% of essential oil composition with blue light resisting and skin care effects in mass percentage.
6. The cosmetic with skin care efficacy against blue light according to claim 4 or 5, characterized in that:
the cosmetic is as follows: essential oils, emulsions, creams, sprays, essences, lotions.
7. The cosmetic with skin care efficacy against blue light according to claim 4 or 5, characterized in that:
the cosmetic is as follows: aqueous preparations and soaps.
8. The cosmetic with skin care efficacy against blue light according to claim 4 or 5, characterized in that:
the cosmetic with the blue light resisting and skin caring effects is blue light resisting and skin caring essence oil, and comprises the following components in percentage by mass: squalane 38%, caprylic/capric triglyceride 22%, isononyl isononanoate 14%, jojoba oil 5%, olive oil 1%, and essential oil composition 20%.
9. The cosmetic with skin care efficacy against blue light according to claim 4 or 5, characterized in that:
the cosmetic with the blue light resisting skin care effect is blue light resisting skin care emulsion and comprises the following components in parts by mass: 6% of dimethyl siloxane, 6% of caprylic/capric triglyceride, 4% of isopropyl palmitate, 0.5% of monoglyceride, 2% of stearic acid, 6% of glycerol, 4% of butanediol, 2% of an essential oil composition, 0.7% of aminomethyl propanol and the balance of deionized water.
10. The cosmetic with skin care efficacy against blue light according to claim 4 or 5, characterized in that:
the cosmetic with the blue light resisting and skin caring effects is blue light resisting and skin caring lotion and comprises the following components in parts by mass: 0.05% of EDTA-2Na, 6% of glycerol, 5% of butanediol, 0.05% of xanthan gum, 1% of sodium hyaluronate solution, 0.5% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1% of essential oil composition, 1% of polydimethylsiloxane and the balance of water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811360637.6A CN109464308B (en) | 2018-11-15 | 2018-11-15 | Essential oil composition with blue light resisting and skin caring effects and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811360637.6A CN109464308B (en) | 2018-11-15 | 2018-11-15 | Essential oil composition with blue light resisting and skin caring effects and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109464308A CN109464308A (en) | 2019-03-15 |
| CN109464308B true CN109464308B (en) | 2021-06-04 |
Family
ID=65673715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811360637.6A Active CN109464308B (en) | 2018-11-15 | 2018-11-15 | Essential oil composition with blue light resisting and skin caring effects and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109464308B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024006751A1 (en) * | 2022-06-29 | 2024-01-04 | Isp Investments Llc | Method of cosmetic treatment for improving the skin night-time renewal process and for protecting the skin from free radicals associated with blue light exposure |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3102930B1 (en) * | 2019-11-13 | 2023-03-10 | Robertet Sa | Cosmetic use of aromatic raw material extract in cosmetics to protect skin against blue light |
| CN113274318A (en) * | 2021-06-24 | 2021-08-20 | 云南雅赫生物科技有限公司 | Skin-tendering essential oil with whitening and spot-lightening functions and preparation method thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104739677A (en) * | 2013-12-25 | 2015-07-01 | 黄顺意 | Emulsion having anti-allergy ray proof efficacy |
| CN106344465A (en) * | 2016-11-16 | 2017-01-25 | 广东轻工职业技术学院 | Moisturizing lotion without preservative |
| CN106511135B (en) * | 2016-12-22 | 2019-10-11 | 江苏耐雀生物工程技术有限公司 | A kind of whitening compound essential oil and preparation method thereof |
| CN107648135A (en) * | 2017-09-25 | 2018-02-02 | 吉安市御美丽健康产业股份有限公司 | A kind of ginseng compounding creme for improving human skin collagen structure and preparation method thereof |
| CN107582981A (en) * | 2017-10-20 | 2018-01-16 | 广东轻工职业技术学院 | It is a kind of to have ultraviolet light concurrently and blue light protects the Chinese medicine composition and application of effect |
| CN107789265A (en) * | 2017-10-20 | 2018-03-13 | 广东轻工职业技术学院 | A kind of all band absorbs composition of plant extracts and the application of ultraviolet light and blue light |
| CN108272690A (en) * | 2018-04-04 | 2018-07-13 | 吕爱延 | Have both anti-blue light and the cosmetic material of UV resistance and the preparation method and application thereof |
| CN108310348A (en) * | 2018-04-18 | 2018-07-24 | 佛山科学技术学院 | A kind of preparation method of breath freshening spraying medicament |
-
2018
- 2018-11-15 CN CN201811360637.6A patent/CN109464308B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 植物精油及萜类成分的生物活性;孙凌峰;《江西师范大学学报（自然科学版）》;20000630;第24卷(第2期);第159-163页 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024006751A1 (en) * | 2022-06-29 | 2024-01-04 | Isp Investments Llc | Method of cosmetic treatment for improving the skin night-time renewal process and for protecting the skin from free radicals associated with blue light exposure |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109464308A (en) | 2019-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006514657A (en) | Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis | |
| CN109464308B (en) | Essential oil composition with blue light resisting and skin caring effects and application thereof | |
| KR20130088912A (en) | Skin external composition containing tangeretin and egcg | |
| CN105496938B (en) | α-bisabolol shin moisturizer | |
| EP2330910B1 (en) | Cosmetic use of leucojum bulb extracts | |
| KR20090111719A (en) | Cosmetic Compositions for whitening Skin containing jujube culture | |
| KR101509848B1 (en) | Composition for skin external application comprising tanshinone ⅱa as the active ingredient | |
| JP2001158728A (en) | Agent for promoting production of hyaluronic acid and skin preparation for external use | |
| KR101208013B1 (en) | A skin-care agent containing mycoleptodonoides aitchisonii mycelium extract | |
| KR101402193B1 (en) | Cosmetic composition for skin whitening containig pleurotus ferulae fruit body extract or pleurotus ferulae mycelium extract or pleurotus ferulae mycelium culture fluid | |
| KR101481208B1 (en) | Composition for skin external application comprising cryptotanshinone as the active ingredient | |
| CN109330917B (en) | Essential oil composition with whitening, anti-aging and moisturizing effects and application thereof | |
| JP2008255043A (en) | Skincare preparation for external use | |
| JP2000096050A (en) | Promoter for production of hyaluronic acid | |
| KR102333132B1 (en) | Cosmetic Composition containing Frangipani Oil or Fermented Frangipani Oil | |
| KR100532633B1 (en) | Cosmetic composition having anti-inflammatory, skin-protecting, skin-elastic effects which comprise mixed plants extract | |
| KR20140081137A (en) | A skin-care agent containig Morchella esculenta fruit body extract or Morchella esculenta mycelium extract | |
| KR101458496B1 (en) | A skin-care agent for anti-inflammatory containig Pleurotus ferulae fruit body extract or Pleurotus ferulae mycelium extract or Pleurotus ferulae mycelium culture fluid | |
| KR100424726B1 (en) | Skin care cosmetic composition containing stabilized vitamin C and phytosphingosine | |
| JPH1171295A (en) | Immunoactivator for preventing lowering of dermal immunofunction due to ultraviolet ray | |
| KR20160000318A (en) | Cosmetic composition containing Fir tree oil | |
| KR20130089559A (en) | Anti-aging composition | |
| US11452681B2 (en) | Cosmetic compositions to prevent and/or ameliorate skin aging and methods of applications | |
| KR100965085B1 (en) | Composition for cosmetic application having skin whitening function | |
| JP5710224B2 (en) | External preparation for skin or cosmetics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210517 Address after: 510920 buildings 5 and 6, 123 Meidu Road, Chengjiao street, Conghua District, Guangzhou City, Guangdong Province Applicant after: Guangzhou tianzhili Industrial Co.,Ltd. Applicant after: GUANGZHOU TIAZHLI BIOTECHNOLOGY Co.,Ltd. Address before: 510300 No. 152 West Xingang Road, Guangzhou, Guangdong, Haizhuqu District Applicant before: Guangdong Industry Technical College |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |