CN107648135A - A kind of ginseng compounding creme for improving human skin collagen structure and preparation method thereof - Google Patents

A kind of ginseng compounding creme for improving human skin collagen structure and preparation method thereof Download PDF

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Publication number
CN107648135A
CN107648135A CN201710871959.6A CN201710871959A CN107648135A CN 107648135 A CN107648135 A CN 107648135A CN 201710871959 A CN201710871959 A CN 201710871959A CN 107648135 A CN107648135 A CN 107648135A
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parts
ginseng
human skin
creme
compounding
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Inventor
尹志明
刘动勤
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Jian Royal Beauty Health Co Ltd
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Jian Royal Beauty Health Co Ltd
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Priority to CN201710871959.6A priority Critical patent/CN107648135A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)

Abstract

The present invention provides a kind of ginseng compounding creme for improving human skin collagen structure, is made up of the material of following parts by weight:3~10 parts of ginseng extract, 1~5 part of collagen tripeptide, 3~10 parts of bamboo extractive, 0.1~0.5 part of capsaicine, 3~10 parts of glycerin monostearate, 1~5 part of vitamin A acid, 20~30 parts of glycerine, 10~20 parts of water.Each component significantly improves human skin collagen structure, the diameter of regular fibrillation and interval, collagen fabric is had more preferable cohesiveness and stability, tighten skin pore, resist the harm of the radiation such as ultraviolet, blue light by synergy.

Description

A kind of ginseng compounding creme for improving human skin collagen structure and its preparation Method
Technical field
The present invention relates to beautifying face and moistering lotion field, and in particular to a kind of ginseng compounding for improving human skin collagen structure Creme and preparation method thereof.
Background technology
Collagen is albumen the abundantest in human body skin, and the main component in extracellular matrix (ECM).Glue The typical structure of former albumen is three spirals, and three strands of collagen polypeptide chains are mutually wound, and form the superhelix of cord-like.It is fine The collagen of dimension shape has I type, II type, III type, V type, Ⅺ type etc. a variety of.Wherein, NTx albumen, it is the widest in human body General collagen, the fibrillation of formation have fabulous tensile strength and elastic resistance.III collagen type, is distributed in blood vessel Comparision contents in surrounding, young woman and infant skin enrich.During the skin senescence of human body, III collagen type can quilt NTx albumen replaces.Type Ⅳ collagen albumen is structural constituent the abundantest in basilar memebrane in the collagen of Non-fibrous.
Skin senescence is shown as:Collagen content is reduced;Fibrillation network confusion;Collagen degradation increase, performance For matrix metalloproteinase (MMP) increase, collagen saccharification, irradiated plus ultraviolet and accelerate skin aging (light aging), led Skin is caused to follow the string, groove mark occurs in Dermatochalasia, forms wrinkle.After human skin aging, I type, III type, type Ⅳ collagen albumen Synthesis is reduced, and degraded increase, causes connective tissue to be damaged, the complete three D results of skin are destroyed.As the age increases, glue Former protein fibril changes, and diameter is irregular, skewness.
The Co., Ltd. Pacific of 200980133627.1 Japan discloses a kind of beautifying skin Orally administered composition, the group Compound has the function that to reduce wrinkle of skin and suppresses wrinkle formation.Said composition contain collagen peptide and selected from by elastin laminin, At least one of group that hyaluronic acid and vitamin C are formed.Because it is Orally taken product, therefore it is easy to gastrointestinal disturbances absorption, but Skin is taken effect not notable.
The content of the invention
The technical problems to be solved by the invention are the defects of overcoming above prior art, there is provided one kind improves human body flesh Ginseng compounding creme of skin collagen structure and preparation method thereof, can significantly improve human skin collagen structure.
The technical solution of the present invention is as follows:A kind of ginseng compounding creme for improving human skin collagen structure, It is made up of the material of following parts by weight:3~10 parts of ginseng extract, 1~5 part of collagen tripeptide, 3~10 parts of bamboo extractive, 0.1~0.5 part of capsaicine, 3~10 parts of glycerin monostearate, 1~5 part of vitamin A acid, 20~30 parts of glycerine, 10~20 parts of water.
Preferably, the ginseng compounding creme for improving human skin collagen structure:3~8 parts of ginseng extract, glue Former 1~3 part of tripeptides, 3~8 parts of bamboo extractive, 0.1~0.3 part of capsaicine, 3~8 parts of glycerin monostearate, vitamin A acid 1~ 3 parts, 20~25 parts of glycerine, 10~20 parts of water.
Preferably, 60~80wt% ginsenoside is contained in the ginseng extract.
Preferably, the bamboo extractive is natural bamboo extractive.
Preferably, the capsaicine is natural capsicum element.Cold, the guarantor of the addition balance bamboo extractive of a small amount of capsaicine The mildness of creme is held, also causes PM2.5, SO of contact skin2、NO2Etc. irritant, harmful substance away from skin, but content Guarantee of checking on will not stimulate human skin;In the computer office environment of height radiation, capsaicine can promote ginseng extract equal Even scattered, boosting ginsenoside, collagen tripeptide are fast and effectively implanted into the collagen of human skin, form protective layer, resistance Radiation;Increase inoxidizability, inject fresh vigor for aged skin.
Ginseng extract includes saponin(e, sugar, inorganic salts, and wherein saponin(e provides bioactivity, enhancing material metabolism, has Antioxidant and anti-aging acts on, and collagen tripeptide has identical basic structure with skin collagen, can be by skin without decomposing Directly absorb, absorptivity is up to 99%.Bamboo extractive, in cold, reduce the hot of ginseng extract so that effectiveness is steadily warm The performance of sum, smearing is salubrious comfortable, and the situation of the long acne of allergy will not be produced to body heat type crowd.Each component by synergy, Human skin collagen structure, the diameter of regular fibrillation and interval are significantly improved, there is collagen fabric more preferable Cohesiveness and stability, tighten skin pore, resist the harm of the radiation such as ultraviolet, blue light.
A kind of preparation method for the ginseng compounding creme for improving human skin collagen structure, comprises the following steps:
1) ginseng extract, bamboo extractive and capsaicine are mixed, grinding, obtains solid phase;
2) glycerine, water and glycerin monostearate are mixed, 80~100 DEG C of 20~40min of stirring, is cooled to 30~40 DEG C, obtain emulsion;
3) solid phase, collagen tripeptide and vitamin A acid are added into emulsion, 30~40 DEG C of 40~60min of stirring, is cooled down, i.e., .
Preferably, the granularity of the solid phase is 200~500 microns.
The beneficial effects of the invention are as follows:
1) diameter of regular fibrillation and interval, make collagen fabric that there is more preferable cohesiveness and stability, improve The structure of human skin collagen;
2) addition of capsaicine can promote ginseng extract dispersed, and balance the cold of bamboo extractive, keep The mildness of creme;
3) suppress protein and saccharification reaction occurs, slow down skin aging, keep elasticity, protect human skin collagen;
4) suppress Collagenase, suppress matrix metalloproteinase, make human skin anti crease and anti senile old;
5) each component significantly improves human skin collagen structure, tightens skin pore, resistance is purple by synergy Outside, the harm of the radiation such as blue light.
Brief description of the drawings
Fig. 1 is to use the tissue in comparative example culture 3 D human body skin model;
Fig. 2 is to use the tissue in inventive formulation culture 3 D human body skin model.
Embodiment
The present invention is described in further details with specific embodiment below, but the present invention is not only limited in detail below in fact Apply example.
Embodiment provided below is simultaneously not used to the scope that the limitation present invention is covered, described step nor with To limit its execution sequence.Those skilled in the art do conspicuously improved with reference to existing common knowledge to the present invention, also fall Enter within the protection domain of application claims.
Embodiment one
A kind of ginseng compounding creme for improving human skin collagen structure, is made up of the material of following parts by weight: 3 parts of ginseng extract, 1 part of collagen tripeptide, 1 part of bamboo extractive, 0.1 part of capsaicine, 3 parts of glycerin monostearate, vitamin A acid 1 Part, 20 parts of glycerine, 10 parts of water.
A kind of preparation method for the ginseng compounding creme for improving human skin collagen structure, comprises the following steps:
1) ginseng extract, bamboo extractive and capsaicine are mixed, grinding, obtains 200 microns of solid phase;
2) glycerine, water and glycerin monostearate are mixed, 80 DEG C of stirring 40min, is cooled to 30 DEG C, obtains emulsion;
3) solid phase, collagen tripeptide and vitamin A acid are added into emulsion, 30 DEG C of stirring 60min, cooling, is produced.
Embodiment two
A kind of ginseng compounding creme for improving human skin collagen structure, is made up of the material of following parts by weight: 10 parts of ginseng extract, 5 parts of collagen tripeptide, 3 parts of bamboo extractive, 0.5 part of capsaicine, 10 parts of glycerin monostearate, Wei Jia 5 parts of acid, 30 parts of glycerine, 20 parts of water.
A kind of preparation method for the ginseng compounding creme for improving human skin collagen structure, comprises the following steps:
1) ginseng extract, bamboo extractive and capsaicine are mixed, grinding, obtains 500 microns of solid phase;
2) glycerine, water and glycerin monostearate are mixed, 100 DEG C of stirring 20min, is cooled to 40 DEG C, obtains emulsion;
3) solid phase, collagen tripeptide and vitamin A acid are added into emulsion, 40 DEG C of stirring 40min, cooling, is produced.
Embodiment three
A kind of ginseng compounding creme for improving human skin collagen structure, is made up of the material of following parts by weight: 3 parts of ginseng extract, 1 part of collagen tripeptide, 1 part of bamboo extractive, 0.1 part of capsaicine, 3 parts of glycerin monostearate, vitamin A acid 1 Part, 20 parts of glycerine, 10 parts of water.
A kind of preparation method for the ginseng compounding creme for improving human skin collagen structure, comprises the following steps:
1) ginseng extract, bamboo extractive and capsaicine are mixed, grinding, obtains 300 microns of solid phase;
2) glycerine, water and glycerin monostearate are mixed, 80 DEG C of stirring 40min, is cooled to 30 DEG C, obtains emulsion;
3) solid phase, collagen tripeptide and vitamin A acid are added into emulsion, 30 DEG C of stirring 60min, cooling, is produced.
Example IV
A kind of ginseng compounding creme for improving human skin collagen structure, is made up of the material of following parts by weight: 8 parts of ginseng extract, 3 parts of collagen tripeptide, 3 parts of bamboo extractive, 0.3 part of capsaicine, 8 parts of glycerin monostearate, vitamin A acid 3 Part, 25 parts of glycerine, 20 parts of water.
A kind of preparation method for the ginseng compounding creme for improving human skin collagen structure, comprises the following steps:
1) ginseng extract, bamboo extractive and capsaicine are mixed, grinding, obtains 400 microns of solid phase;
2) glycerine, water and glycerin monostearate are mixed, 90 DEG C of stirring 20min, is cooled to 30 DEG C, obtains emulsion;
3) solid phase, collagen tripeptide and vitamin A acid are added into emulsion, 30 DEG C of stirring 60min, cooling, is produced.
Embodiment five
A kind of ginseng compounding creme for improving human skin collagen structure, is made up of the material of following parts by weight: 5 parts of ginseng extract, 2 parts of collagen tripeptide, 2 parts of bamboo extractive, 0.2 part of capsaicine, 5 parts of glycerin monostearate, vitamin A acid 2 Part, 25 parts of glycerine, 15 parts of water.
A kind of preparation method for the ginseng compounding creme for improving human skin collagen structure, comprises the following steps:
1) ginseng extract, bamboo extractive and capsaicine are mixed, grinding, obtains 400 microns of solid phase;
2) glycerine, water and glycerin monostearate are mixed, 90 DEG C of stirring 3min, is cooled to 35 DEG C, obtains emulsion;
3) solid phase, collagen tripeptide and vitamin A acid are added into emulsion, 35 DEG C of stirring 50min, cooling, is produced.
Comparative example
Common ginseng extract creme, is made up of the material of following parts by weight:3~10 parts of ginseng extract, single tristearin 3~10 parts of acid glyceride, 1~5 part of vitamin A acid, 20~30 parts of glycerine, 10~20 parts of water.
Product test
1. microscope is tested
By using the tissue in this product culture 3 D human body skin model, tissue is handled with common ginseng extract creme Control, Fig. 1 are using the tissue in comparative example culture 3 D human body skin model, and Fig. 2 is three-dimensional using inventive formulation culture Tissue in human body skin model.
Make histotomy and it is observed with transmission electron microscope.With in the skin model of this product culture Collagen fibrillation is more uniform, fine and smooth.Can improve the structure of human skin collagen, the diameter of regular fibrillation and Interval, makes collagen fabric have more preferable cohesiveness and stability.
2. be saccharified reaction test
Saccharification reaction is a kind of non-matchmaker reaction occurred in protein between free amine group and reducing sugar, in skin, This reaction can allow collagen to generate new residue or crosslink, and damage protein, cause tissue with skin Skin aging gradually loses elasticity and becomes stiff.
The saccharification that a routine is carried out using SOD enzymes is reacted, and the suppression of saccharification reaction is imitated by this experimental evaluation this product Fruit.After this product, SOD activity increases, it was demonstrated that this product can suppress saccharification reaction.
3. fluorometric investigation
Discharged when being hydrolyzed by determining fluorescent quenching gel (collagen of deformation) by people's matrix metalloproteinase Fluorescence content, this product are 58% to the inhibiting rate of matrix metalloproteinase.
Above experimental data shows, the product of this research preparation, anti crease and anti senile old purpose can be reached to human skin.

Claims (7)

1. a kind of ginseng compounding creme for improving human skin collagen structure, it is characterised in that by following parts by weight Material forms:3~10 parts of ginseng extract, 1~5 part of collagen tripeptide, 1~3 part of bamboo extractive, 0.1~0.5 part of capsaicine, 3~10 parts of glycerin monostearate, 1~5 part of vitamin A acid, 20~30 parts of glycerine, 10~20 parts of water;
The ginseng compounding creme for improving human skin collagen structure is prepared by following steps:
1) ginseng extract, bamboo extractive and capsaicine are mixed, grinding, obtains solid phase;
2) glycerine, water and glycerin monostearate are mixed, 80~100 DEG C of 20~40min of stirring, is cooled to 30~40 DEG C, obtains To emulsion;
3) solid phase, collagen tripeptide and vitamin A acid are added into emulsion, 30~40 DEG C of 40~60min of stirring, cooling, is produced.
2. the ginseng compounding creme according to claim 1 for improving human skin collagen structure, it is characterised in that
The ginseng compounding creme for improving human skin collagen structure is made up of the material of following parts by weight:Ginseng carries Take 3~8 parts of thing, 1~3 part of collagen tripeptide, 1~3 part of bamboo extractive, 0.1~0.3 part of capsaicine, glycerin monostearate 3~ 8 parts, 1~3 part of vitamin A acid, 20~25 parts of glycerine, 10~20 parts of water.
3. the ginseng compounding creme according to claim 1 or 2 for improving human skin collagen structure, its feature exist In the ginsenoside containing 60~80wt% in the ginseng extract.
4. the ginseng compounding creme according to claim 1 or 2 for improving human skin collagen structure, its feature exist In the bamboo extractive is natural Herba Lophatheri extract.
5. the ginseng compounding creme according to claim 1 or 2 for improving human skin collagen structure, its feature exist In the capsaicine is natural capsicum element.
A kind of 6. preparation side of the ginseng compounding creme of the improvement human skin collagen structure based on described in claim 1 Method, it is characterised in that comprise the following steps:
1) ginseng extract, bamboo extractive and capsaicine are mixed, grinding, obtains solid phase;
2) glycerine, water and glycerin monostearate are mixed, 80~100 DEG C of 20~40min of stirring, is cooled to 30~40 DEG C, obtains To emulsion;
3) solid phase, collagen tripeptide and vitamin A acid are added into emulsion, 30~40 DEG C of 40~60min of stirring, cooling, is produced.
7. the preparation method of the ginseng compounding creme according to claim 6 for improving human skin collagen structure, its It is characterised by, the granularity of the solid phase is 200~500 microns.
CN201710871959.6A 2017-09-25 2017-09-25 A kind of ginseng compounding creme for improving human skin collagen structure and preparation method thereof Pending CN107648135A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109464308A (en) * 2018-11-15 2019-03-15 广东轻工职业技术学院 A kind of essential oil composition and application with anti-blue light skin-care effect

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258445A (en) * 2011-07-14 2011-11-30 陈俊杰 SOD (superoxide dismutase) collagen peptide facial-beautification anti-aging agent
CN104523554A (en) * 2014-11-20 2015-04-22 彩虹之巅电子商务(上海)有限公司 Anti-wrinkle moisture-retention skin care product containing bioactive peptide ingredient
CN105380862A (en) * 2015-12-09 2016-03-09 广州中国科学院先进技术研究所 Skin care product containing extract of bambusa textilis leaf
CN105769677A (en) * 2016-03-29 2016-07-20 孙大龙 Emulsified cleansing cream containing herba lophatheri
CN106511215A (en) * 2016-12-27 2017-03-22 江西宜信堂医疗科技有限公司 Eye cream with effects of moisturizing and wrinkle resistance and preparation method of eye cream
CN106726760A (en) * 2016-12-24 2017-05-31 严志海 A kind of eye cream and preparation method thereof
CN106727002A (en) * 2016-12-30 2017-05-31 广州市中通生化制品有限公司 A kind of eye cream of multi-efficiency and preparation method thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258445A (en) * 2011-07-14 2011-11-30 陈俊杰 SOD (superoxide dismutase) collagen peptide facial-beautification anti-aging agent
CN104523554A (en) * 2014-11-20 2015-04-22 彩虹之巅电子商务(上海)有限公司 Anti-wrinkle moisture-retention skin care product containing bioactive peptide ingredient
CN105380862A (en) * 2015-12-09 2016-03-09 广州中国科学院先进技术研究所 Skin care product containing extract of bambusa textilis leaf
CN105769677A (en) * 2016-03-29 2016-07-20 孙大龙 Emulsified cleansing cream containing herba lophatheri
CN106726760A (en) * 2016-12-24 2017-05-31 严志海 A kind of eye cream and preparation method thereof
CN106511215A (en) * 2016-12-27 2017-03-22 江西宜信堂医疗科技有限公司 Eye cream with effects of moisturizing and wrinkle resistance and preparation method of eye cream
CN106727002A (en) * 2016-12-30 2017-05-31 广州市中通生化制品有限公司 A kind of eye cream of multi-efficiency and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109464308A (en) * 2018-11-15 2019-03-15 广东轻工职业技术学院 A kind of essential oil composition and application with anti-blue light skin-care effect

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Application publication date: 20180202