CN106726760A

CN106726760A - A kind of eye cream and preparation method thereof

Info

Publication number: CN106726760A
Application number: CN201611210911.2A
Authority: CN
Inventors: 严志海
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-12-24
Filing date: 2016-12-24
Publication date: 2017-05-31

Abstract

The invention belongs to cosmetic technical field, and in particular to a kind of eye cream and preparation method thereof.Eye cream of the present invention is mainly consisted of the following composition：Cetearyl alcohol alcohol ether 2, cetearyl alcohol alcohol ether 21, tocopherol, cetostearyl alcohol, glycerin monostearate, myristyl myristate ester, saualane, Hydrolyzed Collagen, grape-kernel oil, Geranium Essential, lecithin, Acritamer 940, glycerine, propane diols, sodium alginate, vitamin, citric acid, rhodioside, ginsenoside Rg1, azone/Cremophor RH40, preservative and deionized water.Eye cream of the present invention has anti-aging, the multiple efficacies of wrinkle reduction, livid ring around eye, pouch, edema and fat granule.

Description

A kind of eye cream and preparation method thereof

Technical field

The invention belongs to cosmetic technical field, and in particular to a kind of eye cream and preparation method thereof.

Background technology

Eye part skin is one of skin histology of more tender and lovely weakness in human epidermal, and abnormal work and rest, especially Stay up late and easily cause free radical in eye part skin and increase, blood circulation slows down, protein decomposition enzyme burst size increases, and causes eye Portion's skin aging and along with the appearance of pouch, livid ring around eye and crow's feet.

In order to delay periocualr skin aging, in daily life except ensureing sufficient sleep, form good habits and customs and Outer with eye custom, common method is exactly to use crease-resistant moisturizing class eye cream.And presently commercially available or research and development eye creams, most effect list One, take effect slow, and most eye creams are the improvement on surface, can not play a part of to adjust skin internal mechanism.Such as Chinese patent application (CN104958215A) discloses a kind of moisturizing eye cream, and the moisturizing eye cream is made up of following components：Glycerine 20 ~30 parts, 30~40 parts of 20 oxirane of methyl glucoside, 5~10 parts of consummate vitamin C, 5~10 parts of consummate vitamin A, essence Pure vitamin E5~10 part, 10~20 parts of asparagus juice, 10~20 parts of glyceryl monostearate, sodium lauroyl glutamate 5~10 Part.The eye cream strengthens its moistening effect by adding asparagus juice composition, according further to the defect of eye cream absorption difference, in formula Suitable dispersant and surfactant are with the addition of, for strengthening assimilation effect, the patent application is only the guarantor for strengthening eye cream Wet and assimilation effect.

With the raising of people's level of consumption, and the continuous enhancing that skin care is realized, effect is single or acts on slow eye cream Consumer demand can not be met.Therefore, substantially, the rapid eye cream that takes effect is that consumer is badly in need of to vdiverse in function and effect.

The content of the invention

To solve the above problems, the invention provides a kind of eye cream, it has anti-aging, wrinkle reduction, livid ring around eye, eye The multiple efficacies of bag, edema and fat granule.

The present invention is achieved through the following technical solutions：

A kind of eye cream, mainly by following percentage by weight into being grouped into：The 1-3% of cetearyl alcohol alcohol ether -2, cetearyl alcohol The 1-3% of alcohol ether -21, tocopherol 0.1-1%, cetostearyl alcohol 1-5%, glycerin monostearate 0.5-1.5%, myristic acid The tetradecane ester 0.5-3%, saualane 0.1-1%, Hydrolyzed Collagen 1-3%, grape-kernel oil 0.5-0.7%, Geranium Essential 0.01-0.1%, lecithin 1-3%, Acritamer 940 0.05-0.15%, glycerine 1-3%, propane diols 1-5%, sodium alginate 1- 5%, vitamin C 1-2%, citric acid 0.5-1%, rhodioside 4-6%, ginsenoside Rg1 1-10%, azone/PEG40 hydrogen Change castor oil 1-3%, preservative 0.15-0.25% and deionized water 43-83%.

Preferably, the eye cream by following percentage by weight into being grouped into：Cetearyl alcohol alcohol ether -2 1.2%, spermaceti is hard Lipidol ether -21 1.5%, tocopherol 0.5%, cetostearyl alcohol 3%, glycerin monostearate 1.2%, myristyl myristate Ester 1.5%, saualane 0.5%, Hydrolyzed Collagen 1.2%, grape-kernel oil 0.65%, Geranium Essential 0.05%, lecithin 1.5%, Acritamer 940 0.1%, glycerine 1.5%, propane diols 3%, sodium alginate 2.5%, vitamin C 1.5%, citric acid 0.75%, rhodioside 5%, ginsenoside Rg1 3%, azone/Cremophor RH40 2%, preservative 0.2% and go from Sub- water 67.65%.

Rhodioside (molecular formula：C₁₄H₂₀O₇, No. CAS：10338-51-9) internal SOD can be improved with delaying cell aging Activity, suppress the formation of cell lipofuscin and active oxygen；The metabolism and synthesis of cell can be strengthened simultaneously, cell is improved Vigor.

Grape-kernel oil contains linolenic acid and proanthocyanidin, and wherein linolenic acid can resist free radical, anti-aging, promotes The absorption of vitamin C and vitamin E；And the collagen in skin can be protected, the injury of ultraviolet is reduced, prevents black Element precipitation；And proanthocyanidin also has stronger oxidation resistance and removes the effect of free radical simultaneously.Grape-kernel oil penetration By force, salubrious non-greasy, is easily absorbed by the skin, and any skin quality is applicable.

In Geranium Essential containing citronellol, citronellyl formate, loose alkene, gemic acid, Geraniol, terpinol, citral, Menthones and lot of trace mineral element, these active ingredients have very strong compatibility with natural alicyclic organic.Geranium Essential Energy deep layer clean skin, balances sebum secretion, promotes Skin Cell newborn, and can stimulate circulation, while also can be used as perfume (or spice) Essence is used.

Invention technician has found to be used in conjunction with grape pip and Geranium Essential in the range of concentration of the present invention, It is particularly evident to eye part skin action effect,

Lecithin (molecular formula：C₄₂H₈₀NO₈P, No. CAS：8002-43-5) it is the human body indispensable thing of each cell Matter, if lecithin lacks, will reduce the power of regeneration of Skin Cell, cause pachylosis, wrinkle occur.

Tocopherol energy and radical reaction, terminate the chain reaction of liposome free radical, and form the low life of stabilization energy state Phenoxy radical is educated, the free radical of this lower state can not induce the chain reaction of lipid film, and in the work of other antioxidants Tocopherol can be again changed under, it can play a part of anti-aging, reduce wrinkle of skin.

Saualane is closest to a kind of lipid of human sebaceous, and affinity is strong, can with the sebum film of mankind itself melt for Integrally, one layer of natural cover for defense is formed in skin surface, moreover it is possible to suppress the peroxidating of skin lipid, can effectively infiltrate through skin, and Promote the propagation of skin base cell, to delay skin aging, improving and eliminate chloasma has obvious physiologic effect.

Ginsenoside Rg1's (molecular formula：C₄₂H₇₂O14, No. CAS：22427-39-0) epidermal cell can be promoted to be metabolized, increased Strong cell viability.

Vitamin C has whitening, enhances metabolism and remove effect of free radical.Citric acid has and gentle strips off work With, make epidermis that pigment anomaly will not occur after healing is separated with corium, energy skin care effectively reduces colour of skin decline, mitigates and wrinkle Line and aging.

Hydrolyzed Collagen can be absorbed by the skin and be filled between dermal matrix, so that skin is plentiful, wrinkle is unfolded； While the density of skin can be improved, increase skin elasticity, promote skin metabolism, make skin smooth, glossy, reduction Wrinkle.

Cetearyl alcohol alcohol ether -2 and cetearyl alcohol alcohol ether -21 are the emulsifying agent of eye cream of the present invention, azone/PEG40 hydrogenation castors Sesame oil is combined the absorption for promoting active component.The preservative that the present invention is used is propane diols/bis- (methylol) for ACNIBIOASL Imidazolidinyl urea/iodine propilolic alcohol butyl mephenesin Carbamate compound preservative, is liquid spectrum antibacterial agent.

Preferably, the eye cream preparation method, is divided into following steps：

S1 accurately weighs raw material；

S2 by cetearyl alcohol alcohol ether -2, cetearyl alcohol alcohol ether -21, tocopherol, cetostearyl alcohol, glycerin monostearate, Myristyl myristate ester, saualane, grape-kernel oil and the lecithin heating stirring in 70-80 DEG C of water-bath, obtain solution I；

S3 adds Acritamer 940, glycerine, propane diols, sodium alginate, citric acid and deionized water in 75-80 DEG C of water-bath Thermal agitation, obtains solution II.

Be pumped into solution I in solution II by S4, under vacuum homogeneous, 2000-3000r/min homogeneous 3-7 minutes, obtains Solution III；

Solution III is cooled to 40 DEG C by S5, successively plus Geranium Essential, Hydrolyzed Collagen, vitamin C, rhodioside, Ginsenoside Rg1, azone/Cremophor RH40, preservative stirs, and obtains final product.

Eye cream each component collocation of the present invention is scientific and reasonable, has synergy between each component.Compared with prior art, this hair Bright eye cream has advantages below：

(1) eye cream quality stable homogeneous of the present invention, non-greasy, low production cost.

(2) eye cream of the present invention can regulate and control superoxide dismutase activity and hydroxyproline in skin histology, MDA Content, can really play a part of anti-aging.

(3) the eye cream of the present invention also multiple efficacies with wrinkle reduction, livid ring around eye, pouch, edema and fat granule, Neng Gouman The demand of the present people of foot.

Specific embodiment

The present invention is described in further details with reference to embodiment, but this is not limitation of the present invention, ability Field technique personnel basic thought of the invention, various modifications may be made or improves, but without departing from of the invention Basic thought, within the scope of the present invention.

Hydrolyzed Collagen is Brillian-KS18, is purchased from Beijing Brilliance Biochemical Co., Ltd.；Grape pip Oil, is purchased from Shanxi Jian Cun Food Co., Ltd；Geranium Essential brand：SUNWAY, article No.：SA-015.

A kind of eye cream of embodiment 1

A kind of eye cream, by following percentage by weight into being grouped into：Cetearyl alcohol alcohol ether -2 1.2%, cetostearyl alcohol Ether -21 1.5%, tocopherol 0.5%, cetostearyl alcohol 3%, glycerin monostearate 1.2%, myristyl myristate ester 1.5%, saualane 0.5%, Hydrolyzed Collagen 1.2%, grape-kernel oil 0.65%, Geranium Essential 0.05%, lecithin 1.5%, Acritamer 940 0.1%, glycerine 1.5%, propane diols 3%, sodium alginate 2.5%, vitamin C 1.5%, citric acid 0.75%, rhodioside 5%, ginsenoside Rg1 3%, azone/Cremophor RH40 2%, preservative 0.2% and go from Sub- water 67.65%.

Preparation method, is divided into following steps：

S1 accurately weighs raw material；

S2 by cetearyl alcohol alcohol ether -2, cetearyl alcohol alcohol ether -21, tocopherol, cetostearyl alcohol, glycerin monostearate, Myristyl myristate ester, saualane, grape-kernel oil and the lecithin heating stirring in 75 DEG C of water-baths, obtain solution I；

Acritamer 940, glycerine, propane diols, sodium alginate, citric acid and deionized water are heated and stirred by S3 in 75 DEG C of water-baths Mix, obtain solution II.

Be pumped into solution I in solution II by S4, under vacuum homogeneous, 2500r/min homogeneous 6 minutes, obtains solution III；

A kind of eye cream of embodiment 2

A kind of eye cream, by following percentage by weight into being grouped into：Cetearyl alcohol alcohol ether -2 1%, cetearyl alcohol alcohol ether - 21 1%, tocopherol 0.1%, cetostearyl alcohol 1%, glycerin monostearate 0.5%, myristyl myristate ester 0.5%, angle Shark alkane 0.1%, Hydrolyzed Collagen 1%, grape-kernel oil 0.5%, Geranium Essential 0.01%, lecithin 1%, Acritamer 940 0.05%, glycerine 1%, propane diols 1%, sodium alginate 1%, vitamin C 1%, citric acid 0.5%, rhodioside 4%, ginseng Saponin(e Rg1 1%, azone/Cremophor RH40 1%, preservative 0.15% and deionized water 82.59%.

Preparation method is similar to Example 1.

A kind of eye cream of embodiment 3

A kind of eye cream, by following percentage by weight into being grouped into：Cetearyl alcohol alcohol ether -2 3%, cetearyl alcohol alcohol ether - 21 3%, tocopherol 1%, cetostearyl alcohol 5%, glycerin monostearate 1.5%, myristyl myristate ester 3%, saualane 1%, Hydrolyzed Collagen 3%, grape-kernel oil 0.7%, Geranium Essential 0.1%, lecithin 3%, Acritamer 940 0.15%, Glycerine 3%, propane diols 5%, sodium alginate 5%, Catergen %, citric acid 1%, rhodioside 6%, ginsenoside Rg1 10%, azone/Cremophor RH40 3%, preservative 0.25% and deionized water 40.3%.

Preparation method is similar to Example 1.

A kind of eye cream of comparative example 1

A kind of eye cream, by following percentage by weight into being grouped into：Cetearyl alcohol alcohol ether -2 1.2%, cetostearyl alcohol Ether -21 1.5%, tocopherol 0.5%, cetostearyl alcohol 3%, glycerin monostearate 1.2%, myristyl myristate ester 1.5%, saualane 0.5%, Hydrolyzed Collagen 1.2%, grape-kernel oil 0.65%, vetiver essential oil 0.05%, lecithin 1.5%, Acritamer 940 0.1%, glycerine 1.5%, propane diols 3%, sodium alginate 2.5%, vitamin C 1.5%, citric acid 0.75%, rhodioside 5%, ginsenoside Rg1 3%, azone/Cremophor RH40 2%, preservative 0.2% and go from Sub- water 67.65%.

Preparation method is similar to Example 1.

It is that Geranium Essential replaces with vetiver essential oil with the difference of embodiment 1.

A kind of eye cream of comparative example 2

A kind of eye cream, by following percentage by weight into being grouped into：Cetearyl alcohol alcohol ether -2 1.2%, cetostearyl alcohol Ether -21 1.5%, tocopherol 0.5%, cetostearyl alcohol 3%, glycerin monostearate 1.2%, myristyl myristate ester 1.5%, saualane 0.5%, Hydrolyzed Collagen 1.2%, grape-kernel oil 0.65%, Geranium Essential 0.05%, lecithin 1.5%, Acritamer 940 0.1%, glycerine 1.5%, propane diols 3%, sodium alginate 2.5%, vitamin C 1.5%, citric acid 0.75%, ginsenoside Rg1 8%, azone/Cremophor RH40 2%, preservative 0.2% and deionized water 67.65%.

Preparation method is similar to Example 1.

It is to be not added with rhodioside with the difference of embodiment 1, and increases the addition of ginsenoside Rg1.

The eye cream Detection of Stability of test example 1

Subjects：The eye cream that embodiment 1-3 is prepared.

Detection content：

(1) pH value is determined：According to GB/T 13531.1-2008, cosmetics generic inspection method carries out the measure of pH value, inspection Survey result as shown in table 1.

Each eye cream pH value of table 1

Face cream	Embodiment 1	Embodiment 2	Embodiment 3
				PH value	6.1±0.05	6.3±0.1	6.2±0.1

(2) heat resistant test：The sample of Packing Intact is put into insulating box (40 ± 1) DEG C and keeps 24h, recovered to room temperature, Each face cream is without water-oil separating phenomenon.

(3) low temperature resistant test：The sample of Packing Intact is put into -5~-10 DEG C of placement 24h in refrigerator, is recovered to room temperature, Each face cream is without layering, coarse, metachromatism.

(4) centrifugal test：, with 2000 revs/min, will be centrifuged 30 minutes, each face in the sample placement centrifuge of Packing Intact Frost is without water-oil separating phenomenon.

As can be seen here, the eye cream that prepared by embodiment of the present invention 1-3 has good stability.

The eye cream anti-aging of test example 2 is detected

Test object：The eye cream that embodiment 1-3 and comparative example 1-2 are prepared.

Test content：Subacute aging and light aging model are set up, to superoxide dismutase in nude mice skin tissue (SOD) activity, hydroxyproline (HYP) content, MDA (MDA) content are detected.

Method of testing：

Healthy 1 monthly age male nude mouse 70 (raising of IVC rooms), 14 ± 2g of body weight every group 10 is randomly divided into 7 groups：1. just Normal group：Normal condition is raised, and is not injected and photo-irradiation treatment.2. model group：Daily nape part hypodermic injection D- galactolipins (1000mg.kg^-1)；And combine long wavelength (365nm) and short wavelength (254nm) ultraviolet irradiation skin of back, long wavelength ultraviolet Line cumulative exposure intensity is 259.5J/cm², short wavelength's cumulative exposure intensity 6.482J/cm², set up subacute aging and light aging Model.3. 1 group of embodiment：Injection and the same model group of illumination, embodiment 1 is smeared on the basis of injection and illumination to its back again The eye cream for preparing, 2 times a day, 0.2g/ times.4. 2 groups of embodiment：Injection and the same model group of illumination, in injection injection and light According to same model group, the eye cream that embodiment 1 is prepared is smeared to its back again on the basis of injection and illumination, 2 times a day, 0.2g/ times.5. 3 groups of embodiment：Injection and the same model group of illumination, in injection and the same model group of illumination, in injection and the base of illumination The eye cream that embodiment 3 is prepared is smeared to its back again on plinth, 2 times a day, 0.2g/ times.6. 1 group of comparative example：Injection and light According to same model group, in injection injection and the same model group of illumination, comparative example 1 is smeared to its back again on the basis of injection and illumination The eye cream for preparing, 2 times a day, 0.2g/ times.7. 2 groups of comparative example：Injection and the same model group of illumination, in injection injection and light According to same model group, the eye cream that comparative example 1 is prepared is smeared to its back again on the basis of injection and illumination, 2 times a day, 0.2g/ times.

Continuous injection and illumination 6 weeks, treat that model group is slow in action, and back wrinkle substantially, is presented obvious aging sign, stops Medicine is put to death after 2 days and takes skin and carry out the measure of every biochemical indicator, and four groups of nude mice body weight and Organ weight are compared.

(1) skin histology is homogenized the measure of Biochemical Indexes

SOD vigor, HYP contents, the measure of MDA contents in being homogenized to nude mice skin tissue, and build up biology with reference to Nanjing Engineering company SOD, HYP and MDA kit specification method are determined, and unit is respectively U.mL^-1、μg.mL^-1And nmol.mL^-1, examination Test result as shown in table 2.

The testing result of the nude mice skin tissue Biochemical Indexes of table 2

Group	SOD(U.mL^-1)	HYP(μg.mL^-1)	MDA(nmol.mL^-1)
				Normal group	118.52±6.84	1.12±0.48	20.86±6.12
Model group	80.14±7.12^a	0.56±0.54^b	51.24±7.06
				1 group of embodiment	128.86±6.52^a	1.62±0.48^b	9.86±2.16^c
2 groups of embodiment	124.24±7.16	1.58±0.56	10.12±3.44
				3 groups of embodiment	125.16±6.86	1.54±0.62	11.38±2.86
1 group of comparative example	113.48±7.76	1.08±0.54	17.78±4.68
				2 groups of comparative example	111.12±8.12	1.12±0.66	18.92±6.24

Note：Compare with SOD normal groups^aP<0.05；Compare with HYP normal groups^bP<0.05；Compare with MDA normal groups^cP< 0.05,^cdP<0.01。

Superoxide dismutase (SOD) is antioxidase important in organism, is the head that free radical is removed in organism Want material.The height of SOD contents can visual representation organism aging degree.Hydroxyproline (HYP) is intradermal rich content And the amino acid of stabilization, can directly reflect the change of intradermal collagenous fibres, the content reduction alignment target of hydroxyproline The degree of aging of skin.Mda content is the performance of Cell membrane lipids extent of peroxidation, and mda content is high, illustrates cytolipin Matter extent of peroxidation is high, and the injury that cell membrane is received is serious.

As shown in Table 2, compared with model group, model group SOD vigor is substantially reduced and with significant difference (P normal group< 0.05) skin radical protection function reduction, is illustrated, and embodiment 1-3 group SOD vigor is above normal group, and 1 group of embodiment There is significant difference compared with normal group, comparative example 1-2 groups compare without significant difference with normal group.Model group HYP contents with just Often group illustrates that skin occurs aging compared to substantially reduction and with significant difference；HYP contents are above in embodiment 1-3 groups Normal group, and embodiment 1HYP contents are apparently higher than normal group, with significant difference；And comparative example 1-2 group HYP contents with just Often organize thing notable difference.Model group MDA contents are higher than normal group, there is pole significant difference (P<0.01)；And embodiment 1-3 groups and MDA contents are significantly lower than normal group during MDA contents are below normal group, and 1 group of embodiment in comparative example 1-2 groups.

Result above show eye cream that nude mice skin film embodiment of the present invention 1-3 prepares can subacute aging and SOD activity and HYP contents in light aging model skin tissue, and MDA contents can be reduced, illustrate that eye cream of the present invention has anti-skin to decline Old effect.

Test example 3, investigation on probation

Subjects：Eye cream prepared by embodiment 1-3, comparative example 1-2.

Tested crowd：50 people, between 30~50 years old, the people of female 40, male 10 people, random point 5 groups.

Eye problems：Wrinkle, livid ring around eye, pouch, edema, fat granule, everyone at least has one or more eyes Problem.

Test method：After eye is cleaned, each test eye cream is spread in painting, and every group limits the use of a kind of eye cream, sooner or later once daily, makes It is as shown in table 3 with effect assessment after 4 weeks.

Eye cream effect assessment prepared by the embodiment 1-3 of table 3 and comparative example 1-2

From table 3 it is observed that eye cream prepared by embodiment 1-3 is relative to comparative example 1-2, effect is more obvious.

The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe The personage for knowing this technology all can carry out modifications and changes under without prejudice to spirit and scope of the invention to above-described embodiment.Cause This, those of ordinary skill in the art is complete with institute under technological thought without departing from disclosed spirit such as Into all equivalent modifications or change, should be covered by claim of the invention.

Claims

1. a kind of eye cream, it is characterised in that it is main by following percentage by weight into being grouped into：Cetearyl alcohol alcohol ether -21-3%, Cetearyl alcohol alcohol ether -211-3%, tocopherol 0.1-1%, cetostearyl alcohol 1-5%, glycerin monostearate 0.5-1.5%, meat The myristic acid tetradecane ester 0.5-3%, saualane 0.1-1%, Hydrolyzed Collagen 1-3%, grape-kernel oil 0.5-0.7%, India Certain herbaceous plants with big flowers essential oil 0.01-0.1%, lecithin 1-3%, Acritamer 940 0.05-0.15%, glycerine 1-3%, propane diols 1-5%, marine alga Sour sodium 1-5%, vitamin C 1-2%, citric acid 0.5-1%, rhodioside 4-6%, ginsenoside Rg1 1-10%, azone/ Cremophor RH40 1-3%, preservative 0.15-0.25% and deionized water 43-83%.

2. eye cream according to claim 1, it is characterised in that by following percentage by weight into being grouped into：Cetostearyl alcohol Ether -21.2%, cetearyl alcohol alcohol ether -211.5%, tocopherol 0.5%, cetostearyl alcohol 3%, glycerin monostearate 1.2%, Myristyl myristate ester 1.5%, saualane 0.5%, Hydrolyzed Collagen 1.2%, grape-kernel oil 0.65%, Geranium Essential 0.05%, lecithin 1.5%, Acritamer 940 0.1%, glycerine 1.5%, propane diols 3%, sodium alginate 2.5%, vitamin C 1.5%, citric acid 0.75%, rhodioside 5%, ginsenoside Rg1 3%, azone/Cremophor RH40 2%, preservative 0.2% and deionized water 67.65%.

3. the preparation method of eye cream according to claim 1 or claim 2, it is characterised in that be divided into following steps：

S1 accurately weighs raw material；

S2 is by cetearyl alcohol alcohol ether -2, cetearyl alcohol alcohol ether -21, tocopherol, cetostearyl alcohol, glycerin monostearate, Pork and beans Cool sour tetradecane ester, saualane, grape-kernel oil and the lecithin heating stirring in 70-80 DEG C of water-bath obtains solution I；

Acritamer 940, glycerine, propane diols, sodium alginate, citric acid and deionized water are heated and stirred by S3 in 75-80 DEG C of water-bath Mix, obtain solution II.

Solution III is cooled to 40 DEG C by S5, and Geranium Essential, Hydrolyzed Collagen, vitamin C, rhodioside, ginseng are added successively Saponin(e Rg1, azone/Cremophor RH40, preservative stirs, and obtains final product.