CN116850235A - Pharmaceutical preparation for removing eye wrinkles and preparation method thereof - Google Patents
Pharmaceutical preparation for removing eye wrinkles and preparation method thereof Download PDFInfo
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- CN116850235A CN116850235A CN202310020794.7A CN202310020794A CN116850235A CN 116850235 A CN116850235 A CN 116850235A CN 202310020794 A CN202310020794 A CN 202310020794A CN 116850235 A CN116850235 A CN 116850235A
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- eye wrinkles
- pharmaceutical preparation
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- removing eye
- saponin
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- 230000037303 wrinkles Effects 0.000 title claims abstract description 37
- 239000000825 pharmaceutical preparation Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 10
- 229930182490 saponin Natural products 0.000 claims abstract description 10
- 150000007949 saponins Chemical class 0.000 claims abstract description 10
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 6
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 6
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 6
- 240000008397 Ganoderma lucidum Species 0.000 claims abstract description 5
- 235000001637 Ganoderma lucidum Nutrition 0.000 claims abstract description 5
- 241000207925 Leonurus Species 0.000 claims abstract description 5
- 235000017784 Mespilus germanica Nutrition 0.000 claims abstract description 5
- 244000182216 Mimusops elengi Species 0.000 claims abstract description 5
- 235000000560 Mimusops elengi Nutrition 0.000 claims abstract description 5
- 241000220317 Rosa Species 0.000 claims abstract description 5
- 235000007837 Vangueria infausta Nutrition 0.000 claims abstract description 5
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 5
- 235000019717 geranium oil Nutrition 0.000 claims abstract description 5
- 239000010648 geranium oil Substances 0.000 claims abstract description 5
- 229930182494 ginsenoside Natural products 0.000 claims abstract description 5
- 229940089161 ginsenoside Drugs 0.000 claims abstract description 5
- 229940087603 grape seed extract Drugs 0.000 claims abstract description 5
- 235000002532 grape seed extract Nutrition 0.000 claims abstract description 5
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229940032094 squalane Drugs 0.000 claims abstract description 5
- 150000008130 triterpenoid saponins Chemical class 0.000 claims abstract description 5
- 229940046009 vitamin E Drugs 0.000 claims abstract description 5
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 5
- 239000011709 vitamin E Substances 0.000 claims abstract description 5
- 239000001717 vitis vinifera seed extract Substances 0.000 claims abstract description 5
- 239000000341 volatile oil Substances 0.000 claims abstract description 5
- 244000144927 Aloe barbadensis Species 0.000 claims abstract description 4
- 235000002961 Aloe barbadensis Nutrition 0.000 claims abstract description 4
- 235000015655 Crocus sativus Nutrition 0.000 claims abstract description 4
- 244000124209 Crocus sativus Species 0.000 claims abstract description 4
- 238000001816 cooling Methods 0.000 claims abstract description 4
- 239000000284 extract Substances 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 241001116389 Aloe Species 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 230000009759 skin aging Effects 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940006091 aloe polysaccharide Drugs 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000001153 anti-wrinkle effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 230000032677 cell aging Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000001599 crocus sativus l. flower extract Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229940076591 saffron extract Drugs 0.000 description 1
- 231100000245 skin permeability Toxicity 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000036561 sun exposure Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The application discloses a pharmaceutical preparation for removing eye wrinkles, which comprises the following components: grape seed extract, leonurus saponin, ginsenoside, ganoderma lucidum triterpenoid saponin, medlar saponin, rose essential oil, geranium oil, crocus sativus extract, nano pearl powder, vitamin E, squalane, aloe vera gel, hyaluronic acid and water; the preparation method comprises the following steps: 1) Mixing and heating the nano pearl powder, vitamin E, squalane, hyaluronic acid and water to 50-60 ℃ to obtain a component A; 2) Uniformly mixing the rest materials and heating to 40-45 ℃ to obtain a component B; 3) Adding the component A into the component B under stirring, homogenizing for at least 10min, preserving heat at 40-45 ℃ for 20-30 min, cooling, and uniformly mixing to obtain the pharmaceutical preparation for removing eye wrinkles. The finally obtained pharmaceutical preparation for removing the eye wrinkles is easy to absorb, has no side effect and lasting effect.
Description
Technical Field
The application relates to a pharmaceutical preparation, in particular to a pharmaceutical preparation for removing eye wrinkles and a preparation method thereof.
Background
The internal causes of wrinkles are mainly due to viscera dysfunction of human bodies, and the external causes of wrinkles include mental stress, bad lifestyle, sun exposure, improper diet and the like. Products for removing wrinkles on the market are numerous and complicated, few methods such as laser, surgery and injection are truly effective, and the damage to skin caused by removing wrinkles is large. Wrinkles are the result of irresistible skin aging, but their occurrence can be delayed and reduced to an unnoticeable extent by means of healthcare and cosmetology.
The use of the pharmaceutical preparation for removing the eye wrinkles can alleviate the problems, so as to achieve the tight, fine and elastic eye skin state. The pharmaceutical preparation for removing the eye wrinkles on the market has the disadvantages of short moisturizing time, poor skin permeability and poor absorption effectiveness, and influences the using effect of the product.
Disclosure of Invention
The technical problems to be solved by the application are as follows: provides a pharmaceutical preparation which has strong permeability and can effectively moisturize and remove obvious wrinkles and remove the wrinkles of eyes.
In order to solve the problems, the adopted technical scheme is as follows: a pharmaceutical preparation for removing eye wrinkles comprises the following components in parts by mass:
preferably, the pharmaceutical preparation for removing eye wrinkles comprises the following components in parts by mass:
further preferably, the pharmaceutical preparation for removing eye wrinkles comprises the following components in parts by mass:
further preferably, the pharmaceutical preparation for removing eye wrinkles comprises the following components in parts by mass:
further preferably, the particle size of the nano pearl powder is less than 20nm.
The application also provides a preparation method of the pharmaceutical preparation for removing the eye wrinkles, which comprises the following steps:
1) Mixing and heating the nano pearl powder, vitamin E, squalane, hyaluronic acid and water to 50-60 ℃ to obtain a component A;
2) Mixing grape seed extract, leonurus saponin, ginsenoside, ganoderma lucidum triterpenoid saponin, medlar saponin, rose essential oil, geranium oil, crocus sativus extract and aloe vera gel, and heating to 40-45 ℃ to obtain component B;
3) Adding the component A into the component B under stirring, homogenizing for at least 10min, preserving heat at 40-45 ℃ for 20-30 min, cooling, and uniformly mixing to obtain the pharmaceutical preparation for removing eye wrinkles.
The beneficial effects are that: the aloe gel product contains aloe polysaccharide and glycoprotein as main components, and is polymer, and the aloe has skin moistening, antiallergic, repairing and caring effects. Studies have shown that in emulsion or water-based systems, the moisturizing component corresponds to hyaluronic acid and 5% glycerol at aloe gel levels of 40% -80%.
The mucus in aloe contains a unique protein that prevents cell aging and is an important component for the treatment of chronic allergies. The aloe gel has effects of activating cell activity, delaying skin aging, astringing, and harmonizing skin. The special calcium citrate and other components in aloe can expand capillary vessel and promote blood microcirculation. The collagen, vitamins and minerals in the aloe gel have the effects of activating cell activity, effectively locking skin moisture, delaying skin aging, astringing, harmonizing skin, nourishing skin and protecting skin.
The unique performance of aloe gel is fully utilized, various pure natural plant active ingredients are compatible, and the medicinal preparation for removing eye wrinkles is obtained through mutual compatibility of grape seed extract, leonurus saponin, ginsenoside, ganoderma lucidum triterpenoid saponin, medlar saponin, rose essential oil, geranium oil and saffron extract, is easy to absorb, has no side effect and has lasting effect.
Detailed Description
The application is further illustrated by the following examples, which are not intended to limit the same.
A method for preparing a pharmaceutical preparation for removing eye wrinkles, which comprises the following steps:
1) Mixing and heating the nano pearl powder, vitamin E, squalane, hyaluronic acid and water to 50-60 ℃ to obtain a component A;
2) Mixing grape seed extract, leonurus saponin, ginsenoside, ganoderma lucidum triterpenoid saponin, medlar saponin, rose essential oil, geranium oil, crocus sativus extract and aloe vera gel, and heating to 40-45 ℃ to obtain component B;
3) Adding the component A into the component B under stirring, homogenizing for at least 10min, preserving heat at 40-45 ℃ for 20-30 min, cooling, and uniformly mixing to obtain the pharmaceutical preparation for removing eye wrinkles.
Examples 1 to 3
The specific weight components (unit g) of each raw material in the examples are:
anti-wrinkle test was performed on the products obtained in examples 1-3:
300 persons were randomly selected and divided into 4 groups. Subjects dispensed the pharmaceutical preparations for removing ocular wrinkles prepared in examples 1 to 3 and the commercially available eye cream of comparative example, respectively, and instructed the subjects to apply 0.2g of the pharmaceutical preparation for removing ocular wrinkles around eyes for 28 days (continuous use for 27 days, and no use for 28 days) 2 times a day (each time in the morning and evening). The wrinkle effect of the subject was tested by a skin detection analyzer, and the test effect was recorded as follows:
subject wrinkle-removing effect
Claims (6)
1. A pharmaceutical preparation for removing eye wrinkles comprises the following components in parts by mass:
2. a pharmaceutical formulation for removing eye wrinkles as in claim 1, wherein: the pharmaceutical preparation for removing eye wrinkles comprises the following components in parts by mass:
3. a pharmaceutical formulation for removing eye wrinkles as in claim 2, wherein: the pharmaceutical preparation for removing eye wrinkles comprises the following components in parts by mass:
4. a pharmaceutical formulation for removing eye wrinkles as in claim 2, wherein: the pharmaceutical preparation for removing eye wrinkles comprises the following components in parts by mass:
5. a pharmaceutical formulation for removing eye wrinkles according to any one of claims 1 to 4, wherein: the particle size of the nano pearl powder is less than 20nm.
6. A method for preparing a pharmaceutical preparation for removing eye wrinkles as claimed in claims 1 to 5, comprising the steps of:
1) Mixing and heating the nano pearl powder, vitamin E, squalane, hyaluronic acid and water to 50-60 ℃ to obtain a component A;
2) Mixing grape seed extract, leonurus saponin, ginsenoside, ganoderma lucidum triterpenoid saponin, medlar saponin, rose essential oil, geranium oil, crocus sativus extract and aloe vera gel, and heating to 40-45 ℃ to obtain component B;
3) Adding the component A into the component B under stirring, homogenizing for at least 10min, preserving heat at 40-45 ℃ for 20-30 min, cooling, and uniformly mixing to obtain the pharmaceutical preparation for removing eye wrinkles.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310020794.7A CN116850235A (en) | 2023-01-06 | 2023-01-06 | Pharmaceutical preparation for removing eye wrinkles and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310020794.7A CN116850235A (en) | 2023-01-06 | 2023-01-06 | Pharmaceutical preparation for removing eye wrinkles and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726760A (en) * | 2016-12-24 | 2017-05-31 | 严志海 | A kind of eye cream and preparation method thereof |
| CN110680792A (en) * | 2019-11-01 | 2020-01-14 | 崔岩 | Wrinkle-removing eye cream |
| CN111000942A (en) * | 2019-12-23 | 2020-04-14 | 四川一只老鹰中医药股份有限公司 | A topical composition for promoting recovery of vision of eye, and its preparation method |
| CN114831916A (en) * | 2022-05-10 | 2022-08-02 | 四川一只老鹰集团股份有限公司 | Daily eye repair composition, preparation method and application thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726760A (en) * | 2016-12-24 | 2017-05-31 | 严志海 | A kind of eye cream and preparation method thereof |
| CN110680792A (en) * | 2019-11-01 | 2020-01-14 | 崔岩 | Wrinkle-removing eye cream |
| CN111000942A (en) * | 2019-12-23 | 2020-04-14 | 四川一只老鹰中医药股份有限公司 | A topical composition for promoting recovery of vision of eye, and its preparation method |
| CN114831916A (en) * | 2022-05-10 | 2022-08-02 | 四川一只老鹰集团股份有限公司 | Daily eye repair composition, preparation method and application thereof |
Non-Patent Citations (1)
| Title |
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| 翁晓芳，等: "皮肤屏障功能研究及其在化妆品中的应用", 广东化工, vol. 42, no. 04, 28 February 2015 (2015-02-28), pages 61 - 63 * |
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