CN107913218A - A kind of compound elite preparation with senile-resistant efficacy and its preparation method and application - Google Patents
A kind of compound elite preparation with senile-resistant efficacy and its preparation method and application Download PDFInfo
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- CN107913218A CN107913218A CN201711155143.XA CN201711155143A CN107913218A CN 107913218 A CN107913218 A CN 107913218A CN 201711155143 A CN201711155143 A CN 201711155143A CN 107913218 A CN107913218 A CN 107913218A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Abstract
The present invention relates to the cosmetics processing technique field in daily-use chemical industry, more particularly to a kind of compound elite preparation with senile-resistant efficacy and its preparation method and application, the 80 compound elite preparations of PIB with senile-resistant efficacy include：Black Ganoderma extract 1 10%, hamamelis extract 1 10%, purslane extract 1 10%, lactoferrin 1 10%, Cer NP 0.01 1%, collagen 0.1 10%, olea europaea fruit unsaponifiable matter 2 30%, caprylic/capric triglyceride 1 20%, tocopherol 0.1 1%, hydrolecithin 1 10%, sucrose stearate 1 20%, 10 stearate 1 20% of polyglycereol, cholesterine 1 20% and balance deionized water.By forming the liposome of parcel with hydrolecithin, the liquid crystal structure of bilayer is formed, there is fabulous skin-friendly, there is anti-aging, anti-inflammatory, antiallergy, moisturizing to human skin.
Description
Technical field
It is more particularly to a kind of with senile-resistant efficacy the present invention relates to the cosmetics processing technique field in daily-use chemical industry
PIB-80 compound elite preparations and its preparation method and application.
Background technology
The pursuit that skin is fine and smooth, smooth, high resilience is each people seeking beauty, and the symbol of people's youthful vigor.
With the development of society, life stress increases, environmental quality declines, and causes people's skin obscure, color spot, wrinkle etc. occur various
Skin problem.Although the various anti-aging skin care products of commercial type emerge in an endless stream, all contain in most skin care item
Have substantial amounts of chemical synthesis substance, there are easy allergy, absorption difference, it is greasy the problems such as.Thus, using green, free of contamination natural
The anti-aging skin care product that active ingredient makes increasingly is subject to the pro-gaze of people, especially ripe age skin crowd, this part population
It is especially prominent to possessing the skin care item demand of anti-senescence function.Such as Chinese patent (number of patent application 201210384938.9) " one
The natural anti-aging face cream of kind ", it is made of the raw material of following weight：5-15 parts of glycerine, 1-10 parts of ethanol, dimension life
Plain 2-8 parts of E acetic acid esters, 0.1-1 parts of methyl hydroxybenzoate, 5-25 parts of plant extraction liquid, 1-3 parts of vitamin B6, hyaluronic acid 0.5-
1.5 part, 0.5-2.5 parts of essence；The plant extraction liquid carries for radix glycyrrhizae, cordate houttuynia, Chinese gall, the tuber of multiflower knotweed, ginseng or prune
Take one or more of mixtures in thing；The natural anti-aging face cream that the invention provides, contains natural anti-aging plant extract
Liquid, to skin energy face-beautifying sanility-delaying, the progress to boost metabolism, activating skin cells, improve blood circulation, grow skin
Moisten, is wrinkle resistant.A kind of and for example Chinese patent (number of patent application 201210054331.4) " original of grape seed ultramicro-farina face cream facial mask
Material composition and preparation method thereof ", is made of following parts by weight of raw materials：0.5-2 parts of Tween 80,1-3 parts of cetanol, monostearate
2-4 parts of glyceride, 0.5-2 parts of sodium carboxymethylcellulose, 0.5-1.5 parts of sodium alginate, 6-8 parts of glycerine, 0.5-2 parts of sorbierite,
1-3 parts of propane diols, 0.5-0.6 parts of triethanolamine, 0.05-0.02 parts of citric acid, 0.05-0.02 parts of EDETATE SODIUM, tocopherol
0.01-0.02 parts, 0.5-2 parts of grape seed ultramicro-farina, 70-90 parts of 0.1-0.3 parts of sorbic acid and deionized water；The invention face cream face
Film moisturizing rate is high, whitening effect is obvious, but the Shortcomings in terms of Green Tea Extract, anti-aging, anti-inflammatory, antiallergy.
The content of the invention
To overcome disadvantages mentioned above, present invention aims at provide a kind of PIB-80 compound elite systems with senile-resistant efficacy
Agent and its preparation method and application, plays the role of human skin anti-aging, anti-inflammatory, antiallergy, moisturizing, ensure effect and without latent
Threat, security is good.
The technical solution adopted by the present invention is：A kind of PIB-80 compound elite preparations with senile-resistant efficacy, including it is anti-
Aging active material PIB-80, water phase substrate and oil phase substrate, the activity of fighting against senium Substance P IB-80 are extracted including Black Ganoderma
Thing, hamamelis extract, purslane extract, lactoferrin, Cer NP and collagen, the water phase substrate include going
Ionized water, the oil phase substrate include olea europaea fruit unsaponifiable matter, caprylic/capric triglyceride, tocopherol, cholesterine and breast
Agent, the emulsifying agent include hydrolecithin, sucrose stearate and Natrulon H-10 stearate, the weight of feed components
Measuring percentage is：Black Ganoderma extract 1-10%, hamamelis extract 1-10%, purslane extract 1-10%, newborn iron
Albumen 1-10%, Cer NP 0.01-1%, collagen 0.1-10%, olea europaea fruit unsaponifiable matter 2-30%, caprylic/capric are sweet
Three ester 1-20% of oil, tocopherol 0.1-1%, hydrolecithin 1-10%, sucrose stearate 1-20%, Natrulon H-10 are stearic
Acid esters 1-20%, cholesterine 1-20% and balance deionized water.
Preferably, the percentage by weight of feed components is：Black Ganoderma extract 1-5%, hamamelis extract 1-
8%th, purslane extract 1-2%, lactoferrin 2-3%, Cer NP 0.01-1%, collagen 0.1-5%, olea europaea fruit be not
Saponified 5-15%, caprylic/capric triglyceride 1-10%, tocopherol 0.1-1%, hydrolecithin 1-5%, sucrose stearate
Ester 1-5%, Natrulon H-10 stearate 1-10%, cholesterine 1-10% and balance deionized water.
Preferably, the percentage by weight of feed components is：Black Ganoderma extract 2%, hamamelis extract 2%,
Purslane extract 1%, lactoferrin 3%, Cer NP 0.06%, collagen 2%, olea europaea fruit unsaponifiable matter 6%, octanoic acid/
Triglyceride DDD 5%, tocopherol 0.3%, hydrolecithin 3%, sucrose stearate 2%, Natrulon H-10 stearate
6%th, cholesterine 8% and balance deionized water.
The function of each component is described below：
Black Ganoderma extract：Contain ganoderma lucidum triterpene, polysaccharide, protein, amino acid, adenine, steroid saponin, micro member
Plain active ingredient, has the significant free radical intended SOD activity, can significantly remove body generation, so as to prevent free radical to machine
The damage of body, it is therefore prevented that the peroxidating of fat body, protects cell, has delayed cell ageing, it is comprehensive play anti-oxidant, anti-aging,
Antibacterial effect.
Hamamelis extract：It is a variety of as Ellagtannin and Hamamlitannin can adjust skin to include tannin matter
Fat secretion, witch hazel Hydrolyzed Protein and Milk Protein；Promote lymph blood circulation, specially overcome morning eye bladder and livid ring around eye；Have
Effect that is calm, pacifying, to being cracked, tanning severely, acne have improvement；The power of regeneration at skin night can effectively be helped；Remove
Pouch, loosen and relax and have very excellent effect to the skin of what oily skin or allergy；Releive, restrain, antibacterial
Effect, because have convergence oil-control, sterilization significant curative effect；It is comprehensive play anti-oxidant, enhancing skin cell metabolism, it is anti-ageing,
Anti-inflammatory, releive, restrain and the effect of moisturizing.
Purslane extract：Mainly contain flavonoids, polysaccharide, alkaloids, triterpene alcohols, organic acid, catechol
Amine substance, and a variety of nutriments such as other vitamin and minerals, have antibacterial, antiviral, anti-aging, strengthen immunity
And other effects.1. the norepinephrine and neurohormone that contain, have and play vessel retraction effect, hypotension and reduction tissue
The function of bleeding；External application can be used for treating burn, otalgia, insect bites, inflammation, cutaneous pain, ulcer, pruitus, wet
Rash and abscess.2. being used for personal nursing and cleaning products, cytotoxicity caused by surfactant and stimulation can be reduced, is had anti-
Inflammation effect and anti-irritant effect.Damaged 3. can reduce caused by UVA, there is anti-light toxic action.
Lactoferrin：Lactoferrin is present in milk, tears, blood etc., is iron-binding protein sugar, molecular weight is about 8
Ten thousand, lactoferrin and its protein degradation product-lactoferricin have an extensive biological activity, including broad-spectrum antibacterial action,
Anti-inflammatory, suppress growth of tumour cell and adjust organism immune response etc., it is considered to be a kind of novel antibacterial, cancer therapy drug and great
Food, the cosmetic additive agent of potentiality to be exploited, in addition to it can combine the major function with transport ferric iron, lactoferrin also has
There is antibacterial, antiviral, anti parasitic, catalysis, cancer-resisting, antiallergy and radiation proof function and attribute, synthesis have anti-
Oxidation, antibacterial, antiallergy effect.
Cer NP：With hydrone ability of associating by force very much, it passes through forms net structure maintenance skin in cuticula
Moisture, therefore, ceramide, which has, keeps moisture of skin effect.Skin barrier function is maintained, important work is played to skin health
With；Improve skin moisture holding capacity, maintain skin barrier water balance；The situation such as dry skin, furfur, coarse can be improved；Enhancing
Skin elasticity, reduces wrinkle, delay skin aging；Anti-inflammatory.
Collagen：Collagen has improvement wrinkle, moisturizing, promotes collagen to produce, promotes hyaluronic acid to produce, improvement skin
It is coarse and other effects.
Olea europaea fruit unsaponifiable matter：Including free alcohol, triterpene, pigment (Chlorophylls and Carotenoids), tocopherol, more
The components such as phenol, sterol, squalene and steroid saponin, have good antioxygenic property, in terms of particularly understanding free radical, have
Obvious effect.
Caprylic/capric triglyceride：Grease is moistened, there is good spreadability, make skin that there is smooth but not greasy sensation,
Easily be absorbed by the skin, play the role of to the uniform and smooths of cosmetics good, make skin lubrication glossy, can be used as moisturizing because
The base-material of son, the stabilizer of cosmetics, antifreezing agent, homogeneous agent.
Tocopherol：The hydrolysate of vitamin E, has oxidation resistant effect, slows down aging, and effectively reduces the production of wrinkle
It is raw, the appearance to retain youth, murder by poisoning of the anti-oxidation protection body cell from free radical.
Hydrolecithin：It can promote the infiltration of other nutriments, emulsifying agent, the composition being present in yolk and soya bean,
It is suitable as ripe age flesh and moistens use, there is the effect such as moisturizing, anti-oxidant.
Sucrose stearate：It can make emulsifying agent, wetting agent, dispersant, solubilizer and emollient etc..
Natrulon H-10 stearate：It can make emulsifying agent, wetting agent, dispersant, solubilizer and emollient etc..
Cholesterine：As the skin effect of moistening etc..
Present invention also offers a kind of preparation method of the PIB-80 compound elite preparations with senile-resistant efficacy, including such as
Lower step：
(1) stock up：According to above-mentioned percentage by weight, the raw material of each component is chosen respectively, it is spare；
(2) water phase substrate configures：By spare deionized water heat temperature raising, become water phase substrate, it is spare；
(3) hydrated emulsifier configures：By emulsifying agent hydrolecithin, sucrose stearate and Natrulon H-10 stearate
Add in half water phase substrate, heated constant temperature stirring make its it is fully hydrated obtain hydrated emulsifier, it is spare；
(4) oil mixing with water material configures：By caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter
It is added in step (3) hydrated emulsifier, it is spare after being sufficiently stirred mixing；
(5) step (4) oil mixing with water material is added in the other half water phase substrate, then adds activity of fighting against senium Substance P IB-
80, including Black Ganoderma extract, hamamelis extract, purslane extract, lactoferrin, Cer NP and collagen, into
The finished product containing liquid crystal structure can be formed after row homogeneous 3-7min.
Preferably, step (2) is heated to 70-90 DEG C.
Preferably, step (3) heated constant temperature is to 70-75 DEG C.
Preferably, step (5) carries out homogeneous at 50-60 DEG C of temperature, 0.05-0.2MPa pressure conditions.
Present invention also offers a kind of PIB-80 compound elite preparation with senile-resistant efficacy to be used for anti-aging cosmetics
Application in terms of preparation, anti-aging cosmetics can be anti-aging facial cleanser, antisenility skin care water, anti-aging lotion, anti-aging
One kind in cream or anti-ageing face mask.
The present invention is beneficial to be had technical effect that：
1. by the way that the liposome of parcel can be formed with hydrolecithin, active ingredient can be effectively protected, makes it more
Penetrate into skin well；Since such a emulsification can form the liquid crystal structure of bilayer, there is fabulous skin-friendly, more plantations
The active matter of thing collocation has the effect of obvious in terms of Green Tea Extract (anti-aging), anti-inflammatory.
2. principle active component has ganoderma lucidum triterpene, polysaccharide, protein, amino acid, adenine, a steroid saponin, squalene,
Triterpenoidss, phytosterol, vitamin, this formula have the effect of obvious in terms of moisturizing, antiallergy and anti-aging, are making up
There is great meaning in product field.
Embodiment
The content that the present invention is furture elucidated with reference to embodiments, but the present invention is not restricted to the model of following examples
Enclose.
Embodiment 1
A kind of PIB-80 compound elite preparations with senile-resistant efficacy of the present embodiment, including activity of fighting against senium Substance P IB-
80th, water phase substrate and oil phase substrate, the activity of fighting against senium Substance P IB-80 includes Black Ganoderma extract, hamamelis is extracted
Thing, purslane extract, lactoferrin, Cer NP and collagen, the water phase substrate include deionized water, the oil phase base
Bottom includes caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter and emulsifying agent, and the emulsifying agent includes
Hydrolecithin, sucrose stearate and Natrulon H-10 stearate, the percentage by weight of feed components are：Black Ganoderma carries
Take thing 1%, hamamelis extract 1%, purslane extract 10%, lactoferrin 1%, Cer NP 1%, collagen
0.1%th, olea europaea fruit unsaponifiable matter 30%, caprylic/capric triglyceride 1%, tocopherol 0.1%, hydrolecithin 1%, sugarcane
Sugared stearate 1%, Natrulon H-10 stearate 1%, cholesterine 20% and balance deionized water.
A kind of preparation method of the PIB-80 compound elite preparations with senile-resistant efficacy, includes the following steps：
(1) stock up：According to above-mentioned percentage by weight, the raw material of each component is chosen respectively, it is spare；
(2) water phase substrate configures：By 70 DEG C spare of deionized water heat temperature raising, become water phase substrate, it is spare；
(3) hydrated emulsifier configures：By emulsifying agent hydrolecithin, sucrose stearate and Natrulon H-10 stearate
Add in half water phase substrate, heat the stirring of 70 DEG C of constant temperature make its it is fully hydrated obtain hydrated emulsifier, it is spare；
(4) oil mixing with water material configures：By caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter
It is added in step (3) hydrated emulsifier, it is spare after being sufficiently stirred mixing；
(5) step (4) oil mixing with water material is added in the other half water phase substrate, then adds activity of fighting against senium Substance P IB-
80, including Black Ganoderma extract, hamamelis extract, purslane extract, lactoferrin, Cer NP and collagen,
Temperature 50 C, the finished product containing liquid crystal structure can be formed after carrying out homogeneous 3-7min under 0.05MPa pressure conditions.
Embodiment 2
A kind of PIB-80 compound elite preparations with senile-resistant efficacy of the present embodiment, including activity of fighting against senium Substance P IB-
80th, water phase substrate and oil phase substrate, the activity of fighting against senium Substance P IB-80 includes Black Ganoderma extract, hamamelis is extracted
Thing, purslane extract, lactoferrin, Cer NP and collagen, the water phase substrate include deionized water, the oil phase base
Bottom includes caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter and emulsifying agent, and the emulsifying agent includes
Hydrolecithin, sucrose stearate and Natrulon H-10 stearate, the percentage by weight of feed components are：Black Ganoderma carries
Take thing 10%, hamamelis extract 1%, purslane extract 1%, lactoferrin 10%, Cer NP 1%, collagen
10%th, olea europaea fruit unsaponifiable matter 2%, caprylic/capric triglyceride 20%, tocopherol 1%, hydrolecithin 10%, sucrose
Stearate 1%, Natrulon H-10 stearate 1%, cholesterine 1% and balance deionized water.
A kind of preparation method of the PIB-80 compound elite preparations with senile-resistant efficacy, includes the following steps：
(1) stock up：According to above-mentioned percentage by weight, the raw material of each component is chosen respectively, it is spare；
(2) water phase substrate configures：By 80 DEG C spare of deionized water heat temperature raising, become water phase substrate, it is spare；
(3) hydrated emulsifier configures：By emulsifying agent hydrolecithin, sucrose stearate and Natrulon H-10 stearate
Add in half water phase substrate, heat the stirring of 73 DEG C of constant temperature make its it is fully hydrated obtain hydrated emulsifier, it is spare；
(4) oil mixing with water material configures：By caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter
It is added in step (3) hydrated emulsifier, it is spare after being sufficiently stirred mixing；
(5) step (4) oil mixing with water material is added in the other half water phase substrate, then adds activity of fighting against senium Substance P IB-
80, including Black Ganoderma extract, hamamelis extract, purslane extract, lactoferrin, Cer NP and collagen,
55 DEG C of temperature, the finished product containing liquid crystal structure can be formed after carrying out homogeneous 3-7min under 0.1MPa pressure conditions.
Embodiment 3
A kind of PIB-80 compound elite preparations with senile-resistant efficacy of the present embodiment, including activity of fighting against senium Substance P IB-
80th, water phase substrate and oil phase substrate, the activity of fighting against senium Substance P IB-80 includes Black Ganoderma extract, hamamelis is extracted
Thing, purslane extract, lactoferrin, Cer NP and collagen, the water phase substrate include deionized water, the oil phase base
Bottom includes olea europaea fruit unsaponifiable matter, caprylic/capric triglyceride, tocopherol, cholesterine and emulsifying agent, and the emulsifying agent includes
Hydrolecithin, sucrose stearate and Natrulon H-10 stearate, the percentage by weight of feed components are：Black Ganoderma carries
Take thing 1%, hamamelis extract 10%, purslane extract 1%, lactoferrin 2%, Cer NP 0.01%, collagen
0.1%th, olea europaea fruit unsaponifiable matter 5%, caprylic/capric triglyceride 1%, tocopherol 0.1%, hydrolecithin 1%, sucrose
Stearate 20%, Natrulon H-10 stearate 20%, cholesterine 1% and balance deionized water.
A kind of preparation method of the PIB-80 compound elite preparations with senile-resistant efficacy, includes the following steps：
(1) stock up：According to above-mentioned percentage by weight, the raw material of each component is chosen respectively, it is spare；
(2) water phase substrate configures：By 90 DEG C spare of deionized water heat temperature raising, become water phase substrate, it is spare；
(3) hydrated emulsifier configures：By emulsifying agent hydrolecithin, sucrose stearate and Natrulon H-10 stearate
Add in half water phase substrate, heat the stirring of 75 DEG C of constant temperature make its it is fully hydrated obtain hydrated emulsifier, it is spare；
(4) oil mixing with water material configures：By caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter
It is added in step (3) hydrated emulsifier, it is spare after being sufficiently stirred mixing；
(5) step (4) oil mixing with water material is added in the other half water phase substrate, then adds activity of fighting against senium Substance P IB-
80, including Black Ganoderma extract, hamamelis extract, purslane extract, lactoferrin, Cer NP and collagen,
Temperature 60 C, the finished product containing liquid crystal structure can be formed after carrying out homogeneous 3-7min under 0.15MPa pressure conditions.
Embodiment 4
A kind of PIB-80 compound elite preparations with senile-resistant efficacy of the present embodiment, including activity of fighting against senium Substance P IB-
80th, water phase substrate and oil phase substrate, the activity of fighting against senium Substance P IB-80 includes Black Ganoderma extract, hamamelis is extracted
Thing, purslane extract, lactoferrin, Cer NP and collagen, the water phase substrate include deionized water, the oil phase base
Bottom includes olea europaea fruit unsaponifiable matter, caprylic/capric triglyceride, tocopherol, cholesterine and emulsifying agent, and the emulsifying agent includes
Hydrolecithin, sucrose stearate and Natrulon H-10 stearate, the percentage by weight of feed components are：Black Ganoderma carries
Take thing 5%, hamamelis extract 8%, purslane extract 2%, lactoferrin 3%, Cer NP 1%, collagen 5%,
Olea europaea fruit unsaponifiable matter 15%, caprylic/capric triglyceride 10%, tocopherol 1%, hydrolecithin 5%, sucrose stearate
Ester 5%, Natrulon H-10 stearate 10%, cholesterine 10% and balance deionized water.
A kind of preparation method of the PIB-80 compound elite preparations with senile-resistant efficacy, includes the following steps：
(1) stock up：According to above-mentioned percentage by weight, the raw material of each component is chosen respectively, it is spare；
(2) water phase substrate configures：By 72 DEG C spare of deionized water heat temperature raising, become water phase substrate, it is spare；
(3) hydrated emulsifier configures：By emulsifying agent hydrolecithin, sucrose stearate and Natrulon H-10 stearate
Add in half water phase substrate, heat the stirring of 72 DEG C of constant temperature make its it is fully hydrated obtain hydrated emulsifier, it is spare；
(4) oil mixing with water material configures：By caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter
It is added in step (3) hydrated emulsifier, it is spare after being sufficiently stirred mixing；
(5) step (4) oil mixing with water material is added in the other half water phase substrate, then adds activity of fighting against senium Substance P IB-
80, including Black Ganoderma extract, hamamelis extract, purslane extract, lactoferrin, Cer NP and collagen,
Temperature 60 C, the finished product containing liquid crystal structure can be formed after carrying out homogeneous 3-7min under 0.2MPa pressure conditions.
Embodiment 5
A kind of PIB-80 compound elite preparations with senile-resistant efficacy of the present embodiment, including activity of fighting against senium Substance P IB-
80th, water phase substrate and oil phase substrate, the activity of fighting against senium Substance P IB-80 includes Black Ganoderma extract, hamamelis is extracted
Thing, purslane extract, lactoferrin, Cer NP and collagen, the water phase substrate include deionized water, the oil phase base
Bottom includes olea europaea fruit unsaponifiable matter, caprylic/capric triglyceride, tocopherol, cholesterine and emulsifying agent, and the emulsifying agent includes
Hydrolecithin, sucrose stearate and Natrulon H-10 stearate, the percentage by weight of feed components are：Black Ganoderma carries
Take thing 2%, hamamelis extract 2%, purslane extract 1%, lactoferrin 3%, Cer NP 0.06%, collagen
2%th, olea europaea fruit unsaponifiable matter 6%, caprylic/capric triglyceride 5%, tocopherol 0.3%, hydrolecithin 3%, sucrose are hard
Resin acid ester 2%, Natrulon H-10 stearate 6%, cholesterine 8% and balance deionized water.
A kind of preparation method of the PIB-80 compound elite preparations with senile-resistant efficacy, includes the following steps：
(1) stock up：According to above-mentioned percentage by weight, the raw material of each component is chosen respectively, it is spare；
(2) water phase substrate configures：By 90 DEG C spare of deionized water heat temperature raising, become water phase substrate, it is spare；
(3) hydrated emulsifier configures：By emulsifying agent hydrolecithin, sucrose stearate and Natrulon H-10 stearate
Add in half water phase substrate, the stirring of 70 DEG C of heated constant temperature make its it is fully hydrated obtain hydrated emulsifier, it is spare；
(4) oil mixing with water material configures：By caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter
It is added in step (3) hydrated emulsifier, it is spare after being sufficiently stirred mixing；
(5) step (4) oil mixing with water material is added in the other half water phase substrate, then adds activity of fighting against senium Substance P IB-
80, including Black Ganoderma extract, hamamelis extract, purslane extract, lactoferrin, Cer NP and collagen,
Temperature 50 C, the finished product containing liquid crystal structure can be formed after carrying out homogeneous 3-7min under 0.2MPa pressure conditions.
A kind of control group experiment of PIB-80 compound elite preparations with senile-resistant efficacy：
Research object：Computer work person is uniformly chosen, mild acne, has wrinkle or has microgroove, there is blackhead, and pore is thick,
There is whelk, there is sunburn, the people of outwork person totally 400 people, randomly selects 50 people as one group, be divided into out 8 groups, 5 experimental groups
With 3 control groups.
Experimental program：The anti-aging lotion that 5 experimental groups are prepared using embodiment 1-5 respectively, 3 control groups use respectively
In the market radix glycyrrhizae containing plant extraction liquid lotion, the lotion of Angelica sinensis containing plant extraction liquid, the lotion of ginseng containing plant extraction liquid.Embodiment 1
The anti-aging lotion of preparation is experimental group 1, and anti-aging lotion prepared by embodiment 2 is experimental group 2, and embodiment 3 is prepared anti-ageing
Old lotion is experimental group 3, and anti-aging lotion prepared by embodiment 4 is experimental group 4, and anti-aging lotion prepared by embodiment 5 is real
Group 5 is tested, the lotion of radix glycyrrhizae containing plant extraction liquid is experimental group 6, and the lotion of the tuber of multiflower knotweed containing plant extraction liquid is experimental group 7, containing plant extract
Liquid ginseng lotion is experimental group 8.Sooner or later twice daily, it is used continuously 3 months.
Experimental result is shown in Table 1：
The results show：By the way that the liposome of parcel can be formed with hydrolecithin, can be effectively protected effectively
Component, makes it more preferably penetrate into skin；Since such a emulsification can form the liquid crystal structure of bilayer, there is fabulous parent
Skin, the active matter of various plants collocation has the effect of obvious in terms of Green Tea Extract (anti-aging), anti-inflammatory, wherein mainly having
Effect component has ganoderma lucidum triterpene, polysaccharide, protein, amino acid, adenine, a steroid saponin, squalene, Triterpenoidss, phytosterol,
Vitamin, this formula have the effect of obvious in terms of moisturizing, antiallergy and anti-aging.
The technical concepts and features of embodiment of above only to illustrate the invention, its object is to allow be familiar with technique
People understands present disclosure and is carried out, and it is not intended to limit the scope of the present invention, all spiritual according to the present invention
The equivalent change or modification that essence is done, should all cover within the scope of the present invention.
Claims (8)
- A kind of 1. PIB-80 compound elite preparations with senile-resistant efficacy, it is characterised in that：Including activity of fighting against senium material PIB-80, water phase substrate and oil phase substrate, the activity of fighting against senium Substance P IB-80 include Black Ganoderma extract, hamamelis Extract, purslane extract, lactoferrin, Cer NP and collagen, the water phase substrate include deionized water, the oil Phase substrate includes olea europaea fruit unsaponifiable matter, caprylic/capric triglyceride, tocopherol, cholesterine and emulsifying agent, the emulsifying agent Including hydrolecithin, sucrose stearate and Natrulon H-10 stearate, the percentage by weight of feed components is：Black spirit Sesame extract 1-10%, hamamelis extract 1-10%, purslane extract 1-10%, lactoferrin 1-10%, Cer NP 0.01-1%, collagen 0.1-10%, olea europaea fruit unsaponifiable matter 2-30%, caprylic/capric triglyceride 1-20%, tocopherol 0.1- 1%th, hydrolecithin 1-10%, sucrose stearate 1-20%, Natrulon H-10 stearate 1-20%, cholesterine 1-20% and remaining Measure deionized water.
- 2. the PIB-80 compound elite preparations according to claim 1 with senile-resistant efficacy, it is characterised in that：Raw material is each The percentage by weight of component is：Black Ganoderma extract 1-5%, hamamelis extract 1-8%, purslane extract 1-2%, breast Ferritin 2-3%, Cer NP 0.01-1%, collagen 0.1-5%, olea europaea fruit unsaponifiable matter 5-15%, caprylic/capric glycerine three Ester 1-10%, tocopherol 0.1-1%, hydrolecithin 1-5%, sucrose stearate 1-5%, Natrulon H-10 stearate 1-10%, Cholesterine 1-10% and balance deionized water.
- 3. the PIB-80 compound elite preparations according to claim 1 with senile-resistant efficacy, it is characterised in that：Raw material is each The percentage by weight of component is：Black Ganoderma extract 2%, hamamelis extract 2%, purslane extract 1%, lactoferrin 3%th, Cer NP 0.06%, collagen 2%, olea europaea fruit unsaponifiable matter 6%, caprylic/capric triglyceride 5%, tocopherol 0.3%, Hydrolecithin 3%, sucrose stearate 2%, Natrulon H-10 stearate 6%, cholesterine 8% and balance deionized water.
- A kind of 4. preparation of the PIB-80 compound elite preparations with senile-resistant efficacy in claim 1-3 described in any one Method, it is characterised in that：Include the following steps：（1）Stock：According to above-mentioned percentage by weight, the raw material of each component is chosen respectively, it is spare；（2）Water phase substrate configures：By spare deionized water heat temperature raising, become water phase substrate, it is spare；（3）Hydrated emulsifier configures：Emulsifying agent hydrolecithin, sucrose stearate and Natrulon H-10 stearate are added In half water phase substrate, heated constant temperature stirring make its it is fully hydrated obtain hydrated emulsifier, it is spare；（4）Oil mixing with water material configures：Caprylic/capric triglyceride, tocopherol, cholesterine, olea europaea fruit unsaponifiable matter are added To step（3）It is spare after being sufficiently stirred mixing in hydrated emulsifier；（5）By step（4）Oil mixing with water material is added in the other half water phase substrate, then adds activity of fighting against senium Substance P IB-80, Including Black Ganoderma extract, hamamelis extract, purslane extract, lactoferrin, Cer NP and collagen, carry out The finished product containing liquid crystal structure can be formed after homogeneous 3-7min.
- 5. the preparation method of the PIB-80 compound elite preparations according to claim 4 with senile-resistant efficacy, its feature It is：The step（2）It is heated to 70-90 DEG C.
- 6. the preparation method of the PIB-80 compound elite preparations according to claim 4 with senile-resistant efficacy, its feature It is：The step（3）Heated constant temperature is to 70-75 DEG C.
- 7. the preparation method of the PIB-80 compound elite preparations according to claim 4 with senile-resistant efficacy, its feature It is：The step（5）Homogeneous is carried out at 50-60 DEG C of temperature, 0.05-0.2MPa pressure conditions.
- 8. a kind of PIB-80 compound elite preparations with senile-resistant efficacy in claim 1-3 described in any one should With, it is characterised in that：Prepared for anti-aging cosmetics, the anti-aging cosmetics are anti-aging facial cleanser, antisenility skin care One kind in water, anti-aging lotion, anti-aging cream or anti-ageing face mask.
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| CN108379168A (en) * | 2018-05-03 | 2018-08-10 | 杜铭 | A kind of cosmetics and preparation method thereof of phytoremediation cuticula |
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| CN109875910A (en) * | 2019-04-19 | 2019-06-14 | 武汉百思凯瑞生物科技有限公司 | A kind of complex polypeptide nano vesicle and its preparation method and application with skin repair function |
| CN111973472A (en) * | 2019-12-05 | 2020-11-24 | 上海遇鑫生物科技有限公司 | Ceramide activated water and preparation method thereof |
| CN111888459A (en) * | 2020-08-18 | 2020-11-06 | 深圳市俊元生物科技有限公司 | Lyophilized powder containing mesenchymal stem cell secretory factor and solvent thereof |
| CN112294738A (en) * | 2020-11-12 | 2021-02-02 | 厦门鹰君药业有限公司 | Essence water composition and preparation method thereof |
| CN112451411A (en) * | 2020-11-18 | 2021-03-09 | 荣鼎(广东)生物科技有限公司 | Epidermal active collagen stock solution |
| CN112603871A (en) * | 2021-02-05 | 2021-04-06 | 东晟源研究院(广州)有限公司 | Formula and preparation method of wrinkle-reducing eye essence |
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| WO2024028834A1 (en) * | 2022-08-05 | 2024-02-08 | Carbocode S.A. | Reduction of signs of skin aging |
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Application publication date: 20180417 |