CN109395001A - Treat skin disease ointment machin cleaning solution - Google Patents

Treat skin disease ointment machin cleaning solution Download PDF

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CN109395001A
CN109395001A CN201811546726.XA CN201811546726A CN109395001A CN 109395001 A CN109395001 A CN 109395001A CN 201811546726 A CN201811546726 A CN 201811546726A CN 109395001 A CN109395001 A CN 109395001A
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chinese medicine
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吴定
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

Dermopathic Chinese medicine preparation and its application, the dermopathic ointment machin cleaning solution for the treatment of are treated the present invention relates to a kind of, belongs to drug field.The raw material of the Chinese medicine preparation includes cortex dictamni, the fruit of summer cypress, kuh-seng, humulus grass, dandelion, the tuber of stemona, frutus cnidii, realgar, Sagina subulata, persimmon leaves, litharge and borneol.Its abundant raw material, proportion are proper, can be used in treating skin disease.It is used for preparation and treats dermopathic drug, preferably treatment skin eczema can be played and improve the effect of pruritis.The dermopathic ointment for the treatment of provided by the invention be it is heated after ointment bases be obtained by mixing with above-mentioned Chinese medicine preparation, can be applied directly at skin disease disease hair, play the role of antipruritic clearing damp.Treating dermopathic cleaning solution is to extract 8-16h after above-mentioned Chinese medicine preparation is mixed with alcoholic solution under conditions of 40-60 DEG C and obtain, the cleaning solution pharmacological property is mild, can not also cause additional stimulation to skin while playing and preferably treating dermopathic effect.

Description

Treat skin disease ointment machin cleaning solution
Technical field
The present invention relates to drug fields, and in particular to a kind of treat dermopathic Chinese medicine preparation and its application, treatment skin The ointment machin cleaning solution of skin disease.
Background technique
Skin disease is common disease and frequently-occurring disease, and difficult disease is more, causes considerable distress to patient.Dermopathic clinical symptoms In, show as primary lesion has macula, blood stasis, blister, tumour, suppurative, fungoid damage etc.；Show as secondary lesion Have the scales of skin that peel off, dipping, erosion, ulcer, scar and moss etc..
Eczema as it is a kind of as caused by various internal and external factors, refractory and common allergic skin disease easy to recur it One, with the raising and the accelerating rhythm of life of economic level, its disease incidence and consultation rate increase year by year in recent years.
The drug for the treatment of skin disease used in the prior art (such as eczema and pruitus), though have in clinical application Certain curative effect, but every kind of drug specific aim is very strong, when diagnosing not clear enough, drug is selected to have great difficulty.And at present In the dermatological department drug of listing, much all contain hormone, be discontinued and send out, it is difficult to reach the dermopathic purpose of radical cure.
Summary of the invention
Dermopathic Chinese medicine preparation is treated one of the objects of the present invention is to provide a kind of, abundant raw material, proportion are proper, It can be used in treating skin disease.
The second object of the present invention is to provide a kind of above-mentioned Chinese medicine preparation answering in the dermopathic drug of preparation treatment With, such as can be used for preparing the dermopathic ointment for the treatment of or cleaning solution, it can be convenient for being applicable in, and it is wet to play preferably treatment skin Rash and the effect for improving pruritis.
The third object of the present invention be to provide it is a kind of treat dermopathic ointment, be applied directly at skin disease disease hair, Play the role of antipruritic clearing damp and has no drug resistance.
The fourth object of the present invention be to provide it is a kind of treat dermopathic cleaning solution, the cleaning solution pharmacological property is mild, can be Do not cause additional stimulation while playing preferable curative effect to skin also.
The present invention solves its technical problem and adopts the following technical solutions to realize:
The present invention propose it is a kind of treat dermopathic Chinese medicine preparation, raw material includes the cortex dictamni of 14-18 parts by weight, 16 weight of 13- Measure the fruit of summer cypress of part, the kuh-seng of 7-10 parts by weight, the humulus grass of 6-9 parts by weight, the dandelion of 6-7 parts by weight, 2-3 parts by weight hundred Portion, the frutus cnidii of 1-2 parts by weight, the realgar of 1-2 parts by weight, the Sagina subulata of 1-2 parts by weight, 1-2 parts by weight persimmon leaves, The litharge of 0.2-0.5 parts by weight and the borneol of 0.3-0.5 parts by weight.
The invention also provides a kind of above-mentioned Chinese medicine preparations to treat the application in dermopathic drug in preparation, such as can be with It is used to prepare the dermopathic ointment for the treatment of or cleaning solution.
Dermopathic ointment is treated the invention also provides a kind of, the ointment bases after the ointment is heated and above-mentioned Chinese medicine Formula is obtained by mixing.
Dermopathic cleaning solution is treated the invention also provides a kind of, the cleaning solution is mixed through above-mentioned Chinese medicine preparation and alcoholic solution After conjunction, 8-16h is extracted under conditions of 40-60 DEG C and is obtained.
Dermopathic ointment machin cleaning solution is treated in the dermopathic Chinese medicine preparation for the treatment of of the embodiment of the present invention and its application Beneficial effect is:
Using cortex dictamni, the fruit of summer cypress as monarch drug in a prescription in Chinese medicine preparation；Borneol toil cool in nature is minister, external application energy clearing heat for detumescence, antipruritic analgesic； Kuh-seng, humulus grass, dandelion, the tuber of stemona, frutus cnidii, realgar, Sagina subulata, persimmon leaves and litharge are adjuvant altogether.In above-mentioned 12 taste medicine Collective effect under, make Chinese medicine preparation in the embodiment of the present invention that there is preferable removing damp-heat desinsection, dispelling wind itching-relieving efficacies.
Above-mentioned Chinese medicine preparation is used to prepare the dermopathic drug for the treatment of, preferably treatment skin eczema can be played and is changed The effect of kind pruritis, and have no drug resistance.The dermopathic ointment for the treatment of provided in an embodiment of the present invention can be applied directly to skin At the sick hair of skin disease, play the role of antipruritic clearing damp.Further it is provided that the dermopathic cleaning solution pharmacological property for the treatment of it is mild, can play compared with Additional stimulation is not caused to skin also while good treatment dermopathic effect.
Specific embodiment
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, according to normal conditions or manufacturer builds The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase Product.
It is clear to the dermopathic Chinese medicine preparation of the treatment of the embodiment of the present invention and its application, the dermopathic ointment machin for the treatment of below Washing lotion is specifically described.
The embodiment of the present invention provide it is a kind of treat dermopathic Chinese medicine preparation, the raw material of the Chinese medicine preparation includes 14-18 weight Measure the cortex dictamni of part, the fruit of summer cypress of 13-16 parts by weight, the kuh-seng of 7-10 parts by weight, the humulus grass of 6-9 parts by weight, 6-7 parts by weight Dandelion, the tuber of stemona of 2-3 parts by weight, the frutus cnidii of 1-2 parts by weight, the realgar of 1-2 parts by weight, the Sagina subulata of 1-2 parts by weight, 1- The persimmon leaves of 2 parts by weight, the litharge of 0.2-0.5 parts by weight and 0.3-0.5 parts by weight borneol.
Preferably, above-mentioned raw materials include the cortex dictamni of 14-16 parts by weight, the fruit of summer cypress of 14-15 parts by weight, 8-9 parts by weight Kuh-seng, the humulus grass of 7-8 parts by weight, the dandelion of 6.2-6.8 parts by weight, the tuber of stemona of 2.2-2.8 parts by weight, 1.2-1.8 weight Part frutus cnidii, the realgar of 1.2-1.8 parts by weight, the Sagina subulata of 1.2-1.8 parts by weight, 1.2-1.8 parts by weight persimmon leaves, The litharge of 0.3-0.4 parts by weight and the borneol of 0.3-0.5 parts by weight.
It is highly preferred that above-mentioned raw materials include the cortex dictamni of 15 parts by weight, the fruit of summer cypress of 14.5 parts by weight, 8.5 parts by weight Kuh-seng, the humulus grass of 7.5 parts by weight, the dandelion of 6.5 parts by weight, the tuber of stemona of 2.5 parts by weight, the frutus cnidii of 1.5 parts by weight, 1.5 The realgar of parts by weight, the Sagina subulata of 1.5 parts by weight, the persimmon leaves of 1.5 parts by weight, the litharge of 0.35 parts by weight and 0.4 weight The borneol of part.
Wherein, cortex dictamni micro-pungent is cold in nature, returns spleen, stomach, lung channel, being capable of dispelling wind and arresting itching, dispersing pathogen accumulation.Cortex dictamni has fungi There is apparent inhibiting effect, it being capable of anti-inflammatory antiallergy.Specifically, active constituent contained by cortex dictamni can effectively inhibit histamine With the content of serotonin, to contact dermatitis and particulate antigen sheep red blood cell caused by 2,4,6- trinitro-chlorobenzene of haptens Caused footpad reaction has apparent inhibiting effect.
Fruit of summer cypress bitter is cold in nature, returns kidney, bladder meridian, being capable of clearing heat and promoting diuresis, dispelling wind and arresting itching.Its active constituent is small to Austria's Du's big belly The small gemma moss bacterium of gemma moss bacterium, ulotrichy, the small gemma moss bacterium of rust etc. have different degrees of inhibiting effect.Its alcohol extract energy It is enough substantially reduced pruitus attack times and the itch duration of dextran induction, and patient tolerance's phosphoric acid can be increased The itch-threshold of histamine, to play preferable itching-relieving action.
Cortex dictamni and two medicine of the fruit of summer cypress are shared in the embodiment of the present invention, are altogether monarch drug in a prescription, make skin it is damp and hot in disappear it is outer dissipate, Itch from only, wherein cortex dictamni mainly pass through anti-inflammatory mechanisms play the role of it is antipruritic and treat it is dermopathic, the fruit of summer cypress mainly passes through Resisting pathogenic microbes plays the role of antipruritic and treats dermopathic.After said two devices cooperation, controlled through different mode of action collaborations Skin disease is treated, can further improve therapeutic effect.
Kuh-seng bitter is cold in nature, returns liver, kidney, stomach and large intestine channel, being capable of heat-clearing and damp-drying drug, sharp water removing jaundice, wind dispelling insecticide.Kuh-seng contains There is matrine alkaloid, Central nervous has certain inhibiting effect, can be by increasing inhibition in eczema patients brain Neural γ-aminobutyric acid and the content of glycine are to inhibit neuron activation.In addition, matrine can also be by inhibiting phosphatidase Anti-inflammatory effect is played in the release of activity, the proliferation of splenocyte and TNF, IL-1 and IL-6, by reducing serum or inflammation part IL-8 concentration play its anti-inflammatory activity.
Humulus grass contains humulone, lupulones and flavone compound (luteolin, cosmosiin and Vitexin), right Gram positive bacteria, if staphylococcus aureus, streptococcus fecalis and bacillus have apparent inhibiting effect, can treat swollen furuncle, Eczema, skin are scorching.Humulus grass alcohol extract can significantly inhibit the pruitus that 4AP and chloroquine induce, and reduce the content of IL-4 in serum, mention High itch-threshold, thus exogenous histamine and 4-AP induction release endogenous histamine caused by pruitus play preferably it is antipruritic Effect.
Dandelion is to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus and Diplococcus pneumopniae, meningococcus, white Larynx bacillus, pseudomonas aeruginosa, proteus, typhoid bacillus, shigella dysenteriae etc. have certain bactericidal effect, especially to dermatophyte There is apparent inhibiting effect.In addition, the function that dandelion can also excite body's immunity and dismiss with clearing heat and detoxicating, detumescence Effect.
Alkaloid contained by the tuber of stemona has certain inhibiting effect to dermatophyte.The analgesic in addition, tuber of stemona can also ease pain.
Osthole contained by frutus cnidii, bergapten and isopimpinellin can the palpus trichophyton to trichophyton have compared with It is strongly active, also, the xanthotoxol contained by it has significant Antifungal activities.
Realgar can be used in desinsection and treat sore, can play preferably to itch caused by trichomonas, monilial and wet moss Itching-relieving action.Active constituent contained by it is to staphylococcus aureus, human body tubercle bacillus, proteus, green pus coccus and more Kind dermatophyte has different degrees of inhibiting effect.
Longleaf bastardtoadflax herb contained in Sagina subulata element II pair of staphylococcus aureus, micrococcus catarrhalis, typhoid bacillus, proteus, Shigella dysenteriae has inhibiting effect；Succinic acid acts on Candida albicans unrestraint；I pair of staphylococcus aureus of longleaf bastardtoadflax herb element, Micrococcus catarrhalis, shigella dysenteriae have inhibiting effect.
In persimmon leaves persimmon leaves contain a large amount of tannic acids, can effectively kill various bacteriums and fungi, have cleaning and The effect of skin care.
Litharge can be to homocentricity hair moss bacterium, violet hair moss bacterium, red hair moss bacterium, little Bacillus of rust, cotton-shaped table Skin moss bacterium, gypsum sample hair moss bacterium and dermatophyte etc. play different degrees of inhibiting effect.In addition, may be used also as externally applied drug Mitigate inflammation.
Borneol has inhibition to the lose double ball mattress of bacterium, streptococcus, pneumonia, pathogenic dermatophyte of Escherichia coli and part etc. of Portugal Effect.
From the above, in the Chinese medicine preparation of the embodiment of the present invention, using cortex dictamni, the fruit of summer cypress as monarch drug in a prescription；Borneol toil Cool is minister, external application energy clearing heat for detumescence, antipruritic analgesic；Kuh-seng, humulus grass, dandelion, the tuber of stemona, frutus cnidii, realgar, Sagina subulata, persimmon Leaf and litharge are adjuvant altogether.Under the collective effect of above-mentioned 12 taste medicine, make Chinese medicine preparation in the embodiment of the present invention have compared with Good removing damp-heat desinsection, dispelling wind itching-relieving efficacies.
Answering in dermopathic drug is treated in preparation in addition, additionally providing above-mentioned Chinese medicine preparation in the embodiment of the present invention With, such as preparation can be used for and treat dermopathic ointment or cleaning solution.
Optionally, the dermopathic ointment for the treatment of provided in an embodiment of the present invention can with after heated ointment bases with Above-mentioned Chinese medicine preparation is obtained by mixing.
Preferably, above-mentioned ointment bases for example may include glycerol, atoleine, vaseline, beeswax, in dimethicone At least one and water.The weight ratio of ointment bases and Chinese medicine preparation is preferably 80-90:10-20.
Heating can be and handle 20-40min under conditions of 70-90 DEG C so that ointment bases thoroughly melts, in favor of with Chinese medicine preparation is sufficiently mixed.
Preferably, in order to improve the drug action that can sufficiently improve raw material in Chinese medicine preparation, before being mixed with ointment bases, Raw material can also be crushed, such as can be crushed to partial size is 0.1-0.2mm.
Optionally, the dermopathic cleaning solution for the treatment of provided in an embodiment of the present invention can be through above-mentioned Chinese medicine preparation and alcohol After solution mixing, 8-16h is extracted under conditions of 40-60 DEG C and is obtained.
Preferably, the mass concentration of alcohol is 40-70%, the weight ratio of alcoholic solution and Chinese medicine preparation raw material in above-mentioned alcoholic solution Preferably 50-70:1.Active constituent leaching rate highest at this concentration in Chinese medicine preparation raw material.Alcoholic solution is preferably ethyl alcohol, with Solvent is removed conducive to the later period.
Feature and performance of the invention are described in further detail with reference to embodiments.
Embodiment 1
Dermopathic Chinese medicine preparation is treated the present embodiment provides a kind of, raw material contains the cortex dictamni of 14 parts by weight, 13 parts by weight The fruit of summer cypress, the kuh-seng of 7 parts by weight, the humulus grass of 6 parts by weight, the dandelions of 6 parts by weight, the tuber of stemona of 2 parts by weight, 1 parts by weight Frutus cnidii, the realgar of 1 parts by weight, the Sagina subulata of 1 parts by weight, the persimmon leaves of 1 parts by weight, the litharge of 0.2 parts by weight and 0.3 The borneol of parts by weight.
Embodiment 2
Dermopathic Chinese medicine preparation is treated the present embodiment provides a kind of, raw material contains the cortex dictamni of 18 parts by weight, 16 parts by weight The fruit of summer cypress, the kuh-seng of 10 parts by weight, the humulus grass of 9 parts by weight, the dandelions of 7 parts by weight, the tuber of stemona of 3 parts by weight, 2 parts by weight Frutus cnidii, the realgar of 2 parts by weight, the Sagina subulata of 2 parts by weight, the persimmon leaves of 2 parts by weight, the litharge of 0.5 parts by weight and 0.5 The borneol of parts by weight.
Embodiment 3
Dermopathic Chinese medicine preparation is treated the present embodiment provides a kind of, raw material contains the cortex dictamni of 14 parts by weight, 15 parts by weight The fruit of summer cypress, the kuh-seng of 8 parts by weight, the humulus grass of 8 parts by weight, the dandelion of 6.2 parts by weight, the tuber of stemona of 2.8 parts by weight, 1.2 weights Measure the frutus cnidii of part, the realgar of 1.8 parts by weight, the Sagina subulatas of 1.2 parts by weight, the persimmon leaves of 1.8 parts by weight, 0.3 parts by weight The borneol of litharge and 0.5 parts by weight.
Embodiment 4
Dermopathic Chinese medicine preparation is treated the present embodiment provides a kind of, raw material contains the cortex dictamni of 16 parts by weight, 14 parts by weight The fruit of summer cypress, the kuh-seng of 9 parts by weight, the humulus grass of 7 parts by weight, the dandelion of 6.8 parts by weight, the tuber of stemona of 2.2 parts by weight, 1.8 weights Measure the frutus cnidii of part, the realgar of 1.2 parts by weight, the Sagina subulatas of 1.8 parts by weight, the persimmon leaves of 1.2 parts by weight, 0.4 parts by weight The borneol of litharge and 0.3 parts by weight.
Embodiment 5
Dermopathic Chinese medicine preparation is treated the present embodiment provides a kind of, raw material contains the cortex dictamni of 15 parts by weight, 14.5 weight Part the fruit of summer cypress, the kuh-seng of 8.5 parts by weight, the humulus grass of 7.5 parts by weight, the dandelion of 6.5 parts by weight, 2.5 parts by weight the tuber of stemona, The frutus cnidii of 1.5 parts by weight, the realgar of 1.5 parts by weight, the Sagina subulata of 1.5 parts by weight, the persimmon leaves of 1.5 parts by weight, 0.35 weight Measure the litharge of part and the borneol of 0.4 parts by weight.
Embodiment 6
Treat dermopathic ointment the present embodiment provides a kind of, be it is heated after ointment bases and above-described embodiment 1- 5 in Any Chinese medicine preparation is obtained by mixing.
Wherein, the partial size of Chinese medicine preparation is 0.1mm.Ointment bases is heated under conditions of 70 DEG C through vaseline and water 40min and obtain.The weight ratio of ointment bases and Chinese medicine preparation is 80:10.
Embodiment 7
Treat dermopathic ointment the present embodiment provides a kind of, be it is heated after ointment bases and above-described embodiment 1- 5 in Any Chinese medicine preparation is obtained by mixing.
Wherein, the partial size of Chinese medicine preparation is 0.2mm.Ointment bases is the condition through glycerol, atoleine and water at 90 DEG C Lower heating 20min and obtain.The weight ratio of ointment bases and Chinese medicine preparation is 90:20.
Embodiment 8
Treat dermopathic ointment the present embodiment provides a kind of, be it is heated after ointment bases and above-described embodiment 1- 5 in Any Chinese medicine preparation is obtained by mixing.
Wherein, the partial size of Chinese medicine preparation is 0.15mm.Ointment bases is through atoleine, vaseline, beeswax, dimethyl-silicon Oil and water heat 30min under conditions of 80 DEG C and obtain.The weight ratio of ointment bases and Chinese medicine preparation is 85:15.
Embodiment 9
Dermopathic cleaning solution is treated the present embodiment provides a kind of, is through any Chinese medicine preparation of above-described embodiment 1-5 and methanol After solution mixing, 16h is extracted under conditions of 40 DEG C and is obtained.
Wherein, the mass concentration of alcohol is 40% in methanol solution.The weight ratio of methanol solution and Chinese medicine preparation raw material is preferred For 50:1.
Embodiment 10
Dermopathic cleaning solution is treated the present embodiment provides a kind of, is through any Chinese medicine preparation of above-described embodiment 1-5 and ethyl alcohol After solution mixing, 8h is extracted under conditions of 60 DEG C and is obtained.
Wherein, the mass concentration of alcohol is 70% in ethanol solution.The weight ratio of ethanol solution and Chinese medicine preparation raw material is preferred For 70:1.
Embodiment 11
Dermopathic cleaning solution is treated the present embodiment provides a kind of, is through any Chinese medicine preparation of above-described embodiment 1-5 and ethyl alcohol After solution mixing, 12h is extracted under conditions of 50 DEG C and is obtained.
Wherein, the mass concentration of alcohol is 55% in ethanol solution.The weight ratio of ethanol solution and Chinese medicine preparation raw material is preferred For 60:1.
Test example 1
The selection voluntary Patients with 300 Cases of outpatient service skin disease, men and women each 150.Age 18-65 years old, course of disease 2-16.It is equally divided into 6 Group, every group of test group men and women patient each 25.
Treatment method: avoiding pungent Deng irritative foods during taking treatment, spirit of taking good care of oneself, and appropriate activity avoids labor It is tired.The patient of preceding 3 groups of test groups smears ointment obtained by embodiment 6-8 respectively, everyone smears 2g every time and sends out in skin disease disease Place is smeared 3 times, 7 days 1 courses for the treatment of, 3 courses for the treatment of totally daily.The patient of 3 groups of test groups is used respectively obtained by embodiment 9-11 afterwards Cleaning solution cleans at skin disease disease hair, everyone each cleaning solution dosage is 200mL, daily cleaning 3 times, 7 days 1 courses for the treatment of, and totally 10 A course for the treatment of.
It is formulated referring to " People's Republic of China's traditional Chinese medicine industry standard and TCM Dermatology disease Standardization of diagnosis and curative effect " Diagnostic criteria are as follows: morbidity is anxious, and skin lesion flush is scorching hot, and itch is without stopping, sepage stream juice.With restlessness and thirst, stool is dry, urinates short red.Tongue Matter is red, yellow tongue fur or yellow greasy, and slippery or string are sliding.
Curative effect index: " the new Chinese medicine clinical research guidance original promulgated according to Ministry of Health of the People's Republic of China in 2002 Then " execute.Recovery from illness: without itch, skin lesion is oozed out without erythema or dark red spot, no papule or phlysis, object erosion, no body fluid.It is effective: Itch once in a while, when not medication, do not influence work and study.Erythema or dark red spot color are in pale red, and it is unobvious to be higher by skin；Papule Or phlysis color is micro- red, is distributed sparse, no phlysis；Rotten to the corn mild degree (dotted to be dispersed in)；It is (dotted to dissipate that body fluid oozes out mild degree Need to carefully see just can find out).It is effective: moderate itch (paroxysmal itch, when it is light when weight, influence sleep and live, need to use Medicine)；Moderate skin lesion (erythema or dark red spot color are dark red, slightly higher skin out)；Papule or phlysis degree are that (color is light for moderate It is red, be distributed slightly close, it is seen that papulo-vesicle)；Rotten to the corn degree moderate (point sheet, partially merge into each other)；Body fluid exudation moderate (compares It is more, it is easy drenched toilet paper).Invalid: severe itch (seriously affects sleep operation and study)；(color is scarlet, bright for severe skin lesion It is aobvious to be higher by skin)；Papule or phlysis degree are severe (color is redder, and distribution is closeer, and sporadically appear phlysis)；Rotten to the corn degree severe (obviously large stretch of rotten to the corn)；Body fluid exudation is more, is in droplet shape.
Clinical efficacy standard: recovery from illness: clinical symptoms, sign disappear or mostly disappear；Integrated integral slip >=95%；It is aobvious Effect: clinical symptoms, sign are obviously improved, integrated integral slip >=60% and < 95%；Effective: clinical symptoms, sign have It improves, integrated integral slip >=30% and < 60%；Invalid: clinical symptoms, sign are not improved, even it aggravates, up to not To effective standard person, integrated integral slip < 30%.Its result is as shown in Table 1 and Table 2.
The analysis of 1 skin disease efficacy result of table
2 clinical efficacy interpretation of result of table
Cleaning solution made from the ointment made from embodiment 6-8 it can be seen from Tables 1 and 2 and embodiment 9-11 is to skin disease All have preferable therapeutic effect.And the more other implementations respectively of cleaning solution made from ointment made from embodiment 8 and embodiment 11 The healing number of ointment made from example or cleaning solution is more.
Test example 2
Using the treatment method and treatment standard in test example 1, control group 1-12 is set, control group 1-12 and embodiment 8 are unique Difference be in the raw material of control group 1-12 successively without cortex dictamni, the fruit of summer cypress, kuh-seng, humulus grass, dandelion, the tuber of stemona, cnidium monnieri Son, realgar, Sagina subulata, persimmon leaves, litharge and borneol.It is the results show that when lacking any of the above-described ingredient in raw material, ointment institute Ointment of the dermopathic effect for the treatment of played compared with embodiment 8 is declined, especially when raw material lacks cortex dictamni or summer cypress The period of the day from 11 p.m. to 1 a.m, curative effect decline are the most obvious.And the not simple superposition of curative effect that each raw material plays skin disease, but there is collaboration Synergistic effect.
According to same method, control group 13-24 is set, and control group 13-24 is with embodiment 11 only difference is that compareing Cortex dictamni, the fruit of summer cypress, kuh-seng, humulus grass, dandelion, the tuber of stemona, frutus cnidii, realgar, pearl are successively free of in the raw material of group 13-24 Grass, persimmon leaves, litharge and borneol.It is the results show that when lacking any of the above-described ingredient in raw material, treatment that cleaning solution is played Cleaning solution of the dermopathic effect compared with embodiment 11 is declined, especially when raw material lacks cortex dictamni or the fruit of summer cypress, Curative effect decline is the most obvious.And the not simple superposition of curative effect that each raw material plays skin disease, but there is synergistic make With.
Test example 3
Chengdu Mr. Li, male, 18 years old, in January, 2010 was diagnosed as eczema.The ointment of embodiment 8 is smeared, three times a day, each 2g, It smears 21 days altogether, eczema recovery from illness.It is not recurred in 1 month after drug withdrawal.
Changsha Wei so-and-so, female, 32 years old, in July, 2014 was diagnosed as brothers moss.The ointment of embodiment 8 is smeared, three times a day, Each 2g is smeared 21 days altogether, significant in efficacy.It is not recurred in 3 months after drug withdrawal.
Gansu Xing so-and-so, male, 65 years old, in May, 2015 was diagnosed as chronic urticaria.The ointment of smearing embodiment 8, daily three Secondary, each 2g is smeared 21 days altogether, significant in efficacy.It is not recurred in 3 months after drug withdrawal.
Beijing Zhao so-and-so, male, 44 years old, in September, 2013 was diagnosed as neurodermatitis and seborrheic dermatitis.With the cleaning solution of embodiment 11 Skin at sick hair is cleaned, three times a day, each 200mL is cleaned 21 days altogether, state of an illness recovery from illness.It is not recurred in 2 after drug withdrawal.
Chongqing Mr. Lin, female, 28 years old, in July, 2009 was diagnosed as eczema.Skin at disease hair is cleaned with the cleaning solution of embodiment 11 Skin, three times a day, each 200mL clean 21 days altogether, significant in efficacy.It is not recurred in drug withdrawal later six months.
Guizhou Zhang, female, 51 years old, in January, 2017 was diagnosed as piebald moss.It is cleaned at disease hair with the cleaning solution of embodiment 11 Skin, three times a day, each 200mL clean 21 days altogether, significant in efficacy.It is not recurred in 1 year after drug withdrawal.
In conclusion the dermopathic Chinese medicine preparation abundant raw material of the treatment of the embodiment of the present invention, proportion are proper, can be used in Treat multiple dermatosis.It is used for preparation and treats dermopathic drug, preferably treatment skin eczema and improvement can be played The effect of pruritis, and have no drug resistance.The dermopathic ointment for the treatment of provided in an embodiment of the present invention can be applied directly to skin At sick hair, play the role of antipruritic clearing damp.In addition, it is mild to treat dermopathic cleaning solution pharmacological property, preferably treatment skin can played Additional stimulation is not caused to skin also while the effect of skin disease.
Embodiments described above is a part of the embodiment of the present invention, instead of all the embodiments.Reality of the invention The detailed description for applying example is not intended to limit the range of claimed invention, but is merely representative of selected implementation of the invention Example.Based on the embodiments of the present invention, obtained by those of ordinary skill in the art without making creative efforts Every other embodiment, shall fall within the protection scope of the present invention.

Claims (10)

1. a kind of treat dermopathic Chinese medicine preparation, which is characterized in that its raw material includes the cortex dictamni of 14-18 parts by weight, 13-16 The fruit of summer cypress of parts by weight, the kuh-seng of 7-10 parts by weight, the humulus grass of 6-9 parts by weight, the dandelions of 6-7 parts by weight, 2-3 parts by weight The tuber of stemona, the frutus cnidii of 1-2 parts by weight, the realgar of 1-2 parts by weight, the Sagina subulata of 1-2 parts by weight, 1-2 parts by weight persimmon leaves, The litharge of 0.2-0.5 parts by weight and the borneol of 0.3-0.5 parts by weight.
2. Chinese medicine preparation according to claim 1, which is characterized in that its raw material includes the shaggy-fruited dittany of 14-16 parts by weight Skin, the fruit of summer cypress of 14-15 parts by weight, the kuh-seng of 8-9 parts by weight, the humulus grass of 7-8 parts by weight, 6.2-6.8 weight Measure the dandelion of part, the tuber of stemona of 2.2-2.8 parts by weight, the frutus cnidii of 1.2-1.8 parts by weight, 1.2-1.8 weight Measure the realgar of part, the Sagina subulata of 1.2-1.8 parts by weight, the persimmon leaves of 1.2-1.8 parts by weight, 0.3-0.4 weight Measure the litharge of part and the borneol of 0.3-0.5 parts by weight.
3. Chinese medicine preparation according to claim 2, which is characterized in that its raw material include 15 parts by weight the cortex dictamni, The fruit of summer cypress of 14.5 parts by weight, the kuh-seng of 8.5 parts by weight, the humulus grass of 7.5 parts by weight, 6.5 parts by weight institute State dandelion, the tuber of stemona of 2.5 parts by weight, the frutus cnidii of 1.5 parts by weight, the realgar of 1.5 parts by weight, 1.5 weights Measure the Sagina subulata of part, the persimmon leaves of 1.5 parts by weight, the litharge of 0.35 parts by weight and the institute of 0.4 parts by weight State borneol.
4. Chinese medicine preparation as described in any one of claims 1-3 treats the application in dermopathic drug in preparation.
5. Chinese medicine preparation according to claim 4 treats the application in dermopathic drug in preparation, which is characterized in that The Chinese medicine preparation is used to prepare the dermopathic ointment for the treatment of or cleaning solution.
6. a kind of treat dermopathic ointment, which is characterized in that ointment bases and any one of such as claim 1-3 after heated The Chinese medicine preparation is obtained by mixing.
7. ointment according to claim 6, which is characterized in that the ointment bases includes glycerol, atoleine, all scholars At least one of woods, beeswax, dimethicone and water.
8. ointment according to claim 6, which is characterized in that the partial size of the Chinese medicine preparation is 0.1-0.2mm.
9. a kind of treat dermopathic cleaning solution, which is characterized in that through Chinese medicine preparation as described in any one of claims 1-3 After being mixed with alcoholic solution, 8-16h is extracted under conditions of 40-60 DEG C and is obtained.
10. cleaning solution according to claim 9, which is characterized in that the mass concentration of alcohol is 40- in the alcoholic solution 70%.
CN201811546726.XA 2018-12-18 2018-12-18 Treat skin disease ointment machin cleaning solution Withdrawn CN109395001A (en)

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Application publication date: 20190301