CN107496795A - Treat dermopathic Chinese medicine preparation and its application, the dermopathic ointment machin cleaning fluid for the treatment of - Google Patents
Treat dermopathic Chinese medicine preparation and its application, the dermopathic ointment machin cleaning fluid for the treatment of Download PDFInfo
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- CN107496795A CN107496795A CN201710849792.3A CN201710849792A CN107496795A CN 107496795 A CN107496795 A CN 107496795A CN 201710849792 A CN201710849792 A CN 201710849792A CN 107496795 A CN107496795 A CN 107496795A
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Abstract
The present invention relates to one kind to treat dermopathic Chinese medicine preparation and its application, the dermopathic ointment machin cleaning fluid for the treatment of, belongs to drug field.The raw material of the Chinese medicine preparation includes the root bark of shaggy-fruited dittany, the fruit of summer cypress, kuh-seng, humulus grass, dandelion, the tuber of stemona, frutus cnidii, realgar, Sagina subulata, persimmon leaves, litharge and borneol.Its abundant raw material, proportioning are proper, can be used in treating skin disease.Use it for preparing and treat dermopathic medicine, preferably treatment skin eczema can be played and improve the effect of pruritis.The dermopathic ointment for the treatment of provided by the invention be it is heated after ointment bases be obtained by mixing with above-mentioned Chinese medicine preparation, can be applied directly at skin disease disease hair, play antipruritic clearing damp and act on.It is after above-mentioned Chinese medicine preparation mixes with alcoholic solution to treat dermopathic cleaning fluid, and 8 16h are extracted under conditions of 40 60 DEG C and are obtained, the cleaning fluid property of medicine is gentle, extra stimulation can not be also caused to skin while playing and preferably treating dermopathic effect.
Description
Technical field
The present invention relates to drug field, and more particularly to one kind treats dermopathic Chinese medicine preparation and its application, treatment skin
The ointment machin cleaning fluid of skin disease.
Background technology
Skin disease is common disease and frequently-occurring disease, and difficult disease is more, and considerable distress is caused to patient.Dermopathic clinical symptoms
In, show as primary lesion has macula, blood stasis, blister, tumour, suppurative, fungoid infringement etc.；Show as secondary lesion
Have the scales of skin that peel off, dipping, erosion, ulcer, scar and liver moss etc..
Eczema as it is a kind of as caused by various internal and external factors, the refractory and common allergic skin disease that easily recurs it
One, with the raising of economic level and the quickening of rhythm of life, its incidence of disease and consultation rate increase year by year in recent years.
The medicine for the treatment of skin disease (such as eczema and pruitus) used in prior art, though have in clinical practice
Certain curative effect, but every kind of medicine specific aim is very strong, when diagnosing not clear and definite enough, has great difficulty from medicine.And at present
In the dermatological department medicine of listing, much all contain hormone, be discontinued and send out, it is difficult to reach the dermopathic purpose of radical cure.
The content of the invention
An object of the present invention is that providing one kind treats dermopathic Chinese medicine preparation, and its abundant raw material, proportioning are proper,
It can be used in treating skin disease.
The second object of the present invention is in answering in providing a kind of above-mentioned Chinese medicine preparation and treating dermopathic medicine in preparation
With, such as available for the dermopathic ointment for the treatment of or cleaning fluid is prepared, can be easy to be applicable, and it is wet to play preferably treatment skin
Rash and the effect for improving pruritis.
The third object of the present invention is that providing one kind treats dermopathic ointment, is applied directly at skin disease disease hair,
Play antipruritic clearing damp effect and have no drug resistance.
The fourth object of the present invention is that providing one kind treats dermopathic cleaning fluid, and the cleaning fluid property of medicine is gentle, can be
Do not cause extra stimulation while playing preferable curative effect to skin also.
The present invention is solved its technical problem and realized using following technical scheme：
The present invention proposes that one kind treats dermopathic Chinese medicine preparation, and its raw material includes the root bark of shaggy-fruited dittany, the 13- of 14-18 parts by weight
The fruit of summer cypress of 16 parts by weight, the kuh-seng of 7-10 parts by weight, the humulus grass of 6-9 parts by weight, the dandelion of 6-7 parts by weight, 2-3 parts by weight
The tuber of stemona, the frutus cnidii of 1-2 parts by weight, the realgar of 1-2 parts by weight, the Sagina subulata of 1-2 parts by weight, 1-2 parts by weight persimmon leaves,
The litharge of 0.2-0.5 parts by weight and the borneol of 0.3-0.5 parts by weight.
The invention also provides a kind of above-mentioned Chinese medicine preparation is preparing the application in treating dermopathic medicine, such as can be with
Dermopathic ointment or cleaning fluid are treated for preparing.
The invention also provides one kind treats dermopathic ointment, the ointment bases after the ointment is heated and above-mentioned Chinese medicine
Formula is obtained by mixing.
The invention also provides one kind treats dermopathic cleaning fluid, the cleaning fluid mixes through above-mentioned Chinese medicine preparation with alcoholic solution
After conjunction, extract 8-16h under conditions of 40-60 DEG C and obtain.
The dermopathic Chinese medicine preparation for the treatment of of the embodiment of the present invention and its application, treat dermopathic ointment machin cleaning fluid
Beneficial effect is：
Using the root bark of shaggy-fruited dittany, the fruit of summer cypress as monarch drug in a prescription in Chinese medicine preparation；It is minister that borneol toil is cool in nature, external application energy clearing heat for detumescence, antipruritic
Analgesic；Kuh-seng, humulus grass, dandelion, the tuber of stemona, frutus cnidii, realgar, Sagina subulata, persimmon leaves and litharge are adjuvant altogether.Above-mentioned 12
Under the collective effect of taste medicine, make the Chinese medicine preparation in the embodiment of the present invention that there is preferable removing damp-heat desinsection, the antipruritic work(of dispelling wind
Effect.
Above-mentioned Chinese medicine preparation is used to prepare and treats dermopathic medicine, preferably treatment skin eczema can be played and changed
The effect of kind pruritis, and have no drug resistance.The dermopathic ointment for the treatment of provided in an embodiment of the present invention can be applied directly to skin
At the sick hair of skin, antipruritic clearing damp effect is played.Further it is provided that the dermopathic cleaning fluid property of medicine for the treatment of it is gentle, can play compared with
Extra stimulation is not caused to skin also while good treatment dermopathic effect.
Embodiment
, below will be in the embodiment of the present invention to make the purpose, technical scheme and advantage of the embodiment of the present invention clearer
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, it is the conventional production that can be obtained by commercially available purchase
Product.
The dermopathic Chinese medicine preparation for the treatment of and its application, the dermopathic ointment machin for the treatment of below to the embodiment of the present invention is clear
Washing lotion is specifically described.
The embodiment of the present invention provides one kind and treats dermopathic Chinese medicine preparation, and the raw material of the Chinese medicine preparation includes 14-18 weights
Measure the root bark of shaggy-fruited dittany of part, the fruit of summer cypress of 13-16 parts by weight, the kuh-seng of 7-10 parts by weight, the humulus grass of 6-9 parts by weight, 6-7 parts by weight
Dandelion, the tuber of stemona of 2-3 parts by weight, the frutus cnidii of 1-2 parts by weight, the realgar of 1-2 parts by weight, the Sagina subulata of 1-2 parts by weight, 1-
The borneol of the persimmon leaves of 2 parts by weight, the litharge of 0.2-0.5 parts by weight and 0.3-0.5 parts by weight.
Preferably, above-mentioned raw materials include the root bark of shaggy-fruited dittany of 14-16 parts by weight, the fruit of summer cypress of 14-15 parts by weight, 8-9 parts by weight
Kuh-seng, the humulus grass of 7-8 parts by weight, the dandelion of 6.2-6.8 parts by weight, the tuber of stemona of 2.2-2.8 parts by weight, 1.2-1.8 weight
Part frutus cnidii, the realgar of 1.2-1.8 parts by weight, the Sagina subulata of 1.2-1.8 parts by weight, 1.2-1.8 parts by weight persimmon leaves,
The litharge of 0.3-0.4 parts by weight and the borneol of 0.3-0.5 parts by weight.
It is highly preferred that above-mentioned raw materials include the root bark of shaggy-fruited dittanys of 15 parts by weight, the fruit of summer cypress of 14.5 parts by weight, 8.5 parts by weight
Kuh-seng, the humulus grass of 7.5 parts by weight, the dandelion of 6.5 parts by weight, the tuber of stemona of 2.5 parts by weight, the frutus cnidii of 1.5 parts by weight, 1.5
The realgar of parts by weight, the Sagina subulata of 1.5 parts by weight, the persimmon leaves of 1.5 parts by weight, the litharge of 0.35 parts by weight and 0.4 weight
The borneol of part.
Wherein, root bark of shaggy-fruited dittany micro-pungent is cold in nature, returns spleen, stomach, lung channel, being capable of dispelling wind and arresting itching, dispersing pathogen accumulation.The root bark of shaggy-fruited dittany has to fungi
There is obvious inhibitory action, being capable of anti-inflammatory antiallergy.Specifically, the active component contained by the root bark of shaggy-fruited dittany can effectively suppress histamine
With the content of serotonin, to the contact dermatitis and particulate antigen sheep red blood cell caused by the trinitro-chlorobenzene of haptens 2,4,6-
Caused footpad reaction has obvious inhibitory action.
Fruit of summer cypress bitter is cold in nature, returns kidney, bladder warp, being capable of clearing heat and promoting diuresis, dispelling wind and arresting itching.Its active component is small to Austria's Du's big belly
The small gemma moss bacterium of gemma moss bacterium, ulotrichy, the small gemma moss bacterium of rust etc. have different degrees of inhibitory action.Its alcohol extract energy
Enough obvious pruitus attack times for reducing dextran induction and itch duration, and patient tolerance's phosphoric acid can be increased
The itch-threshold of histamine, so as to play preferable itching-relieving action.
The root bark of shaggy-fruited dittany and the medicine of the fruit of summer cypress two are shared in the embodiment of the present invention, are altogether monarch drug in a prescription, make skin it is damp and hot in disappear it is outer dissipate,
Itch is from only, and wherein the root bark of shaggy-fruited dittany mainly plays antipruritic and treats dermopathic effect by anti-inflammatory mechanisms, and the fruit of summer cypress mainly passes through
Resisting pathogenic microbes plays the antipruritic and dermopathic effect for the treatment of.After said two devices coordinate, controlled through different mode of action collaborations
Skin disease is treated, can further improve therapeutic effect.
Kuh-seng bitter is cold in nature, Return liver, kidney, stomach and large intestine channel, being capable of heat-clearing and damp-drying drug, sharp water removing jaundice, wind dispelling insecticide.Kuh-seng contains
There is matrine alkaloid, Central nervous has certain inhibitory action, and it can be by increasing inhibition in eczema patients brain
Neural γ-aminobutyric acid and the content of glycine are to suppress neuron activation.In addition, matrine can also be by suppressing phosphatidase
Antiinflammatory action is played in the release of activity, the propagation of splenocyte and TNF, IL-1 and IL-6, local by reducing serum or inflammation
IL-8 concentration play its anti-inflammatory activity.
Humulus grass contains humulone, lupulones and flavone compound (cyanidenon, cosmosiin and Vitexin), right
Gram positive bacteria, as staphylococcus aureus, streptococcus fecalis and bacillus have obvious inhibitory action, can treat swollen furuncle,
Eczema, skin are scorching.Humulus grass alcohol extract can significantly inhibit the pruitus that 4AP and chloroquine induce, and reduce the content of IL-4 in serum, carry
High itch-threshold, so as to exogenous histamine and 4-AP induction release endogenous histamine caused by pruitus play preferably it is antipruritic
Effect.
Dandelion is to staphylococcus aureus resistance bacterial strain, hemolytic streptococcus and Diplococcus pneumopniae, meningococcus, white
Larynx bacillus, pseudomonas aeruginosa, proteus, typhoid bacillus, shigella dysenteriae etc. have certain bactericidal action, especially to dermatophyte
There is obvious inhibitory action.In addition, dandelion can also excitating organism immunologic function and with it is clearing heat and detoxicating, detumescence dismiss work(
Effect.
Alkaloid contained by the tuber of stemona has certain inhibitory action to dermatophyte.The analgesic in addition, tuber of stemona can also ease pain.
Osthole, bergapten and isopimpinellin contained by frutus cnidii can have to the palpus trichophyton of trichophyton compared with
It is strongly active, also, the xanthotoxol contained by it has significant Antifungal activities.
Realgar can be used in desinsection and treat sore, and itch caused by trichomonas, monilial and wet moss can be played preferably
Itching-relieving action.Active component contained by it is to staphylococcus aureus, human body tubercle bacillus, proteus, green pus coccus and more
Kind dermatophyte has different degrees of inhibitory action.
The plain II pair of staphylococcus aureus of contained longleaf bastardtoadflax herb in Sagina subulata, micrococcus catarrhalis, typhoid bacillus, proteus,
Shigella dysenteriae has inhibitory action；Butanedioic acid is acted on Candida albicans unrestraint；I pair of staphylococcus aureus of longleaf bastardtoadflax herb element,
Micrococcus catarrhalis, shigella dysenteriae have inhibitory action.
Contain a large amount of tannic acids in persimmon leaves persimmon leaves, can effectively kill various bacteriums and fungi, have cleaning and
The effect of skin care.
Litharge can be to homocentricity hair moss bacterium, violet hair moss bacterium, red hair moss bacterium, little Bacillus of rust, cotton-shaped table
Skin moss bacterium, gypsum sample hair moss bacterium and dermatophyte etc. play different degrees of inhibitory action.In addition, may be used also as externally applied drug
Reduce inflammation.
Lost to the Portugal double ball mattress of bacterium, streptococcus, pneumonia, pathogenic dermatophyte of Escherichia coli and part etc. of borneol has suppression
Effect.
From the above, in the Chinese medicine preparation of the embodiment of the present invention, using the root bark of shaggy-fruited dittany, the fruit of summer cypress as monarch drug in a prescription；Borneol toil
Cool is minister, external application energy clearing heat for detumescence, antipruritic analgesic；Kuh-seng, humulus grass, dandelion, the tuber of stemona, frutus cnidii, realgar, Sagina subulata, persimmon
Leaf and litharge are adjuvant altogether.Under the collective effect of above-mentioned 12 taste medicine, make Chinese medicine preparation in the embodiment of the present invention have compared with
Good removing damp-heat desinsection, dispelling wind itching-relieving efficacies.
In addition, above-mentioned Chinese medicine preparation answering in the dermopathic medicine for the treatment of is prepared is additionally provided in the embodiment of the present invention
With, such as can use it for preparing and treat dermopathic ointment or cleaning fluid.
Optionally, the dermopathic ointment for the treatment of provided in an embodiment of the present invention can with the ointment bases after heated with
Above-mentioned Chinese medicine preparation is obtained by mixing.
It is preferred that above-mentioned ointment bases can for example include in glycerine, atoleine, vaseline, beeswax, dimethicone
At least one and water.The weight of ointment bases and Chinese medicine preparation is than preferably 80-90：10-20.
Heating can be that 20-40min is handled under conditions of 70-90 DEG C so that ointment bases thoroughly melts, in favor of with
Chinese medicine preparation is sufficiently mixed.
It is preferred that the drug action of raw material in Chinese medicine preparation can be fully improved in order to improve, before being mixed with ointment bases,
Raw material can also be crushed, such as it is 0.1-0.2mm that can be crushed to particle diameter.
Optionally, the dermopathic cleaning fluid for the treatment of provided in an embodiment of the present invention can be through above-mentioned Chinese medicine preparation and alcohol
After solution mixing, extract 8-16h under conditions of 40-60 DEG C and obtain.
It is preferred that the mass concentration of alcohol is 40-70%, alcoholic solution and Chinese medicine preparation raw material weight ratio in above-mentioned alcoholic solution
Preferably 50-70：1.Active component leaching rate highest at this concentration in Chinese medicine preparation raw material.Alcoholic solution is preferably ethanol, with
Solvent is removed beneficial to the later stage.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
The present embodiment provides one kind and treats dermopathic Chinese medicine preparation, and its raw material contains the root bark of shaggy-fruited dittany of 14 parts by weight, 13 weights
Measure the fruit of summer cypress of part, the kuh-seng of 7 parts by weight, the humulus grass of 6 parts by weight, the dandelion of 6 parts by weight, the tuber of stemona of 2 parts by weight, 1 weight
Part frutus cnidii, the realgar of 1 parts by weight, the Sagina subulata of 1 parts by weight, the persimmon leaves of 1 parts by weight, 0.2 parts by weight litharge and
The borneol of 0.3 parts by weight.
Embodiment 2
The present embodiment provides one kind and treats dermopathic Chinese medicine preparation, and its raw material contains the root bark of shaggy-fruited dittany of 18 parts by weight, 16 weights
Measure the fruit of summer cypress of part, the kuh-seng of 10 parts by weight, the humulus grass of 9 parts by weight, the dandelion of 7 parts by weight, the tuber of stemona of 3 parts by weight, 2 weight
Part frutus cnidii, the realgar of 2 parts by weight, the Sagina subulata of 2 parts by weight, the persimmon leaves of 2 parts by weight, 0.5 parts by weight litharge and
The borneol of 0.5 parts by weight.
Embodiment 3
The present embodiment provides one kind and treats dermopathic Chinese medicine preparation, and its raw material contains the root bark of shaggy-fruited dittany of 14 parts by weight, 15 weights
Measure the fruit of summer cypress of part, the kuh-seng of 8 parts by weight, the humulus grass of 8 parts by weight, the dandelion of 6.2 parts by weight, 2.8 parts by weight the tuber of stemona,
The frutus cnidii of 1.2 parts by weight, the realgar of 1.8 parts by weight, the Sagina subulata of 1.2 parts by weight, the persimmon leaves of 1.8 parts by weight, 0.3 weight
The litharge of part and the borneol of 0.5 parts by weight.
Embodiment 4
The present embodiment provides one kind and treats dermopathic Chinese medicine preparation, and its raw material contains the root bark of shaggy-fruited dittany of 16 parts by weight, 14 weights
Measure the fruit of summer cypress of part, the kuh-seng of 9 parts by weight, the humulus grass of 7 parts by weight, the dandelion of 6.8 parts by weight, 2.2 parts by weight the tuber of stemona,
The frutus cnidii of 1.8 parts by weight, the realgar of 1.2 parts by weight, the Sagina subulata of 1.8 parts by weight, the persimmon leaves of 1.2 parts by weight, 0.4 weight
The litharge of part and the borneol of 0.3 parts by weight.
Embodiment 5
The present embodiment provides one kind and treats dermopathic Chinese medicine preparation, and its raw material contains the root bark of shaggy-fruited dittany of 15 parts by weight, 14.5
The fruit of summer cypress of parts by weight, the kuh-seng of 8.5 parts by weight, the humulus grass of 7.5 parts by weight, the dandelion of 6.5 parts by weight, 2.5 parts by weight
The tuber of stemona, the frutus cnidii of 1.5 parts by weight, the realgar of 1.5 parts by weight, the Sagina subulata of 1.5 parts by weight, 1.5 parts by weight persimmon leaves,
The litharge of 0.35 parts by weight and the borneol of 0.4 parts by weight.
Embodiment 6
The present embodiment provides one kind and treats dermopathic ointment, its be it is heated after ointment bases and above-described embodiment 1-
Any Chinese medicine preparation is obtained by mixing in 5.
Wherein, the particle diameter of Chinese medicine preparation is 0.1mm.Ointment bases is to be heated through vaseline and water under conditions of 70 DEG C
40min and obtain.The weight of ointment bases and Chinese medicine preparation ratio is 80：10.
Embodiment 7
The present embodiment provides one kind and treats dermopathic ointment, its be it is heated after ointment bases and above-described embodiment 1-
Any Chinese medicine preparation is obtained by mixing in 5.
Wherein, the particle diameter of Chinese medicine preparation is 0.2mm.Ointment bases is through the condition of glycerine, atoleine and water at 90 DEG C
Lower heating 20min and obtain.The weight of ointment bases and Chinese medicine preparation ratio is 90：20.
Embodiment 8
The present embodiment provides one kind and treats dermopathic ointment, its be it is heated after ointment bases and above-described embodiment 1-
Any Chinese medicine preparation is obtained by mixing in 5.
Wherein, the particle diameter of Chinese medicine preparation is 0.15mm.Ointment bases is through atoleine, vaseline, beeswax, dimethyl-silicon
Oil and water heat 30min under conditions of 80 DEG C and obtained.The weight of ointment bases and Chinese medicine preparation ratio is 85：15.
Embodiment 9
The present embodiment provides one kind and treats dermopathic cleaning fluid, its be through any Chinese medicine preparations of above-described embodiment 1-5 with
After methanol solution mixing, extract 16h under conditions of 40 DEG C and obtain.
Wherein, the mass concentration of alcohol is 40% in methanol solution.The weight ratio of methanol solution and Chinese medicine preparation raw material is preferred
For 50：1.
Embodiment 10
The present embodiment provides one kind and treats dermopathic cleaning fluid, its be through any Chinese medicine preparations of above-described embodiment 1-5 with
After ethanol solution mixing, extract 8h under conditions of 60 DEG C and obtain.
Wherein, the mass concentration of alcohol is 70% in ethanol solution.The weight ratio of ethanol solution and Chinese medicine preparation raw material is preferred
For 70：1.
Embodiment 11
The present embodiment provides one kind and treats dermopathic cleaning fluid, its be through any Chinese medicine preparations of above-described embodiment 1-5 with
After ethanol solution mixing, extract 12h under conditions of 50 DEG C and obtain.
Wherein, the mass concentration of alcohol is 55% in ethanol solution.The weight ratio of ethanol solution and Chinese medicine preparation raw material is preferred
For 60：1.
Test example 1
Choose the voluntary Patients with 300 Cases of outpatient service skin disease, each 150 of men and women.Age 18-65 year, course of disease 2-16.Average mark
For 6 groups, each 25 of every group of test group men and women patient.
Treatment method：Pungent irritative food of Denging is avoided during taking treatment, spirit of taking good care of oneself, appropriate activity, avoids labor
It is tired.The patient of preceding 3 groups of test groups smears the ointment obtained by embodiment 6-8 respectively, and everyone smears 2g and sent out in skin disease disease every time
Place, smear 3 times daily, 7 days 1 courses for the treatment of, totally 3 courses for the treatment of.The patient of 3 groups of test groups uses obtained by embodiment 9-11 respectively afterwards
At cleaning fluid cleaning skin disease disease hair, everyone each cleaning fluid dosage be 200mL, is cleaned 3 times daily, 7 days 1 courses for the treatment of, totally 10
The individual course for the treatment of.
Reference《People's Republic of China's traditional Chinese medicine industry standard and TCM Dermatology disease Standardization of diagnosis and curative effect》Formulate
Diagnostic criteria is：Morbidity is anxious, and skin lesion flush is scorching hot, and itch is without stopping, sepage stream juice.With restlessness and thirst, stool is dry, and urine is short red.Tongue
Matter is red, yellow tongue fur or yellow greasy, and slippery or string are slided.
Curative effect index：Promulgated according to Ministry of Health of the People's Republic of China in 2002《New Chinese medicine clinical research is instructed former
Then》Perform.Recovery from illness：Without itch, skin lesion is without erythema or dark red spot, and no papule or phlysis, thing is rotten to the corn, and no body fluid oozes out.It is effective：
Itch once in a while, work and study are not influenceed during not medication.Erythema or dark red spot color are in pale red, are higher by skin unobvious；Papule
Or phlysis color and luster is micro- red, sparse, no phlysis is distributed；Rotten to the corn mild degree (point-like is dispersed in)；Body fluid oozes out mild degree, and (point-like dissipates
Need to carefully see can just find out).Effectively：Moderate itch (paroxysmal itch, when it is light when weight, influence to sleep and live, need to use
Medicine)；Moderate skin lesion (erythema or dark red spot color and luster are dark red, slightly higher go out skin)；Papule or phlysis degree are that (color and luster is light for moderate
Red, distribution is slightly close, it is seen that papulo-vesicle)；Rotten to the corn degree moderate (point sheet, partly merge into each other)；Body fluid oozes out moderate and (compared
More, easily drench toilet paper).It is invalid：Severe itch (has a strong impact on sleep operation and study)；(color and luster is scarlet, bright for severe skin lesion
It is aobvious to be higher by skin)；Papule or phlysis degree are severe (color is redder, and distribution is closeer, and sporadically appear phlysis)；Rotten to the corn degree severe
(obviously large stretch of rotten to the corn)；Body fluid ooze out it is more, in globule shape.
Clinical efficacy standard：Recovery from illness：Clinical symptoms, sign disappear or basic disappearance；Integrated integral slip >=95%；It is aobvious
Effect：Clinical symptoms, sign are obviously improved, integrated integral slip >=60% and ＜ 95%；Effectively：Clinical symptoms, sign have
Take a turn for the better, integrated integral slip >=30% and ＜ 60%；It is invalid：Clinical symptoms, sign are not improved, even aggravate, up to not
To effective standard person, integrated integral slip ＜ 30%.Its result is as shown in Table 1 and Table 2.
The skin disease efficacy result of table 1 is analyzed
The clinical efficacy interpretation of result of table 2
Cleaning fluid is to skin made from the ointment made from embodiment 6-8 it can be seen from Tables 1 and 2 and embodiment 9-11
Skin disease is respectively provided with preferable therapeutic effect.And cleaning fluid made from ointment made from embodiment 8 and embodiment 11 is more other respectively
The healing number of ointment made from embodiment or cleaning fluid is more.
Test example 2
Using the treatment method in test example 1 and treatment standard, control group 1-12, control group 1-12 and embodiment 8 are set
Only difference is that in control group 1-12 raw material successively without the root bark of shaggy-fruited dittany, the fruit of summer cypress, kuh-seng, humulus grass, dandelion, the tuber of stemona,
Frutus cnidii, realgar, Sagina subulata, persimmon leaves, litharge and borneol.Its result is shown, soft when lacking any of the above-described composition in raw material
Ointment of the dermopathic effect for the treatment of that cream is played compared with embodiment 8 has declined, particularly when raw material lack the root bark of shaggy-fruited dittany or
During the fruit of summer cypress, its curative effect declines the most obvious.And the effect of being risen to the skin disease not simple superposition of each raw material, but have
Synergistic function.
According to same method, control group 13-24 is set, and control group 13-24 is with embodiment 11 only difference is that compareing
Successively without the root bark of shaggy-fruited dittany, the fruit of summer cypress, kuh-seng, humulus grass, dandelion, the tuber of stemona, frutus cnidii, realgar, pearl in group 13-24 raw material
Grass, persimmon leaves, litharge and borneol.Its result is shown, when lacking any of the above-described composition in raw material, treatment that cleaning fluid is played
Cleaning fluid of the dermopathic effect compared with embodiment 11 has declined, particularly when raw material lacks the root bark of shaggy-fruited dittany or the fruit of summer cypress, its
Curative effect declines the most obvious.And the effect of being risen to the skin disease not simple superposition of each raw material, but make with Synergistic
With.
Test example 3
Chengdu Mr. Li, male, 18 years old, in January, 2010 was diagnosed as eczema.The ointment of embodiment 8 is smeared, three times a day, often
Secondary 2g, smear 21 days altogether, eczema recovery from illness.Do not recurred in 1 month after drug withdrawal.
Changsha Wei so-and-so, female, 32 years old, in July, 2014 was diagnosed as brothers moss.The ointment of embodiment 8 is smeared, three times a day,
Each 2g, smear 21 days altogether, it is evident in efficacy.Do not recurred in 3 months after drug withdrawal.
Gansu Xing so-and-so, man, 65 years old, in May, 2015 was diagnosed as chronic urticaria.The ointment of smearing embodiment 8, daily three
It is secondary, each 2g, smear 21 days altogether, it is evident in efficacy.Do not recurred in 3 months after drug withdrawal.
Beijing Zhao so-and-so, man, 44 years old, in September, 2013 was diagnosed as neurodermatitis and seborrheic dermatitis.With the cleaning fluid of embodiment 11
Skin at disease hair is cleaned, three times a day, each 200mL, is cleaned 21 days altogether, state of an illness recovery from illness.Do not recurred in 2 after drug withdrawal.
Chongqing Lin, female, 28 years old, in July, 2009 was diagnosed as eczema.Skin at disease hair is cleaned with the cleaning fluid of embodiment 11
Skin, three times a day, each 200mL, clean 21 days altogether, it is evident in efficacy.Do not recurred in drug withdrawal later six months.
Guizhou Zhang, female, 51 years old, in January, 2017 was diagnosed as piebald moss.Cleaned with the cleaning fluid of embodiment 11 at disease hair
Skin, three times a day, each 200mL, clean 21 days altogether, it is evident in efficacy.Do not recurred in 1 year after drug withdrawal.
In summary, the dermopathic Chinese medicine preparation abundant raw material of the treatment of the embodiment of the present invention, proportioning are proper, can be used in
Treat multiple dermatosis.Use it for preparing and treat dermopathic medicine, preferably treatment skin eczema and improvement can be played
The effect of pruritis, and have no drug resistance.The dermopathic ointment for the treatment of provided in an embodiment of the present invention can be applied directly to skin
At sick hair, antipruritic clearing damp effect is played.In addition, it is gentle to treat the dermopathic cleaning fluid property of medicine, preferably treatment skin can played
Extra stimulation is not caused to skin also while the effect of skin disease.
Embodiments described above is part of the embodiment of the present invention, rather than whole embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. one kind treats dermopathic Chinese medicine preparation, it is characterised in that its raw material includes the root bark of shaggy-fruited dittany, the 13-16 of 14-18 parts by weight
The fruit of summer cypress of parts by weight, the kuh-seng of 7-10 parts by weight, the humulus grass of 6-9 parts by weight, the dandelions of 6-7 parts by weight, 2-3 parts by weight
The tuber of stemona, the frutus cnidii of 1-2 parts by weight, the realgar of 1-2 parts by weight, the Sagina subulata of 1-2 parts by weight, 1-2 parts by weight persimmon leaves,
The litharge of 0.2-0.5 parts by weight and the borneol of 0.3-0.5 parts by weight.
2. Chinese medicine preparation according to claim 1, it is characterised in that its raw material includes the shaggy-fruited dittany of 14-16 parts by weight
Skin, the fruit of summer cypress of 14-15 parts by weight, the kuh-seng of 8-9 parts by weight, the humulus grass of 7-8 parts by weight, 6.2-6.8 weights
Measure the dandelion of part, the tuber of stemona of 2.2-2.8 parts by weight, the frutus cnidii of 1.2-1.8 parts by weight, 1.2-1.8 weights
Measure the realgar of part, the Sagina subulata of 1.2-1.8 parts by weight, the persimmon leaves of 1.2-1.8 parts by weight, 0.3-0.4 weights
Measure the borneol of litharge and the 0.3-0.5 parts by weight of part.
3. Chinese medicine preparation according to claim 2, it is characterised in that the root bark of shaggy-fruited dittany of its raw material including 15 parts by weight,
The fruit of summer cypress of 14.5 parts by weight, the kuh-seng of 8.5 parts by weight, the humulus grass of 7.5 parts by weight, the institute of 6.5 parts by weight
State dandelion, the tuber of stemona of 2.5 parts by weight, the frutus cnidii of 1.5 parts by weight, the realgar of 1.5 parts by weight, 1.5 weights
Measure the Sagina subulata of part, the persimmon leaves of 1.5 parts by weight, the litharge of 0.35 parts by weight and the institute of 0.4 parts by weight
State borneol.
4. the Chinese medicine preparation as described in claim any one of 1-3 is preparing the application in treating dermopathic medicine.
5. Chinese medicine preparation according to claim 4 is preparing the application in treating dermopathic medicine, it is characterised in that institute
State Chinese medicine preparation be used for prepare the dermopathic ointment for the treatment of or cleaning fluid.
6. one kind treats dermopathic ointment, it is characterised in that ointment bases and such as any one of claim 1-3 after heated
Described Chinese medicine preparation is obtained by mixing.
7. ointment according to claim 6, it is characterised in that the ointment bases includes glycerine, atoleine, all scholars
At least one of woods, beeswax, dimethicone and water.
8. ointment according to claim 6, it is characterised in that the particle diameter of the Chinese medicine preparation is 0.1-0.2mm.
9. one kind treats dermopathic cleaning fluid, it is characterised in that through as described in claim any one of 1-3 Chinese medicine preparation and
After alcoholic solution mixing, extract 8-16h under conditions of 40-60 DEG C and obtain.
10. cleaning fluid according to claim 9, it is characterised in that the mass concentration of alcohol is 40- in the alcoholic solution
70%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110339312A (en) * | 2019-08-20 | 2019-10-18 | 江苏博润医疗集团有限公司 | One kind is for treating dermopathic external drug |
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| CN101559188A (en) * | 2009-05-18 | 2009-10-21 | 甘肃益尔药业股份有限公司 | Traditional Chinese medicine compound preparation used for treating colpitis and tinea manus and pedis and preparation method thereof |
| CN105079644A (en) * | 2015-10-03 | 2015-11-25 | 成都倍加特生物科技有限公司 | Poultice capable of effectively treating tinea manus and pedis and preparation method thereof |
| CN105362869A (en) * | 2015-12-06 | 2016-03-02 | 郑州景鸿畜牧科技有限公司 | Scabies treating medicinal liquor with eleven traditional Chinese medicines |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101559188A (en) * | 2009-05-18 | 2009-10-21 | 甘肃益尔药业股份有限公司 | Traditional Chinese medicine compound preparation used for treating colpitis and tinea manus and pedis and preparation method thereof |
| CN105079644A (en) * | 2015-10-03 | 2015-11-25 | 成都倍加特生物科技有限公司 | Poultice capable of effectively treating tinea manus and pedis and preparation method thereof |
| CN105362869A (en) * | 2015-12-06 | 2016-03-02 | 郑州景鸿畜牧科技有限公司 | Scabies treating medicinal liquor with eleven traditional Chinese medicines |
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| CN110339312A (en) * | 2019-08-20 | 2019-10-18 | 江苏博润医疗集团有限公司 | One kind is for treating dermopathic external drug |
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