CN115969922B

CN115969922B - External traditional Chinese medicine composition for atopic dermatitis and eczema, dehumidification paste based on external traditional Chinese medicine composition and preparation method of dehumidification paste

Info

Publication number: CN115969922B
Application number: CN202310128117.7A
Authority: CN
Inventors: 林颖; 王利胜; 甄庆育; 陈达灿; 黄凯凯
Original assignee: Guangdong Hospital of Traditional Chinese Medicine
Current assignee: Guangdong Hospital of Traditional Chinese Medicine
Priority date: 2023-02-17
Filing date: 2023-02-17
Publication date: 2024-02-27
Anticipated expiration: 2043-02-17
Also published as: CN115969922A

Abstract

The invention discloses an external traditional Chinese medicine composition for treating atopic dermatitis and eczema, dehumidification paste based on the external traditional Chinese medicine composition and a preparation method of the dehumidification paste. The dehumidifying paste provided by the invention is a compound Chinese medicinal paste for external use, and is mainly used for treating atopic dermatitis, swelling, exudation and other dampness symptoms of rash in the period of eczema attack. The formula of the dehumidification paste comprises eight traditional Chinese medicines, wherein the main components are rhizoma atractylodis for strengthening the body resistance and eliminating dampness, purslane for clearing heat and promoting diuresis, dragon's blood for removing blood stasis and promoting granulation, and natural indigo, coptis chinensis, garden burnet root, chinese gall and calcined gypsum are matched for clearing heat and promoting diuresis and astringing. The prescription is suitable for the disease course of atopic dermatitis and eczema in subacute stage, repeated attacks, difficult removal of the deficiency and damp evil and long-term disease and stasis, and the whole prescription has the effects of strengthening the body resistance, resolving dampness and removing stasis. The invention has good efficacy of astringing subacute dermatitis skin lesion exudation liquid, has good clinical curative effect and is worthy of clinical popularization and application.

Description

External traditional Chinese medicine composition for atopic dermatitis and eczema, dehumidification paste based on external traditional Chinese medicine composition and preparation method of dehumidification paste

Technical Field

The invention relates to an external traditional Chinese medicine composition for treating atopic dermatitis and eczema, dehumidification paste based on the external traditional Chinese medicine composition and a preparation method of the dehumidification paste.

Background

Atopic dermatitis (atopic dermatitis, AD) is a genetically predisposed chronic, recurrent, refractory skin disease that is manifested by recurrent episodes of intense skin itching, eczematous changes, frequent combined allergic rhinitis, asthma, and other atopic diseases with elevated blood eosinophils and IgE. Epidemiological surveys have shown that global AD prevalence increases year by year, affecting about 15-30% of children and 2-10% of adults worldwide. The prevalence of AD in China is rapidly increased in the last 10 years, and the investigation of 12 cities in China in 2019 shows that the prevalence of AD in infants of 1-12 months is 30.48%. The disease has long duration and difficult healing, seriously affects the growth and development and physical and mental health of the children, and brings heavy economic burden to families and society because of long-term and repeated discomfort such as itching, rash, damage and appearance, drug side effects and the like. Therefore, research on pathogenesis and therapeutic measures of AD is of great importance.

The prior researches indicate that the external preparation of the traditional Chinese medicine has higher safety, and has wide application space and market for relieving acute attacks of skin lesions and reducing recurrence of skin lesions. Therefore, the research and development of safe and effective external traditional Chinese medicine preparations is an important point and a hot spot of the research on atopic dermatitis and eczema.

The rash exudes in the onset period of the atopic dermatitis, the itching is severe, the treatment is troublesome, the current external medicine for improving subacute exudation skin lesions on the market is less, and the treatment effect for the exudation skin rash is not satisfactory. The AD external medicine is mainly external medicine ointment such as glucocorticoid, calcineurin inhibitor, antibacterial agent and the like, and according to the external medicine principle of skin disease treatment, exudation skin rash is not suitable for external medicine ointment, and paste is required to astringe and exude to protect wound surfaces. Compared with the traditional Chinese medicine external preparation for subacute rash, the traditional Chinese medicine external preparation for subacute rash has certain characteristics and advantages, has very good effects of astringing seepage and improving skin inflammation for subacute exudation rash after the compound traditional Chinese medicine is powdered and clinically observed for a long time, and has great development prospect and economic value.

Disclosure of Invention

In view of the above, the invention provides an external traditional Chinese medicine composition for treating atopic dermatitis and eczema, a dehumidification paste based on the external traditional Chinese medicine composition and a preparation method of the dehumidification paste.

Atopic dermatitis and eczema have complex etiology and are related to wind, dampness, heat, blood deficiency and blood dryness. Dampness is the main pathological product of atopic dermatitis and eczema, and extends through the stages of the disease. The damp evil overflows the skin in the attack stage, which can cause skin erythema, swelling, exudation, palpation as well as moist and burning sensation. The chronic disease patient has the deficiency, the spleen deficiency is dominant, the spleen deficiency generates dampness, the dampness is exuberant to hurt the spleen, the dampness is easy to hurt yang qi, and the dampness and the spleen deficiency are caused by each other. Moreover, damp evil blocks qi movement and long-term disease is necessary to be stasis, so the method of strengthening the body resistance, resolving dampness and removing stasis penetrates through each stage of treatment of atopic dermatitis and eczema.

A topical Chinese medicinal composition for treating atopic dermatitis and eczema comprises rhizoma Atractylodis, herba Portulacae, sanguis Draxonis, indigo naturalis, coptidis rhizoma, radix Sangusorbae, galla chinensis, and Gypsum Fibrosum Preparatum.

Preferably, in the external traditional Chinese medicine composition, 1-40 parts of natural indigo, 1-40 parts of gallnut, 1-40 parts of coptis chinensis, 1-10 parts of dragon's blood, 1-40 parts of garden burnet, 1-40 parts of purslane, 1-40 parts of rhizoma atractylodis and 1-500 parts of calcined gypsum.

Further preferably, in the external traditional Chinese medicine composition, 5-40 parts of natural indigo, 5-40 parts of gallnut, 5-40 parts of coptis chinensis, 2.5-10 parts of dragon's blood, 5-40 parts of garden burnet, 5-40 parts of purslane, 5-40 parts of rhizoma atractylodis and 10-500 parts of calcined gypsum.

A topical Chinese medicinal composition based on claim 1 comprises rhizoma Atractylodis, herba Portulacae, sanguis Draxonis, indigo naturalis, coptidis rhizoma, radix Sangusorbae, galla chinensis, gypsum Fibrosum Preparatum, and zinc oxide.

Preferably, in the dehumidification paste, 1-40 parts of natural indigo, 1-40 parts of gallnut, 1-40 parts of coptis chinensis, 1-10 parts of dragon's blood, 1-40 parts of garden burnet, 1-40 parts of purslane, 1-40 parts of rhizoma atractylodis, 1-500 parts of calcined gypsum and 1-500 parts of zinc oxide.

Further preferably, in the dehumidification paste, 5-40 parts of natural indigo, 5-40 parts of gallnut, 5-40 parts of coptis chinensis, 2.5-10 parts of dragon's blood, 5-40 parts of garden burnet, 5-40 parts of purslane, 5-40 parts of rhizoma atractylodis, 10-500 parts of calcined gypsum and 10-500 parts of zinc oxide.

The preparation method of the dehumidification paste comprises the pretreatment of medicinal materials and/or the extraction of the effective components of the medicinal materials, and the mixing of the medicinal materials and/or the effective components of the medicinal materials with auxiliary materials, wherein,

the pretreatment of the medicinal materials comprises cleaning, soaking, cutting, selecting, stir-frying, drying and crushing;

the extraction of the effective components of the medicinal materials comprises solvent-based decoction, impregnation, percolation, reflux decoction, steam distillation, semi-bionic extraction, cyclone extraction, pressurized countercurrent extraction, enzyme extraction, supercritical fluid extraction and ultrasonic extraction;

the auxiliary materials comprise vaseline and rapeseed oil.

Preferably, the effective components of the medicinal materials are extracted by a reflux decoction method, and the reflux decoction times are 2 times: firstly, using 70% ethanol with the mass of 10 times of that of the medicinal materials as a solvent, heating and refluxing for 1 hour, collecting primary decoction, and storing in a container; continuously refluxing with 70% ethanol of 8 times of the mass of the medicinal materials for 1 hour, collecting the continuous decoction, and combining the two decoctions.

Preferably, the active ingredients of the medicinal materials are extracted by a percolation method: soaking in 70% ethanol for 48 hr, slowly percolating, collecting primary percolate with the amount of 80%, storing in a container, percolating until the percolate is colorless, and collecting subsequent filtrate.

In addition, the invention relates to a mixing mode, which comprises the direct mixing and the stepwise mixing of medicinal materials and extracts thereof existing in any form and auxiliary materials; for example, 9 medicinal materials including rhizoma atractylodis, purslane, dragon's blood, natural indigo, coptis chinensis, sanguisorba officinalis, chinese gall, calcined gypsum and zinc oxide are directly crushed and pass through a No. 6 sieve, and are uniformly mixed with vaseline and rapeseed oil to obtain grease paste; or pulverizing herba Portulacae, rhizoma Atractylodis, radix Sangusorbae, coptidis rhizoma and Galla chinensis 5 dry materials, sieving with No. 2 sieve, adding solvent, heating for extraction, concentrating the extractive solution by rotary evaporation, drying at low temperature to obtain dry extract powder, and pulverizing into dry extract fine powder; pulverizing indigo naturalis, sanguis Draxonis, gypsum Fibrosum Preparatum, and zinc oxide 4 materials, sieving with 6 # sieve, and collecting oleum Rapae; heating vaseline at 70deg.C, adding the fine powder passing through No. 6 sieve while it is hot, stirring, adding the dry extract fine powder, and adding oleum Rapae, stirring thoroughly; subpackaging while the paste is hot, and cooling to obtain the greasy paste; or pulverizing 3 dry medicinal materials including herba Portulacae, rhizoma Atractylodis and radix Sangusorbae, sieving with No. 2 sieve, adding solvent, heating and reflux extracting for times not limited to 1, concentrating the extractive solution by rotary evaporation, drying at low temperature to obtain dry extract powder, and pulverizing into dry extract fine powder; pulverizing indigo naturalis, coptidis rhizoma, galla chinensis, sanguis Draxonis, gypsum Fibrosum Preparatum, and zinc oxide 6 materials, sieving with No. 6 sieve, and collecting oleum Rapae; heating vaseline at 70deg.C, adding the fine powder passing through No. 6 sieve while it is hot, stirring, adding the dry extract fine powder, and adding oleum Rapae, stirring thoroughly; and (5) subpackaging while the paste is hot, and cooling to obtain the greasy paste.

Therefore, the dehumidifying paste provided by the invention is a compound Chinese medicinal external paste, and is mainly used for treating atopic dermatitis, swelling, exudation and other dampness symptoms of rash in the period of eczema attack. The formula of the dehumidification paste comprises eight traditional Chinese medicines, wherein the main components are rhizoma atractylodis for strengthening the body resistance and eliminating dampness, purslane for clearing heat and promoting diuresis, dragon's blood for removing blood stasis and promoting granulation, and natural indigo, coptis chinensis, garden burnet root, chinese gall and calcined gypsum are matched for clearing heat and promoting diuresis and astringing. The prescription is suitable for the disease course of atopic dermatitis and eczema in subacute stage, repeated attacks, difficult removal of the deficiency and damp evil and long-term disease and stasis, and the whole prescription has the effects of strengthening the body resistance, resolving dampness and removing stasis. Years of clinical observation show that the medicine has the advantages of simple, convenient and cheap dehumidification paste, safe use, external use for treating exudation rash, and 3-10 days of one treatment course, can play a good role in astringing liquid seepage, diminishing inflammation and relieving itching, and is accepted and favored by patients.

Rhizoma atractylodis: pungent and bitter in flavor, warm in nature, enter spleen and liver meridians. Has effects of eliminating dampness, invigorating spleen, dispelling pathogenic wind, dispelling cold, improving eyesight, and removing dirt. It is often used for treating abdominal distention and pain, diarrhea, edema, rheumatalgia, tinea pedis , common cold due to wind-cold, sparrow eyes. Pearl sac: it can strengthen stomach and calm spleen, and can not remove all wet swelling. Rhizoma Atractylodis is the key herb for drying dampness.

Purslane: sour, cold, entering the large intestine, liver and spleen meridians. Has effects of clearing heat and detoxicating, dispelling blood and detumescence. For dysentery with purulent blood, stranguria with heat, stranguria with blood, leukorrhagia, carbuncle, malignant boil, erysipelas, and trace. It can be taken orally or applied by pounding juice for treating carbuncle and swelling. The external treatment method has long history, and the Sheng Ji general records record purslane powder compound for treating pseudocellulitis, the Sheng Hui Fang records purslane for treating malignant sore, turnout sore, alopecia areata and the like. The product contains abundant vitamin A-like substances, so that it can promote physiological function of epithelial cells to be normal, and promote ulcer healing. In addition, purslane has an inhibiting effect on escherichia coli, shigella dysenteriae and typhoid bacillus and also has an inhibiting effect on common pathogenic dermatophytes.

Dragon's blood: sweet, pungent and salty, and flat, enter lung, spleen and kidney meridians. Has effects of promoting blood circulation, removing blood stasis, relieving pain, stopping bleeding, healing sore, and promoting granulation. Can be used for treating traumatic injury, pain due to blood stasis, stagnation of qi and blood, traumatic hemorrhage, and persistent abscess.

Natural indigo: salty, cold, enter liver meridian. Has effects of clearing heat and detoxicating, cooling blood and resolving macula, purging pathogenic fire and arresting convulsion. The "Kaibao Bencao" describes: mainly dispel the toxic materials, treat infantile fever, convulsion and fever, headache, cold and heat, and take the decoction. It is also used for treating heat sore, malignant tumor, golden sore, bleeding, snake and dog. It is mainly used for treating epidemic febrile disease, macula, hematemesis, hemoptysis, pharyngalgia, aphtha, infantile convulsion, sore, erysipelas, snake and insect bite, etc.

Coptis root: bitter and cold in nature. It enters heart, spleen, stomach, liver, gall bladder and large intestine meridians. Has effects of clearing heat, eliminating dampness, purging pathogenic fire, and removing toxic substances. Can be used for treating damp-heat distention and fullness, emesis, acid regurgitation, dysentery, jaundice, high fever unconsciousness, excessive heart fire, vexation, insomnia, hematemesis, epistaxis, conjunctival congestion, toothache, diabetes, carbuncle, and furuncle; it is used externally to treat eczema, wet sore and suppurative ear canal. Modern pharmacological researches have found that coptis chinensis contains alkaloids such as berberine, coptisine, methylcoptisine, palmitoleine and the like, and can treat diseases such as acute conjunctivitis, acute bacillary dysentery, acute gastroenteritis, hematemesis, carbuncle, furuncle and sores and the like.

Radix Sanguisorbae: cold in nature, bitter in taste and sour in nature, nontoxic, and enters liver, lung, kidney and large intestine meridians. Has effects of cooling blood, stopping bleeding, clearing heat, detoxicating, detumescence, healing sore, etc. Modern medical research has found that: the garden burnet has the effects of stopping bleeding, cooling blood, clearing heat, detoxicating, astringing, stopping diarrhea and inhibiting various pathogenic microorganisms and tumors, and can be used for treating hematemesis, bloody dysentery, burn, eczema, upper gastrointestinal hemorrhage, ulcer hemorrhage, hematochezia, metrorrhagia and the like.

Gallnut: cold nature, sour and astringent taste, enter lung, large intestine and kidney meridians. Has effects of astringing lung, purging pathogenic fire, relieving diarrhea with astringents, arresting sweating, stopping bleeding, eliminating dampness, and healing sore. Compendium, compendium: the flavor of the tea is sour and salty, can astringe lung to stop bleeding, resolve phlegm, quench thirst and recover sweat; it has effects of dispelling toxic heat, and relieving sore and swelling; it is good at removing diarrhea and damp-rot. "often used for chronic cough due to lung deficiency, cough due to lung heat and phlegm, chronic diarrhea and dysentery, spontaneous sweat and night sweat, diabetes, hematochezia, hemorrhoid blood, traumatic hemorrhage, carbuncle, swelling and sore, and skin damp and rotten.

Calcined gypsum: sweet, pungent and astringent, cold, enter lung and stomach meridians. Has effects of eliminating dampness, promoting granulation, healing sore, and stopping bleeding. It is indicated for external ulcer, eczema, pruritus, scald due to water and fire, traumatic hemorrhage.

The invention has the following beneficial effects:

(1) Compared with the prior art, the external traditional Chinese medicine for treating subacute dermatitis is provided by screening and checking the curative effect in rich traditional Chinese medicines according to the traditional Chinese medicine theory and the basic principle of treatment medication, and the skin diseases such as atopic dermatitis, eczema and the like, which are in subacute stage, are all applicable to the parts which are marked by erosion and exudation skin damage. The invention has the innovation point of having good convergence and seepage effects. Can be clinically used for many years, achieves good clinical curative effect and is worthy of clinical popularization and application.

(2) Has quick response, short treatment course, good curative effect and difficult recurrence.

(3) Has the advantages of small toxic and side effects, safe use, simple and reasonable preparation, wide medicine sources and convenient use.

Drawings

Fig. 1 is a diagram of a pre-application state of a beam.

Fig. 2 is a graph showing the effect of a beam on the third day of a certain application.

Fig. 3 is a graph showing the effect of a certain application of the beam on the seventh day.

Fig. 4 is a graph showing the effect of a beam after a certain withdrawal for two weeks.

Figure 5 is a diagram showing the leg condition of a patient prior to a certain dose of the plum.

Fig. 6 is a diagram showing the leg condition of a third day of a certain medication of plum.

Fig. 7 is a diagram showing the leg condition of a sixth day of a certain medication.

Detailed Description

The present invention will be further described with reference to the accompanying drawings for a clear and intuitive understanding to those skilled in the art.

A Chinese medicinal composition for external use comprises the following raw materials in parts by weight: 1-40 parts of indigo naturalis, 1-40 parts of gallnut, 1-40 parts of coptis chinensis, 1-10 parts of dragon's blood, 1-40 parts of garden burnet root, 1-40 parts of purslane, 1-40 parts of rhizoma atractylodis and 1-500 parts of calcined gypsum. The topical Chinese medicinal composition can be used for treating atopic dermatitis and eczema.

The dehumidifying paste comprises the following raw materials in parts by weight: 1-40 parts of indigo naturalis, 1-40 parts of gallnut, 1-40 parts of coptis chinensis, 1-10 parts of dragon's blood, 1-40 parts of garden burnet, 1-40 parts of purslane, 1-40 parts of rhizoma atractylodis, 1-500 parts of calcined gypsum and 1-500 parts of zinc oxide. The preparation is paste, has good astringing and liquid seepage effects, and achieves good treatment effect in practical application.

Example 1:

the dehumidifying paste of the embodiment comprises 5 parts of natural indigo, 5 parts of Chinese gall, 5 parts of coptis chinensis, 2.5 parts of dragon's blood, 5 parts of garden burnet, 5 parts of purslane, 5 parts of rhizoma atractylodis, 10 parts of calcined gypsum and 10 parts of zinc oxide.

Example 2:

the dehumidifying paste of the embodiment comprises 20 parts of natural indigo, 20 parts of Chinese gall, 20 parts of coptis chinensis, 10 parts of dragon's blood, 20 parts of garden burnet root, 20 parts of purslane, 20 parts of rhizoma atractylodis, 20 parts of calcined gypsum and 20 parts of zinc oxide.

The preparation method of the dehumidification paste comprises the following steps:

1. weighing 3 dry medicinal materials of purslane, rhizoma atractylodis and sanguisorba officinalis, crushing and sieving with a No. 2 sieve; heating and refluxing 10 times of 70% ethanol as solvent for 1 hr, collecting the primary decoction, keeping in a container, continuously heating and refluxing 8 times of 70% ethanol for 1 hr, collecting the continuous decoction, mixing the two decoctions, concentrating by rotary evaporation, drying at low temperature to obtain dry extract powder, and pulverizing into fine powder;

2. weighing 6 medicinal materials of indigo naturalis, coptis chinensis, gallnut, dragon's blood, calcined gypsum and zinc oxide in a prescription amount, crushing the medicinal materials for later use, sieving the medicinal materials by a No. 6 sieve, and weighing rapeseed oil (the rapeseed oil is used as a matrix, and the mass ratio of the rapeseed oil to the Chinese medicinal materials is 8:1) for later use;

3. taking vaseline (the same vaseline is used as a matrix, and the mass ratio of the vaseline to the traditional Chinese medicine is 20:1), heating at 70 ℃, adding the mixture while the mixture is hot, continuously stirring the fine powder in the step 2, adding the dry paste fine powder in the step 1, and fully and uniformly stirring the mixture with rapeseed oil.

4. And (5) subpackaging while the paste is hot, and cooling to obtain the greasy paste. Storing and packaging in a container with good sealing property, and storing in a shade and dry place. The storage temperature should not be too high or too low to prevent the matrix from layering and the chemical degradation of the drug from affecting the uniformity and efficacy of the paste.

Clinical study 1:

study content and method: the patients treated with the dehumidification paste were retrospectively analyzed for dermatological treatments of skin erosion, mild exudation, such as dermatitis eczematous dermatitis, atopic dermatitis, shingles, etc. in our hospital during month 2 to month 9 of 2021.

Inclusion criteria: the rash is in subacute stage, slightly exudes, and has a erosive surface; patients with severe diabetes, heart, brain, kidney disease, and systemic oral adrenocortical hormone drugs, immunosuppressants, are excluded.

The using method comprises the following steps: the dehumidifying paste of example 1 (uniformly prepared by the university of Guangzhou Chinese medicine pharmaceutical institute) is used 3 times a day, rapeseed oil or physiological saline can be used for 5-10 minutes before each application, the previous medicine residue is washed off, and the treatment is continued for 3-7 days.

Standard of efficacy: the evaluation of the skin damage by researchers adopts the target skin damage severity degree to score, and the judgment basis is as follows: 0 min-clear, i.e. no erythema, papule/edema, exudation/crusting, epidermolysis/scratch, hypertrophy/lichenification, dryness, etc.; 1 min-mild, rash can be determined by observation; 2 minutes-moderate, the rash was seen immediately; 3 minutes-severe, the rash is very obvious; the scores of the symptoms can be 0.5 point. Overall improvement rate = (pre-treatment score-post-treatment score)/pre-treatment score x 100. The efficacy of the subjects was classified into 4 grades, i.e. recovery (greater than 90%), significant (60% to 89%), effective (20% to 59%), ineffective (less than 20%) according to overall improvement rate. The recovery, obvious effect and effective total are effective.

Study results: a total of 117 patients, 16 patients from whom the shedding follow-up was removed, and a total of 101 patients were subjected to clinical observation, of which 55 male patients, 46 female patients, and ages 7 months to 92 years, with an average age of about 32 years, and a median of 28 years. The average score for target lesion severity was 12.7 and the maximum was 18. After 3-7 days of administration, no obvious adverse reaction is seen, 6 cases are healed, 38 cases are obvious in effect, 42 cases are effective, 15 cases are ineffective, and the total effective rate is 85.15%. The formula medicine of the invention has mild medicine property and has the effects of strengthening the body resistance, resolving dampness and removing blood stasis. Through long-time clinical observation, the formula of the invention has the advantages of remarkable curative effect, high safety, simple use method, no obvious adverse reaction and easy acceptance by patients.

Clinical study 2:

diagnostic, inclusion and exclusion criteria for subjects

Inclusion criteria: patients with atopic dermatitis who were in the clinic for dermatology, met the criteria for diagnosis of chinese Zhang Jianzhong atopic dermatitis, and the patients had no history of antibiotic, antifungal and glucocorticoid drug use for nearly 1 month, and the observed target lesions were not treated locally (except for emollients) within 1 week; the rash is in subacute phase and symmetrically distributed; and signing written informed consent.

Exclusion criteria: combining other skin diseases; receiving systemic immunosuppressant and glucocorticoid therapy (including systemic and topical administration); patients with other major underlying diseases such as heart and lung; mental disorder patient. Treatment groups and control groups were separated based on random numbers.

The use method and the treatment course are as follows:

dehumidification paste preparation and quality control (example 2, manufactured by the university of chinese medicine, university of guangzhou, unified). The product is a dark gray paste, has fine texture, and is easy to coat skin.

Treatment group: the dehumidification paste of example 2 was applied to exuded rash 3 times daily.

Control group: zinc oxide oil, 40% zinc oxide oil (nosocomial preparation), was applied topically on exuded rash 3 times daily.

Basic treatment: systemic oral and/or intravenous antiallergic treatment (recorded) can be administered depending on patient severity, avoiding hormonal, immunosuppressive and antibiotic drug treatments.

Evaluation index skin damage severity integral:

skin damage symptoms include erythema, edema, exudation, desquamation, lichenification, dryness, each scored on a scale of 0-3. Half points can be recorded between the scores of the symptoms. The skin lesion severity score is the sum of the individual skin lesion symptom scores. Observation time point: day 0, day 3, day 7 (observation time window is ±1 day). Itching degree score: the pruritus efficacy is determined by Visual Analog Scale (VAS) and subjective evaluation of the patient, and the corresponding position of pruritus is marked on the ruler, and then the value or score of the pruritus intensity is measured. The observation time points are day 0, day 3 and day 7 (observation time window is + -1 day).

Results:

each of 24 patients was enrolled and the dehumidification paste (example 2) treatment group healed: 0 cases, 6 cases with obvious effect, 17 cases with effective effect, 1 case with ineffective effect, and the total effective rate is 95.83%. The control group of 40% zinc oxide oil (preparation in hospital) heals 0 cases, has 4 cases of obvious effect, 15 cases of effective effect, 5 cases of ineffective effect, and the total effective rate is 79.17%.

The case is as follows:

men, 66 years old, 9 months and 18 days old in 2021, see the diagnosis by "repeated two lower limb polymorphous rash with liquid seepage and itching for more than 1 year, aggravated for 1 week". It can be seen that the lower limbs of patients are scattered on erythema, pimple, local erosion, exudation and pruritus, and the lower limbs are resolved mainly and distributed symmetrically. The external use of the conventional antiallergic hormone ointment is not improved after the external treatment for multiple times. The rash of the lower limbs is aggravated in the last week, the itching is obvious, and the local rash is eroded and oozes after scratching. The stomach-qi failing to sleep, the stool and urine being regulated, the tongue being pale, the coating being white and the pulse being slippery. Diagnosis of traditional Chinese medicine: sores due to dampness (wind-damp-heat syndrome). Western diagnosis: eczema. Modified Wuling san and Ermiao san are added to the Chinese medicine. The external preparation is treated according to the formula and the using method of the embodiment 1 of the invention, the left lower leg is selected as a test side, the external preparation is used for medical application, the right lower leg is a control side, zinc oxide (40% zinc oxide in-hospital preparation) is used for control external application, and the using methods are the same on both sides. The patient has obvious curative effect on the self-complaint test side compared with the control side after the WeChat follow-up on the 4 th day of medication, and the two sides of the patient are changed into the medicine of the invention. The patients on day 7, 2021, 9 and 27 go to outpatient service for follow-up visit, the rash on both sides is converged, scabs and skin lesions are obviously repaired, a little scale, scabs and color deposit are left, no obvious liquid seepage exists, and no obvious itching exists. The external application of the medicine of the invention is changed into the external application of the hospital preparation compound snake fat ointment, the anti-inflammatory and antipruritic ointment, and the Chinese medicine is modified into the modified oral administration of the five-poria powder and two-Miao powder. After 2 weeks the outpatient service was re-diagnosed and the rash was basically stable.

The pre-dose state is shown in figure 1.

The effect of the third day of administration is shown in fig. 2, with the left leg as the test side and the right leg as the control side.

Both sides were subjected to the dehumidifying paste of example 1 of the present invention after the third day, and the effect on the seventh day of application is shown in fig. 3.

The effect after two weeks of drug withdrawal is shown in figure 4.

Therefore, the traditional conventional antiallergic hormone ointment has an unsatisfactory treatment effect on the disease by a pure zinc oxide product, and the treatment effect of the traditional conventional antiallergic hormone ointment is quite ideal.

Some men, 26 years old, 2022, 3 months and 9 days old, develop polymorphic rashes with itching for 4 years all over the body, aggravate 1 month more hospitalization. Looking up the body: the head, face, chest, back, waist, back and limbs are scattered on erythema, plaque and lichen-like transformation, and the local rash of the two lower limbs has the symptoms of liquid seepage, scabbing, dryness and desquamation, and the rash is symmetrically distributed. The rash area is more than 90% of the body surface area. Generally, poor sleep, difficulty in falling asleep and convenient adjustment. Pale red tongue with thin and white coating, wiry and rapid pulse. Diagnosis of traditional Chinese medicine: four wind-bending and Tartar-skin diseases (wind-damp-heat syndrome). Western diagnosis: erythroderma, atopic dermatitis (moderate to severe). Modified Wuling san is added to the Chinese medicinal decoction. The external preparation is treated according to the formula and the using method of the embodiment 1 of the invention, the skin injury of the left lower leg is selected as a test side, the external preparation is used for external application, the skin injury of the right lower leg is used as a contrast side, 40% zinc oxide oil (preparation in hospital) is used for contrast external application, and the using methods are the same on both sides; and meanwhile, the anti-allergic oral medicine of the system is conventionally used. The skin rash on both sides is converged and scabbed without obvious seepage after the follow-up visit on day 3 and 2022 and day 3 and 11, and the test side has better convergence and itching relieving effects than the contrast side and has better medication comfort. The medicine is taken at the 6 th day 2021 and the 3 rd day 14 later, the target skin lesions on the two sides are obviously improved, the skin lesions are repaired, a little scale, scab and color deposit are left, and obvious pruritus is avoided.

The leg condition of the patient before administration is shown in fig. 5. The leg conditions of the patients on the third day of administration and the sixth day of administration are shown in fig. 6 and 7. From the graph, the severity of the left leg is obviously higher than that of the control side, and the curative effect is obviously equivalent to that of the control side, so that the good curative effect of the dehumidifying paste can be demonstrated.

The previous description of the embodiments is provided to facilitate a person of ordinary skill in the art in order to make and use the present invention. It will be apparent to those skilled in the art that various modifications can be readily made to these embodiments and the generic principles described herein may be applied to other embodiments without the use of the inventive faculty. Therefore, the present invention is not limited to the embodiments described herein, and those skilled in the art, based on the present disclosure, should make improvements and modifications within the scope of the present invention.

Claims

1. The dehumidifying paste for treating atopic dermatitis and eczema is characterized by being prepared from the following medicinal materials in parts by weight:

5 parts of indigo naturalis, 5 parts of gallnut, 5 parts of coptis chinensis, 2.5 parts of dragon's blood, 5 parts of garden burnet, 5 parts of purslane, 5 parts of rhizoma atractylodis, 10 parts of calcined gypsum and 10 parts of zinc oxide; or is prepared from the following medicinal materials in parts by weight:

20 parts of indigo naturalis, 20 parts of gallnut, 20 parts of coptis chinensis, 10 parts of dragon's blood, 20 parts of garden burnet, 20 parts of purslane, 20 parts of rhizoma atractylodis, 20 parts of calcined gypsum and 20 parts of zinc oxide.

2. The dehumidifying paste for treating atopic dermatitis and eczema as claimed in claim 1, wherein the dehumidifying paste is prepared by the following method:

(1) Weighing 3 medicinal materials of purslane, rhizoma atractylodis and garden burnet with prescription amount, drying, crushing, sieving with a No. 2 sieve, heating and refluxing for 1 hour by using 10 times of 70% ethanol as a solvent according to a reflux decoction method, collecting primary decoction, preserving in a container, continuously heating and refluxing for 1 hour by using 8 times of 70% ethanol, and collecting continuous decoction; mixing the two decoctions, concentrating by rotary evaporation, drying at low temperature to obtain dry extract powder, and pulverizing into dry extract fine powder;

(2) Weighing 6 medicinal materials of indigo naturalis, coptis chinensis, chinese gall, dragon's blood, calcined gypsum and zinc oxide according to the prescription, crushing and sieving the medicinal materials with a No. 6 sieve to obtain fine powder of the 6 medicinal materials for later use;

(3) Taking Vaseline according to the mass ratio of Vaseline to medicinal material=20:1, heating at 70 ℃, adding the mixture and the fine powder prepared in the step (2) while the mixture is hot, continuously stirring, adding the dry paste fine powder prepared in the step (1), adding rapeseed oil according to the mass ratio of rapeseed oil to medicinal material=8:1, and fully and uniformly stirring;

(4) And (5) subpackaging while the paste is hot, and cooling to obtain the dehumidifying paste.