CN102357145B - Externally applied ointment for treating baldness - Google Patents
Externally applied ointment for treating baldness Download PDFInfo
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- CN102357145B CN102357145B CN 201110328045 CN201110328045A CN102357145B CN 102357145 B CN102357145 B CN 102357145B CN 201110328045 CN201110328045 CN 201110328045 CN 201110328045 A CN201110328045 A CN 201110328045A CN 102357145 B CN102357145 B CN 102357145B
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Abstract
The invention provides an externally applied ointment for treating baldness, which is prepared by the following raw materials by weight: 0.4-0.6% of rheum officinale, 0.2-0.3% of coptis, 0.2-0.3% of phellodendron, 25-35% of cod liver oil, 25-35% of zinc oxide, 35-45% of white petrolatum, 0.8-1.2% of calamine, and 0.4-0.6% of borneol. The externally applied ointment of the invention has a simple preparation process, is convenient for use, does not need rubbing, has no toxicity or side effect, has fast effect, and has significant effect for patients with alopecia totalis, alopecia areata, alopecia universalis, especially seborrheic alopecia. When hair begins to grow, the hair follicle function is stable, and can be maintained for a long time after the invention is stopped using; the invention has no special requirements for gender or age, and also has satisfactory effect for female and elderly people.
Description
Technical field
The present invention relates to a kind of medicine for external use, be specifically related to a kind of medicine for external use ointment for the treatment of alopecia.
Background technology
Alopecia (Calvities) also claims alopecia, is a kind of common hair diseases, how to fall ill about 20～30 years old, is more common in the male, can be divided into two kinds of congenital alopecia and posteriority alopecias.Congenital alopecia may be autosomal dominant inheritance, AD, and family history is arranged, and the consanguineous marriage history is arranged.The posteriority alopecia comprises the alopecia that various factors causes, and is as alopecia areata, seborrheic alopecia etc., wherein common with seborrheic alopecia.Its cause of disease is not yet fully clear so far, thinks on doctor trained in Western medicine that heredity is a relatively more fixing factor, and is also closely related with androgen in addition, comprises increase or Hyperandrogenism to androgen sensitivity; Think primary disease on the traditional Chinese medical science by damp and hot invasion and attack skin, make battalion defend imbalance, space between skin and muscles is solid, venation block, and essence and blood biochemistry is unfavorable, thereby affects hair growth, and root of hair does not cause admittedly that hair is sparse to come off.Think that at present seborrhea does not play an important role on the pathogenesis of primary disease.The primary disease sickness rate is higher, is more common in Young crowd, due to the impact beauty treatment, often brings a lot of worries and misery to patient.
The Related product for the treatment of in the market alopecia is a lot, and its principle comprises the following aspects:
1: control seborrheic alopecia, increase scalp hair follicle oil extraction function;
2: blood circulation promoting, the expansion dredging pore, fat, the hairy root nourishing of dispelling of invigorating blood circulation strengthens root of hair cell division and metabolism, trichogenous effect;
3: bactericidal, inhibited to fungus-caused dandruff;
4: dispel wind and remove dampness, heat-clearing and toxic substances removing;
5: increase hair tissue nutrition, safeguard normal metabolism, stimulate and trichogenous effect;
6: the effect of trace element.
The factor of alopecia has a variety of, need to consider from the many-side of natural on-off cycles of hair growth, the reason of alopecia is single causing not often, a lot of existing products are the function that a certain partly cause of corresponding alopecia carries out repairing hair follicle, attend to one thing and lose sight of another, do not consider the comprehensive factor of alopecia, so be difficult to the effect that reaches desirable.This causes the existing product Main Problems to be: the recovery of correct fur capsule function is undesirable, can grow hair, but natural on-off cycles of hair growth is slow, and the hair that grows is comparatively very thin, and jaundice is difficult to long-term maintenance, in case stop using, the hair that grows easily comes off.
Summary of the invention
The object of the invention is to: a kind of medicine for external use ointment for the treatment of alopecia is provided, has the advantages such as produce effects is fast, therapeutic effect is lasting.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of medicine for external use ointment for the treatment of alopecia is provided, and it is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.4-0.6%, Rhizoma Coptidis 0.2-0.3%, Cortex Phellodendri 0.2-0.3%, Cod Liver Oil 25-35%, zinc oxide 25-35%, white vaseline 35-45%, Calamina 0.8-1.2%, Borneolum Syntheticum 0.4-0.6%.
The medicine for external use ointment that the present invention preferably treats alopecia is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.4-0.6%, Rhizoma Coptidis 0.2-0.3%, Cortex Phellodendri 0.2-0.3%, Cod Liver Oil 25-30%, zinc oxide 30-35%, white vaseline 35-40%, Calamina 0.8-1.2%, Borneolum Syntheticum 0.4-0.6%.
The medicine for external use ointment of the preferred treatment alopecia of the present invention is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.5%, Rhizoma Coptidis 0.25%, Cortex Phellodendri 0.25%, Cod Liver Oil 30%, zinc oxide 30%, white vaseline 37.5%, Calamina 1%, Borneolum Syntheticum 0.5%.
Medicine for external use ointment preparation method of the present invention is as follows: prepared slices of Chinese crude drugs Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Cortex Phellodendri that cooks was processed as 500 orders with the fine powder of top sieve, evenly mixed rear pressure cooker autoclaving 30 minutes with Cod Liver Oil, zinc oxide, white vaseline, Calamina fine powder in described ratio, with after the mistake 500 mesh sieve borneol powder of described ratio are mixed, make ointment according to conventional method and get final product again.
The process of preparing Chinese medicine of described Radix Et Rhizoma Rhei is carried out according to the concocting method of Radix Et Rhizoma Rhei in " 2005 editions one one of Chinese Pharmacopoeia ", be the process of preparing Chinese medicine mode of Radix Et Rhizoma Rhei: get raw material, the size stepping is removed impurity, and water is cleaned in right amount, time is difficult for oversize, use up medicine thoroughly as degree take water, stripping and slicing or sheet, moistening is even to inside and outside humidity, cold drying, sieve goes chip standby.
The process of preparing Chinese medicine of described Rhizoma Coptidis is carried out according to the concocting method of Rhizoma Coptidis in " 2005 editions one one of Chinese Pharmacopoeia ", is the process of preparing Chinese medicine mode that SHENGHUANG connects: remove impurity, run through rear shave, dry, or the used time smashs to pieces.
The process of preparing Chinese medicine of described Cortex Phellodendri is the process of preparing Chinese medicine mode of phellodendron bark: prescind surperficial rough bark, wash away inside and outside dirt with clear water, use warm water winter, spring, summer, autumn wash with cold water, pick up and are filtered dry moisture, and stewing profit runs through to take out and is cut into horizontal hair or square plate, dries in the shade, and shines variable color.
Described Calamina segmentation can be commercially available product, and for example other calamine stone of analytical pure level of Tianjin Da Mao chemical reagent factory production is last.
Medicine for external use ointment of the present invention is applicable to various posteriority alopecias, and using method is as follows:
Ointment of the present invention is directly smeared at scalp position at alopecia and exiguous human hair, each 3 gram to 5 grams, and according to the area increase and decrease of alopecia, every day is (3 times) for several times; One month is a course for the treatment of.Make ointment continue to be attached on the scalp of alopecia position and exiguous human hair during use as far as possible.
In medicine for external use of the present invention, the action and efficacy of primary raw material is as follows:
(1) medical zinc oxide--the effect of trace element zinc:
1) participate in the composition of body endoenzyme, in body, 200 plurality of enzymes contain zinc, and in different enzymes, zinc plays catalytic decomposition, synthetic, stabilized enzyme albumen quarternary structure, reconciles the multiple vital actions such as enzymatic activity;
2) keep normal morphology, growth and the health of epithelial cell and quilt hair, its biochemical basis is relevant with the acid mucopolysaccharide metabolism with zinc participation cystine, and zinc deficiency will affect its homergy, thereby cause epithelial keratinization and depilation;
3) promote growth promoter and the tissue regeneration of body; For the patient of tissue injury, it is nutrient more importantly.
The effect of (two) Cod Liver Oil--vitamin A:
The major function of vitamin A is to keep body normal growth, reproduction, vision, the sound anti-infectious immunity function that reaches of epithelial tissue.Can cause during vitamin A deficiency: children's's skeletal development retardation; Affect tooth enamel cell development, tooth is unsound; The epithelial tissue structural damage;
(3) effect of Calamina:
Calamina has the removing dampness promoting tissue regeneration and ulcer healing, is used for eczema eczema, ulcer being unable to heal; Be used for department of dermatologry, as anticorrosion, convergence, protective agent treatment scytitis or the surface injury of moderate.External can suppress local aureus growth, can partially absorb wound secretion, and convergence, protective effect are arranged.
(4) effect of Chinese herb rhubarb:
Radix Et Rhizoma Rhei has heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Radix Et Rhizoma Rhei has anti-infectious function, and multiple Gram-positive and negative bacteria are all had inhibitory action, and wherein the most responsive is staphylococcus and streptococcus, is secondly diphtheria corynebacterium, Typhoid and paratyphoid bacillus, Diplococcus pneumoniae, dysentery bacterium etc.; Infected by influenza also has inhibitory action; Due to tannin, therefore the constipation phenomenon is arranged again after rushing down; Function of gallbladder promoting and digestion promoting function are arranged; In addition, stop blooding in addition, protect the liver, the effect such as blood pressure lowering, reduction serum cholesterol.
(5) effect of Chinese Drug Rhizomes of Coptis:
Rhizoma Coptidis has heat clearing and damp drying, eliminating fire and detoxication, and external treatment eczema, eczema, auditory meatus is suppurated.
1, antiulcer: rat gastric ulcer due to the indole suffering is had obvious inhibitory action; Action intensity and cimetidine are suitable;
2, anti-inflammatory and antalgic: with hot plate method, writhing method test, obvious analgesic activity is arranged all; Obvious antiinflammatory action is arranged
3, antibacterial: stronger to golden Portugal, vibrio cholera, group B streptococcus effect, a little less than escherichia coli, Bacillus typhi effect.
(6): the effect of Chinese Medicine Cortex Phellodendri:
Cortex Phellodendri has heat and toxic materials clearing away medicine; Heat clearing and dampness removing medicine
1, antibacterial action:
The Cortex Phellodendri antibiotic effective ingredient is berberine, thus its pharmacological action and Rhizoma Coptidis broadly similar, but content is low than Rhizoma Coptidis.In vitro tests to staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium (except Song Nei Shi), Hemolytic streptococcus, meningococcus, vibrio cholera, anthrax bacillus all effectively or stronger inhibitory action arranged; Bacillus subtilis, bordetella pertussis, clostridium tetani also there is inhibitory action;
2, antifungic action:
The ether extract of Cortex Phellodendri and Cortex Phellodendri has stronger bacteriostasis to Cryptococcus histolyticus and trichophyton purpureatum, and its effect is stronger than nystatin, but a little less than the inhibitory action of Candida albicans is enjoyed than mildew making.
3, on the impact of immunologic function:
The Cortex Phellodendri decoct, 100% concentration, 0.3ml/ gavage continuous 7 days, can increase mice spleen plaque forming cells number.
(7) effect of medical white vaseline:
White vaseline is as substrate, has nothing at all except having chemically inert Hydrocarbon in the inside.But it is not hydrophilic, spreads upon on skin to keep skin wetness, makes the skin histology of wound site keep optimum state, has accelerated the repair ability of skin self.In addition, vaseline does not have sterilizing ability, and it has only stopped from airborne antibacterial and contact skin, thereby has reduced the probability that infects.
(8) effect of Chinese medicine Borneolum Syntheticum:
1), be used for the excess syndrome of stroke coma; 2), be used for skin infection and swell and ache, do not hold back after bursting; This product also has heat-clearing and toxic substances removing, erosion prevention and muscle growing effect; 3), be used for conjunctival congestion and swelling pain, sore throat aphtha; This product bitter cold has the merit of clearing away heat to alleviate pain, detumescence, is the department of eye common medicine; 4), this product is with controlling angina pectoris and toothache, and certain curative effect is arranged; 5), antiinflammatory, antibacterial action.
Innovative point of the present invention is the use of trace element zinc, then vitamin A in addition, is aided with the multiple Chinese herbal medicine of heat clearing and damp drying; The present invention is unguentum on dosage form, has reached high value on the concentration of medicine, can reach the characteristics that drug effect continues during use, the repair time of having accelerated greatly the scalp hair follicle; Scalp has been converted into the pore skin region, effective too for extremely immature fine hair when a hole has become pore, use ointment of the present invention to begin to increase, increase thick after a period of time.
By the above-mentioned preparation technology of the present invention, each component in composition of raw materials is fully mixed, mutually collaborative between medicine, drug effect is given full play to, the epithelial effect of stronger reparation is arranged, also have good antibacterial effect, make the hair follicle can better restore funcitons, pass through again autoclaving, use safer.This ointment has sterilization, disinfective action, has scalp irritation and improves blood circulation, and is antipruritic, promotes the histiocyte vigor, the stem cell growth of effective hair follicle stimulating, and the normal function of recovery hair follicle, anti-loss, promote hair regeneration.
the present invention is from a variety of causes of alopecia, from educating the at all of sending out, adopt multiple raw material chemicals of suiting the medicine to the illness, compatibility through science, carried out a large amount of clinical practices, thereby draw best formula, has bactericidal, activate hair follicle, promote the effect of the division of hair follicle, after using, impaired hair follicle function is restored rapidly, very fast (the fastest 5 days of laboratory observation) hair follicle begins to recover, after hair begins growth, the hair follicle function-stable, stop using that the function of hair follicle can keep for a long time after ointment of the present invention, ointment of the present invention has no special requirements to sex and age, women and old people also there is comparatively satisfied effect.
External application Chinese medicine of the present invention can be with reference to following clinical data in the effect for the treatment of in alopecia:
[diagnostic criteria]
1. Western medicine diagnose standard:
Clinical sign:
1) primary disease mainly betides the male about 20～30 years old, and the women also can occur, but less.
2) alopecia often from forehead both sides, is extended to head gradually, and it is rare very thin that hair becomes gradually, soft unable, tarnishes.Front hair line retreats from both sides, forms " great number " that be commonly called as.Large of final head hair or all come off, but after pillow and head both sides hair keeps normal substantially.Also there is some patients were from the beginning to back down the beginning alopecia.
3) alopecia district's skin smooth or be even, sparse, the soft hair of a slice.
4) process of alopecia is generally very slow.
5) without obvious subjective symptoms or only have gently and itch.
6) primary disease only betides head, and beard and other hair are inviolable.
7) can be with seborrhea or seborrheic dermatitis.
8) relevant with heredity, the patient often has family history, and its father and mother often have same infringement.
Histopathology: variation the earliest is that lower 1/3 place of trophophase hair follicle connective tissue sheath acidophile degeneration occurs around focal blood vessel and the hair follicle peripheral lymphocyte occurs subsequently infiltrates.Hair follicle atrophy gradually stays the hyaloid connective tissue of a branch of sclerosis.Atrophy of epidermis, trochanterellus flatten, and the blood capillary clump almost disappears under epidermis.
2. tcm diagnosis standard:
1) damp-heat in the spleen and stomach: sweet fertilizer is eaten in happiness usually, and hair cream is wet, and squama is greasy, alopecia, scalp itch, red tongue, yellow and greasy fur, slippery and rapid pulse;
2) blood-deficiency and wind-dry: hair is withered, sparse coming off, and squama stacks, scalp itch, yellowish fur on the tongue is red, thready and rapid pulse.
[patient's basic condition]
According in above-mentioned, the Western medicine diagnose standard, select 80 alopecia patients, be all the male; Mean age is 38 ± 3.5 years old; The course of disease was at 1 month to 5 years.State of an illness classification: 35 of alopecia areatas, 45 of androgenetic alopecias.
[therapeutic scheme]
Ointment to above-mentioned patient's administration embodiment of the present invention 1 preparation stops other medications simultaneously, and administrated method is with aforementioned using method.The administration cycle is 30 days.
[the standard of curative effect evaluation]
Cure: natural on-off cycles of hair growth recovers 〉=50%, is terminal hair, substantially reaches cosmetic result, patient satisfaction, and the doctor is satisfied.
Produce effects: the alopecia district generally has the fine hair on birds or animals staple length to go out, and 20%≤become terminal hair≤50%, the patient thinks effectively, the doctor also thinks and take a favorable turn.
Invalid: with before treatment, relatively cosmetic variation is not obvious or only have the fine hair on birds or animals staple length to go out, terminal hair≤20%, patient and doctor are all dissatisfied.
[therapeutic effect]
| Cure rate | Obvious effective rate | Inefficiency | The fastest effective time | The shortest lasting period |
| 53％ | 32％ | 15％ | 5 days | 3 days |
By above-mentioned clinical trial as can be known, externally-applied ointment of the present invention has significant therapeutic effect to male baldness.
The specific embodiment
Embodiment 1.
The medicine for external use ointment for the treatment of alopecia is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.4%, Rhizoma Coptidis 0.2%, Cortex Phellodendri 0.2%, Cod Liver Oil 25%, zinc oxide 28%, white vaseline 45%, Calamina 0.8%, Borneolum Syntheticum 0.4%.
Prepared slices of Chinese crude drugs Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Cortex Phellodendri that will cook according to the method for pharmacopeia record were processed as 500 orders with the fine powder of top sieve, evenly mixed rear pressure cooker autoclaving 30 minutes with Cod Liver Oil, zinc oxide, white vaseline, Calamina fine powder in described ratio, with after the borneol powder of described ratio (crossing 500 mesh sieves) is mixed, make ointment according to conventional method and get final product again.
Embodiment 2.
The medicine for external use ointment for the treatment of alopecia is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.6%, Rhizoma Coptidis 0.3%, Cortex Phellodendri 0.3%, Cod Liver Oil 35%, zinc oxide 25%, white vaseline 37%, Calamina 1.2%, Borneolum Syntheticum 0.6%.
Prepared slices of Chinese crude drugs Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Cortex Phellodendri that will cook according to the method for pharmacopeia record were processed as 500 orders with the fine powder of top sieve, evenly mixed rear pressure cooker autoclaving 30 minutes with Cod Liver Oil, zinc oxide, white vaseline, Calamina fine powder in described ratio, with after the borneol powder of described ratio (crossing 500 mesh sieves) is mixed, make ointment according to conventional method and get final product again.
Embodiment 3.
The medicine for external use ointment for the treatment of alopecia is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.5%, Rhizoma Coptidis 0.25%, Cortex Phellodendri 0.25%, Cod Liver Oil 30%, zinc oxide 30%, white vaseline 37.5%, Calamina 1%, Borneolum Syntheticum 0.5%.
Prepared slices of Chinese crude drugs Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Cortex Phellodendri that will cook according to the method for pharmacopeia record were processed as 500 orders with the fine powder of top sieve, evenly mixed rear pressure cooker autoclaving 30 minutes with Cod Liver Oil, zinc oxide, white vaseline, Calamina fine powder in described ratio, with after the borneol powder of described ratio (crossing 500 mesh sieves) is mixed, make ointment according to conventional method and get final product again.
Claims (4)
1. medicine for external use ointment for the treatment of alopecia, it is characterized in that, it is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.4-0.6%, Rhizoma Coptidis 0.2-0.3%, Cortex Phellodendri 0.2-0.3%, Cod Liver Oil 25-35%, zinc oxide 25-35%, white vaseline 35-45%, Calamina 0.8-1.2%, Borneolum Syntheticum 0.4-0.6%.
2. the medicine for external use ointment for the treatment of alopecia claimed in claim 1, it is characterized in that, it is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.4-0.6%, Rhizoma Coptidis 0.2-0.3%, Cortex Phellodendri 0.2-0.3%, Cod Liver Oil 25-30%, zinc oxide 30-35%, white vaseline 35-40%, Calamina 0.8-1.2%, Borneolum Syntheticum 0.4-0.6%.
3. the medicine for external use ointment for the treatment of alopecia claimed in claim 1, it is characterized in that, it is prepared from by the raw material of following percentage by weight: Radix Et Rhizoma Rhei 0.5%, Rhizoma Coptidis 0.25%, Cortex Phellodendri 0.25%, Cod Liver Oil 30%, zinc oxide 30%, white vaseline 37.5%, Calamina 1%, Borneolum Syntheticum 0.5%.
4. the preparation method of medicine for external use ointment claimed in claim 1, comprise the steps: that prepared slices of Chinese crude drugs Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Cortex Phellodendri that will cook according to the method for pharmacopeia record were processed as 500 orders with the fine powder of top sieve, evenly mixed rear pressure cooker autoclaving 30 minutes with Cod Liver Oil, zinc oxide, white vaseline, Calamina fine powder in described ratio, with after mistake 500 orders of described ratio mix with the borneol powder of top sieve, make ointment according to conventional method and get final product again.
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|---|---|---|---|---|
| CN1128628C (en) * | 2000-07-06 | 2003-11-26 | 吕学海 | Hair-growing powder medicine and preparation process thereof |
| CN101336982A (en) * | 2007-11-07 | 2009-01-07 | 陈红锦 | Composition for preventing alopecia and/or promoting hair regeneration |
| CN101450099A (en) * | 2009-01-06 | 2009-06-10 | 唐又林 | Medicine for treating alopecia and preparation method and use thereof |
| CN102106943A (en) * | 2011-02-23 | 2011-06-29 | 徐海彬 | Liniment for treating alopecia and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1128628C (en) * | 2000-07-06 | 2003-11-26 | 吕学海 | Hair-growing powder medicine and preparation process thereof |
| CN101336982A (en) * | 2007-11-07 | 2009-01-07 | 陈红锦 | Composition for preventing alopecia and/or promoting hair regeneration |
| CN101450099A (en) * | 2009-01-06 | 2009-06-10 | 唐又林 | Medicine for treating alopecia and preparation method and use thereof |
| CN102106943A (en) * | 2011-02-23 | 2011-06-29 | 徐海彬 | Liniment for treating alopecia and preparation method thereof |
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| 朱伟菊等.脱发的中药治疗.《第十届东南亚地区医学美容学术大会论文汇编》.2006,100-103. |
| 脱发的中药治疗;朱伟菊等;《第十届东南亚地区医学美容学术大会论文汇编》;20061231;100-103 * |
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