CN103784590B - A kind of hair growth accelerating Chinese medicine formula - Google Patents
A kind of hair growth accelerating Chinese medicine formula Download PDFInfo
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- CN103784590B CN103784590B CN201410056579.3A CN201410056579A CN103784590B CN 103784590 B CN103784590 B CN 103784590B CN 201410056579 A CN201410056579 A CN 201410056579A CN 103784590 B CN103784590 B CN 103784590B
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Abstract
The invention belongs to technical field of Chinese medicines, be specially a kind of hair growth accelerating Chinese medicine formula.With parts by weight, this formula comprises following four taste Chinese medicine ingredients: 50-100 parts of Radixs Polygoni Multiflori, 50-100 parts of Radix Salviae Miltiorrhizaes, 30-50 parts of Radix Rehmanniaes Preparata, 10-30 parts of ZnO.This formula its all have good therapeutical effect to alopecia areata, the type alopecia such as seborrheica, senile.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specially a kind of hair growth accelerating Chinese medicine formula for the treatment of alopecia areata, the type alopecia such as seborrheica, senile.
Background technology
Alopecia is clinical common disease, can be divided into the types such as alopecia areata, seborrheic alopecia, alopecia due to chemotherapy, senile alopecia, wherein with alopecia areata and seborrheic alopecia sickness rate the highest.
Alopecia areata refer to hair suddenly or gradually fall in flakes be a kind of common dermatosis of feature, doctor trained in Western medicine thinks that this is sick relevant with neurological dysfunction and immunoreation, excessive mental work, long-term spirit is worried, anxious, sad, terrified, all belonging to nervous dysfunction category, is also the modal cause of disease of bringing out alopecia areata; Theory of Chinese medical science think alopecia areata be human body in weakness, psychentonia, frightened, on the basis of rage, outer miopragia, space between skin and muscles using pungent drugs for dispersion and bitter drugs for purgation, " wind " heresy invade scalp, intercept blood vessels, hair lose support, alopecia.
Seborrheic alopecia, also known as androgenetic alopecia, male pattern alopecia, is apt to occur in male person between twenty and fifty, and having genetic predisposition also affects by androgenic.The seborrheic alopecia patient of about more than 70% has obvious family medical history, and research in recent years shows, androgenetic alopecia belongs to autosomal dominant gene heredity, has the easy alopecia of people of genetic predisposition.Classical Hamilton human studies model proves that androgen plays vital effect in seborrheic alopecia pathogeny, even if having genetic predisposition but can not fall ill without androgenic, testosterone is androgen main in body, testosterone is transformed into dihydrotestosterone under 5α-reductase catalysis, dihydrotestosterone can activity hormone response syndrome patient and II type 5-alpha-reductase defect patient hair follicle Sex Hormones receptor, thus bring out androgenetic alopecia.The traditional Chinese medical science scholar think, seborrheic alopecia or because of congenital deficiency of the liver and kindey, and sending out becomes homeless supports and falls; Or because of ferritic heat in blood, blood hot air wind producing, stasis blocking hair key; Or because of eating and drinking without temperance, spleen loses transporting, retention of damp-heat in the interior, top, upper steaming top, corrodes root of hair, and QI and blood is not smooth and cause alopecia.
For alopecia areata, conventional Hormone class medicine prednisone, ion channel medicine minoxidil are treated clinically, but these medicines are for most of androgenetic alopecia patient, can only rise is stop alopecia progress and can not promote natural on-off cycles of hair growth, long-term taking prednisone easily causes Ke Xing Shi to levy, the side effect such as inducing neural mental symptom and digestive system and ulcer, osteoporosis, growth promoter are suppressed; Minoxidil side effect has releasing stimulus dermatitis, slight erythema, pruritus, unspecific allergic react, welt, allergic rhinitis, facial swelling, allergy, breathe hard, have a headache, neuritis, dizziness, faint, dizzy, edema, chest pain, the changes such as blood pressure, cardiopalmus and pulse frequency.
For seborrheic alopecia, Western medicine often adopts 5α-reductase inhibitor, its mechanism suppresses the generation of dihydrotestosterone, its maximum side effect is exactly the sexual function affecting male, conventional Chinese medicine compound has A oral liquid (Radix Polygoni Multiflori Preparata, Fructus Ligustri Lucidi, Fructus Crataegi, Herba Taraxaci, Radix Glycyrrhizae, Rhizoma Polygonati, the Radix Rehmanniae etc.), increasingly B external tincture (Radix Et Caulis Acanthopanacis Senticosi, Folium Ginseng, Fructus Zanthoxyli, Cacumen Platycladi, Rhizoma Chuanxiong, Borneolum Syntheticum), hair growth promoting soup (Radix Rehmanniae Preparata, Fructus Lycii, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae etc.) etc. increasingly, the medical material taste number of their prescriptions is more, and price is also higher.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide a kind of hair growth accelerating Chinese medicine formula, it all has good therapeutical effect to alopecia areata, the type alopecia such as seborrheica, senile.
The technical solution that the present invention realizes foregoing invention is: a kind of hair growth accelerating Chinese medicine formula, with parts by weight, comprises following four taste Chinese medicine ingredients: 50-100 parts of Radixs Polygoni Multiflori, 50-100 parts of Radix Salviae Miltiorrhizaes, 30-50 parts of Radix Rehmanniaes Preparata, 10-30 parts of ZnO.
Beneficial effect of the present invention has:
(1) the present invention has extraordinary therapeutical effect to alopecia areata, the type alopecia such as seborrheica, senile, and existing medicine is basic only has therapeutical effect to wherein a kind of alopecia;
(2) the present invention not only can stop the development (i.e. anti-avulsion effect) of the alopecia state of an illness, to the position of alopecia, also there is good stimulating hair regeneration, and existing medicine, particularly chemical drugs, generally only have anti-avulsion effect, there is no stimulating hair regeneration;
(3) formula of the present invention, particularly makes ointment, through rabbit skin toxicology test, shows no skin irritation, and Clinical practice does not find to have zest to application on human skin yet.
(4) simply, price is low for formula of the present invention and processing technique.
Detailed description of the invention
Preparation technology of the present invention and therapeutic effect is further illustrated below in conjunction with embodiment.
Embodiment 1
The oily molten thing administration of direct use:
(1) proportionally taken by above-mentioned four Chinese medicine material, with parts by weight, the Radix Polygoni Multiflori 100 parts, Radix Salviae Miltiorrhizae 50 parts, 30 parts, Radix Rehmanniae Preparata, ZnO30 part, pulverize with pulverizer after mixing;
(2) measure the Oleum Brassicae campestris of twice medical material volume, heating by electric cooker to oil slightly boils 100 DEG C;
(3) add medicinal powder, continue heating until oil boiling;
(4) extract after two hours, filter and remove residue, oily molten thing is stored in a bottle with cap, saves backup in 4 DEG C of refrigerators;
(5) slough the hair in rabbit back of the body 2cm*2cm region with 10% sodium sulfide, then smear epilating area with oily molten thing, high dose group each medication 0.5g medical material, low dose group each medication 0.25g medical material, every day smears twice; 4th, within 7,10,12,16,20 days, the length growing virgin wool is measured respectively, high dose group average out to 0.75,1.76,2.58,5.27,7.41,14.99 millimeters, low dose group average out to 0.65,1.61,2.22,4.99,6.71,14.27 millimeters, blank is 0.45,0.62,1.16,1.35,2.82,5.33 millimeter, data analysis shows, from the 7th day, low dose group, high dose group were compared with blank, and the length of virgin wool has significant difference;
(6) according to the dosage injection rabbit of Testosterone Propionate 2.5ml/kg, modeling 30 days, within 31st day, slough a hair in rabbit back 2cm*2cm region with 10% sodium sulfide, then epilating area is smeared with oily molten thing, high dose group each medication 0.5g medical material, low dose group each medication 0.25g medical material, every day smears twice; 4th, within 7,10,12,16,20 days, the length growing virgin wool is measured respectively, high dose group average out to 0.73,1.04,1.57,2.57,4.80,9.49 millimeters, low dose group average out to 0.71,0.92,1.37,2.27,4.48,8.53 millimeter, blank is 0.39,0.45,0.66,1.16,2.35,3.47 millimeter, data analysis shows, from the 7th day, low dose group, high dose group were compared with blank, and the length of virgin wool has significant difference;
(7) to 10 routine alopecia areatas, 15 routine seborrheic alopecia, 6 routine senile alopecia patients, according to every day, the medical material of 10g applies oil molten thing, medication 30 days, and anti-avulsion rate and hair growth promoting rate all reach 100%.
Embodiment 2
The oily molten thing administration of direct use:
(1) proportionally taken by above-mentioned four Chinese medicine material, with parts by weight, the Radix Polygoni Multiflori 75 parts, Radix Salviae Miltiorrhizae 90 parts, 40 parts, Radix Rehmanniae Preparata, ZnO20 part, pulverize with pulverizer after mixing;
(2) measure the Oleum Brassicae campestris of twice medical material volume, water-bath is heated to 80 DEG C;
(3) add medicinal powder, water-bath continues heating until 100 DEG C;
(4) extract after two hours, filter and remove residue, oily molten thing is stored in a bottle with cap, saves backup in 4 DEG C of refrigerators;
(5) according to the dosage injection rabbit of Testosterone Propionate 2.5ml/kg, modeling 30 days, within 31st day, slough a hair in rabbit back 2cm*2cm region with 10% sodium sulfide, then epilating area is smeared with oily molten thing, high dose group each medication 0.5g medical material, low dose group each medication 0.25g medical material, every day smears twice; 4th, within 7,10,12,16,20 days, the length growing virgin wool is measured respectively, high dose group average out to 0.67,1.00,1.45,2.49,4.71,9.40 millimeters, low dose group average out to 0.63,0.90,1.31,2.18,4.41,8.45 millimeter, blank is 0.40,0.46,0.67,1.14,2.33,3.46 millimeter, data analysis shows, from the 7th day, low dose group, high dose group were compared with blank, and the length of virgin wool has significant difference;
(6) to 12 routine alopecia areatas, 16 routine seborrheic alopecia, 8 routine senile alopecia patients, according to every day, the medical material of 10g applies oil molten thing, medication 30 days, and anti-avulsion rate and hair growth promoting rate all reach 100%.
Embodiment 3:
The molten thing of oil makes ointment administration:
(1) proportionally taken by above-mentioned four Chinese medicine material, with parts by weight, the Radix Polygoni Multiflori 50 parts, Radix Salviae Miltiorrhizae 100 parts, 50 parts, Radix Rehmanniae Preparata, ZnO10 part, pulverize with pulverizer after mixing;
(2) with the dehydrated alcohol of 8 times, 75 DEG C of reflux, extract, 6 hours;
(3) extract 3 times altogether, merge extractive liquid;
(4) prescription adding to 1000ml according to tristerin 70g, stearic acid 100g, white vaseline 120g, Chinese medicine ethanol extract 20g, liquid Paraffin 100g, glycerol 120g, sodium lauryl sulphate 10g, distilled water prepares ointment;
(5) slough the hair in rabbit back of the body 2cm*2cm region with 10% sodium sulfide, then smear epilating area, high dose group each medication 0.5g medical material, low dose group each medication 0.25g medical material with obtained ointment, every day smears twice; 4th, within 7,10,12,16,20 days, the length growing virgin wool is measured respectively, high dose group average out to 1.14,1.62,3.62,4.85,8.63,13.82 millimeters, low dose group average out to 0.70,1.29,3.43,4.23,8.02,12.61 millimeters, blank is 0.58,0.68,0.85,1.91,3.72,5.04 millimeter, data analysis shows, from the 7th day, low dose group, high dose group were compared with blank, and the length of virgin wool has significant difference;
(6) according to the dosage injection rabbit of Testosterone Propionate 2.5ml/kg, modeling 30 days, within 31st day, slough a hair in rabbit back 2cm*2cm region with 10% sodium sulfide, then epilating area is smeared with obtained ointment, high dose group each medication 0.5g medical material, low dose group each medication 0.25g medical material, every day smears twice; 4th, within 7,10,12,16,20 days, the length growing virgin wool is measured respectively, high dose group average out to 0.71,1.85,2.31,2.88,5.35,9.71 millimeters, low dose group average out to 0.64,1.71,2.06,2.52,5.05,8.42 millimeters, blank is 0.40,0.76,0.88,1.09,1.55,3.81 millimeter, data analysis shows, from the 7th day, low dose group, high dose group were compared with blank, and the length of virgin wool has significant difference;
(7) to 12 routine alopecia areatas, 13 routine seborrheic alopecia, 8 routine senile alopecia patients, according to every day, ointment smeared by the medical material of 10g, medication 30 days, and anti-avulsion rate and hair growth promoting rate all reach 100%.
Embodiment 4
The molten thing of oil makes ointment administration:
(1) proportionally taken by above-mentioned four Chinese medicine material, with parts by weight, the Radix Polygoni Multiflori 85 parts, Radix Salviae Miltiorrhizae 70 parts, 35 parts, Radix Rehmanniae Preparata, ZnO30 part, pulverize with pulverizer after mixing;
(2) with the dehydrated alcohol of 8 times, 75 DEG C of reflux, extract, 6 hours;
(3) extract 3 times altogether, merge extractive liquid;
(4) prescription adding to 1000ml according to tristerin 70g, stearic acid 100g, white vaseline 120g, Chinese medicine ethanol extract 20g, liquid Paraffin 100g, glycerol 120g, sodium lauryl sulphate 10g, distilled water prepares ointment;
(5) according to the dosage injection rabbit of Testosterone Propionate 2.5ml/kg, modeling 30 days, within 31st day, slough a hair in rabbit back 2cm*2cm region with 10% sodium sulfide, then epilating area is smeared with obtained ointment, high dose group each medication 0.5g medical material, low dose group each medication 0.25g medical material, every day smears twice; 4th, within 7,10,12,16,20 days, the length growing virgin wool is measured respectively, high dose group average out to 0.78,1.92,2.43,2.95,5.46,9.85 millimeters, low dose group average out to 0.69,1.75,2.15,2.58,5.16,8.55 millimeters, blank is 0.41,0.77,0.90,1.08,1.56,3.80 millimeter, data analysis shows, from the 7th day, low dose group, high dose group were compared with blank, and the length of virgin wool has significant difference;
(6) to 13 routine alopecia areatas, 13 routine seborrheic alopecia, 10 routine senile alopecia patients, according to every day, ointment smeared by the medical material of 10g, medication 30 days, and anti-avulsion rate and hair growth promoting rate all reach 100%.
Claims (1)
1. a hair growth accelerating Chinese medicine, is characterized in that: with parts by weight, is made up: 50-100 parts of Radixs Polygoni Multiflori, 50-100 parts of Radix Salviae Miltiorrhizaes, 30-50 parts of Radix Rehmanniaes Preparata, 10-30 parts of ZnO of following four taste Chinese medicine ingredients.
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| CN105560998A (en) * | 2016-01-27 | 2016-05-11 | 邓发良 | Hair-loss-preventing and hair-restoring traditional Chinese medicine composition |
| CN108114168A (en) * | 2016-11-30 | 2018-06-05 | 邓炳章 | A kind of Chinese medicine composition for treating alopecia seborrheica |
| CN112656872A (en) * | 2021-01-26 | 2021-04-16 | 忧立舒医药科技(广东)有限公司 | Plant alopecia stopping and hair growing liquid as well as preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1219407A (en) * | 1997-12-12 | 1999-06-16 | 周广刚 | Huofasu of fleece flower root |
| CN1682881A (en) * | 2005-02-23 | 2005-10-19 | 广州固志医药科技开发有限公司 | Chinese medicine composition for treating baldness and its preparing method |
| CN102357145A (en) * | 2011-10-27 | 2012-02-22 | 艾志 | Externally applied ointment for treating baldness |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1219407A (en) * | 1997-12-12 | 1999-06-16 | 周广刚 | Huofasu of fleece flower root |
| CN1682881A (en) * | 2005-02-23 | 2005-10-19 | 广州固志医药科技开发有限公司 | Chinese medicine composition for treating baldness and its preparing method |
| CN102357145A (en) * | 2011-10-27 | 2012-02-22 | 艾志 | Externally applied ointment for treating baldness |
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Effective date of registration: 20201221 Address after: 2-18-202, Longshan Road, Xinwu District, Wuxi City, Jiangsu Province, 214000 Patentee after: Zhonghuan Health Technology Co.,Ltd. Address before: 313000 East Second Ring Road 759, Huzhou City, Wuxing District, Huzhou City, Zhejiang Province Patentee before: HUZHOU TEACHERS College |