CN104922611A - Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating arrhythmia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating arrhythmia. The traditional Chinese medicine composition is prepared by medical materials mainly comprising, by weight, 30 parts of concha haliotidis, 10-20 parts of dried radix rehmanniae, 15-25 parts of apocynum venetum, 5-25 parts of leeches, 15-25 parts of divaricate saposhnikovia roots, 12-24 parts of caulis spatholobi, 10-30 parts of rhizoma alismatis, 10-30 parts of lotus leaves, 10-20 parts of hard rush, 15-35 parts of roots of common peony, 20-30 parts of rhizoma acori graminei, 15-35 parts of wintergreen, 10-30 parts of curcuma zedoary and 5-15 parts of rhodiola rosea. The invention further provides a preparation method of the traditional Chinese medicine composition for treating arrhythmia. Compared with the prior art, the traditional Chinese medicine composition for treating arrhythmia is low in cost, simple in technology, capable of effectively treating arrhythmia and lowering recurrence rate, and capable of effectively obviously reducing side effects of chemical medicine treatment.
Description
Technical field
The present invention relates to one and treat ARR Chinese medicine composition and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.
Background technology
The rhythm of the heart caused by the origin of heart excitement or conduction abnormalities or alteration in heart rate are arrhythmia, and this is one of clinical modal Cardiovasculai appearance in patient.The clinical features of patients with arrhythmia differs; the lighter can without any discomfort; occasionally be found in time having a medical check-up; once scholar was had to observe the dynamic electrocardiogram that the heart of normal person carries out 24 hours; there is premature beat in the normal person finding that there is about 70%; but all without any clinical symptoms, and the clinical manifestation such as severe patient has dizziness, amaurosis, faints, blood pressure drops, jeopardize patient vitals.Arrhythmia belongs to the cardiopalmus category of the traditional Chinese medical science.A kind of symptom that cardiopalmus refers to the conscious palpitation of patient, nervous uneasiness even can not be autonomous.Be similar in modern medicine due to arrhythmia that heart failure, rheumatic heart disease, viral myocarditis etc. cause.The main cause of cardiopalmus is caused to be the obstacle of blood vessels operation and the exception of feelings will thinking.Theory of Chinese medical science is thought, heart governing blood and vessels, the normal rhythm of the heart and blood circulation, and the relative equilibrium that must rely on the heart-yin heart-yang maintains, if the heart-yin heart-yang can not be protected.
At present, the ARR medicine of existing treatment, great majority are chemical medicine, often easily recur, and side effect are large.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides and a kind ofly treat ARR Chinese medicine composition and preparation method thereof.
Technical scheme: for achieving the above object, the invention provides one and treats ARR Chinese medicine composition, its primarily of following weight portion crude drug made by:
Concha Haliotidis 30 parts, Radix Rehmanniae 10-20 part, Herba Apocyni veneti 15-25 part, Hirudo 5-25 part, Radix Saposhnikoviae 15-25 part,
Caulis Spatholobi 12-24 part, Rhizoma Alismatis 10-30 part, Folium Nelumbinis 10-30 part, Medulla Junci 10-20 part, Radix Paeoniae Rubra 15-35 part,
Rhizoma Acori Graminei 20-30 part, Herba pyrolae japonicae 15-35 part, Rhizoma Curcumae 10-30 part, Radix Rhodiolae 5-15 part.
As preferably, the ARR Chinese medicine composition of described treatment is mainly made by the crude drug of following weight portion:
Concha Haliotidis 30 parts, Radix Rehmanniae 12-18 part, Herba Apocyni veneti 18-22 part, Hirudo 10-20 part, Radix Saposhnikoviae 18-22 part,
Caulis Spatholobi 16-20 part, Rhizoma Alismatis 15-25 part, Folium Nelumbinis 15-25 part, Medulla Junci 12-18 part, Radix Paeoniae Rubra 20-30 part,
Rhizoma Acori Graminei 22-28 part, Herba pyrolae japonicae 20-30 part, Rhizoma Curcumae 15-25 part, Radix Rhodiolae 8-12 part.
Preferred as another kind, the ARR Chinese medicine composition of described treatment is mainly made by the crude drug of following weight portion:
Concha Haliotidis 30 parts, 15 parts, the Radix Rehmanniae, Herba Apocyni veneti 20 parts, Hirudo 15 parts, Radix Saposhnikoviae 20 parts,
Caulis Spatholobi 18 parts, Rhizoma Alismatis 20 parts, 20 parts, Folium Nelumbinis, Medulla Junci 15 parts, Radix Paeoniae Rubra 25 parts,
Rhizoma Acori Graminei 25 parts, Herba pyrolae japonicae 25 parts, Rhizoma Curcumae 20 parts, Radix Rhodiolae 10 parts.
Present invention also offers the preparation method of the ARR Chinese medicine composition of described treatment, comprise the following steps:
(1) take Concha Haliotidis, the Radix Rehmanniae, Hirudo, Rhizoma Alismatis, Radix Paeoniae Rubra and Rhizoma Curcumae in proportion, add the 60-80% alcohol reflux 2 times of 6-10 times of body, each 1-3 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) Herba Apocyni veneti, Radix Saposhnikoviae, Caulis Spatholobi, Folium Nelumbinis, Medulla Junci, Rhizoma Acori Graminei, Herba pyrolae japonicae and Radix Rhodiolae is taken in proportion, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 8-12 times of volume, each 1-3 hour, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, 80-90 DEG C of heating 2-4h, be cooled to 1-5 DEG C rapidly, place 48-72h at this temperature, obtain aftertreatment fluid;
(4) above-mentioned aftertreatment fluid is filtered, be condensed into total extractum that relative density is 1.10-1.16, obtain final product.
As preferably, described total extractum conventionally makes liquid preparation or solid preparation.
As preferred further, described liquid preparation is decoction or oral liquid.
As preferred further, described solid preparation is granule, powder, tablet, pill or capsule.
Beneficial effect: relative to prior art, the Chinese medicine composition that the treatment of gained of the present invention is ARR, cost is low, and technique is simple, effectively can not only treat arrhythmia, reduces relapse rate, significantly can also reduce the side effect of chemical medicine treatment.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1
Prescription:
Concha Haliotidis 30g, Radix Rehmanniae 10g, Herba Apocyni veneti 15g, Hirudo 5g, Radix Saposhnikoviae 15g,
Caulis Spatholobi 12g, Rhizoma Alismatis 10g, Folium Nelumbinis 10g, Medulla Junci 10g, Radix Paeoniae Rubra 15g,
Rhizoma Acori Graminei 20g, Herba pyrolae japonicae 15g, Rhizoma Curcumae 10g, Radix Rhodiolae 5g.
Preparation technology:
(1) take Concha Haliotidis, the Radix Rehmanniae, Hirudo, Rhizoma Alismatis, Radix Paeoniae Rubra and Rhizoma Curcumae in proportion, add 60% alcohol reflux 1 time of 6 times of volumes, each 1 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) Herba Apocyni veneti, Radix Saposhnikoviae, Caulis Spatholobi, Folium Nelumbinis, Medulla Junci, Rhizoma Acori Graminei, Herba pyrolae japonicae and Radix Rhodiolae is taken in proportion, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 1 time of 8 times of volumes, each 1 hour, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.10, obtain final product.
Conveniently preparation process, makes tablet.
Embodiment 2
Prescription:
Concha Haliotidis 30g, Radix Rehmanniae 20g, Herba Apocyni veneti 25g, Hirudo 25g, Radix Saposhnikoviae 25g,
Caulis Spatholobi 24g, Rhizoma Alismatis 30g, Folium Nelumbinis 30g, Medulla Junci 20g, Radix Paeoniae Rubra 35g,
Rhizoma Acori Graminei 30g, Herba pyrolae japonicae 35g, Rhizoma Curcumae 30g, Radix Rhodiolae 15g.
Preparation technology:
(1) take Concha Haliotidis, the Radix Rehmanniae, Hirudo, Rhizoma Alismatis, Radix Paeoniae Rubra and Rhizoma Curcumae in proportion, add 80% alcohol reflux 3 times of 10 times of volumes, each 3 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) Herba Apocyni veneti, Radix Saposhnikoviae, Caulis Spatholobi, Folium Nelumbinis, Medulla Junci, Rhizoma Acori Graminei, Herba pyrolae japonicae and Radix Rhodiolae is taken in proportion, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 3 times of 12 times of volumes, each 3 hours, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.16, obtain final product.
Conveniently preparation process, makes capsule.
Embodiment 3
Prescription:
Concha Haliotidis 30g, Radix Rehmanniae 15g, Herba Apocyni veneti 20g, Hirudo 15g, Radix Saposhnikoviae 20g,
Caulis Spatholobi 18g, Rhizoma Alismatis 20g, Folium Nelumbinis 20g, Medulla Junci 15g, Radix Paeoniae Rubra 25g,
Rhizoma Acori Graminei 25g, Herba pyrolae japonicae 25g, Rhizoma Curcumae 20g, Radix Rhodiolae 10g.
Preparation technology:
(1) take Concha Haliotidis, the Radix Rehmanniae, Hirudo, Rhizoma Alismatis, Radix Paeoniae Rubra and Rhizoma Curcumae in proportion, add 70% alcohol reflux 2 times of 8 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) Herba Apocyni veneti, Radix Saposhnikoviae, Caulis Spatholobi, Folium Nelumbinis, Medulla Junci, Rhizoma Acori Graminei, Herba pyrolae japonicae and Radix Rhodiolae is taken in proportion, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 10 times of volumes, each 2 hours, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.13, obtain final product.
Conveniently preparation process, makes pill.
Embodiment 4
Prescription:
Concha Haliotidis 30g, Radix Rehmanniae 12g, Herba Apocyni veneti 18g, Hirudo 10g, Radix Saposhnikoviae 18g,
Caulis Spatholobi 16g, Rhizoma Alismatis 15g, Folium Nelumbinis 15g, Medulla Junci 12g, Radix Paeoniae Rubra 20g,
Rhizoma Acori Graminei 22g, Herba pyrolae japonicae 20g, Rhizoma Curcumae 15g, Radix Rhodiolae 8g.
Preparation technology:
(1) take Concha Haliotidis, the Radix Rehmanniae, Hirudo, Rhizoma Alismatis, Radix Paeoniae Rubra and Rhizoma Curcumae in proportion, add 65% alcohol reflux 2 times of 7 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) Herba Apocyni veneti, Radix Saposhnikoviae, Caulis Spatholobi, Folium Nelumbinis, Medulla Junci, Rhizoma Acori Graminei, Herba pyrolae japonicae and Radix Rhodiolae is taken in proportion, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 9 times of volumes, each 2 hours, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.12, obtain final product.
Conveniently preparation process, makes granule.
Embodiment 5
Prescription:
Concha Haliotidis 30g, Radix Rehmanniae 18g, Herba Apocyni veneti 22g, Hirudo 20g, Radix Saposhnikoviae 22g,
Caulis Spatholobi 20g, Rhizoma Alismatis 25g, Folium Nelumbinis 25g, Medulla Junci 18g, Radix Paeoniae Rubra 30g,
Rhizoma Acori Graminei 28g, Herba pyrolae japonicae 30g, Rhizoma Curcumae 25g, Radix Rhodiolae 12g.
Preparation technology:
(1) take Concha Haliotidis, the Radix Rehmanniae, Hirudo, Rhizoma Alismatis, Radix Paeoniae Rubra and Rhizoma Curcumae in proportion, add 75% alcohol reflux 1 time of 9 times of volumes, each 2 hours, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) Herba Apocyni veneti, Radix Saposhnikoviae, Caulis Spatholobi, Folium Nelumbinis, Medulla Junci, Rhizoma Acori Graminei, Herba pyrolae japonicae and Radix Rhodiolae is taken in proportion, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 11 times of volumes, each 1 hour, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, be condensed into total extractum that relative density is 1.14, obtain final product.
Conveniently preparation process, makes powder.
Reference examples
According to above-described embodiment 3 prescription and preparation technology, remove the step of step (3) heating, rapidly cooling, low temperature placement, finally obtained same pill.
The ARR test of experimental example traditional Chinese medicine composition for treating of the present invention
1, Therapeutic Method
Carry out clinical diagnosis with reference to the diagnosis basis in " Chinese medical disease Standardization of diagnosis and curative effect ", choose 210 routine patients with arrhythmia, age 40-72 year, 54.8 years old mean age.
210 routine patients are divided into 5 groups at random, often organize 42 people, be respectively blank group, matched group, treatment 1 group, treat 2 groups and treatment 3 groups;
Blank group only carries out chemical medicine treatment, and patient uses procamide sheet (Beijing Double-Crane Pharmaceutical Co., Ltd's production), and using method uses to specifications;
Matched group, on the basis of blank group Therapeutic Method, uses above-mentioned reference examples products obtained therefrom, and consumption is with treatment 1 group.
Treat 1 group, treat 2 groups and treatment 3 groups on the basis of blank group Therapeutic Method, use the embodiment of the present invention 3,4 and 5 products obtained therefrom.(in embodiment, the amount of prescription is the consumption of every day)
January is 1 course for the treatment of, often organizes three courses for the treatment of of treatment.
2, therapeutic outcome
Total effective rate=healing, effective and effective total number of cases/total case load.
Relapse rate=recurrent cases number/total case load
Side effect comprises dizziness, nauseating, dizzy, vomiting, diarrhoea etc.
Table 1 respectively organizes patient treatment outcome
Note: compared with blank group, * P<0.05; Compared with matched group, #P<0.05.
Can be obtained by upper table 1 result, compare blank group, the embodiment of the present invention 3,4 and 5 products obtained therefrom, significantly improve, and rate of side effects and relapse rate all significantly reduces for ARR treatment total effective rate.
In addition, compared with matched group, the embodiment of the present invention 3,4 and 5 products obtained therefrom, also significantly improve, and rate of side effects and relapse rate also all significantly reduces for ARR treatment total effective rate.
Claims (7)
1. treat an ARR Chinese medicine composition, it is characterized in that, its primarily of following weight portion crude drug made by:
Concha Haliotidis 30 parts, Radix Rehmanniae 10-20 part, Herba Apocyni veneti 15-25 part, Hirudo 5-25 part, Radix Saposhnikoviae 15-25 part,
Caulis Spatholobi 12-24 part, Rhizoma Alismatis 10-30 part, Folium Nelumbinis 10-30 part, Medulla Junci 10-20 part, Radix Paeoniae Rubra 15-35 part,
Rhizoma Acori Graminei 20-30 part, Herba pyrolae japonicae 15-35 part, Rhizoma Curcumae 10-30 part, Radix Rhodiolae 5-15 part.
2. the ARR Chinese medicine composition for the treatment of according to claim 1, is characterized in that, it is mainly made by the crude drug of following weight portion:
Concha Haliotidis 30 parts, Radix Rehmanniae 12-18 part, Herba Apocyni veneti 18-22 part, Hirudo 10-20 part, Radix Saposhnikoviae 18-22 part,
Caulis Spatholobi 16-20 part, Rhizoma Alismatis 15-25 part, Folium Nelumbinis 15-25 part, Medulla Junci 12-18 part, Radix Paeoniae Rubra 20-30 part,
Rhizoma Acori Graminei 22-28 part, Herba pyrolae japonicae 20-30 part, Rhizoma Curcumae 15-25 part, Radix Rhodiolae 8-12 part.
3. the ARR Chinese medicine composition for the treatment of according to claim 1, is characterized in that, it is mainly made by the crude drug of following weight portion:
Concha Haliotidis 30 parts, 15 parts, the Radix Rehmanniae, Herba Apocyni veneti 20 parts, Hirudo 15 parts, Radix Saposhnikoviae 20 parts,
Caulis Spatholobi 18 parts, Rhizoma Alismatis 20 parts, 20 parts, Folium Nelumbinis, Medulla Junci 15 parts, Radix Paeoniae Rubra 25 parts,
Rhizoma Acori Graminei 25 parts, Herba pyrolae japonicae 25 parts, Rhizoma Curcumae 20 parts, Radix Rhodiolae 10 parts.
4. treat the preparation method of ARR Chinese medicine composition described in any one of claim 1-3, it is characterized in that, comprise the following steps:
(1) take Concha Haliotidis, the Radix Rehmanniae, Hirudo, Rhizoma Alismatis, Radix Paeoniae Rubra and Rhizoma Curcumae in proportion, add the 60-80% alcohol reflux 2 times of 6-10 times of body, each 1-3 hour, merge extractive liquid, reclaim ethanol to without alcohol taste, obtain extracting solution A;
(2) Herba Apocyni veneti, Radix Saposhnikoviae, Caulis Spatholobi, Folium Nelumbinis, Medulla Junci, Rhizoma Acori Graminei, Herba pyrolae japonicae and Radix Rhodiolae is taken in proportion, merge with residue after the alcohol extraction of step (1) gained, add the water reflux, extract, 2 times of 8-12 times of volume, each 1-3 hour, merge extractive liquid, obtains extracting solution B;
(3) merge said extracted liquid A and extracting solution B, 80-90 DEG C of heating 2-4h, be cooled to 1-5 DEG C rapidly, place 48-72h at this temperature, obtain aftertreatment fluid;
(4) above-mentioned aftertreatment fluid is filtered, be condensed into total extractum that relative density is 1.10-1.16, obtain final product.
5. treat the preparation method of ARR Chinese medicine composition according to claim 4, it is characterized in that, described total extractum conventionally makes liquid preparation or solid preparation.
6. treat the preparation method of ARR Chinese medicine composition according to claim 5, it is characterized in that, described liquid preparation is decoction or oral liquid.
7. treat the preparation method of ARR Chinese medicine composition according to claim 5, it is characterized in that, described solid preparation is granule, powder, tablet, pill or capsule.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075118A (en) * | 2016-06-29 | 2016-11-09 | 江苏苏南药业实业有限公司 | ARR Chinese medicine composition of a kind of prevention and preparation method thereof |
| CN106138970A (en) * | 2016-08-26 | 2016-11-23 | 闫福林 | One treats ARR Chinese medicine composition |
| CN106344606A (en) * | 2016-11-01 | 2017-01-25 | 侯建生 | Medical applications and administration route for ozonized oil |
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| CN101653528A (en) * | 2008-08-20 | 2010-02-24 | 桂林三金药业股份有限公司 | Use of Chinese medicinal composition in preparation of medicaments for inhibiting cell apoptosis |
| CN104117020A (en) * | 2014-08-01 | 2014-10-29 | 范广慈 | Traditional Chinese medicinal formula for treating atrial fibrillation |
| CN104208415A (en) * | 2014-08-16 | 2014-12-17 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treatment of arrhythmia |
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2015
- 2015-07-17 CN CN201510424631.0A patent/CN104922611B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653528A (en) * | 2008-08-20 | 2010-02-24 | 桂林三金药业股份有限公司 | Use of Chinese medicinal composition in preparation of medicaments for inhibiting cell apoptosis |
| CN104117020A (en) * | 2014-08-01 | 2014-10-29 | 范广慈 | Traditional Chinese medicinal formula for treating atrial fibrillation |
| CN104208415A (en) * | 2014-08-16 | 2014-12-17 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treatment of arrhythmia |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075118A (en) * | 2016-06-29 | 2016-11-09 | 江苏苏南药业实业有限公司 | ARR Chinese medicine composition of a kind of prevention and preparation method thereof |
| CN106138970A (en) * | 2016-08-26 | 2016-11-23 | 闫福林 | One treats ARR Chinese medicine composition |
| CN106344606A (en) * | 2016-11-01 | 2017-01-25 | 侯建生 | Medical applications and administration route for ozonized oil |
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