CN104922611B - A kind of Chinese medicine composition for treating arrhythmia cordis and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating arrhythmia cordis and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of Chinese medicine composition for treating arrhythmia cordis, mainly as made by the bulk pharmaceutical chemicals of following parts by weight：30 parts of the shell of seaear, 10 20 parts of Radix Rehmanniae, 15 25 parts of bluish dogbane, 5 25 parts of leech, 15 25 parts windproof, 12 24 parts of Caulis Spatholobi, 10 30 parts of rhizoma alismatis, 10 30 parts of lotus leaf, 10 20 parts of rush, 15 35 parts of the radix paeoniae rubrathe, 20 30 parts of grass-leaved sweetflag, 15 35 parts of wintergreen, 10 30 parts of curcuma zedoary, 5 15 parts of rhodiola root.The present invention also provides the preparation methods of the treatment arrhythmia cordis Chinese medicine composition.Compared with prior art, the treatment arrhythmia cordis Chinese medicine composition of present invention gained, it is at low cost, it is simple for process, arrhythmia cordis can not only be effectively treated, reduces recurrence rate, moreover it is possible to significantly reduce the side effect of chemical drug treatment.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions for treating arrhythmia cordis and preparation method thereof, belong to Chinese medicine preparation technology neck
Domain.
Background technology
The rhythm of the heart or alteration in heart rate caused by the origin of heart excitement or conduction abnormalities arrhythmia cordis, this be it is clinical most
One of common Cardiovasculai appearance in patient.The clinical features of patients with arrhythmia differ, and the lighter can be even in physical examination without any discomfort
When be found, once have scholar to normal human heart carry out 24 it is small when dynamic electrocardiogram observe, find have 70% or so it is normal
There is premature beat in people, but without any clinical symptoms, and severe patient has the clinical manifestations such as dizziness, amaurosis, syncope, blood pressure decline, danger
And patient vitals.Arrhythmia cordis belongs to the palpitaition scope of the traditional Chinese medical science.Palpitaition refers to that patient feels palpitation, nervous uneasiness not even
A kind of autonomous symptom of energy.Similar in modern medicine since heart failure, rheumatic heart disease, vital myocarditis etc. cause
Arrhythmia cordis.The main reason for causing palpitaition is the obstacle of blood vessels operation and the exception of feelings will thinking.Theory of traditional Chinese medical science thinks, the heart
Controlling blood and vessel, the normal rhythm of the heart and blood circulation, it is necessary to the relative equilibrium of the heart-yin heart-yang is relied on to maintain, if the heart-yin heart-yang cannot
It protects.
At present, the drug of existing treatment arrhythmia cordis, most of is chemical drug, tends to recur, and side effect is big.
The content of the invention
Goal of the invention：In order to overcome the deficiencies in the prior art, the present invention provides a kind of arrhythmia cordis for the treatment of
Chinese medicine composition and preparation method thereof.
Technical solution：To achieve the above object, the present invention provides a kind of Chinese medicine composition for treating arrhythmia cordis, masters
It will be as made by the bulk pharmaceutical chemicals of following parts by weight：
30 parts of the shell of seaear, 10-20 parts of Radix Rehmanniae, 15-25 parts of bluish dogbane, 5-25 parts of leech, it is 15-25 parts windproof,
12-24 parts of Caulis Spatholobi, 10-30 parts of rhizoma alismatis, 10-30 parts of lotus leaf, 10-20 parts of rush, 15-35 parts of the radix paeoniae rubrathe,
20-30 parts of grass-leaved sweetflag, 15-35 parts of wintergreen, 10-30 parts of curcuma zedoary, 5-15 parts of rhodiola root.
Preferably, the Chinese medicine composition of the treatment arrhythmia cordis is mainly made by the bulk pharmaceutical chemicals of following parts by weight
Into：
30 parts of the shell of seaear, 12-18 parts of Radix Rehmanniae, 18-22 parts of bluish dogbane, 10-20 parts of leech, it is 18-22 parts windproof,
16-20 parts of Caulis Spatholobi, 15-25 parts of rhizoma alismatis, 15-25 parts of lotus leaf, 12-18 parts of rush, 20-30 parts of the radix paeoniae rubrathe,
22-28 parts of grass-leaved sweetflag, 20-30 parts of wintergreen, 15-25 parts of curcuma zedoary, 8-12 parts of rhodiola root.
As another preferred embodiment, the Chinese medicine composition of the treatment arrhythmia cordis is mainly the raw material by following parts by weight
Made by medicine：
30 parts of the shell of seaear, 15 parts of Radix Rehmanniae, 20 parts of bluish dogbane, 15 parts of leech, it is 20 parts windproof,
18 parts of Caulis Spatholobi, 20 parts of rhizoma alismatis, 20 parts of lotus leaf, 15 parts of rush, 25 parts of the radix paeoniae rubrathe,
25 parts of grass-leaved sweetflag, 25 parts of wintergreen, 20 parts of curcuma zedoary, 10 parts of rhodiola root.
The present invention also provides the preparation methods of the Chinese medicine composition of the treatment arrhythmia cordis, comprise the following steps：
(1) shell of seaear, Radix Rehmanniae, leech, rhizoma alismatis, the radix paeoniae rubrathe and curcuma zedoary are weighed in proportion, add in the 60-80% second of 6-10 times of body
Alcohol reflux extracts 2 times, when each 1-3 is small, merges extracting solution, recycling ethyl alcohol obtains extracting solution A to no alcohol taste；
(2) bluish dogbane, windproof, Caulis Spatholobi, lotus leaf, rush, grass-leaved sweetflag, wintergreen and rhodiola root are weighed in proportion, with
Residue merges after alcohol extracting obtained by step (1), adds in the water refluxing extraction 2 times of 8-12 times of volume, and when each 1-3 is small, merging carries
Liquid is taken, obtains extracting solution B；
(3) said extracted liquid A and extracting solution B is merged, 80-90 DEG C of heating 2-4h is rapidly cooled to 1-5 DEG C, at a temperature of this
48-72h is placed, obtains aftertreatment fluid；
(4) above-mentioned aftertreatment fluid is filtered, be condensed into relative density be 1.10-1.16 total medicinal extract to get.
Preferably, liquid preparation or solid pharmaceutical preparation is conventionally made in total medicinal extract.
As further preferred, the liquid preparation is decoction or oral liquid.
As further preferred, the solid pharmaceutical preparation is granule, powder, tablet, pill or capsule.
Advantageous effect：Compared with the prior art, the Chinese medicine composition of the treatment arrhythmia cordis of present invention gained, cost
It is low, it is simple for process, arrhythmia cordis can not only be effectively treated, reduces recurrence rate, moreover it is possible to significantly reduce the side effect of chemical drug treatment.
Specific embodiment
The present invention is further described with reference to embodiment.
Embodiment 1
Prescription：
Shell of seaear 30g, Radix Rehmanniae 10g, bluish dogbane 15g, leech 5g, windproof 15g,
Caulis Spatholobi 12g, rhizoma alismatis 10g, lotus leaf 10g, rush 10g, radix paeoniae rubrathe 15g,
Grass-leaved sweetflag 20g, wintergreen 15g, curcuma zedoary 10g, rhodiola root 5g.
Preparation process：
(1) shell of seaear, Radix Rehmanniae, leech, rhizoma alismatis, the radix paeoniae rubrathe and curcuma zedoary are weighed in proportion, and 60% ethyl alcohol for adding in 6 times of volumes returns
Stream extraction 1 time, every time 1 it is small when, merge extracting solution, recycling ethyl alcohol to no alcohol taste, obtain extracting solution A；
(2) bluish dogbane, windproof, Caulis Spatholobi, lotus leaf, rush, grass-leaved sweetflag, wintergreen and rhodiola root are weighed in proportion, with
Residue merges after alcohol extracting obtained by step (1), adds in the water refluxing extraction 1 time of 8 times of volumes, every time 1 it is small when, merge extracting solution,
Obtain extracting solution B；
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density be 1.10 total medicinal extract to get.
According to conventional formulation technique, tablet is made.
Embodiment 2
Prescription：
Shell of seaear 30g, Radix Rehmanniae 20g, bluish dogbane 25g, leech 25g, windproof 25g,
Caulis Spatholobi 24g, rhizoma alismatis 30g, lotus leaf 30g, rush 20g, radix paeoniae rubrathe 35g,
Grass-leaved sweetflag 30g, wintergreen 35g, curcuma zedoary 30g, rhodiola root 15g.
Preparation process：
(1) shell of seaear, Radix Rehmanniae, leech, rhizoma alismatis, the radix paeoniae rubrathe and curcuma zedoary are weighed in proportion, add in 80% ethyl alcohol of 10 times of volumes
Refluxing extraction 3 times, every time 3 it is small when, merge extracting solution, recycling ethyl alcohol to no alcohol taste, obtain extracting solution A；
(2) bluish dogbane, windproof, Caulis Spatholobi, lotus leaf, rush, grass-leaved sweetflag, wintergreen and rhodiola root are weighed in proportion, with
Residue merges after alcohol extracting obtained by step (1), adds in the water refluxing extraction 3 times of 12 times of volumes, every time 3 it is small when, merge extracting solution,
Obtain extracting solution B；
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density be 1.16 total medicinal extract to get.
According to conventional formulation technique, capsule is made.
Embodiment 3
Prescription：
Shell of seaear 30g, Radix Rehmanniae 15g, bluish dogbane 20g, leech 15g, windproof 20g,
Caulis Spatholobi 18g, rhizoma alismatis 20g, lotus leaf 20g, rush 15g, radix paeoniae rubrathe 25g,
Grass-leaved sweetflag 25g, wintergreen 25g, curcuma zedoary 20g, rhodiola root 10g.
Preparation process：
(1) shell of seaear, Radix Rehmanniae, leech, rhizoma alismatis, the radix paeoniae rubrathe and curcuma zedoary are weighed in proportion, and 70% ethyl alcohol for adding in 8 times of volumes returns
Stream extraction 2 times, every time 2 it is small when, merge extracting solution, recycling ethyl alcohol to no alcohol taste, obtain extracting solution A；
(2) bluish dogbane, windproof, Caulis Spatholobi, lotus leaf, rush, grass-leaved sweetflag, wintergreen and rhodiola root are weighed in proportion, with
Residue merges after alcohol extracting obtained by step (1), adds in the water refluxing extraction 2 times of 10 times of volumes, every time 2 it is small when, merge extracting solution,
Obtain extracting solution B；
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density be 1.13 total medicinal extract to get.
According to conventional formulation technique, pill is made.
Embodiment 4
Prescription：
Shell of seaear 30g, Radix Rehmanniae 12g, bluish dogbane 18g, leech 10g, windproof 18g,
Caulis Spatholobi 16g, rhizoma alismatis 15g, lotus leaf 15g, rush 12g, radix paeoniae rubrathe 20g,
Grass-leaved sweetflag 22g, wintergreen 20g, curcuma zedoary 15g, rhodiola root 8g.
Preparation process：
(1) shell of seaear, Radix Rehmanniae, leech, rhizoma alismatis, the radix paeoniae rubrathe and curcuma zedoary are weighed in proportion, and 65% ethyl alcohol for adding in 7 times of volumes returns
Stream extraction 2 times, every time 2 it is small when, merge extracting solution, recycling ethyl alcohol to no alcohol taste, obtain extracting solution A；
(2) bluish dogbane, windproof, Caulis Spatholobi, lotus leaf, rush, grass-leaved sweetflag, wintergreen and rhodiola root are weighed in proportion, with
Residue merges after alcohol extracting obtained by step (1), adds in the water refluxing extraction 2 times of 9 times of volumes, every time 2 it is small when, merge extracting solution,
Obtain extracting solution B；
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density be 1.12 total medicinal extract to get.
According to conventional formulation technique, granule is made.
Embodiment 5
Prescription：
Shell of seaear 30g, Radix Rehmanniae 18g, bluish dogbane 22g, leech 20g, windproof 22g,
Caulis Spatholobi 20g, rhizoma alismatis 25g, lotus leaf 25g, rush 18g, radix paeoniae rubrathe 30g,
Grass-leaved sweetflag 28g, wintergreen 30g, curcuma zedoary 25g, rhodiola root 12g.
Preparation process：
(1) shell of seaear, Radix Rehmanniae, leech, rhizoma alismatis, the radix paeoniae rubrathe and curcuma zedoary are weighed in proportion, and 75% ethyl alcohol for adding in 9 times of volumes returns
Stream extraction 1 time, every time 2 it is small when, merge extracting solution, recycling ethyl alcohol to no alcohol taste, obtain extracting solution A；
(2) bluish dogbane, windproof, Caulis Spatholobi, lotus leaf, rush, grass-leaved sweetflag, wintergreen and rhodiola root are weighed in proportion, with
Residue merges after alcohol extracting obtained by step (1), adds in the water refluxing extraction 2 times of 11 times of volumes, every time 1 it is small when, merge extracting solution,
Obtain extracting solution B；
(3) merge said extracted liquid A and extracting solution B, be condensed into relative density be 1.14 total medicinal extract to get.
According to conventional formulation technique, powder is made.
Reference examples
According to 3 prescription of above-described embodiment and preparation process, remove step (3) heating, rapid cooling, the step of low temperature placement
Suddenly, same pill is finally made.
The experiment of experimental example traditional Chinese medicine composition for treating arrhythmia cordis of the present invention
1st, therapy
Reference《Chinese medical disease Standardization of diagnosis and curative effect》In diagnosis basis carry out clinical diagnosis, choose 210 arrhythmia cordis
Patient, age 40-72 Sui, average age 54.8 years old.
210 patients are randomly divided into 5 groups, and every group of 42 people are respectively blank group, control group, 1 group for the treatment of, 2 groups for the treatment of and are controlled
Treat 3 groups；
Blank group only carries out chemical drug treatment, and patient uses procamide piece (the limited public affairs of Beijing Double-Crane Pharmaceutical Co., Ltd share
Department's production), application method uses to specifications；
Control group is on the basis of blank group therapy, and using above-mentioned reference examples products obtained therefrom, dosage is the same as 1 group for the treatment of.
1 group is treated, treat 2 groups and treats 3 groups on the basis of blank group therapy, uses the embodiment of the present invention 3,4
With 5 products obtained therefroms.(amount of prescription is daily dosage in embodiment)
January be 1 course for the treatment of, three courses for the treatment of of every group for the treatment of.
2nd, treatment results
Total effective rate=healing, effective and effective total number of cases/total case load.
Recurrence rate=recurrent cases number/total case load
Side effect includes dizziness, nausea, dizziness, vomiting, diarrhea etc..
1 each group patient treatment outcome of table
Note：Compared with blank group, * P<0.05；Compared with the control group compared with #P<0.05.
It can be obtained by 1 result of upper table, compare blank group, the embodiment of the present invention 3,4 and 5 products obtained therefroms, for arrhythmia cordis
Treatment total effective rate significantly improve, and rate of side effects and recurrence rate significantly reduce.
In addition, compared with the control group compared with the embodiment of the present invention 3,4 and 5 products obtained therefroms always have for the treatment of arrhythmia cordis
Efficiency also significantly improves, and rate of side effects and recurrence rate also significantly reduce.
Claims (7)
1. a kind of Chinese medicine composition for treating arrhythmia cordis, which is characterized in that it is as made by the bulk pharmaceutical chemicals of following parts by weight：
30 parts of the shell of seaear, 10-20 parts of Radix Rehmanniae, 15-25 parts of bluish dogbane, 5-25 parts of leech, it is 15-25 parts windproof,
12-24 parts of Caulis Spatholobi, 10-30 parts of rhizoma alismatis, 10-30 parts of lotus leaf, 10-20 parts of rush, 15-35 parts of the radix paeoniae rubrathe, grass-leaved sweetflag 20-
30 parts, 15-35 parts of wintergreen, 10-30 parts of curcuma zedoary, 5-15 parts of rhodiola root；
The preparation method of the Chinese medicine composition of the treatment arrhythmia cordis comprises the following steps：
(1) shell of seaear, Radix Rehmanniae, leech, rhizoma alismatis, the radix paeoniae rubrathe and curcuma zedoary are weighed in proportion, and the 60-80% ethyl alcohol for adding in 6-10 times of body returns
Stream extraction 2 times when each 1-3 is small, merges extracting solution, and recycling ethyl alcohol obtains extracting solution A to no alcohol taste；
(2) bluish dogbane, windproof, Caulis Spatholobi, lotus leaf, rush, grass-leaved sweetflag, wintergreen and rhodiola root are weighed in proportion, with step
(1) residue merges after the alcohol extracting obtained by, adds in the water refluxing extraction 2 times of 8-12 times of volume, when each 1-3 is small, merges extracting solution,
Obtain extracting solution B；
(3) said extracted liquid A and extracting solution B is merged, 80-90 DEG C of heating 2-4h is rapidly cooled to 1-5 DEG C, places at a temperature of this
48-72h obtains aftertreatment fluid；
(4) above-mentioned aftertreatment fluid is filtered, be condensed into relative density be 1.10-1.16 total medicinal extract to get.
2. the Chinese medicine composition for the treatment of arrhythmia cordis according to claim 1, which is characterized in that it is by following parts by weight
Bulk pharmaceutical chemicals made by：
30 parts of the shell of seaear, 12-18 parts of Radix Rehmanniae, 18-22 parts of bluish dogbane, 10-20 parts of leech, it is 18-22 parts windproof,
16-20 parts of Caulis Spatholobi, 15-25 parts of rhizoma alismatis, 15-25 parts of lotus leaf, 12-18 parts of rush, 20-30 parts of the radix paeoniae rubrathe, grass-leaved sweetflag 22-
28 parts, 20-30 parts of wintergreen, 15-25 parts of curcuma zedoary, 8-12 parts of rhodiola root.
3. the Chinese medicine composition for the treatment of arrhythmia cordis according to claim 1, which is characterized in that it is by following parts by weight
Bulk pharmaceutical chemicals made by：
30 parts of the shell of seaear, 15 parts of Radix Rehmanniae, 20 parts of bluish dogbane, 15 parts of leech, it is 20 parts windproof,
18 parts of Caulis Spatholobi, 20 parts of rhizoma alismatis, 20 parts of lotus leaf, 15 parts of rush, 25 parts of the radix paeoniae rubrathe,
25 parts of grass-leaved sweetflag, 25 parts of wintergreen, 20 parts of curcuma zedoary, 10 parts of rhodiola root.
4. the preparation method of the Chinese medicine composition of any one of the claim 1-3 treatment arrhythmia cordis, which is characterized in that including
Following steps：
(1) shell of seaear, Radix Rehmanniae, leech, rhizoma alismatis, the radix paeoniae rubrathe and curcuma zedoary are weighed in proportion, and the 60-80% ethyl alcohol for adding in 6-10 times of body returns
Stream extraction 2 times when each 1-3 is small, merges extracting solution, and recycling ethyl alcohol obtains extracting solution A to no alcohol taste；
(2) bluish dogbane, windproof, Caulis Spatholobi, lotus leaf, rush, grass-leaved sweetflag, wintergreen and rhodiola root are weighed in proportion, with step
(1) residue merges after the alcohol extracting obtained by, adds in the water refluxing extraction 2 times of 8-12 times of volume, when each 1-3 is small, merges extracting solution,
Obtain extracting solution B；
(3) said extracted liquid A and extracting solution B is merged, 80-90 DEG C of heating 2-4h is rapidly cooled to 1-5 DEG C, places at a temperature of this
48-72h obtains aftertreatment fluid；
(4) above-mentioned aftertreatment fluid is filtered, be condensed into relative density be 1.10-1.16 total medicinal extract to get.
5. the preparation method of the Chinese medicine composition of arrhythmia cordis is treated according to claim 4, which is characterized in that total leaching
Liquid preparation or solid pharmaceutical preparation is conventionally made in cream.
6. the preparation method of the Chinese medicine composition of arrhythmia cordis is treated according to claim 5, which is characterized in that the liquid
Preparation is decoction or oral liquid.
7. the preparation method of the Chinese medicine composition of arrhythmia cordis is treated according to claim 5, which is characterized in that the solid
Preparation is granule, powder, tablet, pill or capsule.
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| CN106075118A (en) * | 2016-06-29 | 2016-11-09 | 江苏苏南药业实业有限公司 | ARR Chinese medicine composition of a kind of prevention and preparation method thereof |
| CN106138970A (en) * | 2016-08-26 | 2016-11-23 | 闫福林 | One treats ARR Chinese medicine composition |
| CN106344606A (en) * | 2016-11-01 | 2017-01-25 | 侯建生 | Medical applications and administration route for ozonized oil |
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| CN101653528A (en) * | 2008-08-20 | 2010-02-24 | 桂林三金药业股份有限公司 | Use of Chinese medicinal composition in preparation of medicaments for inhibiting cell apoptosis |
| CN104117020A (en) * | 2014-08-01 | 2014-10-29 | 范广慈 | Traditional Chinese medicinal formula for treating atrial fibrillation |
| CN104208415A (en) * | 2014-08-16 | 2014-12-17 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treatment of arrhythmia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101653528A (en) * | 2008-08-20 | 2010-02-24 | 桂林三金药业股份有限公司 | Use of Chinese medicinal composition in preparation of medicaments for inhibiting cell apoptosis |
| CN104117020A (en) * | 2014-08-01 | 2014-10-29 | 范广慈 | Traditional Chinese medicinal formula for treating atrial fibrillation |
| CN104208415A (en) * | 2014-08-16 | 2014-12-17 | 济南伟传信息技术有限公司 | Traditional Chinese medicine for treatment of arrhythmia |
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