CN102451366A - Anti-arrhythmia traditional Chinese medicine capsule - Google Patents
Anti-arrhythmia traditional Chinese medicine capsule Download PDFInfo
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Abstract
The invention relates to an anti-arrhythmia traditional Chinese medicine capsule, which is used for treating arrhythmia. The method comprises the following steps: using red ginseng, ophiopogon root, radix glehniae, red sage root, longan, dens draconis, semen zizyphi spinosae and Schisandra; crushing red sage root, radix glehniae, longan and dens draconis to crude powder, adding water and extracting twice, filtering and merging a filtrate, concentrating for preparation; crushing gen-seng, ophiopogon root, Schisandra, and semen zizyphi spinosae to crude powder, adding 70% of ethanol for backflow extraction twice, filtrating, merging the filtrate, carrying out pressure reduction and recovering ethanol, concentrating, and merging a concentrate of red sage root and the like, concentrating to stiff paste, drying, crushing the dry substrate to fine powder, sieving and adding beta-cyclodextrin, using 95% ethanol spray to prepare a soft material, sieving and pelletizing, shaping granules, adding 1% of talcum powder and a proper amount of starch, uniformly mixing, filling into a capsule casing to obtain the product. The invention has the advantages of replenishing qi and nourishing yin, nourishing blood and tranquillizing, tranquillizing cardioversion and palpitation, the anti-arrhythmia traditional Chinese medicine capsule has good curative effect.
Description
One, technical field
The present invention relates to field of medicaments, particularly a kind of arrhythmia Chinese medicinal capsule.
Two, background technology
Arrhythmia is very common clinically, is not detected in the cardiovascular diseases, also is shown in many non-cardiovascular diseases and minority normal healthy people.ARR of a great variety, wherein the highest with the premature beat incidence rate, be atrial fibrillation, atrioventricular block, tachycardia, atrial flutter etc. secondly; And it is common with tachyarrhythmias such as premature beat, atrial fibrillation, supraventricular tachycardias; The lighter is harmless to the health, and weight person can cause hemodynamics disorderly, symptom occurs; Even cause sudden death, threat to life.Arrhythmia is the modal death and one of the reason that disables, and accounts for all natural death crowds' 11% greatly.In the U.S., annual nearly 300,000 people die suddenly, and wherein most people's the cause of the death is relevant with ventricular tachycardia or ventricular fibrillation (quivering in the chamber).
Existing 4 big types in present treatment arrhythmia Western medicine, the generation of the fine control premature beat of part medicine ability.But the multi-center clinical trial result who met evidence-based medicine EBM in the last few years in a large number shows that antiarrhythmic drug has tangible arrhythmogenic effect, and part has certain infringement to patient's cardiac function with other internal organs, and prolonged application can increase mortality in said patients.Arrhythmia belongs to categories such as motherland's medical science " palpitation with fear ", " palpitation with a distress feeling ".At " Huang di's Canon of Medicine element ask lift general survey " promptly relevant for ARR argumentation, " the frightened then heart does not have institute and leans on, refreshing do not have return, the worry nothing is decided ".In Chinese medicine, seek the emphasis that safe and effective antiarrhythmic drug becomes arrhythmia research.
At present, clinical arrhythmia Chinese patent medicine commonly used mainly contains 3 kinds of ginseng loose heart tonifying capsule, step-length WENXIN KELI, heart speed Yiganning capsules.Wherein joining loose heart tonifying capsule is made up of Radix Ginseng, Radix Ophiopogonis, Fructus Corni, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, Radix Et Rhizoma Nardostachyos, Rhizoma Coptidis, Fructus Schisandrae Sphenantherae, Os Draconis; Has supplementing QI and nourishing YIN; Promoting blood circulation to remove obstruction in the collateral; The clearing away heart-fire for tranquillization effect is used to treat deficiency of both QI and YIN, the arrhythmia that the resistance of the heart network stasis of blood causes.The step-length WENXIN KELI is made up of Radix Codonopsis, Rhizoma Polygonati, Radix Notoginseng, succinum, Radix Et Rhizoma Nardostachyos, has supplementing QI and nourishing YIN, the multiple arteries and veins of throbbing with fear surely, and blood circulation promoting and blood stasis dispelling cures mainly the deficiency of both QI and YIN arrhythmia due to the heart arteries and veins stasis of blood resistance of holding concurrently.Heart speed Yiganning capsule by Rhizoma Coptidis, the Rhizoma Pinelliae, Poria, long-pending reality, Radix Dichroae, Plumula Nelumbinis, Radix Sophorae Flavescentis, punt-pole, Radix Ginseng, winter wheat, Radix Glycyrrhizae are formed clearly, have removing heat-phlegm, the mind calming effect of throbbing with fear surely cures mainly the arrhythmia of caused by heart disturbed by phlegm heat.More than 3 kinds of arrhythmia Chinese patent medicines, mainly start with for preceding two kinds from deficiency of qi and yin, obstruction of collaterals by blood stasis, the latter starts with from type of phlegm-heat attacking the heart, has all ignored " deficiency of heart-blood " effect in the arrhythmia morbidity.Therefore, develop new arrhythmia Chinese medicine, it is imperative to remedy existing arrhythmia Chinese medicine deficiency.
Three, summary of the invention
To above-mentioned situation, for remedying the deficiency of existing arrhythmia Chinese patent medicine, the present invention's purpose provides a kind of arrhythmia Chinese medicinal capsule, can be effective to solve ARR treatment problem.The technical scheme of its solution is ARR theory to be thought that this disease should be controlled from " cardiopalmus ", " palpitation with a distress feeling " opinion according to Chinese medicine; From theory of Chinese medical science, in conjunction with Yan Yonghe " husband palpitation with a distress feeling person, this deficiency of heart-blood also ... " and Zhu Danxi " danxi's experiential therapy palpitation with fear palpitation with a distress feeling " cloud: " palpitation with fear person's blood deficiency; palpitation with fear sometimes ", " palpitation with a distress feeling person's blood deficiency is not when palpitation with a distress feeling has; the insufficiency of blood person is many, deposits to ponder over just movingly, belongs to empty; The time as the time person of ending, expectorant is moving because of fire " scheduling theory, from Chinese medical discrimination, catch pathological factors such as the deficiency of vital energy, blood deficiency, the deficiency of YIN, blood stasis, the merit that clinical practice has benefiting qi and nourishing yin, nourishing blood to tranquillize the mind, conversion to throb with fear surely.In view of the above, the present invention adopts following medicine to process: Radix Ginseng Rubra 200-220g, Radix Ophiopogonis 300-330g, Radix Glehniae 300-330g; Radix Salviae Miltiorrhizae 300-330g, Arillus Longan 300-330g, Dens Draconis 200-220g, Semen Ziziphi Spinosae 300-330g; Fructus Schisandrae Chinensis 200-220g, ethanol, β-ring is the spermatophore compound recklessly; Pulvis Talci and starch are processed, wherein: get Radix Salviae Miltiorrhizae, Radix Glehniae, Arillus Longan, Dens Draconis and be ground into coarse powder, add 8 times of water gagings and extract 2 each 1h.Filter, merging filtrate, filtrating is concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density), and is subsequent use.Get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, spiny jujuba seed powder and be broken into coarse powder, add 8 times of amount volume fraction 70% alcohol reflux 2 times, each 1h.Filter, merging filtrate, decompression recycling ethanol continues to be concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density); Merge the concentrated solution of above-mentioned Radix Salviae Miltiorrhizae etc., continue to be concentrated into the thick paste that relative density is 1.30～1.35 (50～60 ℃), carry out drying by following condition respectively, dry thing is ground into fine powder; Cross 100 mesh sieves, add β-ring spermatophore compound recklessly, process soft material, cross 40 mesh sieves and granulate with the spraying of 95% ethanol; Granulate adds 1% Pulvis Talci and appropriate amount of starch, mixing; Incapsulate shell, process 1000, promptly get.The present invention has the function that benefiting qi and nourishing yin, nourishing blood to tranquillize the mind, conversion are throbbed with fear surely, can obviously reduce patients with arrhythmia premature beat number of times, improves symptoms such as patient's cardiopalmus, weak, vexed, insomnia.Curative effect is high, takes safety, convenient, is the good medicine of antiarrhythmic, and clinical meaning is huge, and economic and social benefit is outstanding.
Four, the specific embodiment
Elaborate below in conjunction with the embodiment specific embodiments of the invention.
Embodiment one
In concrete production, the present invention adopts Radix Ginseng Rubra 210g, Radix Ophiopogonis 315g, Radix Glehniae 315g; Radix Salviae Miltiorrhizae 315g, Arillus Longan 315g, Dens Draconis 210g, Semen Ziziphi Spinosae 315g; Fructus Schisandrae Chinensis 210g, ethanol, β-ring is the spermatophore compound recklessly; Pulvis Talci and starch are processed, wherein: get Radix Salviae Miltiorrhizae, Radix Glehniae, Arillus Longan, Dens Draconis and be ground into coarse powder, add 8 times of water gagings and extract 2 each 1h.Filter, merging filtrate, filtrating is concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density), and is subsequent use.Get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, spiny jujuba seed powder and be broken into coarse powder, add 8 times of amount volume fraction 70% alcohol reflux 2 times, each 1h.Filter, merging filtrate, decompression recycling ethanol continues to be concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density); Merge the concentrated solution of above-mentioned Radix Salviae Miltiorrhizae etc., continue to be concentrated into the thick paste that relative density is 1.30～1.35 (50～60 ℃), carry out drying by following condition respectively, dry thing is ground into fine powder; Cross 100 mesh sieves, add β-ring spermatophore compound recklessly, process soft material, cross 40 mesh sieves and granulate with the spraying of 95% ethanol; Granulate adds 1% Pulvis Talci and appropriate amount of starch, mixing; Incapsulate shell, process 1000, promptly get.
Embodiment two
The present invention adopts Radix Ginseng Rubra 200g, Radix Ophiopogonis 300g, Radix Glehniae 300g, Radix Salviae Miltiorrhizae 300g; Arillus Longan 300g, Dens Draconis 200g, Semen Ziziphi Spinosae 300g; Fructus Schisandrae Chinensis 200g, ethanol, β-ring is the spermatophore compound recklessly; Pulvis Talci and starch are processed, wherein: get Radix Salviae Miltiorrhizae, Radix Glehniae, Arillus Longan, Dens Draconis and be ground into coarse powder, add 8 times of water gagings and extract 2 each 1h.Filter, merging filtrate, filtrating is concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density), and is subsequent use.Get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, spiny jujuba seed powder and be broken into coarse powder, add 8 times of amount volume fraction 70% alcohol reflux 2 times, each 1h.Filter, merging filtrate, decompression recycling ethanol continues to be concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density); Merge the concentrated solution of above-mentioned Radix Salviae Miltiorrhizae etc., continue to be concentrated into the thick paste that relative density is 1.30～1.35 (50～60 ℃), carry out drying by following condition respectively, dry thing is ground into fine powder; Cross 100 mesh sieves, add β-ring spermatophore compound recklessly, process soft material, cross 40 mesh sieves and granulate with the spraying of 95% ethanol; Granulate adds 1% Pulvis Talci and appropriate amount of starch, mixing; Incapsulate shell, process 1000, promptly get.
Embodiment three
The present invention adopts Radix Ginseng Rubra 220g, Radix Ophiopogonis 330g, Radix Glehniae 330g, Radix Salviae Miltiorrhizae 330g; Arillus Longan 330g, Dens Draconis 220g, Semen Ziziphi Spinosae 330g; Fructus Schisandrae Chinensis 220g, ethanol, β-ring is the spermatophore compound recklessly; Pulvis Talci and starch are processed, wherein: get Radix Salviae Miltiorrhizae, Radix Glehniae, Arillus Longan, Dens Draconis and be ground into coarse powder, add 8 times of water gagings and extract 2 each 1h.Filter, merging filtrate, filtrating is concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density), and is subsequent use.Get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, spiny jujuba seed powder and be broken into coarse powder, add 8 times of amount volume fraction 70% alcohol reflux 2 times, each 1h.Filter, merging filtrate, decompression recycling ethanol continues to be concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density); Merge the concentrated solution of above-mentioned Radix Salviae Miltiorrhizae etc., continue to be concentrated into the thick paste that relative density is 1.30～1.35 (50～60 ℃), carry out drying by following condition respectively, dry thing is ground into fine powder; Cross 100 mesh sieves, add β-ring spermatophore compound recklessly, process soft material, cross 40 mesh sieves and granulate with the spraying of 95% ethanol; Granulate adds 1% Pulvis Talci and appropriate amount of starch, mixing; Incapsulate shell, process 1000, promptly get.
Technical scheme of the present invention is not only the scheme that the foregoing description provides, and the present invention can or dwindle by the expansion of the proportionate relationship between the above-mentioned medicine that provides, and makes the Chinese medicinal capsule of any amount.
The present invention takes safety, and good effect is the antiarrhythmic active drug, and clinical having obtained fully with zoopery proves that physical resource is following:
1. physical data: from Henan Province institute of traditional Chinese medicine outpatient service in-2009 in 2006 and ward patients with arrhythmia.Be divided into treatment group, matched group immediately.140 examples are organized in treatment, male 79 examples, women 61 examples; The oldest person 74 years old, reckling 18 years old.Matched group 140 examples, male 76 examples, women 64 examples; The oldest person 75 years old, reckling 18 years old.
2. diagnostic criteria: premature beat diagnostic criteria: as if compile " cardiovascular diseases's diagnostic criteria " with reference to yellow the 5th edition " clinical electrocardiography " and Cortex Phellodendri democracy.
24h ambulatory electrocardiogram standard: press the LownShi classification: 0 grade: do not have; I level first: find once in a while (30 times/h, 1 time/min); I level second: find once in a while (30 times/h,＞1 time/min); The II level: often occur (＞30 times/h); III level: polyphyly; IV level first: occur repeatedly continuous 2 times; IV level second: occur a short battle array bunchiness repeatedly, connect together for the longest 7 times; The V level: the R ripple that occurs ahead of time drops on the T ripple, and 3 persons appear in 1h continuously among the 24h.Remove the case of I level, IV level second and V level.
3. include standard in:
(1) meets arrhythmia premature beat diagnostic criteria person.
(2) ambulatory electrocardiogram Lown classification I-IV first class person.
(3) age 18-75 year, male or female.
4. exclusion standard:
(1) ambulatory electrocardiogram Lown classification 0, IV second, V level person.
(2) other arrhythmia beyond the premature beat such as atrial fibrillation, conduction block, chamber speed, supraventricular tachycardia, sick sinus syndrome etc.
(3) merge respiratory failure, valvular heart disease, obstructive myocardiosis, constrictive pericarditis, pulmonary infarction, acute myocardial infarction, blood patient.
(4) severe hepatic renal function injury person.
(5) tumor patients in heilongjiang.
(6) psychotic.
(7) gestation, women breast-feeding their children.
(8) allergic constitution or known to used Chinese medicine and western medicine allergy sufferers in the scheme.
(9) age＞75 year old person or age＜18 year old person.
5. Therapeutic Method:
The treatment group to be originally delivering capsule oral, and 4/inferior, 3 times/day.30 days courses of treatment.
Matched group is oral to join loose heart tonifying capsule, and 4/inferior, 3 times/day.30 days courses of treatment.
6. criterion of therapeutical effect:
With reference to national prevention and treatment in Chinese and western coronary heart disease, angina pectoris, the arrhythmia research forum arrhythmia order of severity and curative effect reference standard.
Produce effects: the obviously improvement of treatment back symptom, cardiac auscultation and electrocardiogram are not seen premature beat, and 24 hr Ambulatory EKG Monitoring show that premature beat reduces more than 75%.
Effectively: treatment back symptom is obviously improved, and the accidental premature beat of cardiac auscultation and electrocardiogram is though 24 hr Ambulatory EKG Monitoring show that the more preceding minimizing of premature beat number of times more than 75%, still has running fire premature beat; Or 24 hr Ambulatory EKG Monitoring show that the premature beat number of times reduces 50%～75%, is single-shot, single form person.
Invalid: as not reach above-mentioned standard after the treatment.
7. clinical statistics is handled
Table 1: two groups of curative effects relatively
Annotate: through chi-square criterion,
#P＞0.05.
Found out that by table 1 the present invention is the active drug of treatment arrhythmia premature beat, clinical meaning is outstanding.
8. zoopery situation
8.1 to acute toxicity test in mice
Get 40 of body weight 18～22g mices, male and female half and half, adaptability was raised after 5 days, was divided into two groups according to sex and body weight: female group and male group.Behind mice fasting (can't help water) 8h, every Mus is irritated stomach extractum concentrated solution of the present invention 0.4ml/10g body weight (maximum volume), and administration 1 time is normally raised behind the medicine, observes continuously 14 days.Weigh before the medication once, observe general reaction situation and the death condition such as feed, drinking-water, defecation, hair color, active situation and mental status of mice after the medication, and behind medicine, respectively weighed once in the 7th day, the 14th day.The result is following:
Table 2: the mensuration of the oral maximum dosage-feeding of mice of the present invention
Table 3: the oral influence of extractum of the present invention
to the mice body weight
Can find out that by table 2,3 the oral maximum dosage-feeding of extractum mice of the present invention is 480g/kg,, be equivalent to 1450 times of clinical Coming-of-Age Day consumption according to kg body weight conversion; According to body surface area conversion, be equivalent to 186 times of clinical Coming-of-Age Day consumption, after mice press maximum dosage-feeding filling stomach; Feed, drinking-water, defecation, hair color, active situation and mental status etc. are not all seen any difference reaction; Do not see animal dead, the mice body weight obviously increases, and upgrowth situation is good.Show that oral toxicity of the present invention is low, clinical practice is safer.
8.2 to rat acute toxicity test
Get 40 of body weight 180～220g rats, male and female half and half, adaptability was raised after 5 days, was divided into two groups according to sex and body weight: female group and male group.Behind rat fasting (can't help water) 8h, every Mus is irritated stomach extractum concentrated solution of the present invention 2ml/100g body weight (maximum volume), and administration 1 time is normally raised behind the medicine, observes continuously 14 days.Weigh before the medication once, observe general reaction situation and the death condition such as feed, drinking-water, defecation, hair color, active situation and mental status of rat after the medication, and behind medicine, respectively weighed once in the 7th day, the 14th day.The result is following:
Table 4: the mensuration of the oral maximum dosage-feeding of rat of the present invention
Table 5: extractum gourmet's luck of the present invention is to the influence
of rat body weight
By table 4,5 visible, the oral maximum dosage-feeding of rat of the present invention is 240g/kg, according to the kg body weight conversion, is equivalent to 725 times of clinical Coming-of-Age Day consumption; According to body surface area conversion, be equivalent to 134 times of clinical Coming-of-Age Day consumption, after rat press maximum dosage-feeding filling stomach; Feed, drinking-water, defecation, hair color, active situation and mental status etc. are not all seen any difference reaction; Do not see animal dead, rat body weight obviously increases, and upgrowth situation is good.Show that oral toxicity of the present invention is low, clinical practice is safer.
8.3 rat acute toxicity test
Get 40 of body weight 180～220g rats, male and female half and half, adaptability was raised after 5 days, was divided into two groups according to sex and body weight: female group and male group.Behind rat fasting (can't help water) 8h, every Mus is irritated the Weishang and states extractum concentrated solution 2ml/100g body weight of the present invention (maximum volume), and administration 1 time is normally raised behind the medicine, observes continuously 14 days.Weigh before the medication once, observe general reaction situation and the death condition such as feed, drinking-water, defecation, hair color, active situation and mental status of rat after the medication, and behind medicine, respectively weighed once in the 7th day, the 14th day.The result is following:
Table 6: the mensuration of the oral maximum dosage-feeding of rat of the present invention
Table 7: the oral influence of extractum of the present invention
to rat body weight
By table 6,7 visible, the oral maximum dosage-feeding of extractum rat of the present invention is 240g/kg, according to the kg body weight conversion, is equivalent to 725 times of clinical Coming-of-Age Day consumption; According to body surface area conversion, be equivalent to 134 times of clinical Coming-of-Age Day consumption, after rat press maximum dosage-feeding filling stomach; Feed, drinking-water, defecation, hair color, active situation and mental status etc. are not all seen any difference reaction; Do not see animal dead, rat body weight obviously increases, and upgrowth situation is good.Show that oral toxicity of the present invention is low, clinical practice is safer.
9. conclusion
Use clinical treatment arrhythmia premature beat curative effect of the present invention certainly, zoopery shows safety, and letter, just, honest and clean, test, for the treatment by Chinese herbs arrhythmia provides effective assurance, economic and social benefit is huge.
Claims (4)
1. an arrhythmia Chinese medicinal capsule is characterized in that, is by Radix Ginseng Rubra 200-220g, Radix Ophiopogonis 300-330g; Radix Glehniae 300-330g, Radix Salviae Miltiorrhizae 300-330g, Arillus Longan 300-330g, Dens Draconis 200-220g; Semen Ziziphi Spinosae 300-330g, Fructus Schisandrae Chinensis 200-220g, ethanol, β-ring is the spermatophore compound recklessly; Pulvis Talci and starch are processed, wherein: get Radix Salviae Miltiorrhizae, Radix Glehniae, Arillus Longan, Dens Draconis and be ground into coarse powder, add 8 times of water gagings and extract 2 each 1h; Filter, merging filtrate, filtrating is concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density), and is subsequent use; Get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, spiny jujuba seed powder and be broken into coarse powder, add 8 times of amount volume fraction 70% alcohol reflux 2 times, each 1h; Filter, merging filtrate, decompression recycling ethanol continues to be concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density); Merge the concentrated solution of above-mentioned Radix Salviae Miltiorrhizae etc., continue to be concentrated into the thick paste that relative density is 1.30～1.35 (50～60 ℃), carry out drying by following condition respectively, dry thing is ground into fine powder; Cross 100 mesh sieves, add β-ring spermatophore compound recklessly, process soft material, cross 40 mesh sieves and granulate with the spraying of 95% ethanol; Granulate adds 1% Pulvis Talci and appropriate amount of starch, mixing; Incapsulate shell, process 1000, promptly get.
2. arrhythmia Chinese medicinal capsule according to claim 1 is characterized in that, by Radix Ginseng Rubra 210g, Radix Ophiopogonis 315g; Radix Glehniae 315g, Radix Salviae Miltiorrhizae 315g, Arillus Longan 315g, Dens Draconis 210g; Semen Ziziphi Spinosae 315g, Fructus Schisandrae Chinensis 210g, ethanol, β-ring is the spermatophore compound recklessly; Pulvis Talci and starch are processed, wherein: get Radix Salviae Miltiorrhizae, Radix Glehniae, Arillus Longan, Dens Draconis and be ground into coarse powder, add 8 times of water gagings and extract 2 each 1h; Filter, merging filtrate, filtrating is concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density), and is subsequent use; Get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, spiny jujuba seed powder and be broken into coarse powder, add 8 times of amount volume fraction 70% alcohol reflux 2 times, each 1h; Filter, merging filtrate, decompression recycling ethanol continues to be concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density); Merge the concentrated solution of above-mentioned Radix Salviae Miltiorrhizae etc., continue to be concentrated into the thick paste that relative density is 1.30～1.35 (50～60 ℃), carry out drying by following condition respectively, dry thing is ground into fine powder; Cross 100 mesh sieves, add β-ring spermatophore compound recklessly, process soft material, cross 40 mesh sieves and granulate with the spraying of 95% ethanol; Granulate adds 1% Pulvis Talci and appropriate amount of starch, mixing; Incapsulate shell, process 1000, promptly get.
3. arrhythmia Chinese medicinal capsule according to claim 1 is characterized in that, by Radix Ginseng Rubra 200g, Radix Ophiopogonis 300g; Radix Glehniae 300g, Radix Salviae Miltiorrhizae 300g, Arillus Longan 300g, Dens Draconis 200g; Semen Ziziphi Spinosae 300g, Fructus Schisandrae Chinensis 200g, ethanol, β-ring is the spermatophore compound recklessly; Pulvis Talci and starch are processed, wherein: get Radix Salviae Miltiorrhizae, Radix Glehniae, Arillus Longan, Dens Draconis and be ground into coarse powder, add 8 times of water gagings and extract 2 each 1h; Filter, merging filtrate, filtrating is concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density), and is subsequent use; Get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, spiny jujuba seed powder and be broken into coarse powder, add 8 times of amount volume fraction 70% alcohol reflux 2 times, each 1h; Filter, merging filtrate, decompression recycling ethanol continues to be concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density); Merge the concentrated solution of above-mentioned Radix Salviae Miltiorrhizae etc., continue to be concentrated into the thick paste that relative density is 1.30～1.35 (50～60 ℃), carry out drying by following condition respectively, dry thing is ground into fine powder; Cross 100 mesh sieves, add β-ring spermatophore compound recklessly, process soft material, cross 40 mesh sieves and granulate with the spraying of 95% ethanol; Granulate adds 1% Pulvis Talci and appropriate amount of starch, mixing; Incapsulate shell, process 1000, promptly get.
4. arrhythmia Chinese medicinal capsule according to claim 1 is characterized in that, by Radix Ginseng Rubra 220g, Radix Ophiopogonis 330g; Radix Glehniae 330g, Radix Salviae Miltiorrhizae 330g, Arillus Longan 330g, Dens Draconis 220g; Semen Ziziphi Spinosae 330g, Fructus Schisandrae Chinensis 220g, ethanol, β-ring is the spermatophore compound recklessly; Pulvis Talci and starch are processed, wherein: get Radix Salviae Miltiorrhizae, Radix Glehniae, Arillus Longan, Dens Draconis and be ground into coarse powder, add 8 times of water gagings and extract 2 each 1h; Filter, merging filtrate, filtrating is concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density), and is subsequent use; Get Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis, spiny jujuba seed powder and be broken into coarse powder, add 8 times of amount volume fraction 70% alcohol reflux 2 times, each 1h; Filter, merging filtrate, decompression recycling ethanol continues to be concentrated into the concentrated solution that relative density is 1.20～1.25 (50～60 ℃) (it is that 1.05～1.10 (50～60 ℃) are used for spray drying that a copy of it is concentrated into relative density); Merge the concentrated solution of above-mentioned Radix Salviae Miltiorrhizae etc., continue to be concentrated into the thick paste that relative density is 1.30～1.35 (50～60 ℃), carry out drying by following condition respectively, dry thing is ground into fine powder; Cross 100 mesh sieves, add β-ring spermatophore compound recklessly, process soft material, cross 40 mesh sieves and granulate with the spraying of 95% ethanol; Granulate adds 1% Pulvis Talci and appropriate amount of starch, mixing; Incapsulate shell, process 1000, promptly get.
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| CN107432910A (en) * | 2016-12-07 | 2017-12-05 | 徐中平 | A kind of Chinese medicine preparation for treating arrhythmia cordis and preparation method thereof |
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| CN103181434A (en) * | 2012-06-06 | 2013-07-03 | 严丰丽 | Comfortable health-care tea and preparation method thereof |
| CN103181434B (en) * | 2012-06-06 | 2014-09-10 | 严丰丽 | Comfortable health-care tea and preparation method thereof |
| CN107432910A (en) * | 2016-12-07 | 2017-12-05 | 徐中平 | A kind of Chinese medicine preparation for treating arrhythmia cordis and preparation method thereof |
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Application publication date: 20120516 |