CN103182025B - Traditional Chinese medicine composition for treating bradyarrhythmia, and application thereof - Google Patents
Traditional Chinese medicine composition for treating bradyarrhythmia, and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating bradyarrhythmia, which comprises the following raw material medicine in weight percentage: 20-40 parts of Chinese ephedra, 2-4 parts of cassia twig, 1-3 parts of magnolia vine fruit, 15-25 parts of aconite root, 10-20 parts of dried rehmannia root, 5-15 parts of astragalus root, 2-6 parts of asarum herb, 10-20 parts of lilyturf root and 4-8 parts of prepared licorice root. The invention also provides an application of the traditional Chinese medicine composition in the treatment of bradyarrhythmia, particularly in the treatment of sick sinus syndrome and atrioventricular block. The clinical test and animal test show that the traditional Chinese medicine composition has high total effective rate of treating the bradyarrhythmia, works better than the isoprenaline, and has the remarkable significance in treatment of sick sinus syndrome and atrioventricular block; meanwhile, the acute toxicity test shows that the traditional Chinese medicine composition is extremely low in toxicity, thereby being easy to be accepted by patients; and additionally, the traditional Chinese medicine composition is less in components of the raw material medicine, rich, easily obtained, low in price, simple in preparation process, and suitable for universal popularization and application.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and application thereof for the treatment of slow arrhythmia, specifically, is a kind of Chinese patent medicine of preparing taking Chinese herbal medicine as raw material.
Background technology
Slow arrhythmia refers to the diseases taking decreased heart rate as feature such as sinus bradycardia, atrioventricular junction heart rate, idioventricular rhythm, conduction block (comprising sinoatrial block, intra-auricular conductional block, atrioventricular block).Clinically common are sinus bradycardia, sick sinus syndrome, atrioventricular block.Sinus bradycardia refers to that sinus rhythm is slower than 60 times per minute, and within 24 hours, heart beating sum is less than 86400 times.Sick sinus syndrome is because the organic disease of sinuatrial node or its surrounding tissue causes malfunction, thereby produce the syndrome of multiple arrhythmia and multiple symptom, main feature is bradycardia, is called bradycardia-tachycardia syndrome in the time that merging rapidity supraventricular arrhythmia shows effect repeatedly.Atrioventricular block refers to that atrium, to the conduction block of ventricle direction or ventricle to atrium direction conduction block, is divided into I, II, the conduction block of III degree by the difference of conduction block.
Chinese patent literature CN 200810054809.7, applying date 2008-04-18, the application of a kind of Chinese medicine composition in preparation treatment slow arrhythmia medicine disclosed, this Chinese medicine composition is made up of Chinese medicines such as Radix Ginseng, Radix Ophiopogonis, Fructus Corni, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae (parched), Herba Taxilli, Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, Radix Et Rhizoma Nardostachyos, and clinical experiment confirms that this Chinese medicine composition has significant clinical efficacy to bradyarrhythmia.Chinese patent literature CN 200910079261.6, applying date 2009-03-05, a kind of medicine that is used for the treatment of slow arrhythmia sick sinus syndromes and preparation method thereof is disclosed, this is used for the treatment of the medicine of slow arrhythmia sick sinus syndromes, its composition and effectiveness is to be made up of the raw material by following weight proportion: Radix Ginseng Rubra 1-90g, Radix Aconiti Lateralis Preparata 1-90g, Radix Glycyrrhizae Preparata 1-90g, Ramulus Cinnamomi 1-90g, Typhonium flagelliforme (Lodd.) Blume 1-90g, Poria 1-90g, this medicine is obviously better than atropine improving in clinical symptoms, can improve Cardiac Function of Patients, improve patients ' life quality, in improving the curative effect index such as heart rate and Holter, electrocardiogram, improving cardiac ultrasonic parameters of left ventricular function, the aspect such as EF, CO value and ECG ST section is better than atropine, in research process there is not obvious harmful effect in treatment group, safe and effective clinically.Very necessary and research and develop more kinds for the treatment of slow arrhythmias Chinese medicine composition evident in efficacy and that toxic and side effects is little, so that patient selects.
Chinese periodical " Chinese patent medicine ", 05 phase in 1997, be entitled as " the clinical and experimentation of multiple arteries and veins spirit Chongji for Treatment slow arrhythmia ", a kind of multiple arteries and veins spirit electuary is disclosed, formed by Herba Ephedrae, ripe Radix Aconiti Lateralis Preparata, Herba Asari etc., but also unexposed its concrete ingredients and proportioning, therefore do not form prior art.The present invention is intended to this Chinese medicine composition of request protection.
Summary of the invention
The object of the invention is for deficiency of the prior art, a kind of Chinese medicine composition for the treatment of slow arrhythmia is provided.
One object more of the present invention is that the purposes of above-mentioned Chinese medicine composition is provided.
For achieving the above object, the technical scheme that the present invention takes is:
Treat a Chinese medicine composition for slow arrhythmia, described Chinese medicine composition is to be made up of the crude drug of following percentage by weight: Herba Ephedrae 20-40 part, Ramulus Cinnamomi 2-4 part, Fructus Schisandrae Chinensis 1-3 part, Radix Aconiti Lateralis Preparata 15-25 part, Radix Rehmanniae 10-20 part, Radix Astragali 5-15 part, Herba Asari 2-6 part, Radix Ophiopogonis 10-20 part, Radix Glycyrrhizae Preparata 4-8 part.
Preferably, described Chinese medicine composition is to be made up of the crude drug of following percentage by weight: Herba Ephedrae 25-35 part, Ramulus Cinnamomi 2.5-3.5 part, Fructus Schisandrae Chinensis 1.5-2.5 part, Radix Aconiti Lateralis Preparata 18-22 part, Radix Rehmanniae 13-17 part, Radix Astragali 7-13 part, Herba Asari 3-5 part, Radix Ophiopogonis 12-18 part, Radix Glycyrrhizae Preparata 5-7 part.
Preferred, described Chinese medicine composition is to be made up of the crude drug of following percentage by weight: 30 parts, Herba Ephedrae, 3 parts of Ramulus Cinnamomi, 2 parts of Fructus Schisandrae Chinensis, 20 parts of Radix Aconiti Lateralis Preparatas, 15 parts, the Radix Rehmanniae, 10 parts of the Radixs Astragali, 4 parts of Herba Asaris, 15 parts of Radix Ophiopogonis, 6 parts of Radix Glycyrrhizae Preparatas.
The medicament of described Chinese medicine composition is capsule, granule, tablet, oral liquid, mixture, syrup or injection.
For realizing above-mentioned second object, the technical scheme that the present invention takes is:
As above the application of arbitrary described Chinese medicine composition in preparation treatment slow arrhythmia medicine;
As above the application of arbitrary described Chinese medicine composition in the preparation sick hole for the treatment of and atrioventricular block medicine.
It should be noted that, described Herba Ephedrae is used clean Herba Ephedrae, has removed the dis-medicinal part of minor matters root hair and so on; Described Radix Glycyrrhizae Preparata (radix glycyrrhizae preparata) is leguminous plant, is the Radix Glycyrrhizae of smoking with honey according to conventional method.
The invention has the advantages that:
1, confirm through clinical trial and animal experiment, traditional Chinese medicine composition for treating slow arrhythmia total effective rate of the present invention is high, and effect is better than isoproterenol, and sick hole and atrioventricular block are had to significant treatment meaning;
2, made by pure Chinese medicine, and acute toxicity test proves that its toxicity is minimum, be easy to be accepted by patient;
3, crude drug component is few, and abundant raw materials is easy to get, low price, and preparation technology is simple, is suitable for generally applying.
Detailed description of the invention
Below detailed description of the invention provided by the invention is elaborated.
The present invention's herbal raw material medicine used is all purchased from Shanghai Xiu Long Chinese medicine company limited, what described Radix Aconiti Lateralis Preparata was selected is RADIX ACONITI LATERALIS PREPARATA, it is to be concocted and form according to conventional method by Radix Aconiti Lateralis Preparata, the present invention is directly purchased from Shanghai Xiu Long Chinese medicine company limited, also can concoct voluntarily according to conventional method: get Radix Aconiti Lateralis Preparata, soak and float with clear water, change water 2-3 every day, float most to salinity, with Radix Glycyrrhizae, the Semen sojae atricolor well-done heart altogether that adds water, when cutting deutostoma and taste without numb feeling in the tongue, take out, remove Radix Glycyrrhizae, Semen sojae atricolor, shave, dry, wherein every 100kg Radix Aconiti Lateralis Preparata, use Radix Glycyrrhizae 5kg, Semen sojae atricolor 10kg.
embodiment 1 Chinese medicine composition of the present invention (one)
20 parts, Herba Ephedrae, 4 parts of Ramulus Cinnamomi, 1 part of Fructus Schisandrae Chinensis, 25 parts of RADIX ACONITI LATERALIS PREPARATAs, 10 parts, the Radix Rehmanniae, 15 parts of the Radixs Astragali, 2 parts of Herba Asaris, 20 parts of Radix Ophiopogonis, 4 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 2 Chinese medicine composition of the present invention (two)
40 parts, Herba Ephedrae, 2 parts of Ramulus Cinnamomi, 3 parts of Fructus Schisandrae Chinensis, 15 parts of RADIX ACONITI LATERALIS PREPARATAs, 20 parts, the Radix Rehmanniae, 5 parts of the Radixs Astragali, 6 parts of Herba Asaris, 10 parts of Radix Ophiopogonis, 8 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 3 Chinese medicine composition of the present invention (three)
20 parts, Herba Ephedrae, 2 parts of Ramulus Cinnamomi, 3 parts of Fructus Schisandrae Chinensis, 25 parts of RADIX ACONITI LATERALIS PREPARATAs, 10 parts, the Radix Rehmanniae, 5 parts of the Radixs Astragali, 6 parts of Herba Asaris, 20 parts of Radix Ophiopogonis, 4 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 4 Chinese medicine composition of the present invention (four)
40 parts, Herba Ephedrae, 4 parts of Ramulus Cinnamomi, 1 part of Fructus Schisandrae Chinensis, 15 parts of RADIX ACONITI LATERALIS PREPARATAs, 20 parts, the Radix Rehmanniae, 15 parts of the Radixs Astragali, 2 parts of Herba Asaris, 10 parts of Radix Ophiopogonis, 8 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 5 Chinese medicine composition of the present invention (five)
20 parts, Herba Ephedrae, 4 parts of Ramulus Cinnamomi, 3 parts of Fructus Schisandrae Chinensis, 25 parts of RADIX ACONITI LATERALIS PREPARATAs, 20 parts, the Radix Rehmanniae, 5 parts of the Radixs Astragali, 6 parts of Herba Asaris, 10 parts of Radix Ophiopogonis, 4 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 6 Chinese medicine composition of the present invention (six)
25 parts, Herba Ephedrae, 3.5 parts of Ramulus Cinnamomi, 1.5 parts of Fructus Schisandrae Chinensis, 22 parts of RADIX ACONITI LATERALIS PREPARATAs, 13 parts, the Radix Rehmanniae, 13 parts of the Radixs Astragali, 3 parts of Herba Asaris, 18 parts of Radix Ophiopogonis, 5 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 7 Chinese medicine composition of the present invention (seven)
35 parts, Herba Ephedrae, 2.5 parts of Ramulus Cinnamomi, 2.5 parts of Fructus Schisandrae Chinensis, 18 parts of RADIX ACONITI LATERALIS PREPARATAs, 17 parts, the Radix Rehmanniae, 7 parts of the Radixs Astragali, 5 parts of Herba Asaris, 12 parts of Radix Ophiopogonis, 5 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 8 Chinese medicine composition of the present invention (eight)
25 parts, Herba Ephedrae, 4 parts of Ramulus Cinnamomi, 1 part of Fructus Schisandrae Chinensis, 22 parts of RADIX ACONITI LATERALIS PREPARATAs, 20 parts, the Radix Rehmanniae, 7 parts of the Radixs Astragali, 5 parts of Herba Asaris, 12 parts of Radix Ophiopogonis, 8 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 9 Chinese medicine composition of the present invention (nine)
35 parts, Herba Ephedrae, 2.5 parts of Ramulus Cinnamomi, 3 parts of Fructus Schisandrae Chinensis, 15 parts of RADIX ACONITI LATERALIS PREPARATAs, 13 parts, the Radix Rehmanniae, 7 parts of the Radixs Astragali, 3 parts of Herba Asaris, 18 parts of Radix Ophiopogonis, 8 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
embodiment 10 Chinese medicine composition of the present invention (ten)
30 parts, Herba Ephedrae, 3 parts of Ramulus Cinnamomi, 2 parts of Fructus Schisandrae Chinensis, 20 parts of RADIX ACONITI LATERALIS PREPARATAs, 15 parts, the Radix Rehmanniae, 10 parts of the Radixs Astragali, 4 parts of Herba Asaris, 15 parts of Radix Ophiopogonis, 6 parts of Radix Glycyrrhizae Preparatas, conventional method decocts.
It should be noted that, it is the manufacture method of Chinese medicine decoction routine that the conventional method described in embodiment 1-10 decocts, and decocts with water into decoction by described crude drug.
the preparation of embodiment 11 Chinese medicine composition tablet/capsules of the present invention
Get the arbitrary described medicine of embodiment 1-10, add 9-11 times of water gaging, decoct 2-3.5 hour, leach medicine juice.Add again 9 times of water gagings, decoct 2.5 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add 3 times of amount ethanol of concentrated solution, stir precipitation and spend the night.Get supernatant, be concentrated into thick extractum; Add pharmaceutical aids, vacuum drying, pulverizes and granulates, and is pressed into tablet or fills encapsulated.
the preparation of embodiment 12 Chinese medicine composition composition granule of the present invention
get the arbitrary described medicine of embodiment 1-10, add 8-10 times of water gaging, decoct 3 hours, leach medicine juice.Add again 10 times of water gagings, decoct 2.5 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add 2 times of amount ethanol of concentrated solution, stir precipitation and spend the night.Get supernatant, be concentrated into thick extractum; Add suitable pharmaceutical aids, granulate, dry, granulate, obtains 20g granule, subpackage 10g/ bag.
the preparation of embodiment 13 Chinese medicine composition mixture/oral liquid/syrup of the present invention
Get the arbitrary described medicine of embodiment 1-10, add 8-11 times of water gaging, decoct 3 hours, leach medicine juice.Add again 8 times of water gagings, decoct 3 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add 3.5 times of amount ethanol of concentrated solution, stir precipitation and spend the night.Get supernatant, be concentrated into thick extractum; Add suitable pharmaceutical aids, make mixture, oral liquid or syrup.
the preparation of embodiment 14 Chinese medicine composition composition injection of the present invention
Get the arbitrary described medicine of embodiment 1-10, add 8-11 times of water gaging, decoct 3 hours, leach medicine juice.Add again 8 times of water gagings, decoct 3 hours, leach medicine juice, merge secondary decocting liquid, leave standstill, leaching supernatant, concentrated, let cool, add 3.5 times of amount ethanol of concentrated solution, stir precipitation and spend the night.Get supernatant, be concentrated into thick extractum; After distillation, add suitable pharmaceutical aids, make injection.
the clinical trial of embodiment 15 Chinese medicine compositions of the present invention
One, physical data
If treatment group 100 examples, matched group 50 examples.Mix to learn by statistics in dividing of age, sex for two groups and process there was no significant difference.Types of arrhythmia has: sinus bradycardia (SB), sinoatrial block (SAB), sinus standstill (SA), atrioventricular block (AVB), the boundary rhythm of the heart (JR).Classification of diseases has coronary heart disease, viral myocarditis, vagus nerve function hyperfunction.Diagnosis meets ISFC and WHO standard.
Two, Therapeutic Method
Treatment group is taken the granule of the Chinese medicine composition that embodiment 10 fills a prescription, and each serving with 40g, every gram containing crude drug 2.575g/ml, every day 4 times.
Matched group take build ginseng sheet (Shanghai Chinese medicine three factory's lot numbers: 921011), each 5, every day 4 times.
Double blinding is observed, and taking 28 days is a course for the treatment of.
Three, criterion of therapeutical effect
With reference to national prevention and treatment in Chinese and western coronary heart disease forum revision ECG curative effect standard in 1979.
Four, therapeutic outcome
Effective 40 examples for the treatment of group, effective 44 examples, invalid 16 examples, total effective rate is 84%.Build effective 11 examples of ginseng sheet group, effective 13 examples, invalid 26 examples, total effective rate is 48%.By X 2 test: X
2=Σ (A-T)
2/ T, X
2=20.43, P<0.01, two groups of total effective rates highly significant meaning of having compared.
Before and after treatment group treatment, heart rate is more satisfied: SB(sinus bradycardia)+SAB(sinoatrial block), SB(sinus bradycardia)+SA(sinus standstill), I ° ~ III ° AVB(atrioventricular block) P<0.05, SB(sinus bradycardia) P<0.01.
the animal experiment of embodiment 16 Chinese medicine compositions of the present invention
One, the therapeutical effect of Chinese medicine composition of the present invention to rabbit sinuatrial node disease model
The Chinese medicine composition preparation of filling a prescription with embodiment 10 is containing crude drug 2.5g/ml intravenous injection.Experiment is grouped into: dosage group (0.625g/kg), Chinese medicine high dose group (1.25g/kg), isoproterenol group (2g/kg) and normal saline group in Chinese medicine low dose group (0.3125g/kg), Chinese medicine.10 of every group of rabbit, male and female half and half.
With formaldehyde damage Cor Leporis sinuatrial node, rabbit decreased heart rate after 30s, 10min decreased heart rate is more than 50%.P ripple majority disappears in 1-2min again, forms boundary property heart rate, ventricular escape etc.ST section is offset after 1min after putting ring again, is one-way type or hunchbacked type is raised, and T ripple is two-way or tubulose T.After putting ring 5min, make ear iv.
Chinese medicine composition 1.25g/kg of the present invention and isoproterenol 2mg/kg all can improve the heart rate of sick hole rabbit.When administration 1min, before by administration 121.4 and 135.8 beats/min of heart rate add near 163.5 and 200.3 beats/min, improve respectively 39.1% and 50%, with before administration and normal saline matched group more all have utmost point significant difference (P<0.01), and more than can maintaining 30min.Chinese medicine composition 0.625g/kg of the present invention also can accelerate heart rate, but only in the time of administration 5min, there were significant differences (P<0.05).Chinese medicine composition 0.3125g/kg of the present invention is without obviously accelerating heart rate function.
Three dosage groups of Chinese medicine composition of the present invention all can significantly increase the discovery number of P ripple and obviously shorten the time (P<0.01) that P ripple is found, wherein the P ripple discovery time of Chinese medicine high dose group is 0.6 ± 0.2min, with significantly (P<0.05) of isoproterenol group comparing difference.Experimental result: the effect that Chinese medicine composition 1.25g/kg of the present invention treats disease hole rabbit is better than the curative effect of isoproterenol 2mg/kg.
Two, the impact of Chinese medicine composition of the present invention on the atrioventricular block of verapamil induced mice
The Chinese medicine composition preparation of filling a prescription with embodiment 10 contains crude drug 3g/ml, 1.5g/ml, tri-kinds of oral liquids of 0.75g/ml, and is made as respectively dosage group and Chinese medicine low dose group in Chinese medicine high dose group, Chinese medicine.Establish again atropine group (5mg/kg) and normal saline group (0.1ml/10g).12 of every group of kunming mices, male and female half and half.Before testing the first two day and experiment, be respectively administered once, and trace II road connection electrocardiogram.After tail vein injection verapamil 20s, there is bradycardia and I, II Aminophyline, each group trace 0.5 ', 1 ', 3 ', 5 ', 10 ', 15 ', 20 ' and 30 ' electrocardiogram, taking II Aminophyline extinction time and animal dead number as observe the curative effect index.Observe the effect of Chinese medicine composition of the present invention to experimental slow arrhythmia with mice atrioventricular block model.
Experimental result shows: dead 7 of normal saline group, and mortality rate is 58.5%; Dead 3 of Chinese medicine high dose group, dead 3 of atropine group, mortality rate is respectively 25%.Chinese medicine low dose group, in Chinese medicine dosage group to this model without remarkable effect, and though Chinese medicine high dose group and atropine group can not stop the slow arrhythmia due to verapamil to occur, but can significantly reduce the extinction time of mortality rate and shortening II Aminophyline, relatively there is utmost point significant difference (P<0.01) with normal saline, the curative effect no significant difference (P>0.05) of two medicines, illustrate and use Chinese medicine composition of the present invention, according to 30g/kg gavage, the mice atrioventricular block due to verapamil is had to certain control and therapeutic effect.
Three, the determination of acute toxicity of Chinese medicine composition of the present invention
By 40 of body weight 18-22g kunming mices, male and female half and half, viscous solution (10g crude drug/ml) gavage of the Chinese medicine composition of filling a prescription with 0.3ml/10g embodiment 10, can not record the median lethal dose(LD 50) of Chinese medicine composition of the present invention through prerun.Through observing two weeks, all mices are movable normal, none Mus death, and the maximum tolerated dose >300g crude drug/kg recording, points out Chinese medicine composition oral toxicity of the present invention very little.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, do not departing under the prerequisite of the inventive method; can also make some improvement and supplement, these improvement and the supplementary protection scope of the present invention that also should be considered as.
Claims (6)
1. treat the Chinese medicine composition of slow arrhythmia for one kind, it is characterized in that, described Chinese medicine composition is to be made up of the crude drug of following percentage by weight: Herba Ephedrae 20-40 part, Ramulus Cinnamomi 2-4 part, Fructus Schisandrae Chinensis 1-3 part, Radix Aconiti Lateralis Preparata 15-25 part, Radix Rehmanniae 10-20 part, Radix Astragali 5-15 part, Herba Asari 2-6 part, Radix Ophiopogonis 10-20 part, Radix Glycyrrhizae Preparata 4-8 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition is to be made up of the crude drug of following percentage by weight: Herba Ephedrae 25-35 part, Ramulus Cinnamomi 2.5-3.5 part, Fructus Schisandrae Chinensis 1.5-2.5 part, Radix Aconiti Lateralis Preparata 18-22 part, Radix Rehmanniae 13-17 part, Radix Astragali 7-13 part, Herba Asari 3-5 part, Radix Ophiopogonis 12-18 part, Radix Glycyrrhizae Preparata 5-7 part.
3. Chinese medicine composition according to claim 2, it is characterized in that, described Chinese medicine composition is to be made up of the crude drug of following percentage by weight: 30 parts, Herba Ephedrae, 3 parts of Ramulus Cinnamomi, 2 parts of Fructus Schisandrae Chinensis, 20 parts of Radix Aconiti Lateralis Preparatas, 15 parts, the Radix Rehmanniae, 10 parts of the Radixs Astragali, 4 parts of Herba Asaris, 15 parts of Radix Ophiopogonis, 6 parts of Radix Glycyrrhizae Preparatas.
4. according to the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, the medicament of described Chinese medicine composition is capsule, granule, tablet, mixture or injection.
5. the application of the arbitrary described Chinese medicine composition of claim 1-3 in preparation treatment slow arrhythmia medicine.
6. the application of the arbitrary described Chinese medicine composition of claim 1-3 in the preparation sick hole for the treatment of and atrioventricular block medicine.
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| CN102698222A (en) * | 2012-05-18 | 2012-10-03 | 廖天源 | Drug for treating bradycardia and preparation method of drug |
Non-Patent Citations (3)
| Title |
|---|
| 中药复方治疗心律失常的用药分析;周鲁等;《陕西中医》;20051231;第26卷(第02期);163-165 * |
| 周鲁等.中药复方治疗心律失常的用药分析.《陕西中医》.2005,第26卷(第02期),163-165. * |
| 杨思澍主编.温阳益气复脉汤.《中国现代名医验方荟海》.湖北科学技术出版社,1996,(第1版),第243页. * |
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