CN102488877A - Traditional Chinese medicine composition for treating lung heat - Google Patents
Traditional Chinese medicine composition for treating lung heat Download PDFInfo
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- CN102488877A CN102488877A CN2011104220596A CN201110422059A CN102488877A CN 102488877 A CN102488877 A CN 102488877A CN 2011104220596 A CN2011104220596 A CN 2011104220596A CN 201110422059 A CN201110422059 A CN 201110422059A CN 102488877 A CN102488877 A CN 102488877A
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Abstract
The invention relates to an orally administrated traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for treating lung heat. The traditional Chinese medicine composition for treating lung heat is characterized in that the traditional Chinese medicine composition is prepared by raw materials of traditional Chinese medicine including, by weight, from 10 to 15 parts of radix bupleuri, from 2 to 6 parts of radix scutellariae, from 5 to 10 parts of pinellia ternate, from 4 to 10 parts of ginger, from 1 to 5 parts of sward, from 5 to 10 parts of the root of red-rooted salvia, from 5 to 10 parts of pericarpium citri reticulatae, from 5 to 15 parts of endothelium corneum gigeriae galli, from 5 to 12 parts of bighead atractylodes rhizome, from 5 to 10 parts of dark malt, coke hawthorn and dark shenqu combination, from 3 to 6 parts of asarum and from 5 to 10 parts of fingered citron. The traditional Chinese medicine composition for treating lung heat has effects of tonifying spleen, nourishing the stomach, clearing heat, drying damp, warming lung, relieving a cough, reducing phlegm, realizing hidroschesis and the like. The traditional Chinese medicine composition for treating lung heat is few in side effects and effective in treatment after being taken by a patient.
Description
Technical field
The present invention relates to a kind of oral Chinese medicine preparation, particularly a kind of Chinese medicine composition of treating lung-heat.
Background technology
Heat is a kind of disease that pulmonary's pus infections forms.Common clinically cardinal symptom has heating, cough, chest pain, the amount of coughing up phlegm many, and abnormal smells from the patient is stench, or pus and blood is held concurrently mutually.Many patients are not knowing under the situation of situation and can treat as flu to lung-heat; Do not note causing easily serious consequence in the time of in the early stage; Some patient curative effect after taking some Chinese patent medicines is not obvious, even treatment not only causes burden economically but also do not obtain radical cure for a long time.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of treating lung-heat, it and also have strengthening the spleen and nourishing the stomach, heat clearing and damp drying, warming the lung to relieve cough, reduce phlegm, effect such as hidroschesis.It is little, evident in efficacy that this Chinese medicine composition is taken the back side effect.
Technical scheme of the present invention is: a kind of Chinese medicine composition of treating lung-heat is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated: Radix Bupleuri 10-15 part, Radix Scutellariae 2-6 part, Rhizoma Pinelliae 5-10 part, Rhizoma Zingiberis Recens 4-10 part, SHENGCAO 1-5 part, Radix Salviae Miltiorrhizae 5-10 part, Pericarpium Citri Reticulatae 5-10 part, Endothelium corneum 5-15 part, Rhizoma Atractylodis Macrocephalae 5-12 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 5-10 part, Herba Asari 3-6 part, Fructus Citri Sarcodactylis 5-10 part.
Said a kind of weight portion of treating the Chinese medicine composition of lung-heat is: 12 parts of Radix Bupleuri, 5 parts of Radix Scutellariaes, 8 parts of the Rhizoma Pinelliaes, 8 parts in Rhizoma Zingiberis Recens, 3 parts of SHENGCAOs, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Endothelium corneum, 9 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 5 parts of Herba Asaris, 8 parts of Fructus Citri Sarcodactylis.
Said a kind of weight portion of treating the Chinese medicine composition of lung-heat is: 10 parts of Radix Bupleuri, 2 parts of Radix Scutellariaes, 5 parts of the Rhizoma Pinelliaes, 4 parts in Rhizoma Zingiberis Recens, 1 part of SHENGCAO, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Endothelium corneum, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 3 parts of Herba Asaris, 5 parts of Fructus Citri Sarcodactylis.
Said a kind of weight portion of treating the Chinese medicine composition of lung-heat is: 15 parts of Radix Bupleuri, 6 parts of Radix Scutellariaes, 10 parts of the Rhizoma Pinelliaes, 10 parts in Rhizoma Zingiberis Recens, 5 parts of SHENGCAOs, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Endothelium corneum, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 6 parts of Herba Asaris, 10 parts of Fructus Citri Sarcodactylis.
The present invention also provides the method for preparing of above-mentioned Chinese medicine composition, comprises the steps:
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, subsequent use;
2), Radix Bupleuri, Rhizoma Zingiberis Recens, Pericarpium Citri Reticulatae are extracted volatile oil with the way of distillation, subsequent use;
3), decocting that all the other crude drug are added 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;
4), with step 2) medicinal residues that the obtain decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;
5), with step 2) volatile oil and the step 3), 4 that obtain) filtrating the mixing that obtain be incorporated in 70 ℃ and be evaporated to the thick paste that relative density is 1.20-1.25, and be subsequent use;
6), thick paste that step 4) is obtained is dry, is ground into fine powder, processes capsule.
Every of this medicament specification contains active ingredient 0.5g, oral one time 2,2 times on the 1st, serveing on 15 days was 1 course of treatment.
Characteristics of the present invention are reasonable recipe, meet theory of Chinese medical science: the Radix Bupleuri bitter in the mouth, and evacuation is brought down a fever, the yang invigorating soothing liver-QI; The Radix Scutellariae bitter in the mouth, heat clearing and damp drying, eliminating fire and detoxication; The hot temperature of the Rhizoma Pinelliae, the removing dampness spleen invigorating, antidiarrheal helps digestion; Rhizoma Zingiberis Recens is warm in nature, relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough; The Radix Salviae Miltiorrhizae bitter in the mouth, promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, the relieving restlessness that clears away heart-fire, nourishing blood to tranquillize the mind; The hot temperature of Pericarpium Citri Reticulatae, regulating qi-flowing for strengthening spleen, in the accent, dampness is reduced phlegm; The Endothelium corneum bitter in the mouth is controlled all a fishbone or other bone caught in the throat, dysphagic regurgitation of food from the stomach; Rhizoma Atractylodis Macrocephalae sweet in the mouth, invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis; Herba Asari has cold expelling and dispels the wind; Pain relieving; Warming the lung to resolve fluid-retention; Sensible effect; Fructus Citri Sarcodactylis is arduous, activating QI to eliminate phlegm, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating.
The above-mentioned raw materials medicine is made mixing ratio respectively and is mixed together and boils drug effect and improve greatly, and have strengthening the spleen and nourishing the stomach, heat clearing and damp drying, warming the lung to relieve cough, reduce phlegm, effect such as hidroschesis.
The specific embodiment
Through the specific embodiment that provides the present invention is described clearly further below, but not as to qualification of the present invention.
Embodiment 1
Said a kind of weight portion of treating the Chinese medicine composition of lung-heat is: 12 parts of Radix Bupleuri, 5 parts of Radix Scutellariaes, 8 parts of the Rhizoma Pinelliaes, 8 parts in Rhizoma Zingiberis Recens, 3 parts of SHENGCAOs, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Endothelium corneum, 9 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 5 parts of Herba Asaris, 8 parts of Fructus Citri Sarcodactylis.
The present invention also provides the method for preparing of above-mentioned Chinese medicine composition, comprises the steps:
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, subsequent use;
2), Radix Bupleuri, Rhizoma Zingiberis Recens, Pericarpium Citri Reticulatae are extracted volatile oil with the way of distillation, subsequent use;
3), decocting that all the other crude drug are added 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;
4), with step 2) medicinal residues that the obtain decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;
5), with step 2) volatile oil and the step 3), 4 that obtain) filtrating the mixing that obtain be incorporated in 70 ℃ and be evaporated to the thick paste that relative density is 1.20-1.25, and be subsequent use;
6), thick paste that step 4) is obtained is dry, is ground into fine powder, processes capsule.
Embodiment 2
Said a kind of weight portion of treating the Chinese medicine composition of lung-heat is: 10 parts of Radix Bupleuri, 2 parts of Radix Scutellariaes, 5 parts of the Rhizoma Pinelliaes, 4 parts in Rhizoma Zingiberis Recens, 1 part of SHENGCAO, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Endothelium corneum, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 3 parts of Herba Asaris, 5 parts of Fructus Citri Sarcodactylis.
Preparation and method for using are with embodiment 1.
Embodiment 3
Said a kind of weight portion of treating the Chinese medicine composition of lung-heat is: 15 parts of Radix Bupleuri, 6 parts of Radix Scutellariaes, 10 parts of the Rhizoma Pinelliaes, 10 parts in Rhizoma Zingiberis Recens, 5 parts of SHENGCAOs, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Endothelium corneum, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 6 parts of Herba Asaris, 10 parts of Fructus Citri Sarcodactylis.
Preparation and method for using are with embodiment 1.
More than the prescription effect of three embodiment be more significant prescription; But so long as comparatively significantly curative effect, Radix Bupleuri 10-15 part, Radix Scutellariae 2-6 part, Rhizoma Pinelliae 5-10 part, Rhizoma Zingiberis Recens 4-10 part, SHENGCAO 1-5 part, Radix Salviae Miltiorrhizae 5-10 part, Pericarpium Citri Reticulatae 5-10 part, Endothelium corneum 5-15 part, Rhizoma Atractylodis Macrocephalae 5-12 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 5-10 part, Herba Asari 3-6 part, Fructus Citri Sarcodactylis 5-10 part all can be arranged by following prescription proportioning.
The umber of Chinese medicine component can be got gram (g), kilogram (kg), ton (t).
Main pharmacodynamics test is following:
Zoopery
60 of mices are got in the preparation of experimental lung-heat animal model, through feed high protein, high caloric diet, make the lung-heat mouse model; Be divided into 5 groups at random, 12 every group, 1 group is blank normal group; 2 groups is model group, and 3 groups is the MAXINGSHIGAN TANG group, and 4 groups is the Decoction for Reliving Dryness of the Lung group; 5 groups is drug group of the present invention, and establishes MAXINGSHIGAN TANG treatment group and compare perfusion every day 3 times; Be separated by 2 hours at every turn, and observed the survival in the infecting mouse 20 days, calculate mortality rate, dead protective rate, mean survival time.Duplicate the mouse lung thermal model according to last method, and with the Drug therapy of the embodiment of the invention 1, embodiment 2, embodiment 3.If the Decoction for Reliving Dryness of the Lung group compares, infected the back the 8th day, the mouse death rate that infects lung-heat is 80%, mean survival time is 8.30 days.Compare with model group, MAXINGSHIGAN TANG mortality of mice, mean survival time have significant difference and (are respectively P＜0.01, P＜0.15; P＜0.2, P＜0.05, P＜0.05).Compare with model group, Decoction for Reliving Dryness of the Lung group, MAXINGSHIGAN TANG group mouse lung index all significantly reduce (being respectively P＜0.001, P＜0.05, P＜0.05).Decoction for Reliving Dryness of the Lung group and MAXINGSHIGAN TANG group compare, and latter's effect is better, not statistically significant (P＞0.05).
In order to show the therapeutic effect of medicine of the present invention, the present invention has carried out clinical trial.
The clinical trial of a kind of Chinese medicine composition of treating lung-heat proposed by the invention is following: select age 15-60 year patient 120 examples, 35 years old mean age, the course of disease 7 days-30 days, average course of disease 15 days.Patient's clinical symptoms is roughly: heating, cough, chest pain, the amount of coughing up phlegm are many, and abnormal smells from the patient is stench, or pus and blood is held concurrently mutually.The patient did not accept other treatment before this treatment.15 days is a course of treatment, carries out symptom score after 10 days.120 routine patients are divided into 4 groups at random, every group 30 example, and treatment group 1 adopts medicine of the present invention; Material component and treatment group 1 that treatment group 2 adopts are the same materials components, and production technology is different, and treatment group 2 is first together the mixing together of all material components to be brewed into paste medicine; Contrast A group is used lilium compound antiphlogistic pill; Contrast B group is used Lonicerae and Forsythiae Powder; Be careful in one's diet during this time and have a rest.
Curative effect judging standard:
1, cures: various transference cures.
2, take a turn for the better: the normal or improvement of various glucose recoveries.
3, invalid: various sxs or do not have improvement.
Therapeutic outcome:
Treat after 10 days, therapeutic effect is relatively seen table 1.
Table 1 pharmaceutical treatment of the present invention is the effect comparison after 20 days
| Group | Number | Produce effects | Take a turn for the better | Invalid | 15 days effective percentage |
| Treatment group 1 | 30 | 14 | 10 | 6 | 80% |
| Treatment group 2 | 30 | 13 | 8 | 9 | 70% |
| Contrast A group | 30 | 11 | 10 | ? | 70% |
| Contrast B group | 30 | 10 | 12 | ? | 73.3% |
Visible by table 1: the effect of treatment group 1 of using the made Chinese medicine of the present invention is apparently higher than treatment group 2 (P < 0.05); Explain that production technology has very big influence to therapeutic effect; The effect of treatment group 1 is apparently higher than contrast A group and contrast B group (P < 0.05); And symptom takes a turn for the better apparently higher than lilium compound antiphlogistic pill and Lonicerae and Forsythiae Powder, shows that the therapeutic effect of the powder that use the present invention is made is good, and obvious effective rate is high.
Claims (5)
1. Chinese medicine composition of treating lung-heat, it is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated: Radix Bupleuri 10-15 part, Radix Scutellariae 2-6 part, Rhizoma Pinelliae 5-10 part, Rhizoma Zingiberis Recens 4-10 part, SHENGCAO 1-5 part, Radix Salviae Miltiorrhizae 5-10 part, Pericarpium Citri Reticulatae 5-10 part, Endothelium corneum 5-15 part, Rhizoma Atractylodis Macrocephalae 5-12 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 5-10 part, Herba Asari 3-6 part, Fructus Citri Sarcodactylis 5-10 part.
2. according to the said a kind of Chinese medicine composition of treating lung-heat of claim 1, it is characterized in that: its weight portion is: 12 parts of Radix Bupleuri, 5 parts of Radix Scutellariaes, 8 parts of the Rhizoma Pinelliaes, 8 parts in Rhizoma Zingiberis Recens, 3 parts of SHENGCAOs, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Pericarpium Citri Reticulataes, 10 parts of Endothelium corneum, 9 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 5 parts of Herba Asaris, 8 parts of Fructus Citri Sarcodactylis.
3. according to the said a kind of Chinese medicine composition of treating lung-heat of claim 1, it is characterized in that: its weight portion is: 10 parts of Radix Bupleuri, 2 parts of Radix Scutellariaes, 5 parts of the Rhizoma Pinelliaes, 4 parts in Rhizoma Zingiberis Recens, 1 part of SHENGCAO, 5 parts of Radix Salviae Miltiorrhizaes, 5 parts of Pericarpium Citri Reticulataes, 5 parts of Endothelium corneum, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 3 parts of Herba Asaris, 5 parts of Fructus Citri Sarcodactylis.
4. according to the said a kind of Chinese medicine composition of treating lung-heat of claim 1, it is characterized in that: its weight portion is: 15 parts of Radix Bupleuri, 6 parts of Radix Scutellariaes, 10 parts of the Rhizoma Pinelliaes, 10 parts in Rhizoma Zingiberis Recens, 5 parts of SHENGCAOs, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts of Pericarpium Citri Reticulataes, 15 parts of Endothelium corneum, 12 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 6 parts of Herba Asaris, 10 parts of Fructus Citri Sarcodactylis.
5. according to the described a kind of method for preparing of treating the Chinese medicine composition of lung-heat of claim 1-4, comprise the steps:
1) crude drug of getting in the above-mentioned raw materials carries out roguing respectively, and clean, dry, subsequent use;
2), Radix Bupleuri, Rhizoma Zingiberis Recens, Pericarpium Citri Reticulatae are extracted volatile oil with the way of distillation, subsequent use;
3), decocting that all the other crude drug are added 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;
4), with step 2) medicinal residues that the obtain decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;
5), with step 2) volatile oil and the step 3), 4 that obtain) filtrating the mixing that obtain be incorporated in 70 ℃ and be evaporated to the thick paste that relative density is 1.20-1.25, and be subsequent use;
6), thick paste that step 4) is obtained is dry, is ground into fine powder, processes capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011104220596A CN102488877A (en) | 2010-12-16 | 2011-12-16 | Traditional Chinese medicine composition for treating lung heat |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010591914.1 | 2010-12-16 | ||
| CN2010105919141A CN102008701A (en) | 2010-12-16 | 2010-12-16 | Chinese medicinal composite for treating lung heat |
| CN2011104220596A CN102488877A (en) | 2010-12-16 | 2011-12-16 | Traditional Chinese medicine composition for treating lung heat |
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| CN102488877A true CN102488877A (en) | 2012-06-13 |
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| CN2011104220596A Pending CN102488877A (en) | 2010-12-16 | 2011-12-16 | Traditional Chinese medicine composition for treating lung heat |
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| CN105126049A (en) * | 2015-08-26 | 2015-12-09 | 朱小芬 | Pharmaceutical composition for treating cough and preparation method of pharmaceutical composition |
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Application publication date: 20120613 |