CN105126049A - Pharmaceutical composition for treating cough and preparation method of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating cough and preparation method of pharmaceutical composition Download PDFInfo
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- CN105126049A CN105126049A CN201510530919.6A CN201510530919A CN105126049A CN 105126049 A CN105126049 A CN 105126049A CN 201510530919 A CN201510530919 A CN 201510530919A CN 105126049 A CN105126049 A CN 105126049A
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Abstract
The invention discloses a pharmaceutical composition for treating cough and a preparation method of the pharmaceutical composition; the medicine consists of the following raw materials: broadleaf holly leaf, lychee leaf, carp's gallbladder, human nail, hippocampus japonicus, crocodilian blood, repent jussiaea herb, amphibious crab, fingered citron, fresh ginger, fragrant citrus pericarp, cricket, sterculia nobilis and longan mistletoe. The preparation method comprises the following steps: weighing various components according to parts by weight in a prescription; grinding the human nail, drying the amphibious crab and the cricket in the sun, and frying the materials in a pot above heavy fire for 2-5 minutes for later use; adding other components, except for the carp's gallbladder, to the pot of the step B, and decocting the components with 10-20 times of water for 20-120 minutes; and adding bile of the carp's gallbladder to the step C so as to obtain the pharmaceutical composition. In order to overcome shortcomings of the prior art, the invention provides a pharmaceutical composition which is reasonable in proportion and rapid to take effect on treating cough. The invention also aims at providing a method for preparing the medicine for treating cold and cough.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for coughing, the invention still further relates to a kind of method preparing above-mentioned treatment cold cough medicine.
Background technology
Cold cough is a kind of commonly encountered diseases and frequently-occurring disease, coughs frequently unhealthful, and especially child and old man, coughs larger to its health effect.Not only endanger own health, also affect surrounding population.At present, the medicine having many treatment coughs of market medicine store merchandising, as: JIZHI TANGJIANG, MILIAN CHUANBEI PIPA GAO, cough spirit, Succus Fel Serpentis et Bulbus Fritillariae Cirrhosae etc., but patient takes rear reaction, and curative effect is not very good.
The existing pharmaceutical composition for coughing takes effect slowly, can not meet the demand of patient, so the existing pharmaceutical composition for coughing needs to be further improved.
Summary of the invention
The object of the invention is in order to overcome weak point of the prior art, to provide a kind of reasonable mixture ratio, the pharmaceutical composition for coughing that curative effect is fast.
Another object of the present invention is to provide a kind of method preparing above-mentioned treatment cold cough medicine.
In order to achieve the above object, the present invention adopts following scheme:
For a pharmaceutical composition of coughing, it is characterized in that comprising following component by weight:
A pharmaceutical composition as above for coughing, is characterized in that also comprising following component by weight:
A pharmaceutical composition as above for coughing, is characterized in that also comprising following component by weight:
A pharmaceutical composition as above for coughing, is characterized in that also comprising following component by weight:
A kind of method preparing treatment cold cough medicine as mentioned above of the present invention, is characterized in that comprising the following steps:
A, take each component by the weight portion in prescription;
B, get Concha and grind into powder, Sesarmae dehaani, Gryllus Chinensis are dried, enter together a pot big fire stir-fry 2-5 minute for subsequent use;
C, in the pot in step B, add other component except Fel Cyprinus carpio, add 10-20 times of soak by water 20-120 minute;
D, in step C, add the bile of Fel Cyprinus carpio.
In sum, the present invention relative to its beneficial effect of prior art is:
Reasonable mixture ratio of the present invention, Fang Zhong:
1, Folium Ilicis: blood pressure lowering, blood fat reducing, convenient, pathogenic fire reducing, pharynx-clearing throat-benefiting, control gingiva, dental inflammation etc.
2, Folium Litchi at the bottom of the pool: property is flat, lightly seasoned, heat-clearing and toxic substances removing;
3, Fel Cyprinus carpio: bitter in the mouth, cold in nature, clearing away heat to improve acuity of vision, nebula removing is subsided a swelling, sore-throat relieving.
4, Concha: sweet in the mouth, salty, property is put down.For epistaxis, hematuria, laryngopharynx swelling and pain, dysuria, the raw cataracta of order, otitis media.
5, Hippocampus: there is the medicinal functions such as building body, kidney invigorating and YANG supporting, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic, tranquillizing and allaying excitement, relieving cough and asthma.
6, crocodile blood: there is the effects such as antiinflammatory, heat-clearing and toxic substances removing, treating tumor;
7, Herba Jussiaeae Repentis: there is heat clearing away, diuresis, effect of removing toxic substances.Be usually used in cold, fever, cough caused by dryness-heat, high hot excessive thirst, drench pain, edema, pharyngalgia, larynx swells, aphtha, acute toothache, and carbuncle sore furuncle swells, burn and scald, and traumatic injury wound is swollen, poisonous snake, lyssodexis.
8, Sesarmae dehaani: the effect with detoxicating, relieving inflammation, effective especially to treatment laryngopharynx swelling and pain, come from " China's book on Chinese herbal medicine ";
9, Fructus Citri Sarcodactylis: have activating QI to eliminate phlegm, preventing or arresting vomiting relieving distension, the liver soothing and the spleen invigorating, the more kinds of medicinal function of stomach function regulating.
10, Rhizoma Zingiberis Recens: the pungent and loose temperature of Rhizoma Zingiberis Recens, strengthening the spleen stomach, kind warming middle-JIAO to send down the adverse QI preventing or arresting vomiting, dehumidify the painful abdominal mass that disappears, and eliminating phlegm and stopping cough take stopping nausea and vomiting by lowering the adverse flow of QI as length.
11, Pericarpium citri sinensis: fast diarrhea due to disorder of QI every, eliminating phlegm and lowering adverse QI, the stomach function regulating that helps digestion, neutralize the effect of alcoholic drinks, kill fish Eriocheir sinensis poison.The main chest and diaphragm stagnation of QI, cough with copious phlegm, diet do not disappear, nausea and vomiting, drunk.
12, Gryllus Chinensis: diuresis, removing blood stasis, sore-throat relieving.For edema, urinary obstruction, lithangiuria, cirrhotic ascites, laryngopharynx swelling and pain.
13, sterculia nobilis: sweet, temperature.Yao Kecheng " food book on Chinese herbal medicine ": " control the infested and children's of internal organs and eat earth, stomachache, addiction block is long-pending hard.Nourishing the liver gallbladder, improving eyesight removing nebula, suppressing cough and abating fever, separates sharp ailment said due to cold or exposure, and disappear tired pathogenic fire reducing.”
14, Arillus Longan is parasitic: wind-damp dispelling; Invigorating the liver and kidney; Promoting blood circulation and stopping pain; Cough-relieving; Dysentery relieving.Main air pain of dampness syndrome; Soreness of waist and knee joint; Have a dizzy spell; Alopecia; Traumatic injury; Swelling and pain of hemorrhoid; Cough; Hemoptysis; Dysentery.
15, Herba Gerberae Piloselloidis: cure mainly lung qi dispersing, cough-relieving, diaphoresis, diuretic, circulation of qi promoting, invigorates blood circulation.Control the cough due to common cold, asthma, edema, distension, urinary obstruction, food stagnation of child, married woman's amenorrhea, traumatic injury, carbuncle, furuncle, multiple abscess.
16, heronsbill: tool heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the function such as anticancer.
17, Caulis menispermi: blood pressure lowering, antipyretic, analgesia.
18, Cyrtomium fortunei J. Sm.: heat-clearing and toxic substances removing, cooling blood for calming endogenous wind, loose expectorant hemostasis, cures cold.
19, Herba Asparagi Setacei: nourishing the lung to arrest cough, reducing heat in the blood and treating stranguria, diuresis is detoxified..Cure mainly pulmonary tuberculosis cough, acute bronchitis, amebic dysentery, lung-dryness syndrome due to deficiency of YIN; Cough; Spitting of blood; Dribbling urination.
20, Rhizoma Helminthostachydis Zeylanicae: removing heat-phlegm, antidotes against snake bite.For pharyngitis, tonsillitis, cough, asthma; Venom is controlled in external.
21, Cortex Syringae: eliminate the phlegm and cough-relieving.
22, Radix Achyranthis: have heat-clearing and toxic substances removing, diuresis effect, cures mainly cold, fever, tonsillitis, diphtheria, mumps, urinary system calculus, the diseases such as oedema due to nephritis.
23, Herba nepenthis: clearing away lung-heat and moistening for dryness, row water, removing toxic substances.Control xeropulmonary cough, pertussis, jaundice, stomachache, dysentery, edema, carbuncle, insect bite is hindered.
24, Herba Buddlejae Lindleyanae: cure mainly and dispel the wind, parasite killing, invigorates blood circulation.Control influenza, cough, asthma etc.
25, Radix Zanthoxyli Avicennae: control laryngopharynx swelling and pain, general edema with yellowish skin, malaria, rheumatic ostalgia, traumatic injury is dampened.
26, Herba Iridis japonicae: heat-clearing and toxic substances removing, dissipating blood stasis, cough-relieving, diuresis.For cough, infantile scrofula, innominate toxic swelling.
27, Semen Benincasae: lung moistening, reduces phlegm, eliminating carbuncle, diuretic.Control phlegm-heat cough, lung abscess, acute appendicitis, gonorrhea, edema, beriberi, hemorrhoid, nasal surface wine Zha.
28, Fel Anseris domestica: heat-clearing and toxic substances removing, controls hemorrhoid, cough.
29, floral disc of sunflower: removing heat-phlegm, the merit of cooling blood for hemostasis, to headache, dizziness etc. effectively.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the invention will be further described:
Embodiment 1
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 2
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 3
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 4
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 5
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 6
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 7
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 8
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 9
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 10
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 11
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 12
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 13
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 14
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 15
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 16
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 17
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 18
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 19
For a pharmaceutical composition of coughing, comprise following component by weight:
Embodiment 20
For a pharmaceutical composition of coughing, comprise following component by weight:
Medicine in embodiment of the present invention 1-20 can be prepared by the following method:
A, take each component by the weight portion in prescription;
B, get Concha and grind into powder, Sesarmae dehaani, Gryllus Chinensis are dried, enter together a pot big fire stir-fry 2-5 minute for subsequent use;
C, in the pot in step B, add other component except Fel Cyprinus carpio, add 10-20 times of soak by water 20-120 minute;
D, in step C, add the bile of Fel Cyprinus carpio.
In order to show the therapeutic effect of the present invention in treatment cold cough, invention has been following animal experiment and clinical trial:
Get body weight 18-22g mice 100, be divided into 4 groups at random, blank group gives gavage normal saline, and the other gavage of test component gives medicine 0.5g/kg, 1.0g/kg of the present invention, 2.0g/kg; Positive control gives Folium Eriobotryae cough-relieving electuary 2.0g/kg, and gavage volume is 2ml/100g successive administration 5 days.After last administration 30 minutes, mice is put in closed glass case, quantitatively spray into strong aqua ammonia aerosol to lure and cough, record in mouse cough incubation period and 3 minutes number of times of coughing, result: the average cough latent period of tested combination positive drug control group all extend more than 25 seconds, average cough number of times obviously reduces, and shows that this product has obvious antitussive effect:
Expectorant test:
The impact phenol red on mice trachea excretion: get body weight 18-22g mice, the other gavage of test component gives medicine 0.5g/kg, 1.0g/kg of the present invention, 2.0g/kg; Positive control gives Folium Eriobotryae cough-relieving electuary 2.0g/kg, and blank group gives gavage normal saline, successive administration 5 days.After last administration 30 minutes, the phenol red normal saline solution of lumbar injection 0.25%.Put to death mice after 30 minutes, rinse pulmonary branches trachea and collect irrigating solution, measure OD value, result shows that medicine of the present invention significantly can increase the phenol red amount of mice trachea excretion, has obvious phlegm-dispelling functions.
Clinical trial:
The cough after flu, pharyngolaryngitis is selected, the Patients with 300 Cases of the symptoms such as aphonia, xerostomia pharyngalgia, wherein course of disease 1-5 days 126 examples, 5-10 days 104 examples, more than 10 days 70 examples from clinic case.
Take medicine decoction of the present invention, every twice-daily.Cough in 1-3 days disappears substantially, the transference cures such as pharyngalgia, effective percentage 100%.
Impact on Hair of Rat tubule expectoration amount: rat is divided into 4 groups, after the anesthesia of lumbar injection pentobarbital sodium, cuts cervical region, is separated trachea, insert glass capillary, record the amount of sucking-off expectorant in 2 hours.Be put to the test and organize gavage respectively and give medicine 0.5g/kg, 1.0g/kg of the present invention, 2.0g/kg; Matched group gives gavage normal saline, and gavage volume is 2ml/100g, continues observation 2 hours amounts of expectoration, record administration forward backward averaging secretory volume per hour.Result shows that tested group of high and low dose group all can increase rat trachea expectoration amount, has obvious phlegm-dispelling functions.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
Claims (5)
1. the pharmaceutical composition for coughing, is characterized in that comprising following component by weight:
2. a kind of pharmaceutical composition for coughing according to claim 1, is characterized in that also comprising following component by weight:
3. a kind of pharmaceutical composition for coughing according to claim 1 and 2, is characterized in that also comprising following component by weight:
4. a kind of pharmaceutical composition for coughing according to claim 3, is characterized in that also comprising following component by weight:
5. preparing the method for pharmaceutical composition as claimed in claim 1 or 2 for coughing, it is characterized in that comprising the following steps:
A, take each component by the weight portion in prescription;
B, get Concha and grind into powder, Sesarmae dehaani, Gryllus Chinensis are dried, enter together a pot big fire stir-fry 2 ?5 minutes for subsequent use;
C, in the pot in step B, add other component except Fel Cyprinus carpio, add 10 ?20 times of soak by water 20 ?120 minutes;
D, in step C, add the bile of Fel Cyprinus carpio.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510530919.6A CN105126049A (en) | 2015-08-26 | 2015-08-26 | Pharmaceutical composition for treating cough and preparation method of pharmaceutical composition |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510530919.6A CN105126049A (en) | 2015-08-26 | 2015-08-26 | Pharmaceutical composition for treating cough and preparation method of pharmaceutical composition |
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| CN105126049A true CN105126049A (en) | 2015-12-09 |
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| CN201510530919.6A Pending CN105126049A (en) | 2015-08-26 | 2015-08-26 | Pharmaceutical composition for treating cough and preparation method of pharmaceutical composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031365A (en) * | 2015-08-26 | 2015-11-11 | 唐媚英 | Traditional Chinese medicine for preventing and treating cold and cough and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803667A (en) * | 2010-02-03 | 2010-08-18 | 汕头市生奥保健食品有限公司 | Fingered citron food and preparation method thereof |
| CN102008701A (en) * | 2010-12-16 | 2011-04-13 | 西安谦坤商务咨询管理有限公司 | Chinese medicinal composite for treating lung heat |
-
2015
- 2015-08-26 CN CN201510530919.6A patent/CN105126049A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803667A (en) * | 2010-02-03 | 2010-08-18 | 汕头市生奥保健食品有限公司 | Fingered citron food and preparation method thereof |
| CN102008701A (en) * | 2010-12-16 | 2011-04-13 | 西安谦坤商务咨询管理有限公司 | Chinese medicinal composite for treating lung heat |
Non-Patent Citations (2)
| Title |
|---|
| 本书专家组: "《中医助理医师应试指导》", 31 January 2015, 中国协和医科大学出版社 * |
| 邱保国，等: "《简明中药临床实用手册》", 31 January 2012, 中原农民出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105031365A (en) * | 2015-08-26 | 2015-11-11 | 唐媚英 | Traditional Chinese medicine for preventing and treating cold and cough and preparation method thereof |
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Application publication date: 20151209 |