CN108066600A - A kind of Chinese medicine preparation for treating angiocardiopathy and preparation method thereof - Google Patents
A kind of Chinese medicine preparation for treating angiocardiopathy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine preparation for treating angiocardiopathy and preparation method thereof, include the raw material of following parts by weight：46 parts of 12 18 parts of dragon's blood, 8 16 parts of Rhizoma Chuanxiong, 8 12 parts of Radix Astragali, 12 15 parts of borneol, 20 30 parts of hawthorn, 6 12 parts of the fleece-flower root, 24 35 parts of Radix Angelicae Sinensis, 5 15 parts of American Ginseng, 10 18 parts of Poria cocos, 5 20 parts of Radix Ophiopogonis, 5 10 parts of jujube and Radix Glycyrrhizae.Raw material sources of the present invention are extensive; preparation process is simple; the finished product of preparation has effects that releive blood vessel, easing pain and diminishing inflammation, protection cardiac muscle; there is the effect of notable to a variety of angiocardiopathies such as treatment coronary heart diseases and angina pectoris, myocardial ischemia, cardiac arrhythmia, heart failure; the product of the present invention is quick; without any side effects, prospect of the application is wide.
Description
Technical field
The present invention relates to the field of Chinese medicines, are specifically a kind of Chinese medicine preparation for treating angiocardiopathy.
Background technology
Angiocardiopathy, also known as circulation system disease, are a series of diseases for being related to the circulatory system, are clinical very normal
That sees endangers one group of important diseases of human health, and the circulatory system refers to hemophoric organ and tissue in human body, cardiovascular disease
Disease including coronary heart diseases and angina pectoris etc., coronary heart diseases and angina pectoris be due to coronary insufficiency, cardiac muscle drastically, it is temporary scarce
Caused by blood, anoxic, there is the characteristics of " incidence is high, and the death rate is high, and complication is more ", belong to the traditional Chinese medical science " obstruction of qi in the chest " scope.From
Since last century the fifties, the angiocardiopathies such as coronary heart diseases and angina pectoris have become in addition to cranial vascular disease, malignant tumour
The third-largest death factors of the mankind
At present, the method for coronary heart diseases and angina pectoris is treated to expand blood vessel, reduce blood glucose viscosity, platelet aggregation-against, anti-freezing
Based on blood etc., people are usually based on Western medicine.Traditional Western medicine of application is nitric acid lipid, beta-receptor hinders preparation, Ca2+ overloading
Agent etc. though it is rapid to work, there is larger toxic side effect, should not take, and these medicines are mostly symptomatic control for a long time
It treats, can only mitigate or delay disease to develop, it is necessary to long-term use of, it is impossible to be discontinued, this all brings hidden danger for the use of patient.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation for treating angiocardiopathy, to solve in above-mentioned background technology
The problem of proposition.
To achieve the above object, the present invention provides following technical solution：
A kind of Chinese medicine preparation for treating angiocardiopathy includes the raw material of following parts by weight：12-18 parts of dragon's blood, 8-16 parts of Rhizoma Chuanxiong,
8-12 parts of Radix Astragali, 12-15 parts of borneol, 20-30 parts of hawthorn, 6-12 parts of the fleece-flower root, 24-35 parts of Radix Angelicae Sinensis, 5-15 parts of American Ginseng, Poria cocos
4-6 parts of 10-18 parts, Radix Ophiopogonis 5-20 part, 5-10 parts of jujube and Radix Glycyrrhizae.
As further embodiment of the present invention：The Chinese medicine preparation of the treatment angiocardiopathy, including following parts by weight
Raw material：15-18 parts of dragon's blood, 11-16 parts of Rhizoma Chuanxiong, 10-12 parts of Radix Astragali, 13-15 parts of borneol, 23-30 parts of hawthorn, fleece-flower root 8-12
4.5-6 parts of part, 28-35 parts of Radix Angelicae Sinensis, 8-15 parts of American Ginseng, 12-18 parts of Poria cocos, Radix Ophiopogonis 9-20 part, 6.6-10 parts of jujube and Radix Glycyrrhizae.
As further embodiment of the present invention：The Chinese medicine preparation of the treatment angiocardiopathy, including following parts by weight
Raw material：16.5 parts of dragon's blood, 14 parts of Rhizoma Chuanxiong, 11 parts of Radix Astragali, 14 parts of borneol, 27 parts of hawthorn, 10 parts of the fleece-flower root, 33 parts of Radix Angelicae Sinensis, the West
5 parts of 12.5 parts of ginseng, 15 parts of Poria cocos, 16 parts of Radix Ophiopogonis, 8.5 parts of jujube and Radix Glycyrrhizae.
The preparation method of the Chinese medicine preparation of the treatment angiocardiopathy, is as follows：
Dragon's blood, Poria cocos and borneol are extracted volatile oil by step 1, spare, and the dregs of a decoction are added with the ethyl alcohol that mass fraction is 60-80%
It when circumfluence distillation 2-4 times, each 1-2 are small, filter and recycles filtrate, it is 1.06-1.25's to be concentrated under reduced pressure into relative density
Thick paste is dried and is ground into medicinal powder, spare；
Rhizoma Chuanxiong, Radix Astragali, hawthorn and the fleece-flower root are cleaned and crushed by step 2, and the ethyl alcohol stirring for adding in 2-4 times of total weight is equal
It is even and seal, filtering is taken out after impregnating 45-55 days, obtains the first mixing filtrate, by the dregs of a decoction filtered out water decoction 1-3
It is secondary, the water of each 3-6 times of dregs of a decoction weight, decoct every time arrive close to it is gluey when stop, merging filtrate is filtered, removed slag, and obtains the
One decoction liquor；
Step 3, by Radix Angelicae Sinensis, American Ginseng, Radix Ophiopogonis, jujube and Radix Glycyrrhizae clean and add in 6-10 times of total weight water impregnate 4-6 it is small
When, then boil 1.5-3 it is small when, extraction obtains the first extracting solution, then add in thereto 5-8 times boiling boiling 2-3 it is small when, extract
The second extracting solution is obtained, merge the first extracting solution and the second extracting solution and is filtered, obtains the second mixing filtrate；
Step 4 mixes the volatile oil in step 1 and medicinal powder, the first mixing filtrate, the first decoction liquor and the second mixing filtrate
It closes, is prepared into pill, capsule or tablet using suitable technique, you can obtain finished product.
As further embodiment of the present invention：It is 65-76 degrees Celsius that temperature is decocted in step 2.
Compared with prior art, the beneficial effects of the invention are as follows：Raw material sources of the present invention are extensive, and preparation process is simple, system
Standby finished product has effects that releive blood vessel, easing pain and diminishing inflammation, protection cardiac muscle, to treatment coronary heart diseases and angina pectoris, myocardial ischemia, the heart
Restraining a variety of angiocardiopathies such as uneven, heart failure has the effect of notable, and product of the invention is quick, and no any poison is secondary to be made
With prospect of the application is wide.
Specific embodiment
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
A kind of Chinese medicine preparation for treating angiocardiopathy includes the raw material of following parts by weight：12 parts of dragon's blood, 8 parts of Rhizoma Chuanxiong, Radix Astragali 8
Part, 12 parts of borneol, 20 parts of hawthorn, 6 parts of the fleece-flower root, 24 parts of Radix Angelicae Sinensis, 5 parts of American Ginseng, 10 parts of Poria cocos, 5 parts of Radix Ophiopogonis, 5 parts of jujube and
4 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine preparation of the treatment angiocardiopathy, is as follows：
Dragon's blood, Poria cocos and borneol are extracted volatile oil by step 1, spare, and the ethyl alcohol that dregs of a decoction mass fraction is 66% is heated back
Stream extraction 3 times, every time 1.5 it is small when, filter and recycle filtrate, be concentrated under reduced pressure into the thick paste that relative density is 1.12, it is dry simultaneously
And medicinal powder is ground into, it is spare；
Rhizoma Chuanxiong, Radix Astragali, hawthorn and the fleece-flower root are cleaned and crushed by step 2, and the ethyl alcohol for adding in 3 times of total weight stirs evenly
And it seals, takes out filtering after impregnating 48 days, obtain the first mixing filtrate, the dregs of a decoction filtered out water is decocted 2 times, each medicine
The water that 4 times of slag weight, stops, merging filtrate when decocted every time to close to glue, and filtering removes slag, obtains the first decoction liquor；
Step 3, by Radix Angelicae Sinensis, American Ginseng, Radix Ophiopogonis, jujube and Radix Glycyrrhizae clean and add in 8 times of total weight water impregnate 5 it is small when, then
Boil 2.5 it is small when, extraction obtains the first extracting solution, then add in thereto 6 times boiling boiling 2 it is small when, extraction obtains the second extraction
Liquid merges the first extracting solution and the second extracting solution and filters, obtains the second mixing filtrate；
Step 4 mixes the volatile oil in step 1 and medicinal powder, the first mixing filtrate, the first decoction liquor and the second mixing filtrate
It closes, is prepared into pill, capsule or tablet using suitable technique, you can obtain finished product.
Embodiment 2
A kind of Chinese medicine preparation for treating angiocardiopathy includes the raw material of following parts by weight：15 parts of dragon's blood, 11 parts of Rhizoma Chuanxiong, Radix Astragali
10 parts, 13 parts of borneol, 23 parts of hawthorn, 8 parts of the fleece-flower root, 28 parts of Radix Angelicae Sinensis, 8 parts of American Ginseng, 12 parts of Poria cocos, 9 parts of Radix Ophiopogonis, jujube 6.6
4.5 parts of part and Radix Glycyrrhizae.
The preparation method of the Chinese medicine preparation of the treatment angiocardiopathy, is as follows：
Dragon's blood, Poria cocos and borneol are extracted volatile oil by step 1, spare, and the ethyl alcohol that dregs of a decoction mass fraction is 75% is heated back
Stream extraction 4 times, every time 2 it is small when, filter and recycle filtrate, be concentrated under reduced pressure into the thick paste that relative density is 1.24, it is dry and
Medicinal powder is ground into, it is spare；
Rhizoma Chuanxiong, Radix Astragali, hawthorn and the fleece-flower root are cleaned and crushed by step 2, and the ethyl alcohol for adding in 4 times of total weight stirs evenly
And it seals, takes out filtering after impregnating 52 days, obtain the first mixing filtrate, the dregs of a decoction water filtered out is decocted 2 at 72 degrees Celsius
Secondary, the water of each 4 times of dregs of a decoction weight stops, merging filtrate when decocted every time to close to glue, and filtering removes slag, obtains first
Decoction liquor；
Step 3, by Radix Angelicae Sinensis, American Ginseng, Radix Ophiopogonis, jujube and Radix Glycyrrhizae clean and add in 8 times of total weight water impregnate 6 it is small when, then
Boil 3 it is small when, extraction obtains the first extracting solution, then add in thereto 6 times boiling boiling 3 it is small when, extraction obtains the second extracting solution,
Merge the first extracting solution and the second extracting solution and filter, obtain the second mixing filtrate；
Step 4 mixes the volatile oil in step 1 and medicinal powder, the first mixing filtrate, the first decoction liquor and the second mixing filtrate
It closes, is prepared into pill, capsule or tablet using suitable technique, you can obtain finished product.
Embodiment 3
A kind of Chinese medicine preparation for treating angiocardiopathy includes the raw material of following parts by weight：16.5 parts of dragon's blood, 14 parts of Rhizoma Chuanxiong, Huang
11 parts of stilbene, 14 parts of borneol, 27 parts of hawthorn, 10 parts of the fleece-flower root, 33 parts of Radix Angelicae Sinensis, 12.5 parts of American Ginseng, 15 parts of Poria cocos, 16 parts of Radix Ophiopogonis,
5 parts of 8.5 parts of jujube and Radix Glycyrrhizae.
The preparation method of the Chinese medicine preparation of the treatment angiocardiopathy, is as follows：
Dragon's blood, Poria cocos and borneol are extracted volatile oil by step 1, spare, and the ethyl alcohol that dregs of a decoction mass fraction is 75% is heated back
Stream extraction 4 times, every time 2 it is small when, filter and recycle filtrate, be concentrated under reduced pressure into the thick paste that relative density is 1.15, it is dry and
Medicinal powder is ground into, it is spare；
Rhizoma Chuanxiong, Radix Astragali, hawthorn and the fleece-flower root are cleaned and crushed by step 2, and the ethyl alcohol for adding in 4 times of total weight stirs evenly
And it seals, takes out filtering after impregnating 52 days, obtain the first mixing filtrate, the dregs of a decoction filtered out water is decocted 2 times, each dregs of a decoction
The water that 5 times of weight, stops, merging filtrate when decocted every time to close to glue, and filtering removes slag, obtains the first decoction liquor；
Step 3, by Radix Angelicae Sinensis, American Ginseng, Radix Ophiopogonis, jujube and Radix Glycyrrhizae clean and add in 8 times of total weight water impregnate 5 it is small when, then
Boil 2.5 it is small when, extraction obtains the first extracting solution, then add in thereto 6 times boiling boiling 3 it is small when, extraction obtains the second extraction
Liquid merges the first extracting solution and the second extracting solution and filters, obtains the second mixing filtrate；
Step 4 mixes the volatile oil in step 1 and medicinal powder, the first mixing filtrate, the first decoction liquor and the second mixing filtrate
It closes, is prepared into pill, capsule or tablet using suitable technique, you can obtain finished product.
Embodiment 4
A kind of Chinese medicine preparation for treating angiocardiopathy includes the raw material of following parts by weight：18 parts of dragon's blood, 16 parts of Rhizoma Chuanxiong, Radix Astragali
12 parts, 15 parts of borneol, 30 parts of hawthorn, 12 parts of the fleece-flower root, 35 parts of Radix Angelicae Sinensis, 15 parts of American Ginseng, 18 parts of Poria cocos, 20 parts of Radix Ophiopogonis, jujube
10 parts and 6 parts of Radix Glycyrrhizae.
The preparation method of the Chinese medicine preparation of the treatment angiocardiopathy, is as follows：
Dragon's blood, Poria cocos and borneol are extracted volatile oil by step 1, spare, and the ethyl alcohol that dregs of a decoction mass fraction is 75% is heated back
Stream extraction 3 times, every time 1.5 it is small when, filter and recycle filtrate, be concentrated under reduced pressure into the thick paste that relative density is 1.22, it is dry simultaneously
And medicinal powder is ground into, it is spare；
Rhizoma Chuanxiong, Radix Astragali, hawthorn and the fleece-flower root are cleaned and crushed by step 2, and the ethyl alcohol for adding in 3 times of total weight stirs evenly
And it seals, takes out filtering after impregnating 52 days, obtain the first mixing filtrate, the dregs of a decoction filtered out are decocted 2 at 72 degrees Celsius with water
Secondary, the water of each 5 times of dregs of a decoction weight stops, merging filtrate when decocted every time to close to glue, and filtering is removed slag, and obtains first and decocts
Boil liquid；
Step 3, by Radix Angelicae Sinensis, American Ginseng, Radix Ophiopogonis, jujube and Radix Glycyrrhizae clean and add in 8 times of total weight water impregnate 5 it is small when, then
Boil 2 it is small when, extraction obtains the first extracting solution, then add in thereto 6 times boiling boiling 2.5 it is small when, extraction obtains the second extraction
Liquid merges the first extracting solution and the second extracting solution and filters, obtains the second mixing filtrate；
Step 4 mixes the volatile oil in step 1 and medicinal powder, the first mixing filtrate, the first decoction liquor and the second mixing filtrate
It closes, is prepared into pill, capsule or tablet using suitable technique, you can obtain finished product.
200 clinical observations of cardiovascular patient made a definite diagnosis are selected, patient is randomly divided into treatment group and control group two
Group, wherein treatment group 100, male 50, women 50, age 40-72 Sui, average age 55.4 years old, the most short person 3 of the course of disease
Month, most elder 11 years is 5.9 years average.Control group 100, wherein male 48, women 52, age 41-71
Year, average age 56.7 years old, the course of disease most short person 4 months, most elder 10 years are 5.3 years average.
The course of disease, the degrees of symptoms of two groups of cases for the treatment of group and control group are basically identical, no significant difference, have comparable
Property.
The Chinese medicine preparation of embodiment 2 in the present invention is taken by treatment group, takes orally, 2 times a day, each 1 time sooner or later, warm water after meal
It takes；8 days are 1 course for the treatment of, and 1 course for the treatment of of the lighter, 2-3 course for the treatment of of severe one can fully recover.Control group takes salt acid amide nitre
Acid esters, sublingual administration or oral：Daily 3 times, each 5-10mk；10 days be 1 course for the treatment of, 2 courses for the treatment of of the lighter,
3-5 course for the treatment of of severe one can fully recover, and serious patient is invalid.
Efficacy determination：It cures：Clinical symptom and sign disappears, and electrocardiogram ischaemic episodes recover normal, and cardiovascular function is extensive
It is multiple normal.It improves：Clinical symptom and sign disappears substantially, and electrocardiogram ischaemic episodes change, and cardiovascular function is extensive
It is multiple.It is invalid：Clinical symptom and sign does not disappear, and electrocardiogram ischaemic episodes are without substantially changeing.
The effect for the treatment of group and control group, is shown in Table 1.
Table 1
| Cure number | Improvement number | Invalid number | Cure rate | It is efficient | |
| Treatment group | 72 | 26 | 2 | 72% | 98% |
| Control group | 45 | 29 | 26 | 45% | 74% |
As can be seen that the cure rate for the treatment of group and effective percentage illustrate controlling for product of the invention obviously higher than control group in table 1
Therapeutic effect is good.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned exemplary embodiment, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requirement rather than above description limit, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
Moreover, it will be appreciated that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
Using specification as an entirety, the technical solutions in each embodiment can also be properly combined, forms those skilled in the art
It is appreciated that other embodiment.
Claims (5)
1. a kind of Chinese medicine preparation for treating angiocardiopathy, which is characterized in that include the raw material of following parts by weight：Dragon's blood 12-18
Part, 8-16 parts of Rhizoma Chuanxiong, 8-12 parts of Radix Astragali, 12-15 parts of borneol, 20-30 parts of hawthorn, 6-12 parts of the fleece-flower root, 24-35 parts of Radix Angelicae Sinensis, west
4-6 parts of 5-15 parts of American ginseng, 10-18 parts of Poria cocos, Radix Ophiopogonis 5-20 part, 5-10 parts of jujube and Radix Glycyrrhizae.
2. the Chinese medicine preparation for the treatment of angiocardiopathy according to claim 1, which is characterized in that including following parts by weight
Raw material：15-18 parts of dragon's blood, 11-16 parts of Rhizoma Chuanxiong, 10-12 parts of Radix Astragali, 13-15 parts of borneol, 23-30 parts of hawthorn, fleece-flower root 8-12
4.5-6 parts of part, 28-35 parts of Radix Angelicae Sinensis, 8-15 parts of American Ginseng, 12-18 parts of Poria cocos, Radix Ophiopogonis 9-20 part, 6.6-10 parts of jujube and Radix Glycyrrhizae.
3. the Chinese medicine preparation for the treatment of angiocardiopathy according to claim 1, which is characterized in that including following parts by weight
Raw material：16.5 parts of dragon's blood, 14 parts of Rhizoma Chuanxiong, 11 parts of Radix Astragali, 14 parts of borneol, 27 parts of hawthorn, 10 parts of the fleece-flower root, 33 parts of Radix Angelicae Sinensis, the West
5 parts of 12.5 parts of ginseng, 15 parts of Poria cocos, 16 parts of Radix Ophiopogonis, 8.5 parts of jujube and Radix Glycyrrhizae.
4. a kind of preparation method of the Chinese medicine preparation for the treatment of angiocardiopathy as described in claim 1-3 is any, feature exist
In being as follows：
Dragon's blood, Poria cocos and borneol are extracted volatile oil by step 1, spare, and the dregs of a decoction are added with the ethyl alcohol that mass fraction is 60-80%
It when circumfluence distillation 2-4 times, each 1-2 are small, filter and recycles filtrate, it is 1.06-1.25's to be concentrated under reduced pressure into relative density
Thick paste is dried and is ground into medicinal powder, spare；
Rhizoma Chuanxiong, Radix Astragali, hawthorn and the fleece-flower root are cleaned and crushed by step 2, and the ethyl alcohol stirring for adding in 2-4 times of total weight is equal
It is even and seal, filtering is taken out after impregnating 45-55 days, obtains the first mixing filtrate, by the dregs of a decoction filtered out water decoction 1-3
It is secondary, the water of each 3-6 times of dregs of a decoction weight, decoct every time arrive close to it is gluey when stop, merging filtrate is filtered, removed slag, and obtains the
One decoction liquor；
Step 3, by Radix Angelicae Sinensis, American Ginseng, Radix Ophiopogonis, jujube and Radix Glycyrrhizae clean and add in 6-10 times of total weight water impregnate 4-6 it is small
When, then boil 1.5-3 it is small when, extraction obtains the first extracting solution, then add in thereto 5-8 times boiling boiling 2-3 it is small when, extract
The second extracting solution is obtained, merge the first extracting solution and the second extracting solution and is filtered, obtains the second mixing filtrate；
Step 4 mixes the volatile oil in step 1 and medicinal powder, the first mixing filtrate, the first decoction liquor and the second mixing filtrate
It closes, is prepared into pill, capsule or tablet using suitable technique, you can obtain finished product.
5. the preparation method of the Chinese medicine preparation for the treatment of angiocardiopathy according to claim 4, which is characterized in that the step
It is 65-76 degrees Celsius that temperature is decocted in rapid two.
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| CN108714188A (en) * | 2018-08-24 | 2018-10-30 | 刘大秀 | A kind of Chinese medicine preparation and preparation method thereof for treating cardiovascular and cerebrovascular |
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