CN111437378B - Traditional Chinese medicine composition and medicine for preventing and treating chronic heart failure and preparation method thereof - Google Patents

Traditional Chinese medicine composition and medicine for preventing and treating chronic heart failure and preparation method thereof Download PDF

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CN111437378B
CN111437378B CN202010476734.2A CN202010476734A CN111437378B CN 111437378 B CN111437378 B CN 111437378B CN 202010476734 A CN202010476734 A CN 202010476734A CN 111437378 B CN111437378 B CN 111437378B
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heart failure
ginseng
prepared
chronic heart
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CN111437378A (en
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曹雪滨
孟宏伟
张刚
黄河玲
徐鹏
平政
田攀
张杨
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Hospital Of 82nd Group Army Of Pla
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating chronic heart failure, a medicine and a preparation method thereof, relating to the technical field of traditional Chinese medicines; the composition is prepared from the following components: ginseng, astragalus, prepared monkshood, tuckahoe, rhodiola rosea, pseudo-ginseng, cistanche, herba epimedii, semen plantaginis, morinda officinalis, dried ginger, cinnamon, fructus psoraleae, juncus effuses, radix paeoniae alba, bighead atractylodes rhizome, wolfberry fruit, fructus amomi and saffron; the composition can be decocted or prepared into pills or powder, is convenient for patients to carry and take, can delay the development speed of chronic heart failure and quickly relieve the discomfort of the patients with heart failure, and has remarkable treatment effect.

Description

Traditional Chinese medicine composition and medicine for preventing and treating chronic heart failure and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition and a medicine for preventing and treating chronic heart failure and a preparation method thereof.
Background
Chronic heart failure is a complex group of clinical syndromes in which ventricular filling or the ability to eject blood is impaired due to any structural or functional abnormality of the heart. Its main clinical manifestations are dyspnea and weakness, and fluid retention. Heart failure is a serious and terminal stage of various heart diseases, has high morbidity and difficult treatment, belongs to a chronic progressive disease, can cause dysfunction of multiple organs due to disease progression, and can be prevented. At present, western medicines are mainly used for treating the disease, and some patents for treating the disease by adopting the traditional Chinese medicine composition exist, but the disease is only treated, the disease is not fundamentally prevented, and the aim of completely treating the disease by preventing is achieved.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for preventing and treating chronic heart failure, a medicine and a preparation method thereof, and the traditional Chinese medicine composition starts from a place which is firstly prevented from being affected by pathogens, and achieves the aim of treating the chronic heart failure by cultivating the primordial yang, strengthening the five internal organs, consolidating the primordial qi, replenishing essence and nourishing marrow, protecting the five internal organs and actively defending.
In order to achieve the above purpose, one of the technical solutions provided by the present invention is: a traditional Chinese medicine composition for preventing and treating chronic heart failure is prepared from the following components: ginseng, astragalus, prepared monkshood, tuckahoe, rhodiola rosea, pseudo-ginseng, cistanche, herba epimedii, semen plantaginis, morinda officinalis, dried ginger, cinnamon, fructus psoraleae, juncus effuses, radix paeoniae alba, bighead atractylodes rhizome, wolfberry fruit, fructus amomi and saffron.
Further, the preparation method comprises the following steps: 1-4 parts of ginseng, 12-15 parts of astragalus membranaceus, 2-6 parts of prepared monkshood, 9-12 parts of poria cocos, 6-10 parts of rhodiola rosea, 1-4 parts of pseudo-ginseng, 6-10 parts of cistanche, 6-10 parts of herba epimedii, 6-10 parts of semen plantaginis, 6-10 parts of morinda officinalis, 2-6 parts of dried ginger, 2-6 parts of cinnamon, 6-10 parts of fructus psoraleae, 1-3 parts of juncus effuses, 9-12 parts of radix paeoniae alba, 6-10 parts of bighead atractylodes rhizome, 6-10 parts of wolfberry fruit, 2-6 parts of fructus amomi and 1-4 parts of saffron.
Further, the compound is prepared from the following components: 2-3 parts of ginseng, 13-14 parts of astragalus membranaceus, 3-5 parts of prepared monkshood, 10-11 parts of poria cocos, 7-9 parts of rhodiola rosea, 2-3 parts of pseudo-ginseng, 7-9 parts of cistanche, 7-9 parts of herba epimedii, 7-9 parts of semen plantaginis, 7-9 parts of morinda officinalis, 3-5 parts of dried ginger, 3-5 parts of cinnamon, 7-9 parts of fructus psoraleae, 2 parts of rush, 10-11 parts of radix paeoniae alba, 7-9 parts of bighead atractylodes rhizome, 7-9 parts of wolfberry fruit, 3-5 parts of fructus amomi and 2-3 parts of saffron.
Further, the compound is prepared from the following components: 1.5 parts of ginseng, 14 parts of astragalus, 4 parts of prepared monkshood, 11 parts of poria cocos, 8 parts of rhodiola rosea, 2.5 parts of pseudo-ginseng, 8 parts of cistanche, 8 parts of epimedium, 8 parts of semen plantaginis, 8 parts of morinda officinalis, 4 parts of dried ginger, 4 parts of cinnamon, 8 parts of fructus psoraleae, 2 parts of rush, 11 parts of white paeony root, 8 parts of bighead atractylodes rhizome, 8 parts of wolfberry fruit, 4 parts of fructus amomi and 2.5 parts of saffron.
The second technical scheme provided by the invention is as follows: a Chinese medicinal composition for preventing and treating chronic heart failure.
Furthermore, the dosage form of the medicine is powder or pills.
Further, the preparation method of the powder comprises the following steps:
s1, mixing radix astragali, radix Aconiti lateralis Preparata, Poria, radix Rhodiolae, herba cistanches, herba Epimedii, semen plantaginis, radix Morindae officinalis, rhizoma Zingiberis, cortex Cinnamomi, fructus Psoraleae, medulla Junci, radix Paeoniae alba, rhizoma Atractylodis Macrocephalae, fructus Lycii, and fructus Amomi, decocting in water, filtering, and decocting the filtrate to obtain extract;
s2, pulverizing radix Ginseng, stigma croci, and radix Notoginseng, and sieving;
s3, mixing the extract prepared in the step S1 with the powdered medicine in the step S2, and then granulating.
Further, the weight of the added water is 8-10 times of the total weight of the medicine.
Further, the decoction process is divided into two phases: the first stage decocting temperature is 100-; the second stage decocting temperature is 100-.
The invention has the beneficial effects that:
the invention relates to a traditional Chinese medicine composition for treating chronic heart failure, wherein prepared monkshood, dried ginger, cinnamon, cistanche, herba epimedii, morinda officinalis and fructus psoraleae are used for warming yang and protecting yang qi, and warming shaoyin heart and kidney channels, which are taken as main components, and also serve as taiyin spleen jueyin liver channels, which are taken as monarch components; the ginseng and the astragalus root tonify the original qi and are ministerial; stigma croci, radix Notoginseng, and radix Rhodiolae have effects of promoting blood circulation and removing blood stasis, and rhizoma Atractylodis Macrocephalae, Poria, semen plantaginis, and medulla Junci have effects of eliminating dampness and promoting urination, and are used as adjuvant drugs; radix Paeoniae alba, fructus Lycii and yin essence supplement, used as guiding drugs for preventing yin injury due to excessive warm dryness, and fructus Amomi for warming kidney and receiving qi, and promoting qi circulation without stagnation; the normal operation of the five internal organs requires the vigorous qi of the five internal organs and yang qi, the recipe can greatly supplement the qi of the five internal organs and yang qi, and the qi of the five internal organs is vigorous to delay the progress of chronic heart failure, the recipe can effectively prevent or delay the progress of chronic heart failure, and the recipe has good treatment effect when being matched with other medicines for taking.
In addition to the objects, features and advantages described above, other objects, features and advantages of the present invention are also provided. The present invention will be described in further detail below.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The traditional Chinese medicine composition for preventing and treating chronic heart failure provided by the embodiment of the invention is prepared from the following components: ginseng, astragalus, prepared monkshood, tuckahoe, rhodiola rosea, pseudo-ginseng, cistanche, herba epimedii, semen plantaginis, morinda officinalis, dried ginger, cinnamon, fructus psoraleae, juncus effuses, radix paeoniae alba, bighead atractylodes rhizome, wolfberry fruit, fructus amomi and saffron.
Ginseng: the ginseng is dry root and rhizome of Panax ginseng C.A. Meyer of Panax genus of Araliaceae family, and contains multiple chemical components including ginsenoside, polysaccharide, protein, amino acid, flavone, inorganic elements, vitamins, organic acids, alkaloids, fats, sterols, nucleosides, lignin, volatile oil, etc., wherein the ginsenoside can weaken myocardial damage, increase survival rate of myocardial cells, and protect myocardial contraction function by up-regulating the expression of Nrf2, glutathione cysteine ligase catalytic subunit (GCLC) and regulatory subunit (GCLM).
Astragalus root: sweet in flavor and slightly warm in nature; spleen and lung meridian entered; tonify qi, strengthen superficies, expel toxin, expel pus, induce diuresis, and promote granulation. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, proctoptosis, spontaneous perspiration, edema, uterine prolapse, albuminuria due to chronic nephritis, diabetes, and unhealed sore; astragaloside IV in Astragalus can improve cardiac function and myocardial reconstruction of chronic heart failure patients, increase expression of peroxisome proliferator-activated receptor a (PPRa) and PPRa target gene, promote recovery of fatty acid beta oxidase activity, improve mitochondrial function, and increase ATP production.
Preparing monkshood: pungent, sweet, big-heat and toxic; heart, kidney and spleen meridians entered; restoring yang and relieving collapse, tonifying fire and supporting yang, dispelling pathogenic wind, cold and dampness, and can be used for treating yang exhaustion, collapse, cold limbs, slight pulse, sexual impotence, cold womb, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, yin-cold edema, yang deficiency, exogenous pathogenic factor, and arthralgia due to cold-dampness.
Tuckahoe, poria cocos: also called Yuling, Fu Ling, Wanling Gui and Fu Tu, are dry sclerotia of Poria cocos (a fungus) belonging to family Hymenomycetes, often parasitize on pine roots, and are in the shape of a sweet potato, a sphere, light brown or dark brown outer skin, pink or white inner part, and are called white Poria cocos or poria cocos after refining; it is sweet, mild and nontoxic; enter heart meridian, lung meridian, spleen meridian, kidney meridian; has the effects of lowering turbid pathogen, expelling toxin, promoting blood circulation and removing blood stasis; it is suitable for acute and chronic gouty arthritis.
Rhodiola root: sweet and cold in flavor; spleen and lung meridian entered; has the effects of invigorating spleen, replenishing qi, clearing lung-heat, relieving cough, promoting blood circulation, and removing blood stasis; it is used for treating spleen qi deficiency, asthenia, lung yin deficiency, cough due to lung heat, and blood stasis, and can be combined with other blood-activating herbs for treating blood stasis such as traumatic injury.
Pseudo-ginseng: sweet, slightly bitter and warm in taste; entering liver and stomach meridians; has the effects of removing blood stasis, stopping bleeding, relieving swelling and relieving pain; can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic injury with swelling and pain.
Cistanche deserticola: sweet, salty and warm in taste; entering kidney and large intestine meridians; tonify kidney yang, replenish essence and blood, moisten intestines to relieve constipation; can be used for treating sexual impotence, infertility, soreness of waist and knees, weakness of tendons and bones, constipation due to intestinal dryness.
Herba Epimedii: herba Epimedii is known, warm in nature, pungent and sweet in flavor; entering liver and kidney meridians; has the effects of invigorating kidney yang, strengthening tendons and bones, and dispelling pathogenic wind and dampness.
Plantain seed: sweet and light taste, slightly cold in nature; it enters lung, liver, kidney and bladder meridians; has the effects of clearing heat, promoting urination, excreting dampness, stopping diarrhea, improving eyesight and eliminating phlegm.
Morinda officinalis: pungent and sweet in flavor and slightly warm in nature; entering kidney and liver meridian; has the effects of tonifying kidney, supporting yang, dispelling wind and removing dampness.
Dried ginger: pungent taste and hot property; spleen, stomach, heart and lung meridians entered; has the effects of warming spleen and stomach for dispelling cold, restoring yang and promoting blood circulation, and warming lung and resolving fluid retention.
Cinnamon: pungent and sweet in flavor and strongly hot in nature. Entering kidney, spleen, heart and liver meridians; has the effects of tonifying fire, supporting yang, guiding fire to the origin, dispelling cold, relieving pain, and warming and dredging channels and collaterals.
Psoralea fruit: bitter taste and warm nature; entering liver and kidney meridians; has the effects of promoting blood circulation, healing wound, tonifying kidney and strengthening bone.
Rush, rush: slightly cold; sweet and bland; returning to the heart; a lung; the small intestine; the bladder channel; has the effects of promoting diuresis and treating stranguria; clearing away heart-fire and purging pathogenic fire.
White peony root: bitter and sour taste, slightly cold nature; entering liver and spleen meridians; has the effects of nourishing blood, astringing yin, softening liver, relieving pain and calming liver yang.
White atractylodes rhizome: bitter, sweet and warm in taste; meridian tropism, spleen and stomach meridian tropism; has the effects of strengthening spleen, tonifying qi, eliminating dampness, promoting diuresis, suppressing sweating and preventing miscarriage.
Wolfberry fruit: sweet in taste and neutral in nature; entering liver, kidney and lung meridians; has the effects of nourishing liver and kidney, replenishing vital essence and improving eyesight.
Amomum fruit: pungent and warm; spleen, stomach and kidney meridians entered; has the effects of eliminating dampness, promoting qi circulation, warming middle energizer, relieving diarrhea, and preventing miscarriage.
Saffron: sweet in taste and neutral in nature; heart and liver meridian entered; has the effects of promoting blood circulation, removing blood stasis, resolving stagnation, removing pathogenic accumulation, cooling blood and removing toxic substance.
The traditional Chinese medicine composition for treating chronic heart failure provided by the embodiment of the invention is mainly used for warming yang and protecting yang qi, warming shaoyin heart and kidney meridians and warming taiyin spleen jueyin liver meridians, and is a monarch drug, wherein prepared monkshood, dried ginger, cinnamon, cistanche, herba epimedii, morinda officinalis and fructus psoraleae are used for warming yang and protecting yang qi; the ginseng and the astragalus root tonify the original qi and are ministerial; stigma croci, radix Notoginseng, and radix Rhodiolae have effects of promoting blood circulation and removing blood stasis, and rhizoma Atractylodis Macrocephalae, Poria, semen plantaginis, and medulla Junci have effects of eliminating dampness and promoting urination, and are used as adjuvant drugs; radix Paeoniae alba, fructus Lycii and yin essence supplement, which are used as guiding drugs for preventing yin injury due to excessive warm-dryness, and fructus Amomi warms kidney and receives qi, and promotes qi circulation without stagnation.
The normal operation of the five internal organs requires the vigorous qi of the five internal organs and yang qi, the recipe can greatly supplement the qi of the five internal organs and yang qi, and the qi of the five internal organs is vigorous to delay the progress of chronic heart failure, so the recipe can effectively prevent or delay the progress of chronic heart failure, and has good treatment effect when being matched with other medicines for taking.
In one embodiment, the composition may comprise the following components in parts by weight: 1-4 parts of ginseng, 12-15 parts of astragalus membranaceus, 2-6 parts of prepared monkshood, 9-12 parts of poria cocos, 6-10 parts of rhodiola rosea, 1-4 parts of pseudo-ginseng, 6-10 parts of cistanche, 6-10 parts of herba epimedii, 6-10 parts of semen plantaginis, 6-10 parts of morinda officinalis, 2-6 parts of dried ginger, 2-6 parts of cinnamon, 6-10 parts of fructus psoraleae, 1-3 parts of juncus effuses, 9-12 parts of radix paeoniae alba, 6-10 parts of bighead atractylodes rhizome, 6-10 parts of wolfberry fruit, 2-6 parts of fructus amomi and 1-4 parts of saffron.
In order to achieve better treatment effect, in one embodiment, the weight parts of the components of the composition can also be as follows: 2-3 parts of ginseng, 13-14 parts of astragalus membranaceus, 3-5 parts of prepared monkshood, 10-11 parts of poria cocos, 7-9 parts of rhodiola rosea, 2-3 parts of pseudo-ginseng, 7-9 parts of cistanche, 7-9 parts of herba epimedii, 7-9 parts of semen plantaginis, 7-9 parts of morinda officinalis, 3-5 parts of dried ginger, 3-5 parts of cinnamon, 7-9 parts of fructus psoraleae, 2 parts of rush, 10-11 parts of radix paeoniae alba, 7-9 parts of bighead atractylodes rhizome, 7-9 parts of wolfberry fruit, 3-5 parts of fructus amomi and 2-3 parts of saffron.
In order to achieve the best treatment effect, in one embodiment, the weight parts of the components of the composition can also be as follows: 1.5 parts of ginseng, 14 parts of astragalus, 4 parts of prepared monkshood, 11 parts of poria cocos, 8 parts of rhodiola rosea, 2.5 parts of pseudo-ginseng, 8 parts of cistanche, 8 parts of epimedium, 8 parts of semen plantaginis, 8 parts of morinda officinalis, 4 parts of dried ginger, 4 parts of cinnamon, 8 parts of fructus psoraleae, 2 parts of rush, 11 parts of white paeony root, 8 parts of bighead atractylodes rhizome, 8 parts of wolfberry fruit, 4 parts of fructus amomi and 2.5 parts of saffron.
The embodiment of the invention also provides a medicament prepared from the traditional Chinese medicine composition for preventing and treating chronic heart failure.
In the embodiment of the invention, the medicine is preferably prepared into powder or pills. Thus being convenient for the patient to carry and take.
The preparation method of the powder provided by the embodiment of the invention comprises the following steps:
s1, mixing radix astragali, radix Aconiti lateralis Preparata, Poria, radix Rhodiolae, herba cistanches, herba Epimedii, semen plantaginis, radix Morindae officinalis, rhizoma Zingiberis, cortex Cinnamomi, fructus Psoraleae, medulla Junci, radix Paeoniae alba, rhizoma Atractylodis Macrocephalae, fructus Lycii, and fructus Amomi, decocting in water, filtering, and decocting the filtrate to obtain extract;
s2, pulverizing radix Ginseng, stigma croci, and radix Notoginseng, and sieving;
s3, mixing the extract prepared in the step S1 with the powdered medicine in the step S2, and then granulating.
In one embodiment of the invention, when the powder is prepared and a part of traditional Chinese medicines in the traditional Chinese medicine composition are decocted, the weight of the added water is 2-3 times of the total weight of the medicines.
In one embodiment of the present invention, when preparing the powder, and when decocting a part of the traditional Chinese medicines in the traditional Chinese medicine composition, the decocting process is divided into two stages: the first stage decocting temperature is 100-; the second stage decocting at 80-100 deg.C for 20 min.
The technical solution of the present invention will be further explained with reference to the following examples:
example 1
A composition for preventing and treating chronic heart failure is prepared from the following components in parts by weight: 1 part of ginseng, 15 parts of astragalus, 6 parts of prepared monkshood, 9 parts of poria cocos, 10 parts of rhodiola rosea, 1 part of pseudo-ginseng, 10 parts of cistanche, 6 parts of epimedium, 10 parts of plantain seed, 6 parts of morinda officinalis, 6 parts of dried ginger, 2 parts of cinnamon, 10 parts of fructus psoraleae, 1 part of juncus effuses, 12 parts of white paeony root, 6 parts of bighead atractylodes rhizome, 10 parts of wolfberry fruit, 2 parts of fructus amomi and 1 part of saffron.
A powder medicine prepared from the composition for preventing and treating chronic heart failure comprises the following steps:
s1, mixing radix astragali, radix Aconiti lateralis Preparata, Poria, radix Rhodiolae, herba cistanches, herba Epimedii, semen plantaginis, radix Morindae officinalis, rhizoma Zingiberis, cortex Cinnamomi, fructus Psoraleae, medulla Junci, radix Paeoniae alba, rhizoma Atractylodis Macrocephalae, fructus Lycii, and fructus Amomi, adding water 8-10 times of the weight of the raw materials, and decocting in two stages: the first stage decocting temperature is 150 deg.C, and decocting for 30 min; decocting at 100 deg.C for 20min, filtering, and decocting the filtrate to obtain extract;
s2, grinding ginseng, saffron and pseudo-ginseng and then sieving the ground ginseng, saffron and pseudo-ginseng with a 100-mesh sieve;
s3, mixing the extract prepared in the step S1 with the powdered medicine in the step S2, and granulating to obtain the powder medicine.
Example 2
A traditional Chinese medicine composition for preventing and treating heart failure is prepared from the following components in parts by weight: 4 parts of ginseng, 12 parts of astragalus, 2 parts of prepared monkshood, 12 parts of tuckahoe, 6 parts of rhodiola rosea, 4 parts of pseudo-ginseng, 6 parts of cistanche, 10 parts of epimedium, 6 parts of plantain seed, 10 parts of morinda officinalis, 2 parts of dried ginger, 6 parts of cinnamon, 6 parts of fructus psoraleae, 3 parts of rush, 12 parts of white paeony root, 10 parts of bighead atractylodes rhizome, 6 parts of medlar, 6 parts of fructus amomi and 4 parts of saffron.
A powder medicine prepared from the composition for preventing and treating chronic heart failure comprises the following steps:
s1, mixing radix astragali, radix Aconiti lateralis Preparata, Poria, radix Rhodiolae, herba cistanches, herba Epimedii, semen plantaginis, radix Morindae officinalis, rhizoma Zingiberis, cortex Cinnamomi, fructus Psoraleae, medulla Junci, radix Paeoniae alba, rhizoma Atractylodis Macrocephalae, fructus Lycii, and fructus Amomi, and decocting with 10 times of water, wherein the decoction process comprises two steps: the first stage decocting temperature is 150 deg.C, and decocting for 30 min; decocting at 120 deg.C for 20min, filtering, and decocting the filtrate to obtain extract;
s2, grinding ginseng, saffron and pseudo-ginseng and then sieving the ground ginseng, saffron and pseudo-ginseng with a 100-mesh sieve;
s3, mixing the extract prepared in the step S1 with the powdered medicine in the step S2, and granulating to obtain the powder medicine.
Example 3
A traditional Chinese medicine composition for preventing and treating heart failure is prepared from the following components in parts by weight: 2 parts of ginseng, 14 parts of astragalus, 3 parts of prepared monkshood, 11 parts of poria cocos, 7 parts of rhodiola rosea, 3 parts of pseudo-ginseng, 7 parts of cistanche, 9 parts of epimedium, 7 parts of semen plantaginis, 9 parts of morinda officinalis, 3 parts of dried ginger, 5 parts of cinnamon, 7 parts of fructus psoraleae, 2 parts of rush, 10 parts of white paeony root, 9 parts of bighead atractylodes rhizome, 7 parts of fructus lycii, 5 parts of fructus amomi and 2 parts of saffron.
A pill medicine prepared from the composition for preventing and treating chronic heart failure comprises the following steps:
s1, mixing radix astragali, radix Aconiti lateralis Preparata, Poria, radix Rhodiolae, herba cistanches, herba Epimedii, semen plantaginis, radix Morindae officinalis, rhizoma Zingiberis, cortex Cinnamomi, fructus Psoraleae, medulla Junci, radix Paeoniae alba, rhizoma Atractylodis Macrocephalae, fructus Lycii, and fructus Amomi, and decocting with water 8 times of the weight of the materials, wherein the decoction process comprises two steps: the first stage decocting temperature is 100 deg.C, and decocting for 30 min; decocting at 120 deg.C for 20min, filtering, and decocting the filtrate to obtain extract;
s2, grinding ginseng, saffron and pseudo-ginseng and then sieving the ground ginseng, saffron and pseudo-ginseng with a 100-mesh sieve;
s3, mixing the extract prepared in the step S1 with the powdered medicine in the step S2, and pressing into pills.
Example 4
A traditional Chinese medicine composition for preventing and treating heart failure is prepared from the following components in parts by weight: 3 parts of ginseng, 13 parts of astragalus membranaceus, 5 parts of prepared monkshood, 10 parts of poria cocos, 9 parts of rhodiola rosea, 2 parts of pseudo-ginseng, 9 parts of cistanche, 7 parts of epimedium, 9 parts of semen plantaginis, 7 parts of morinda officinalis, 5 parts of dried ginger, 3 parts of cinnamon, 9 parts of fructus psoraleae, 2 parts of rush, 11 parts of radix paeoniae alba, 7 parts of bighead atractylodes rhizome, 9 parts of fructus lycii, 3 parts of fructus amomi and 3 parts of saffron.
A pill medicine prepared from the composition for preventing and treating chronic heart failure comprises the following steps:
s1, mixing radix astragali, radix Aconiti lateralis Preparata, Poria, radix Rhodiolae, herba cistanches, herba Epimedii, semen plantaginis, radix Morindae officinalis, rhizoma Zingiberis, cortex Cinnamomi, fructus Psoraleae, medulla Junci, radix Paeoniae alba, rhizoma Atractylodis Macrocephalae, fructus Lycii, and fructus Amomi, and decocting with 9 times of water, wherein the decoction process comprises two steps: the first stage decocting temperature is 130 deg.C, and decocting for 30 min; decocting at 110 deg.C for 20min, filtering, and decocting the filtrate to obtain extract;
s2, grinding ginseng, saffron and pseudo-ginseng and then sieving the ground ginseng, saffron and pseudo-ginseng with a 100-mesh sieve;
s3, mixing the extract prepared in the step S1 with the powdery medicine in the step S2, and then granulating to obtain the pill medicine.
Example 5
A traditional Chinese medicine composition for preventing and treating heart failure is prepared from the following components in parts by weight: 1.5 parts of ginseng, 14 parts of astragalus, 4 parts of prepared monkshood, 11 parts of poria cocos, 8 parts of rhodiola rosea, 2.5 parts of pseudo-ginseng, 8 parts of cistanche, 8 parts of epimedium, 8 parts of semen plantaginis, 8 parts of morinda officinalis, 4 parts of dried ginger, 4 parts of cinnamon, 8 parts of fructus psoraleae, 2 parts of rush, 11 parts of white paeony root, 8 parts of bighead atractylodes rhizome, 8 parts of wolfberry fruit, 4 parts of fructus amomi and 2.5 parts of saffron.
A powder medicine prepared from the composition for preventing and treating chronic heart failure is prepared by the same method as in example 1
Experimental example 1
The general case data:
all cases come from patients outpatient service from 2017 to 2017 of 12 months in the second fifth and fifth hospitals of the people's liberation military of China, after the consent of the patients and the family members is obtained, 96 clinically diagnosed chronic heart failure patients are randomly divided into an experimental group and a control group, the experimental group withdraws from 3 cases due to reasons, the control group withdraws from 5 cases due to reasons, the actual cases enter the group, the experimental group withdraws from 45 cases, and the control group withdraws from 43 cases.
(II) diagnosis standard: diagnosis was confirmed according to the 2016 European Heart Association "guidelines for diagnosis and treatment of acute and chronic heart failure".
(III) the treatment method comprises the following steps:
the experimental group orally took fosinopril 10 mg/time, bisoprolol 2.5 mg/time and spironolactone 20 mg/time on the market once a day, and the powder prepared by the traditional Chinese medicine composition of the embodiment 5 is 2.5 g each time and is taken three times a day;
the control group orally took fosinopril 10 mg/time, bisoprolol 2.5 mg/time and spironolactone 20mg once a day, and stopped taking other Chinese and western medicines during the treatment period.
(IV) judging the treatment effect standard: the clinical efficacy is evaluated by detecting blood routine, myocardial enzyme, NT-Pro-BNP, renal function, liver function, electrocardiogram, cardiac ultrasound and the like before treatment and 4, 8 and 12 weeks after treatment and combining clinical symptoms.
And (3) curing: symptoms and signs such as dyspnea, physical activity limitation, edema and the like disappear, the NT-Pro-BNP reaches normal values, and electrocardiogram and heart ultrasonic heart failure indexes are normal.
The method has the following advantages: the clinical symptoms and physical signs are reduced, and the NT-Pro-BNP, the electrocardiogram and the cardiac ultrasonic examination are obviously improved or basically recovered to be normal compared with the treatment.
And (4) invalidation: clinical symptoms, physical signs, NT-Pro-BNP, electrocardiogram and cardiac ultrasound are not obviously improved.
5. The treatment results are as follows:
after 4 weeks of treatment, the clinical efficacy was observed as shown in table 1.
Table 1 clinical efficacy observation of the Chinese medicinal composition for treating chronic heart failure
Figure GDA0003238604900000111
As can be seen from table 1, the powder prepared by taking the traditional Chinese medicine composition of example 5 of the present invention has a good curative effect in clinical prevention and treatment of chronic heart failure, and among 45 patients with chronic heart failure, 13 patients are cured after taking the traditional Chinese medicine composition of the present invention for 4 weeks, the cure rate is 28.89%, the total effective rate is 84.44%, the ineffective rate is 7 patients, and the ineffective rate is 15.56%. The preparations prepared from the traditional Chinese medicine compositions for preventing and treating chronic heart failure prepared in examples 1 to 4 have similar clinical effects to the traditional Chinese medicine composition powder for preventing and treating chronic heart failure prepared in example 1, and have no statistical difference.
After 8 weeks of treatment, the clinical efficacy was observed as shown in table 2.
Table 2 clinical efficacy observation of the Chinese medicinal composition for treating chronic heart failure
Figure GDA0003238604900000112
As can be seen from table 2, the pill prepared by taking the traditional Chinese medicine composition of example 3 of the present invention has a good curative effect in clinical prevention and treatment of chronic heart failure, and among 45 patients with chronic heart failure, after taking the traditional Chinese medicine composition of the present invention for 8 weeks, 17 patients are cured, the cure rate is 37.78%, the total effective rate is 88.89%, the ineffective rate is 5 patients, and the ineffective rate is 11.11%. The preparations prepared from the traditional Chinese medicine compositions for preventing and treating chronic heart failure prepared in examples 1 to 4 have similar clinical effects to the traditional Chinese medicine composition powder for preventing and treating chronic heart failure prepared in example 1, and have no statistical difference.
After 12 weeks of treatment, clinical efficacy was observed as shown in table 3.
Table 3 clinical efficacy observation of the Chinese medicinal composition for treating chronic heart failure
Figure GDA0003238604900000121
As can be seen from table 3, the traditional Chinese medicine composition of the present invention has a good curative effect in clinical prevention and treatment of chronic heart failure, and among 45 patients with chronic heart failure, after taking the traditional Chinese medicine composition of the present invention for 12 weeks, 19 patients are cured, the cure rate is 42.22%, the total effective rate is 91.11%, the ineffective rate is 4 patients, and the ineffective rate is 8.89%; compared with the control group, the cure rate is improved by 32.92 percent, and the effective rate is improved by 37.61 percent. The preparations prepared from the traditional Chinese medicine compositions for preventing and treating chronic heart failure prepared in examples 1 to 4 have similar clinical effects to the traditional Chinese medicine composition powder for preventing and treating chronic heart failure prepared in example 1, and have no statistical difference.
From the results, the cure rate and the effective rate of the experimental group are obviously superior to those of the control group, and the difference has statistical significance (P is less than 0.05). After 4 weeks in the experimental group, the cure rate and the effective rate are further improved. After 4 weeks in the control group, the improvement of the cure rate and the effective rate is not as obvious as that in the control group. The effective rate of the experimental group is continuously improved along with the prolonging of the taking time, and the effective rate of the control group has no obvious change after 8 weeks and 12 weeks of treatment. From the data, the cure rate and the effective rate of the experimental group are obviously improved compared with the control group in 4 weeks, 8 weeks and 12 weeks, and the difference has statistical significance (P is less than 0.05).
(V), clinical cases:
XX, 67 years old, Baoding city, dyspnea and suffocation, palpitation with edema of the lower limbs for 2 years, difficulty in daily life self-care. NT-Pro-BNP8310pg/ml at the time of diagnosis, cardiac ultrasound: LVEF 39%, diagnosed as: chronic heart failure. After 2 years, the symptoms are aggravated repeatedly after fatigue or exogenous infection. The doctor came in 2017 in 9 months. 2.5 g of the traditional Chinese medicine composition is taken every time and three times a day, and meanwhile, 10 mg/time of fosinopril, 2.5 mg/time of bisoprolol and 20 mg/time of spironolactone are taken once a day for regular treatment for 2 months. NT-Pro-BNP120pg/ml, cardiac ultrasound: LVEF 52%, symptom relief, self-care in daily life.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (8)

1. A traditional Chinese medicine composition for preventing and treating chronic heart failure is characterized by being prepared from the following components:
1-4 parts of ginseng, 12-15 parts of astragalus membranaceus, 2-6 parts of prepared monkshood, 9-12 parts of poria cocos, 6-10 parts of rhodiola rosea, 1-4 parts of pseudo-ginseng, 6-10 parts of cistanche, 6-10 parts of herba epimedii, 6-10 parts of semen plantaginis, 6-10 parts of morinda officinalis, 2-6 parts of dried ginger, 2-6 parts of cinnamon, 6-10 parts of fructus psoraleae, 1-3 parts of juncus effuses, 9-12 parts of radix paeoniae alba, 6-10 parts of bighead atractylodes rhizome, 6-10 parts of wolfberry fruit, 2-6 parts of fructus amomi and 1-4 parts of saffron.
2. The traditional Chinese medicine composition for preventing and treating chronic heart failure according to claim 1, which is prepared from the following components: 2-3 parts of ginseng, 13-14 parts of astragalus membranaceus, 3-5 parts of prepared monkshood, 10-11 parts of poria cocos, 7-9 parts of rhodiola rosea, 2-3 parts of pseudo-ginseng, 7-9 parts of cistanche, 7-9 parts of herba epimedii, 7-9 parts of semen plantaginis, 7-9 parts of morinda officinalis, 3-5 parts of dried ginger, 3-5 parts of cinnamon, 7-9 parts of fructus psoraleae, 2 parts of rush, 10-11 parts of radix paeoniae alba, 7-9 parts of bighead atractylodes rhizome, 7-9 parts of wolfberry fruit, 3-5 parts of fructus amomi and 2-3 parts of saffron.
3. The traditional Chinese medicine composition for preventing and treating chronic heart failure according to claim 1, which is prepared from the following components: 1.5 parts of ginseng, 14 parts of astragalus, 4 parts of prepared monkshood, 11 parts of poria cocos, 8 parts of rhodiola rosea, 2.5 parts of pseudo-ginseng, 8 parts of cistanche, 8 parts of epimedium, 8 parts of semen plantaginis, 8 parts of morinda officinalis, 4 parts of dried ginger, 4 parts of cinnamon, 8 parts of fructus psoraleae, 2 parts of rush, 11 parts of white paeony root, 8 parts of bighead atractylodes rhizome, 8 parts of wolfberry fruit, 4 parts of fructus amomi and 2.5 parts of saffron.
4. A medicament prepared from the traditional Chinese medicine composition for preventing and treating chronic heart failure as claimed in any one of claims 1-3.
5. The medicament of claim 4, wherein the medicament is in the form of powder or pill.
6. The process for preparing a medicament according to claim 5, wherein the process for preparing the powder comprises the steps of:
s1, mixing radix astragali, radix Aconiti lateralis Preparata, Poria, radix Rhodiolae, herba cistanches, herba Epimedii, semen plantaginis, radix Morindae officinalis, rhizoma Zingiberis, cortex Cinnamomi, fructus Psoraleae, medulla Junci, radix Paeoniae alba, rhizoma Atractylodis Macrocephalae, fructus Lycii, and fructus Amomi, decocting in water, filtering, and decocting the filtrate to obtain extract;
s2, pulverizing radix Ginseng, stigma croci, and radix Notoginseng, and sieving;
s3, mixing the extract prepared in the step S1 with the powdered medicine in the step S2, granulating, drying and sterilizing.
7. The preparation method of the traditional Chinese medicine composition for preventing and treating chronic heart failure according to claim 6, wherein the weight of the added water is 8-10 times of the total weight of the medicine.
8. The method for preparing a Chinese medicinal composition for preventing and treating chronic heart failure as claimed in claim 6, wherein the water is added for decoction at 150 ℃ for 30 min; decocting the filtrate at 80-120 deg.C for 20 min.
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