CN109328059B - Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂 - Google Patents

Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂 Download PDF

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CN109328059B
CN109328059B CN201780016875.2A CN201780016875A CN109328059B CN 109328059 B CN109328059 B CN 109328059B CN 201780016875 A CN201780016875 A CN 201780016875A CN 109328059 B CN109328059 B CN 109328059B
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CN109328059A (zh
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Y.宋
A.J.布里奇斯
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Jiangsu Kingsley Pharmaceutical Co ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52—Amides or imides
    • C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F20/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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CN201780016875.2A 2016-01-07 2017-01-06 Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂 Active CN109328059B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662276221P 2016-01-07 2016-01-07
US62/276,221 2016-01-07
US201662399730P 2016-09-26 2016-09-26
US62/399,730 2016-09-26
PCT/US2017/012466 WO2017120429A1 (en) 2016-01-07 2017-01-06 Selective inhibitors of clinically important mutants of the egfr tyrosine kinase

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CN109328059A CN109328059A (zh) 2019-02-12
CN109328059B true CN109328059B (zh) 2021-08-17

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US (1) US10435388B2 (enExample)
EP (1) EP3399968B8 (enExample)
JP (2) JP2019501222A (enExample)
KR (1) KR20180105161A (enExample)
CN (1) CN109328059B (enExample)
TW (1) TWI726968B (enExample)
WO (1) WO2017120429A1 (enExample)

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