CN1092185C - 二苯并异喹啉二酮及其药物组合物、用途和制备方法 - Google Patents

二苯并异喹啉二酮及其药物组合物、用途和制备方法 Download PDF

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Publication number
CN1092185C
CN1092185C CN95193192A CN95193192A CN1092185C CN 1092185 C CN1092185 C CN 1092185C CN 95193192 A CN95193192 A CN 95193192A CN 95193192 A CN95193192 A CN 95193192A CN 1092185 C CN1092185 C CN 1092185C
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CN
China
Prior art keywords
formula
compound
dihydro
dibenzo
isoquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN95193192A
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English (en)
Chinese (zh)
Other versions
CN1148851A (zh
Inventor
M·夫南兹布拉纳
J·M·卡斯特拉诺博兰加
C·罗莫达尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Publication of CN1148851A publication Critical patent/CN1148851A/zh
Application granted granted Critical
Publication of CN1092185C publication Critical patent/CN1092185C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CN95193192A 1994-04-28 1995-04-12 二苯并异喹啉二酮及其药物组合物、用途和制备方法 Expired - Fee Related CN1092185C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23399894A 1994-04-28 1994-04-28
US08/233,998 1994-04-28

Publications (2)

Publication Number Publication Date
CN1148851A CN1148851A (zh) 1997-04-30
CN1092185C true CN1092185C (zh) 2002-10-09

Family

ID=22879465

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95193192A Expired - Fee Related CN1092185C (zh) 1994-04-28 1995-04-12 二苯并异喹啉二酮及其药物组合物、用途和制备方法

Country Status (11)

Country Link
EP (1) EP0757676A1 (enrdf_load_stackoverflow)
JP (1) JPH09512539A (enrdf_load_stackoverflow)
CN (1) CN1092185C (enrdf_load_stackoverflow)
AU (1) AU2306595A (enrdf_load_stackoverflow)
CA (1) CA2188833A1 (enrdf_load_stackoverflow)
HR (1) HRP950250A2 (enrdf_load_stackoverflow)
IL (1) IL113415A (enrdf_load_stackoverflow)
SG (1) SG73418A1 (enrdf_load_stackoverflow)
TW (1) TW307764B (enrdf_load_stackoverflow)
WO (1) WO1995029895A1 (enrdf_load_stackoverflow)
ZA (1) ZA953379B (enrdf_load_stackoverflow)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6121278A (en) * 1997-09-03 2000-09-19 Guilford Pharmaceuticals, Inc. Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity
US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
US6291425B1 (en) 1999-09-01 2001-09-18 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage
US6380193B1 (en) 1998-05-15 2002-04-30 Guilford Pharmaceuticals Inc. Fused tricyclic compounds, methods and compositions for inhibiting PARP activity
PT103503B (pt) * 2006-06-19 2009-05-18 Univ Do Porto Novos derivados do bisnaftalimidopropil, processo para a sua preparação, composições farmacêuticas que os contêm e sua utilização em doenças cancerígenas e parasitárias, nomeadamente leishmanioses, tripanossomíases e malária.
CN101638389B (zh) * 2008-03-03 2012-09-05 河南大学 一种含萘酰亚胺结构的多胺衍生物及其制备方法和应用
CN117074567B (zh) * 2023-08-25 2025-06-27 四川汇宇制药股份有限公司 高效液相色谱法检测氨磷汀中间体纯度及其有关物质的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281902A1 (de) * 1987-03-10 1988-09-14 Knoll Ag Bis-naphthalimide, ihre Herstellung und Verwendung
WO1992000281A1 (en) * 1990-06-26 1992-01-09 Research Corporation Technologies, Inc. 1,2-dihydro-3h-dibenzisoquinoline-1,3-dione anticancer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125439B1 (en) * 1983-04-01 1990-01-24 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
EP0660824A1 (en) * 1992-09-11 1995-07-05 Research Corporation Technologies 1,2 DIHYDRO-3-H-DIBENZ(de,h) ISOQUINOLINE 1,3 DIONE AND THEIR USE AS ANTICANCER AGENTS
DE4232739A1 (de) * 1992-09-30 1994-03-31 Knoll Ag Neue asymmetrisch substituierte bis-Naphthalimide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281902A1 (de) * 1987-03-10 1988-09-14 Knoll Ag Bis-naphthalimide, ihre Herstellung und Verwendung
WO1992000281A1 (en) * 1990-06-26 1992-01-09 Research Corporation Technologies, Inc. 1,2-dihydro-3h-dibenzisoquinoline-1,3-dione anticancer agents

Also Published As

Publication number Publication date
IL113415A (en) 1999-11-30
JPH09512539A (ja) 1997-12-16
CN1148851A (zh) 1997-04-30
IL113415A0 (en) 1995-07-31
AU2306595A (en) 1995-11-29
ZA953379B (en) 1996-10-28
EP0757676A1 (en) 1997-02-12
CA2188833A1 (en) 1995-11-09
WO1995029895A1 (en) 1995-11-09
TW307764B (enrdf_load_stackoverflow) 1997-06-11
SG73418A1 (en) 2000-06-20
HRP950250A2 (en) 1997-10-31

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