CN109125719B - 一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用 - Google Patents

一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用 Download PDF

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CN109125719B
CN109125719B CN201710464584.1A CN201710464584A CN109125719B CN 109125719 B CN109125719 B CN 109125719B CN 201710464584 A CN201710464584 A CN 201710464584A CN 109125719 B CN109125719 B CN 109125719B
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porcine circovirus
circovirus type
immunogenic composition
type
gene
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CN109125719A (zh
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田克恭
袁于人
李向东
殷波
肖燕
陆洲
胡冬学
孙进忠
莫小兵
张许科
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Aidi Weixin Suzhou Biological Products Co ltd
Sihui Biotechnology Jiangsu Co ltd
Pulaike Biological Engineering Co Ltd
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SA Biotech (suzhou) Pte Ltd
Pulaike Biological Engineering Co Ltd
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Priority to CN201710464584.1A priority Critical patent/CN109125719B/zh
Priority to PCT/CN2017/118696 priority patent/WO2018233264A1/zh
Priority to JP2020519165A priority patent/JP6882602B2/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/10011Circoviridae
    • C12N2750/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CN201710464584.1A 2017-06-19 2017-06-19 一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用 Active CN109125719B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201710464584.1A CN109125719B (zh) 2017-06-19 2017-06-19 一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用
PCT/CN2017/118696 WO2018233264A1 (zh) 2017-06-19 2017-12-26 一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用
JP2020519165A JP6882602B2 (ja) 2017-06-19 2017-12-26 豚サーコウイルス3型及び豚サーコウイルス2型である抗原を含有する免疫原性組成物並びにその用途

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CN201710464584.1A CN109125719B (zh) 2017-06-19 2017-06-19 一种含猪圆环病毒3型、猪圆环病毒2型抗原的免疫原性组合物及其应用

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CN109125719A CN109125719A (zh) 2019-01-04
CN109125719B true CN109125719B (zh) 2022-06-14

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Families Citing this family (9)

* Cited by examiner, † Cited by third party
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CN109010818B (zh) * 2017-06-09 2021-11-09 普莱柯生物工程股份有限公司 一种预防和/或治疗猪圆环病毒感染的二联疫苗组合物及其制备方法和应用
CN114014916B (zh) * 2019-01-18 2023-04-25 南京农业大学 猪圆环病毒3型Cap重组蛋白、其编码基因及在ELISA抗体检测中的应用
CN114222579A (zh) * 2019-04-04 2022-03-22 勃林格殷格翰动物保健美国有限公司 猪圆环病毒3型(pcv3)疫苗及其生产和用途
CN110174510A (zh) * 2019-04-26 2019-08-27 华南农业大学 一种pcv3的荧光免疫层析检测卡的制备方法
CN111187781B (zh) * 2019-09-12 2023-09-15 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 一种优化后的猪圆环病毒3型衣壳蛋白基因及其在制备病毒样颗粒中的应用
CN110981945B (zh) * 2019-12-08 2021-10-19 中牧实业股份有限公司 一种猪圆环病毒2型重组Cap蛋白的表达制备及应用
PE20211141A1 (es) * 2019-12-19 2021-06-25 Farm Veterinarios S A C Salmonella enteritidis recombinante y su uso como vacuna porcina
CN111558037A (zh) * 2020-06-08 2020-08-21 武汉科前生物股份有限公司 一种二价亚单位疫苗及其制备方法和应用
CN115819567B (zh) * 2022-11-19 2023-09-01 深圳盛源生物技术有限公司 一种单克隆抗体及其在检测试剂盒中的应用

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CN101240264A (zh) * 2008-03-21 2008-08-13 南京农业大学 猪圆环病毒2型灭活疫苗
CN101768218A (zh) * 2010-03-02 2010-07-07 福建省农业科学院畜牧兽医研究所 猪圆环病毒Ⅱ型Cap蛋白单克隆抗体的制备方法、抗体及应用
CN102080074A (zh) * 2010-11-29 2011-06-01 北京大北农科技集团股份有限公司 猪圆环病毒ⅱ型-猪肺炎支原体表达菌株的构建及应用
CN104334186A (zh) * 2012-04-04 2015-02-04 硕腾有限责任公司 Pcv/猪肺炎支原体组合疫苗

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KR20110090711A (ko) * 2010-02-04 2011-08-10 녹십자수의약품(주) 신규한 돼지 써코바이러스 타입 2 및 그의 용도
CN102174086B (zh) * 2011-03-07 2014-04-02 南京农业大学 一种猪圆环病毒2型重组Cap蛋白和亚单位疫苗
KR101527861B1 (ko) * 2011-12-30 2015-06-12 대한민국 돼지써코바이러스2 캡시드 단백질의 이용방법
CN105039405A (zh) * 2015-05-20 2015-11-11 吉林和元生物工程有限公司 重组表达载体及其构建方法、重组病毒毒株及其应用、重组蛋白及亚单位疫苗
BR112018007525A2 (pt) * 2015-10-16 2018-10-30 Kansas State University Research Foundation composições imunogênicas de circovírus suíno tipo 3 e métodos de produzir e usar as mesmas
CN107233566B (zh) * 2017-01-13 2022-05-27 浙江海隆生物科技有限公司 猪瘟-猪圆环二联亚单位的疫苗及其制备方法和应用

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
CN101240264A (zh) * 2008-03-21 2008-08-13 南京农业大学 猪圆环病毒2型灭活疫苗
CN101768218A (zh) * 2010-03-02 2010-07-07 福建省农业科学院畜牧兽医研究所 猪圆环病毒Ⅱ型Cap蛋白单克隆抗体的制备方法、抗体及应用
CN102080074A (zh) * 2010-11-29 2011-06-01 北京大北农科技集团股份有限公司 猪圆环病毒ⅱ型-猪肺炎支原体表达菌株的构建及应用
CN104334186A (zh) * 2012-04-04 2015-02-04 硕腾有限责任公司 Pcv/猪肺炎支原体组合疫苗

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JP6882602B2 (ja) 2021-06-02
JP2020524182A (ja) 2020-08-13
CN109125719A (zh) 2019-01-04

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Address after: 471000 No. 5 Lingbo Road, Luoyang High-tech Zone, Henan Province

Patentee after: PULIKE BIOLOGICAL ENGINEERING, Inc.

Country or region after: China

Patentee after: Aidi Weixin (Suzhou) Biological Products Co.,Ltd.

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Patentee before: Aidi Weixin (Suzhou) Biological Products Co.,Ltd.