CN109071636A - 用于选择特异性结合糖基化免疫检查点蛋白的抗体的方法 - Google Patents

用于选择特异性结合糖基化免疫检查点蛋白的抗体的方法 Download PDF

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CN109071636A
CN109071636A CN201780027804.2A CN201780027804A CN109071636A CN 109071636 A CN109071636 A CN 109071636A CN 201780027804 A CN201780027804 A CN 201780027804A CN 109071636 A CN109071636 A CN 109071636A
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antibody
icp
cell
glycosylation
antigen
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Chinese (zh)
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S·S·刘
M-C·洪
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Stcube & Co inc
University of Texas System
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Stcube & Co inc
University of Texas System
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CN201780027804.2A 2016-03-29 2017-03-24 用于选择特异性结合糖基化免疫检查点蛋白的抗体的方法 Pending CN109071636A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662314940P 2016-03-29 2016-03-29
US62/314,940 2016-03-29
US201662361298P 2016-07-12 2016-07-12
US62/361,298 2016-07-12
PCT/US2017/024024 WO2017172517A1 (en) 2016-03-29 2017-03-24 Methods for selecting antibodies that specifically bind glycosylated immune checkpoint proteins

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CN109071636A true CN109071636A (zh) 2018-12-21

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US (1) US12059474B2 (https=)
EP (1) EP3436475A1 (https=)
JP (2) JP7572146B2 (https=)
KR (2) KR20180130541A (https=)
CN (1) CN109071636A (https=)
WO (1) WO2017172517A1 (https=)

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CN108699511A (zh) * 2016-01-15 2018-10-23 加图立大学校产学协力团 包含过氧蛋白的无血清培养基添加剂组合物及其用途
CN110456079A (zh) * 2019-09-20 2019-11-15 四川大学华西医院 Tapbp自身抗体检测试剂在制备肺癌筛查试剂盒中的用途
CN110997724A (zh) * 2017-06-06 2020-04-10 斯特库伯株式会社 使用结合btn1a1或btn1a1-配体的抗体和分子治疗癌症的方法
CN114173801A (zh) * 2019-08-02 2022-03-11 詹森生物科技公司 用于多向生物转运的材料和方法
CN114630841A (zh) * 2019-08-29 2022-06-14 真和制药有限公司 抗体以及阻断vista及其结合配偶体的相互作用
CN114729045A (zh) * 2019-09-26 2022-07-08 斯特库比公司 对糖基化的ctla-4特异性的抗体及其使用方法
CN114829404A (zh) * 2019-10-09 2022-07-29 斯特库比公司 对糖基化的lag3特异的抗体及其使用方法
CN115807090A (zh) * 2022-11-17 2023-03-17 中国医学科学院肿瘤医院 Slamf9在肿瘤免疫治疗中的应用
CN115991780A (zh) * 2022-12-29 2023-04-21 盖普思药业(重庆)有限公司 一种抗人血小板胶原蛋白受体gp-vi抗体或其抗原结合片段及其应用
CN116139275A (zh) * 2021-11-19 2023-05-23 复旦大学 Cd300ld抑制剂在制备预防、诊断或治疗肿瘤产品中的用途
CN118878686A (zh) * 2024-08-13 2024-11-01 中山大学孙逸仙纪念医院 一种靶向糖基化pd-l1蛋白的单链抗体及其制备方法与应用
CN120078878A (zh) * 2025-03-20 2025-06-03 复旦大学附属中山医院 Tim-3蛋白在治疗肝损伤中的应用

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US11933786B2 (en) 2015-03-30 2024-03-19 Stcube, Inc. Antibodies specific to glycosylated PD-L1 and methods of use thereof
WO2017055404A1 (en) 2015-10-02 2017-04-06 F. Hoffmann-La Roche Ag Bispecific antibodies specific for pd1 and tim3
ES2883297T3 (es) * 2016-03-29 2021-12-07 Stcube Inc Anticuerpos de función doble específicos para PD-L1 glucosilado y métodos de uso de los mismos
EP3568157A4 (en) * 2017-01-13 2021-01-06 National Research Council of Canada PROCESS FOR THE OPTIMIZATION OF PEPTIDIC IMMUNO-EPITOPE BY GLYCOSYLATION, ASSOCIATED OPTIMIZED PEPTIDE AND ITS USE FOR CONJUGATE VACCINES
MY201482A (en) 2017-04-03 2024-02-26 Hoffmann La Roche Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
EP4516809A3 (en) 2017-04-05 2025-09-03 F. Hoffmann-La Roche AG Bispecific antibodies specifically binding to pd1 and lag3
US11525002B2 (en) 2017-10-11 2022-12-13 Board Of Regents, The University Of Texas System Human PD-L1 antibodies and methods of use therefor
EP4501355A3 (en) 2018-03-23 2025-04-30 Board Of Regents, The University Of Texas System Dual specificity antibodies to pd-l1 and pd-l2 and methods of use therefor
CN119101158A (zh) 2018-03-23 2024-12-10 得克萨斯州大学系统董事会 人pd-l2抗体及其使用方法
SG11202009258RA (en) 2018-03-23 2020-10-29 Univ Texas Dual specificity antibodies to human pd-l1 and pd-l2 and methods of use therefor
CN112584901A (zh) * 2018-04-04 2021-03-30 真和制药有限公司 用于阻断非糖基化的pd-1多肽之间的相互作用的方法和组合物
WO2019237012A1 (en) * 2018-06-07 2019-12-12 Board Of Regents, The University Of Texas System Detection of immune checkpoint molecules by deglycosylation
US11098093B2 (en) 2019-01-07 2021-08-24 Shattuck Labs, Inc. Heterodimeric proteins for modulating gamma delta T cells
PH12021551475A1 (en) 2019-01-07 2022-05-02 Shattuck Labs Inc Heterodimeric proteins for modulating gamma delta t cells
CN111751545A (zh) * 2019-03-28 2020-10-09 中国科学院上海药物研究所 一种筛选pd-l1/pd-1检测点抑制剂的方法
TW202122420A (zh) * 2019-08-30 2021-06-16 美商艾吉納斯公司 抗ｃｄ９６抗體及其使用方法
CN111574627A (zh) * 2020-05-11 2020-08-25 潘宗富 抗vsig4单克隆抗体及其用途
CN111995683B (zh) * 2020-09-02 2022-03-11 福州迈新生物技术开发有限公司 抗pd-l1蛋白单克隆抗体、细胞株及其制备方法和应用
KR20240154675A (ko) * 2022-03-16 2024-10-25 주식회사 에스티큐브앤컴퍼니 Btn1a1 결합 단백질 및 이의 이용 방법
JP2025538171A (ja) * 2022-11-09 2025-11-26 センティ バイオサイエンシズ インコーポレイテッド 抗原結合ドメイン及びその使用方法

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CN104736168A (zh) * 2012-05-31 2015-06-24 索伦托治疗有限公司 与pd-l1结合的抗原结合蛋白

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