KR20180130541A - 글리코실화된 면역체크포인트 단백질에 특이적으로 결합하는 항체를 선택하는 방법 - Google Patents

글리코실화된 면역체크포인트 단백질에 특이적으로 결합하는 항체를 선택하는 방법 Download PDF

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KR20180130541A
KR20180130541A KR1020187031149A KR20187031149A KR20180130541A KR 20180130541 A KR20180130541 A KR 20180130541A KR 1020187031149 A KR1020187031149 A KR 1020187031149A KR 20187031149 A KR20187031149 A KR 20187031149A KR 20180130541 A KR20180130541 A KR 20180130541A
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antibody
glycosylated
icp
binding
antigen
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스테판 에스. 유
미엔-치에 흥
Original Assignee
주식회사 에스티큐브앤컴퍼니
보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템
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Priority to KR1020237005614A priority Critical patent/KR102778941B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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KR1020187031149A 2016-03-29 2017-03-24 글리코실화된 면역체크포인트 단백질에 특이적으로 결합하는 항체를 선택하는 방법 Ceased KR20180130541A (ko)

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KR1020237005614A KR102778941B1 (ko) 2016-03-29 2017-03-24 글리코실화된 면역체크포인트 단백질에 특이적으로 결합하는 항체를 선택하는 방법

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662314940P 2016-03-29 2016-03-29
US62/314,940 2016-03-29
US201662361298P 2016-07-12 2016-07-12
US62/361,298 2016-07-12
PCT/US2017/024024 WO2017172517A1 (en) 2016-03-29 2017-03-24 Methods for selecting antibodies that specifically bind glycosylated immune checkpoint proteins

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KR1020237005614A Division KR102778941B1 (ko) 2016-03-29 2017-03-24 글리코실화된 면역체크포인트 단백질에 특이적으로 결합하는 항체를 선택하는 방법

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KR1020187031149A Ceased KR20180130541A (ko) 2016-03-29 2017-03-24 글리코실화된 면역체크포인트 단백질에 특이적으로 결합하는 항체를 선택하는 방법
KR1020237005614A Active KR102778941B1 (ko) 2016-03-29 2017-03-24 글리코실화된 면역체크포인트 단백질에 특이적으로 결합하는 항체를 선택하는 방법

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US (1) US12059474B2 (https=)
EP (1) EP3436475A1 (https=)
JP (2) JP7572146B2 (https=)
KR (2) KR20180130541A (https=)
CN (1) CN109071636A (https=)
WO (1) WO2017172517A1 (https=)

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KR101928488B1 (ko) * 2016-01-15 2018-12-12 가톨릭대학교 산학협력단 페록시다신을 포함하는 무혈청 배지 첨가제 조성물 및 이의 이용
ES2883297T3 (es) * 2016-03-29 2021-12-07 Stcube Inc Anticuerpos de función doble específicos para PD-L1 glucosilado y métodos de uso de los mismos
EP3568157A4 (en) * 2017-01-13 2021-01-06 National Research Council of Canada PROCESS FOR THE OPTIMIZATION OF PEPTIDIC IMMUNO-EPITOPE BY GLYCOSYLATION, ASSOCIATED OPTIMIZED PEPTIDE AND ITS USE FOR CONJUGATE VACCINES
MY201482A (en) 2017-04-03 2024-02-26 Hoffmann La Roche Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15
EP4516809A3 (en) 2017-04-05 2025-09-03 F. Hoffmann-La Roche AG Bispecific antibodies specifically binding to pd1 and lag3
KR20200026209A (ko) * 2017-06-06 2020-03-10 주식회사 에스티큐브앤컴퍼니 Btn1a1 또는 btn1a1-리간드에 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법
US11525002B2 (en) 2017-10-11 2022-12-13 Board Of Regents, The University Of Texas System Human PD-L1 antibodies and methods of use therefor
EP4501355A3 (en) 2018-03-23 2025-04-30 Board Of Regents, The University Of Texas System Dual specificity antibodies to pd-l1 and pd-l2 and methods of use therefor
CN119101158A (zh) 2018-03-23 2024-12-10 得克萨斯州大学系统董事会 人pd-l2抗体及其使用方法
SG11202009258RA (en) 2018-03-23 2020-10-29 Univ Texas Dual specificity antibodies to human pd-l1 and pd-l2 and methods of use therefor
CN112584901A (zh) * 2018-04-04 2021-03-30 真和制药有限公司 用于阻断非糖基化的pd-1多肽之间的相互作用的方法和组合物
WO2019237012A1 (en) * 2018-06-07 2019-12-12 Board Of Regents, The University Of Texas System Detection of immune checkpoint molecules by deglycosylation
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CN111751545A (zh) * 2019-03-28 2020-10-09 中国科学院上海药物研究所 一种筛选pd-l1/pd-1检测点抑制剂的方法
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CN114630841A (zh) * 2019-08-29 2022-06-14 真和制药有限公司 抗体以及阻断vista及其结合配偶体的相互作用
TW202122420A (zh) * 2019-08-30 2021-06-16 美商艾吉納斯公司 抗ｃｄ９６抗體及其使用方法
CN110456079B (zh) * 2019-09-20 2020-06-02 四川大学华西医院 Tapbp自身抗体检测试剂在制备肺癌筛查试剂盒中的用途
US20220411511A1 (en) * 2019-09-26 2022-12-29 Stcube & Co. Antibodies specific to glycosylated ctla-4 and methods of use thereof
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