CN1090275A - 咪唑羧酸类作血管紧张肽ii受体拮抗剂的前药 - Google Patents

咪唑羧酸类作血管紧张肽ii受体拮抗剂的前药 Download PDF

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Publication number
CN1090275A
CN1090275A CN93117634A CN93117634A CN1090275A CN 1090275 A CN1090275 A CN 1090275A CN 93117634 A CN93117634 A CN 93117634A CN 93117634 A CN93117634 A CN 93117634A CN 1090275 A CN1090275 A CN 1090275A
Authority
CN
China
Prior art keywords
alkyl
methyl
alkoxyl group
group
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93117634A
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English (en)
Chinese (zh)
Inventor
R·J·阿德基
J·R·普卢伊特
C·L·恩辛格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of CN1090275A publication Critical patent/CN1090275A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN93117634A 1992-08-06 1993-08-06 咪唑羧酸类作血管紧张肽ii受体拮抗剂的前药 Pending CN1090275A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/926,795 US5310929A (en) 1992-08-06 1992-08-06 Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
US926,795 1992-08-06

Publications (1)

Publication Number Publication Date
CN1090275A true CN1090275A (zh) 1994-08-03

Family

ID=25453732

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93117634A Pending CN1090275A (zh) 1992-08-06 1993-08-06 咪唑羧酸类作血管紧张肽ii受体拮抗剂的前药

Country Status (18)

Country Link
US (1) US5310929A (cg-RX-API-DMAC10.html)
EP (1) EP0654027A1 (cg-RX-API-DMAC10.html)
JP (1) JP2892838B2 (cg-RX-API-DMAC10.html)
CN (1) CN1090275A (cg-RX-API-DMAC10.html)
AU (1) AU688735B2 (cg-RX-API-DMAC10.html)
BR (1) BR9306911A (cg-RX-API-DMAC10.html)
CA (1) CA2141692C (cg-RX-API-DMAC10.html)
FI (1) FI950485L (cg-RX-API-DMAC10.html)
HU (1) HU9500349D0 (cg-RX-API-DMAC10.html)
IL (1) IL106553A0 (cg-RX-API-DMAC10.html)
MX (1) MX9304787A (cg-RX-API-DMAC10.html)
NO (1) NO950404D0 (cg-RX-API-DMAC10.html)
PL (1) PL307309A1 (cg-RX-API-DMAC10.html)
SG (1) SG47108A1 (cg-RX-API-DMAC10.html)
SK (1) SK13195A3 (cg-RX-API-DMAC10.html)
TW (1) TW239131B (cg-RX-API-DMAC10.html)
WO (1) WO1994003435A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA935693B (cg-RX-API-DMAC10.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
TW259786B (cg-RX-API-DMAC10.html) * 1992-12-17 1995-10-11 Sankyo Co
PT795326E (pt) * 1994-03-16 2002-01-30 Sankyo Co Redutor de tensao ocular
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
US5510495A (en) * 1994-09-19 1996-04-23 The Du Pont Merck Pharmaceutical Company Process for the isolation and purification of ester functionalized imidazole intermediates by selective hydrolysis
ES2129850T3 (es) * 1994-09-20 1999-06-16 Wakunaga Seiyaku Kk Procedimiento de produccion de un derivado de n-bifenilmetiltiadiazolina o una sal de este y su producto intermediario de produccion.
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
IT1295405B1 (it) * 1997-09-30 1999-05-12 Merck Sharp & Dohme Italia S P Uso di un antagonista recettoriale di angiotensina ii per la preparazione di farmaci per aumentare il tasso di sopravvivenza di
DE19820064A1 (de) * 1998-05-06 1999-11-11 Hoechst Marion Roussel De Gmbh Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832428A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
ES2154191B1 (es) * 1998-11-24 2001-10-16 Ferrer Int Nuevos acetales derivados de los 2-alquil-5-halo-3-(2'-(tetrazol-5-il)-bifenil-4-ilmetil)-3h-imidazol-4-carbaldehidos.
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
DK1395566T3 (da) 2001-05-31 2008-01-07 Vicore Pharma Ab Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister
EP1509517B1 (en) * 2003-01-16 2008-06-11 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
KR20060129393A (ko) 2004-01-20 2006-12-15 아이치 프레펙츄러 ＨＬＡ－Ａ2402-제한 Ｅｐ－ＣＡＭ 특이적 ＣＴＬ에인식되는 에피토프/펩티드 및 그 용도
US7157584B2 (en) * 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
WO2006029057A1 (en) * 2004-09-02 2006-03-16 Teva Pharmaceutical Industries, Ltd. Purification of olmesartan medoxomil
CN101160126A (zh) * 2005-04-20 2008-04-09 默克公司 血管紧张肽ⅱ受体拮抗剂
ES2302671T1 (es) * 2006-08-29 2008-08-01 Teva Pharmaceutical Industries Ltd. Procedimientos para la sintesis de 5-fenil-1-tritil-1h-tetrazol.
WO2008043996A2 (en) * 2006-10-09 2008-04-17 Cipla Limited Process for preparing trityl olmesartan medoxomil and olmesartan medoxomil
AU2006351517B8 (en) * 2006-12-06 2012-01-19 Shenzhen Salubris Pharmaceuticals Co., Ltd. The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
WO2011084848A2 (en) * 2010-01-07 2011-07-14 Alkermes, Inc. Prodrugs of heteraromatic compounds
EP2455388A1 (en) 2010-11-23 2012-05-23 LanthioPep B.V. Novel angiotensin type 2 (AT2) receptor agonists and uses thereof.
CN104610232B (zh) * 2013-11-01 2019-09-20 深圳信立泰药业股份有限公司 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物
WO2021023698A1 (en) 2019-08-02 2021-02-11 Lanthiopep B.V Angiotensin type 2 (at2) receptor agonists for use in the treatment of cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
WO1991000277A1 (en) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
WO1991000281A2 (en) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
GB8927277D0 (en) * 1989-12-01 1990-01-31 Glaxo Group Ltd Chemical compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5137902A (en) * 1990-07-13 1992-08-11 E. I. Du Pont De Nemours And Company 4-alkylimidazole derivatives and anti-hypertensive use thereof
EP0573218B1 (en) * 1992-06-02 2001-03-07 Sankyo Company Limited 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use

Also Published As

Publication number Publication date
CA2141692C (en) 2006-05-30
HU9500349D0 (en) 1995-03-28
FI950485A0 (fi) 1995-02-03
CA2141692A1 (en) 1994-02-17
US5310929A (en) 1994-05-10
JP2892838B2 (ja) 1999-05-17
NO950404D0 (no) 1995-02-03
IL106553A0 (en) 1993-12-08
EP0654027A1 (en) 1995-05-24
WO1994003435A1 (en) 1994-02-17
SG47108A1 (en) 1998-03-20
JPH08500103A (ja) 1996-01-09
AU4790393A (en) 1994-03-03
FI950485A7 (fi) 1995-02-03
PL307309A1 (en) 1995-05-15
TW239131B (cg-RX-API-DMAC10.html) 1995-01-21
MX9304787A (es) 1995-01-31
BR9306911A (pt) 1998-12-08
SK13195A3 (en) 1995-07-11
ZA935693B (en) 1995-02-06
AU688735B2 (en) 1998-03-19
FI950485L (fi) 1995-02-03

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C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication