CN108938509B

CN108938509B - Anti-dandruff and itching-relieving composition, and preparation method and application thereof

Info

Publication number: CN108938509B
Application number: CN201811199640.4A
Authority: CN
Inventors: 王玮; 项光刚; 陈贤; 安磊
Original assignee: Scalp Doctor Health Management China Co ltd
Current assignee: Scalp Doctor Health Management China Co ltd
Priority date: 2018-10-16
Filing date: 2018-10-16
Publication date: 2021-06-18
Anticipated expiration: 2038-10-16
Also published as: CN108938509A

Abstract

The invention relates to an anti-dandruff and anti-itching composition, a preparation method and application thereof. The raw materials for preparing the anti-dandruff itching-relieving composition comprise the following components in percentage by mass: 3 to 30 percent of Usnea barbata extract, 5 to 20 percent of wrinkled giant hyssop extract, 2 to 20 percent of Kochiae fructus extract, 1 to 25 percent of gentian extract, 30 to 65 percent of propylene glycol and 5 to 30 percent of deionized water. The active ingredients in the anti-dandruff itching-relieving compound are all from plant extracts, the irritation to a human body is small, and tests prove that the anti-dandruff itching-relieving composition has the effects of removing dandruff and relieving itching.

Description

Anti-dandruff and itching-relieving composition, and preparation method and application thereof

Technical Field

The invention relates to the field of daily chemical products, in particular to an anti-dandruff and anti-itching composition, a preparation method and application thereof.

Background

The hair is used as an accessory of the skin, can retain heat, has a certain modification effect, and is an important component of a human body. Studies have found that in China, 60% of adults suffer from dandruff to varying degrees, mainly due to the lack of attention by domestic consumers to head skin care or the use of inappropriate hair care products.

The dandruff removing and itching relieving agents adopted by the dandruff removing washing and caring products in the domestic market at present are basically chemical substances artificially synthesized by ZPT, climbazole and the like. These substances have a certain anti-dandruff and anti-itching effect, but have certain irritation, and can affect the scalp after long-term use, thereby causing other hair problems.

Disclosure of Invention

In view of the above, there is a need for an anti-dandruff anti-itch composition that is less irritating.

In addition, a preparation method and application of the anti-dandruff and anti-itching composition are also provided.

The anti-dandruff and anti-itching composition is prepared from the following raw materials in percentage by mass:

3 to 30 percent of Usnea barbata extract, 5 to 20 percent of wrinkled giant hyssop extract, 2 to 20 percent of Kochiae fructus extract, 1 to 25 percent of gentian extract, 30 to 65 percent of propylene glycol and 5 to 30 percent of deionized water.

The active ingredients in the anti-dandruff and anti-itching composition are all derived from plant extracts, so that the anti-dandruff and anti-itching composition is less irritant to human bodies, and tests prove that the anti-dandruff and anti-itching composition has the anti-dandruff and anti-itching effects.

In one embodiment, the Usnea barbata extract is supercritical CO of Usnea barbata₂Extract, wherein the agastache extract is supercritical CO of agastache₂The extract is supercritical CO of Kochia scoparia₂The extract is supercritical CO of radix Gentianae₂And (3) extracting.

In one embodiment, the raw materials for preparing the anti-dandruff and anti-itching composition comprise the following components in percentage by mass:

20% of usnea barbata extract, 10% of wrinkled gianthyssop herb extract, 10% of belvedere fruit extract, 10% of gentian extract, 40% of propylene glycol and the balance of deionized water.

The preparation method of the anti-dandruff and anti-itching composition comprises the following steps:

mixing the water and the propylene glycol, heating to 75-85 ℃, and stirring for 25-35 min;

adding the Usnea barbata extract, the Agastache rugosus extract, the Kochiae fructus extract and the gentian extract, and stirring until the components are dissolved to obtain the anti-dandruff and anti-itching composition.

In one embodiment, the method further comprises the steps of preparing the usnea barbata extract, preparing the agastache rugosa extract, preparing the belvedere fruit extract and preparing the gentian extract:

the preparation steps of the usnea barbata extract are as follows: pulverizing Usnea barbata, and sieving to obtain Usnea barbata powder(ii) a By supercritical CO₂Extracting the usnea barbata powder by using a fluid to obtain an usnea barbata extraction mixture; separating the usnea barbata extraction mixture to obtain usnea barbata isolate; mixing the usnea barbata isolate with water, heating, distilling and extracting, and condensing to obtain an usnea barbata extract;

the preparation steps of the ageratum extract are as follows: pulverizing herba Agastaches, and sieving to obtain herba Agastaches powder; by supercritical CO₂Extracting the agastache rugosa powder by using a fluid to obtain an agastache rugosa extraction mixture; separating the agastache rugosa extract mixture to obtain an agastache rugosa isolate; mixing the Agastache rugosa extract with water, distilling and extracting under heating, and condensing to obtain Agastache rugosa extract;

the preparation method of the belvedere fruit extract comprises the following steps:

pulverizing Kochiae fructus, and sieving to obtain Kochiae fructus powder; by supercritical CO₂Extracting the belvedere fruit powder by using a fluid to obtain a belvedere fruit extraction mixture; separating the fructus kochiae extraction mixture to obtain a fructus kochiae root isolate; mixing the broom cypress fruit isolate with water, heating, distilling and extracting, and condensing to obtain a broom cypress fruit extract; and

the preparation steps of the gentian extract are as follows: pulverizing radix Gentianae, and sieving to obtain radix Gentianae powder; by supercritical CO₂Extracting the gentian powder by using a fluid to obtain a gentian extraction mixture; separating the gentian extraction mixture to obtain a gentian isolate; mixing the gentian isolate and water, and heating, distilling and extracting to obtain the gentian extract.

In one embodiment, the step of sieving has a screen with a mesh size of 300 mesh or larger.

In one embodiment, the use of supercritical CO₂CO in the extraction step₂The flow rate is 1.5 kg/h-8 kg/h, the extraction pressure is 15 MPa-25 MPa, the extraction temperature is 35 ℃, and the extraction time is 5 h.

In one embodiment, the separation pressure in the separation step is 4MPa to 6MPa, the separation temperature is 38 ℃ to 40 ℃, and the separation time is 4h to 6 h.

In one embodiment, in the step of distilling and extracting, the feed-liquid ratio of the isolate to the water is 1 g/L-5 g/L, and the distillation time is 6 h-8 h.

The application of the anti-dandruff and anti-itching composition in preparing a hair washing product or a hair care product.

Drawings

FIG. 1 is a flow chart of a method of preparing an anti-dandruff, anti-itch composition according to one embodiment;

fig. 2 is a flow chart of a method for preparing an usnea barbata extract according to an embodiment.

Detailed Description

To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

The raw materials for preparing the anti-dandruff and anti-itching composition according to the mass percentage content comprise the following components:

3 to 30 percent of Usnea barbata extract, 5 to 20 percent of wrinkled giant hyssop extract, 2 to 20 percent of Kochiae fructus extract, l to 25 percent of gentian extract, 30 to 65 percent of propylene glycol and 5 to 30 percent of deionized water.

In one embodiment, the Usnea barbata extract is supercritical CO of Usnea barbata₂The extract and herba Agastaches extract are supercritical CO of herba Agastaches₂The extract and Kochia scoparia extract are supercritical CO of Kochia scoparia₂The extract is supercritical CO of radix Gentianae₂And (3) extracting. It can be understood that the above four kinds areThe extract is used as an active ingredient of the anti-dandruff and anti-itching composition, is completely from plants, has mild performance and causes less irritation to human bodies.

The active ingredients in the anti-dandruff itching-relieving composition are all derived from plant extracts, have small irritation to human bodies, and have the effects of removing dandruff and relieving itching through test verification.

As shown in fig. 1, a method for preparing an anti-dandruff and anti-itch composition according to an embodiment includes the steps of:

step S110: mixing the water and the propylene glycol, heating to 75-85 ℃, and stirring for 25-35 min.

Step S120: adding the Usnea barbata extract, the Agastache rugosus extract, the Kochiae fructus extract and the gentian extract, and stirring until the components are dissolved to obtain the anti-dandruff and anti-itching composition.

Wherein, water and propylene glycol are used as solvents, and the propylene glycol has the function of antibiosis. Usnea barbata extract is used as an antibacterial component. Usnea barbata has strong antibacterial and antiprotozoal effects, and usnic acid has outstanding antibacterial effect, and has effects of clearing liver-fire, eliminating phlegm, stopping bleeding, and removing toxic substance. Agastache rugosa extract is used as another antibacterial ingredient, and has antifungal effect. The Kochiae fructus extract is used as antibacterial and antipruritic component, has antifungal and antipruritic effects, and can maintain good growth environment of hair follicle. The radix Gentianae extract has antipruritic and antiinflammatory effects.

As shown in fig. 2, in one embodiment, the method further comprises a step of preparing the usnea extract, a step of preparing the agastache extract, a step of preparing the kochia scoparia extract and a step of preparing the gentian extract:

the preparation method of the usnea barbata extract comprises the following steps:

step S121: pulverizing Usnea barbata, and sieving to obtain Usnea barbata powder.

Wherein the aperture of the sieved screen is larger than or equal to 300 meshes.

Step S122: by supercritical CO₂Fluid is used for extracting the usnea barbata powder to obtain the usnea barbata extraction mixture.

Wherein, supercritical CO₂The flow rate is 1.5 kg/h-8 kg/h, the extraction pressure is 15 MPa-25 MPa, the extraction temperature is 35 ℃, and the extraction time is 5 h.

Step S123: separating the usnea barbata extract mixture to obtain usnea barbata isolate.

Wherein the separation pressure is 4 MPa-6 MPa, the separation temperature is 38-40 ℃, and the separation time is 4-6 h.

Step S124: mixing Usnea barbata isolate with water, and extracting by heating and distilling to obtain Usnea barbata extract.

Wherein the ratio of the usnea barbata isolate to water is 1-5 g/L, and the distillation time is 6-8 h.

The preparation method of the agastache rugosus extract comprises the following steps:

(1) pulverizing herba Agastaches, and sieving to obtain herba Agastaches powder.

(2) By supercritical CO₂Fluid is used for extracting the agastache rugosus powder to obtain an agastache rugosus extraction mixture.

(3) Separating the extract mixture to obtain herba Agastaches isolate.

(4) Mixing herba Agastaches extract with water, and extracting by heating and distilling to obtain herba Agastaches extract.

Wherein, the ratio of the agastache rugosus isolate to the water material liquid is 1 g/L-5 g/L, and the distillation time is 6 h-8 h.

(1) pulverizing Kochiae fructus, and sieving to obtain Kochiae fructus powder.

(2) By supercritical CO₂And (4) extracting the belvedere fruit powder by using the fluid to obtain a belvedere fruit extraction mixture.

(3) And (4) separating the fructus kochiae extraction mixture to obtain the fructus kochiae isolate.

(4) Mixing the fructus Kochiae isolate with water, heating, distilling, and extracting to obtain fructus Kochiae extract.

Wherein, the ratio of the belvedere fruit isolate to the water solution is 1 g/L-5 g/L, and the distillation time is 6 h-8 h.

The preparation method of the gentian extract comprises the following steps:

(1) pulverizing radix Gentianae, and sieving to obtain radix Gentianae powder.

(2) By supercritical CO₂And (4) extracting the gentian powder by using a fluid to obtain a gentian extraction mixture.

(3) And separating the gentian extraction mixture to obtain a gentian isolate.

(4) Mixing the radix Gentianae extract with water, and extracting by heating and distilling to obtain radix Gentianae extract.

Wherein the ratio of the gentian isolate to the water is 1-5 g/L, and the distillation time is 6-8 h.

Note that by advanced supercritical CO₂The plant extract extracted by the extraction process has more active ingredients, less impurities and better effect than the traditional water boiling type extract.

The anti-dandruff and anti-itching composition or the anti-dandruff and anti-itching composition prepared by the preparation method of the anti-dandruff and anti-itching composition is applied to preparing a hair washing product or a hair care product.

A hair washing product or a hair care product prepared from the anti-dandruff and itching-relieving composition has the effects of removing dandruff and relieving itching, and has small irritation to a human body.

The following are specific examples (the following examples do not contain other components except inevitable impurities which are not specifically indicated), table 1 is the percentage of each component in examples 1 to 5 and comparative examples, and table 2 is the process parameters for preparing the plant extract in each example and comparative example.

Example 1

The procedure for preparing the anti-dandruff and anti-itch composition of this example is as follows:

(1) according to the percentage content listed in the table 1, deionized water and propylene glycol are weighed, mixed and heated to 75-85 ℃, and stirred for 25-35 min.

(2) Adding the usnea barbata extract, the agastache rugosa extract, the broom cypress fruit extract and the gentian extract in the percentage content listed in the table 1, and stirring until the components are dissolved to obtain the anti-dandruff and anti-itching composition.

TABLE 1 percentage of each raw material in examples 1 to 5 and comparative examples

(1) pulverizing Usnea barbata, and sieving with 300 mesh sieve to obtain Usnea barbata powder.

(2) With supercritical CO at a flow rate of 1.5kg/h₂Fluid is used for extracting the usnea barbata powder to obtain the usnea barbata extraction mixture.

Wherein the extraction pressure is 15MPa, the extraction temperature is 35 ℃, and the extraction time is 5 h.

(3) Separating the usnea barbata extract mixture for 4 hours under the conditions that the separation pressure is 4MPa and the separation temperature is 38 ℃ to obtain the usnea barbata isolate.

(4) Mixing Usnea barbata isolate and water, and heating, distilling and extracting, wherein the material-liquid ratio of the isolate to the water is 1g/L, and the distilling time is 6h to obtain Usnea barbata extract.

It is understood that the preparation steps of the agastache rugosus extract, the broom cypress fruit extract and the gentian extract are the same as the preparation steps of the usnea barbata extract, and only the plant raw materials are different, so that the detailed description is omitted.

Examples 2 to 5 and comparative examples

The procedure for preparing the anti-dandruff and anti-itch compositions of examples 2 to 5 and comparative example was exactly the same as example 1, except that the percentage of each raw material was different, and the percentage of each raw material is shown in table 1.

The preparation steps of the respective plant extracts (usnea barbata extract, pogostemon cablin extract, kochia scoparia extract and gentian extract) in examples 2 to 5 and comparative example were the same as those of the corresponding plant extracts usnea barbata extract, pogostemon cablin extract, kochia scoparia extract and gentian extract in example 1, and the process parameters in the preparation steps were different only, and the process parameters in the preparation of the plant extracts were shown in table 2.

TABLE 2 Process parameters for the preparation of plant extracts in the examples

EXAMPLES Effect test of the prepared anti-dandruff anti-itching composition and the commercially available anti-dandruff anti-itching product

1. Dandruff removal and itching relief test

The test method comprises the following steps: 140 volunteers aged 40-50 years and having severe dandruff symptoms were selected, wherein 52 women and 88 men were selected, and the volunteers were randomly divided into 7 groups of 20 persons each, and the anti-dandruff anti-itch composition of examples 1-5 and comparative example and the commercially available anti-dandruff anti-itch solution were used, respectively.

The using method comprises the following steps: after washing hair, the shampoo is smeared on the scalp for 3 weeks 1 time a day, 3ml to 5ml each time.

The evaluation method comprises the following steps: the evaluation of the improvement of the anti-dandruff effect of the product after 3 weeks of use was made by the subjects using a questionnaire.

The judgment result is divided into: the effect is not obvious, general, obvious and very obvious. The obvious effective rate is very obvious (example)/number of tested persons (example) × 100%.

The test results are shown in table 3:

TABLE 3 dandruff removal and itching relief test results

From the results of table 3, it can be seen that: in the volunteers using the anti-dandruff and anti-itching composition of examples 1 to 5, 50%, 55%, 65%, 55% and 50% of the volunteers felt very obvious anti-dandruff and anti-itching effects, while in the volunteers using the comparative example and the commercially available anti-dandruff and anti-itching solution, only 25% and 15% of the volunteers felt very obvious anti-dandruff and anti-itching effects, which indicates that the anti-dandruff and anti-itching composition of the present invention has significantly better anti-dandruff and anti-itching effects than the comparative example and the commercially available anti-dandruff and anti-itching solution.

2. Security assessment

280 subjects were selected, 130 men and 150 women, aged 20-40 years, and people with sensitive skin. The subjects were randomly divided into 7 groups of 40 persons each, and the plaque test experiments were performed on the subjects in each group.

The spot test method comprises the following steps: selecting a qualified spot tester, applying about 0.02-0.025 ml of a test object to the spot tester by a closed spot test method, externally applying a special adhesive tape to the curved side of the forearm of a subject, removing the test object after 24 hours, observing skin reaction after the spot tester of the test object is removed for 30min, and recording the result according to the skin reaction grading standard in the cosmetic hygiene standard.

And (4) evaluating the results: the results of the reactions were recorded as in Table 4 (criteria for grading adverse skin reactions), and the results are shown in Table 5.

TABLE 4 grading Standard of adverse skin reactions

TABLE 5 results of safety evaluation

The results in table 5 show: in examples 1 to 5 and the comparative example, all the subjects showed negative reactions (rating scale: 0). According to the judgment standard of human skin patch test of cosmetic hygiene standard, the sample has no adverse skin reaction to human body. On the other hand, the commercial dandruff-removing and itching-relieving liquid showed grade 1 reaction of 5 cases. This indicates that the anti-dandruff anti-itch lotion of the present invention exhibits higher safety without any abnormal reaction even in the population who uses it on sensitive skin.

Combining the above-mentioned dandruff-removing and itching-relieving test and the safety test, it can be known that: the anti-dandruff and anti-itching composition has the effects of removing dandruff and relieving itching and is less irritant to human bodies.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. The anti-dandruff and anti-itching composition is characterized by being prepared from the following raw materials in percentage by mass:

3% -30% of Usnea barbata extract, 5% -20% of wrinkled gianthyssop extract, 2% -20% of Kochiae fructus extract, 1% -25% of Gentiana scabra extract, 30% -65% of propylene glycol and 5% -30% of deionized water;

the Usnea barbata extract is supercritical CO of Usnea barbata₂Extract, wherein the agastache extract is supercritical CO of agastache₂The extract is supercritical CO of Kochia scoparia₂The extract is supercritical CO of radix Gentianae₂Extracting the extract;

mixing the deionized water and propylene glycol, heating to 75-85 ℃, and stirring for 25-35 min;

adding the usnea barbata extract, the agastache rugosus extract, the belvedere fruit extract and the gentian extract, and stirring until the components are dissolved to obtain the dandruff-removing and itching-relieving composition;

the preparation steps of the usnea barbata extract are as follows: pulverizing Usnea barbata, and sieving to obtain Usnea barbata powder; by supercritical CO₂Extracting the usnea barbata powder by using a fluid to obtain an usnea barbata extraction mixture; separating the usnea barbata extraction mixture to obtain usnea barbata isolate; mixing the usnea barbata isolate with water, heating, distilling and extracting, and condensing to obtain an usnea barbata extract;

pulverizing Kochiae fructus, and sieving to obtain Kochiae fructus powder(ii) a By supercritical CO₂Extracting the belvedere fruit powder by using a fluid to obtain a belvedere fruit extraction mixture; separating the fructus kochiae extraction mixture to obtain fructus kochiae isolate; mixing the broom cypress fruit isolate with water, heating, distilling and extracting, and condensing to obtain a broom cypress fruit extract; and

2. The composition for removing dandruff and relieving itching according to claim 1, wherein the composition for removing dandruff and relieving itching is prepared from the following raw materials in percentage by mass:

25% of usnea barbata extract, 20% of wrinkled gianthyssop herb extract, 10% of belvedere fruit extract, 10% of gentian extract, 30% of propylene glycol and 5% of deionized water;

or 30% of usnea barbata extract, 5% of wrinkled gianthyssop herb extract, 15% of belvedere fruit extract, 8% of gentian extract, 37% of propylene glycol and 5% of deionized water.

3. The composition for removing dandruff and relieving itching according to claim 1, wherein the composition for removing dandruff and relieving itching is prepared from the following raw materials in percentage by mass:

4. A method for preparing an antidandruff and antipruritic composition according to any one of claims 1 to 3, comprising the steps of:

5. The method for preparing the composition for removing dandruff and relieving itching according to claim 4, further comprising the steps of preparing the Usnea barbata extract, preparing the Agastache rugosa extract, preparing the Kochia scoparia extract and preparing the gentian extract:

pulverizing Kochiae fructus, and sieving to obtain Kochiae fructus powder; by supercritical CO₂Extracting the belvedere fruit powder by using a fluid to obtain a belvedere fruit extraction mixture; separating the fructus kochiae extraction mixture to obtain fructus kochiae isolate; mixing the broom cypress fruit isolate with water, heating, distilling and extracting, and condensing to obtain a broom cypress fruit extract; and

6. The method for preparing an antidandruff and antipruritic composition according to claim 5, wherein the size of the mesh in the sieving step is 300 mesh or larger.

7. The method of preparing an antidandruff and antipruritic composition according to claim 5, wherein the composition is prepared by supercritical CO₂In the step of extraction, CO₂The flow rate of the extraction is 1.5 kg/h-8 kg/h, the extraction pressure is 15 MPa-25 MPa, the extraction temperature is 35 ℃, and the extraction time is 5 h.

8. The method for preparing the composition for removing dandruff and relieving itching according to claim 5, wherein the separation pressure in the separation step is 4MPa to 6MPa, the separation temperature is 38 ℃ to 40 ℃, and the separation time is 4h to 6 h.

9. The method for preparing the composition for removing dandruff and relieving itching according to claim 5, wherein in the step of distilling and extracting, the feed-liquid ratio of the isolate to the water is 1g/L to 5g/L, and the distilling time is 6h to 8 h.

10. Use of the anti-dandruff anti-itch composition according to any one of claims 1 to 3 or the anti-dandruff anti-itch composition prepared by the method for preparing the same according to any one of claims 4 to 9, in the preparation of a hair washing product or a hair care product.