CN109157474A - Oil-control anti-hair loss composition and preparation method thereof and its application - Google Patents

Oil-control anti-hair loss composition and preparation method thereof and its application Download PDF

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CN109157474A
CN109157474A CN201811199596.7A CN201811199596A CN109157474A CN 109157474 A CN109157474 A CN 109157474A CN 201811199596 A CN201811199596 A CN 201811199596A CN 109157474 A CN109157474 A CN 109157474A
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extract
oil
hair loss
root extract
fructus forsythiae
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王玮
项光刚
陈贤
安磊
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Scalp Doctor Health Management (china) Co Ltd
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Scalp Doctor Health Management (china) Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/008—Preparations for oily hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

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Abstract

The present invention relates to a kind of oil-control anti-hair loss compositions and preparation method thereof and its application.According to mass percentage meter, the raw material for preparing above-mentioned oil-control anti-hair loss composition includes following component: ginseng root extract 2%~20%, ginger-root extract 1%~25%, Fructus Forsythiae berry extract 1%~15%, kuh-seng root extract 2%~10%, butanediol 20%~70% and deionized water 10%~50%.Active constituent in the oil-control anti-hair loss composition comes all from plant extracts, smaller to human body irritation, and experiment proves that the oil-control anti-hair loss composition has the effect of oil-control anticreep.

Description

Oil-control anti-hair loss composition and preparation method thereof and its application
Technical field
The present invention relates to daily chemical product fields, answer more particularly to a kind of oil-control anti-hair loss composition and preparation method thereof with it With.
Background technique
Adjunct of the hair as skin is the important component of human body.Alopecia even because bald caused by alopecia, Great mental burden is brought to patient.Oil alopecia, also referred to as alopecia seborrheica are to cause a kind of bald main class Type, it mostly occurs in the vigorous person between twenty and fifty of smegma, and the gradually alopecia since the crown spreads to forehead.Scalp it is greasy and Azarin ties yellow oil scab.
Excessive sebum secretion object is deposited in perifollicolar, or even compressing or blocking hair follicle hole, gives hair normal growth system Obstacle is made, so as to cause alopecia seborrheica；In addition, oleic acid, linoleic acid in sebum secretion object etc. is toxic to hair follicle when excessive Effect, also results in hair and is poisoned, withers, falls off.
Effective component in the anti-product-stripping mechanism of oil-control on the market is mostly artificial synthesized chemical substance, although these substances There are some effects, but there is very big irritation, scalp health may be influenced by being used for a long time, and other hairs is caused to ask Topic.
Summary of the invention
Based on this, it is necessary to provide a kind of lesser oil-control anti-hair loss composition of irritation.
In addition, also providing the preparation method and its application of a kind of above-mentioned oil-control anti-hair loss composition.
A kind of oil-control anti-hair loss composition prepares the raw material packet of the oil-control anti-hair loss composition according to mass percentage meter Include following component:
Ginseng root extract 2%~20%, ginger-root extract 1%~25%, Fructus Forsythiae berry extract 1%~15%, kuh-seng Root extract 2%~10%, butanediol 20%~70% and deionized water 10%~50%.
Active constituent in above-mentioned oil-control anti-hair loss composition is all from plant extracts, smaller to human body irritation, and Experiment proves that the oil-control anti-hair loss composition has the effect of oil-control anticreep.
The ginseng root extract, which is behaved, in one of the embodiments, joins the supercritical CO of root2Extract, the race Extract is the supercritical CO of race2Extract, the Fructus Forsythiae berry extract are the supercritical CO of Fructus Forsythiae fruit2Extract, the hardship Join the supercritical CO that root extract is radix sophorae2Extract.
In one of the embodiments, according to mass percentage meter, the raw material packet of the oil-control anti-hair loss composition is prepared Include following component:
Ginseng root extract 10%, ginger-root extract 8%, Fructus Forsythiae berry extract 5%, kuh-seng root extract 5%, butanediol 50% and deionized water surplus.
A kind of preparation method of above-mentioned oil-control anti-hair loss composition, includes the following steps:
The deionized water and butanediol are mixed and heated to 75 DEG C~85 DEG C, stir 25min~35min；
The ginseng root extract, ginger-root extract, Fructus Forsythiae berry extract and kuh-seng root extract, stirring to each group is added Divide dissolution, obtains oil-control anti-hair loss composition.
It in one of the embodiments, further include the preparation step of the ginseng root extract, the ginger-root extract The preparation step of preparation step, the preparation step of the Fructus Forsythiae berry extract and the kuh-seng root extract:
The preparation step of the ginseng root extract are as follows: ginseng is crushed, sieving, obtain ginseng powder；Faced with super Boundary CO2Fluid extracts the ginseng powder, obtains ginseng extraction mixture；Mixture is extracted to the ginseng It is separated, obtains ginseng isolate；The ginseng isolate and water are mixed and carry out heating distillation extraction, after condensation To ginseng root extract；
The preparation step of the ginger-root extract are as follows: race is crushed, sieving, obtain ginger root powder；Use supercritical CO2Stream Body extracts the ginger root powder, obtains race extraction mixture；Race extraction mixture is separated, is obtained Race isolate；The race isolate and water are mixed and carry out heating distillation extraction, obtains ginger-root extract after condensation；
The preparation step of the Fructus Forsythiae berry extract are as follows: Fructus Forsythiae fruit powder is broken, sieving obtains Fructus Forsythiae fruit powder end；Faced with super Boundary CO2Fluid extracts Fructus Forsythiae fruit powder end, obtains Fructus Forsythiae fruit extraction mixture；Mixture is extracted to the Fructus Forsythiae fruit It is separated, obtains Fructus Forsythiae fruit root isolate；The Fructus Forsythiae fruit isolate and water are mixed and carry out heating distillation extraction, after condensation Obtain Fructus Forsythiae berry extract；And
The preparation step of the kuh-seng root extract are as follows: radix sophorae is crushed, sieving, obtain radix sophorae powder；Faced with super Boundary CO2Fluid extracts the radix sophorae powder, obtains radix sophorae extraction mixture；Mixture is extracted to the radix sophorae It is separated, obtains radix sophorae isolate；The even radix sophorae and water are mixed and carry out heating distillation extraction, obtains hardship after condensation Join root extract.
The aperture of sieve is greater than or equal to 300 mesh in the step of sieving in one of the embodiments,.
It is described in one of the embodiments, to use supercritical CO2CO in the step of extraction2Flow velocity is 2kg/h~8kg/h, Extracting pressure is 15MPa~25MPa, and extraction temperature is 35 DEG C, extraction time 5h.
Separating pressure is 4MPa~6MPa, separation temperature 38 in the step of separation in one of the embodiments, DEG C~40 DEG C, disengaging time is 4h~6h.
In one of the embodiments, in the step of distillation extraction, the solid-liquid ratio of the isolate and the water is 1g/L~5g/L, distillation time are 6h~8h.
Above-mentioned oil-control anti-hair loss composition is preparing the application in hair washing product or hair products.
Detailed description of the invention
Fig. 1 is the flow chart of the preparation method of the oil-control anti-hair loss composition of an embodiment；
Fig. 2 is the flow chart of the preparation method of the ginseng root extract of an embodiment.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing Give preferred embodiment of the invention.But the invention can be realized in many different forms, however it is not limited to herein Described embodiment.On the contrary, purpose of providing these embodiments is keeps the understanding to the disclosure more saturating It is thorough comprehensive.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool The purpose of the embodiment of body, it is not intended that in the limitation present invention.
The oil-control anti-hair loss composition of one embodiment prepares the original of oil-control anti-hair loss composition according to mass percentage meter Material includes following component:
Ginseng root extract 2%~20%, ginger-root extract 1%~25%, Fructus Forsythiae berry extract 1%~15%, kuh-seng Root extract 2%~10%, butanediol 20%~70% and deionized water 10%~50%.
Ginseng root extract, which is behaved, in one of the embodiments, joins the supercritical CO of root2Extract, ginger-root extract are The supercritical CO of race2Extract, Fructus Forsythiae berry extract are the supercritical CO of Fructus Forsythiae fruit2Extract, kuh-seng root extract are kuh-seng The supercritical CO of root2Extract.It is appreciated that ginseng root extract, ginger-root extract, Fructus Forsythiae berry extract and radix sophorae extract Active constituent of the object as oil-control anti-hair loss composition, all from plant, performance is mild, smaller to human body irritation.
In one of the embodiments, according to mass percentage meter, the raw material packet of above-mentioned oil-control anti-hair loss composition is prepared Include following component:
Ginseng root extract 10%, ginger-root extract 8%, Fructus Forsythiae berry extract 5%, kuh-seng root extract 5%, butanediol 50% and deionized water surplus.
Active constituent in above-mentioned oil-control anti-hair loss composition comes all from plant extracts, smaller to human body irritation, And experiment proves that having the effect of oil-control anticreep.
As shown in Figure 1, the preparation method of the oil-control anti-hair loss composition of an embodiment, includes the following steps:
Step S110: being mixed and heated to 75 DEG C~85 DEG C for above-mentioned deionized water and butanediol, and stirring 25min~ 35min；
Step S120: being added above-mentioned ginseng root extract, ginger-root extract, Fructus Forsythiae berry extract and kuh-seng root extract, Stirring to each component dissolves, and obtains oil-control anti-hair loss composition.
Wherein, deionized water and butanediol are solvent, and butanediol has the function of antibiotic effect.Ginseng root extract conduct Anticreep ingredient has the blood circulation for improving perifollicolar, increases the supply of hair follicle nutrition, activation hair follicle cell activity, enhancing The effects of papilla nerve growth factor, so that hair be promoted to generate, and can enhance the toughness of hair, be not easy alopecia.Race mentions It takes object as another anticreep ingredient, skin of head blood circulation can be promoted, have additional nutrients and energy supply, promotion scalp are newly old Metabolism activates hair follicle tissue, so that hair be promoted to generate and grow.Fructus Forsythiae berry extract has aobvious as sterilizing and itch-relieving ingredient The Controlling oil effect of work inhibits smegma excessively prosperous, prevents sebum from accumulating in hair follicle.And various toxin in hair follicle can be removed, Keep the good growing environment of hair follicle.Kuh-seng root extract has antibacterial anti-inflammatory, desinsection is antipruritic to be gone as sterilizing and itch-relieving ingredient Bits remove hair follicle toxin, keep the effect of scalp health.
As shown in Fig. 2, in one of the embodiments, further including the preparation step of ginseng root extract, ginger-root extract Preparation step, the preparation step of the preparation step of Fructus Forsythiae berry extract and kuh-seng root extract:
Wherein, the preparation step of ginseng root extract are as follows:
Step S121: ginseng is crushed, sieving, obtains ginseng powder.
Wherein, the aperture of the sieve of sieving is greater than or equal to 300 mesh.
Step S122: supercritical CO is used2Fluid extracts ginseng powder, obtains ginseng extraction mixture.
Wherein, supercritical CO2Flow velocity is 2kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, extraction temperature 35 DEG C, extraction time 5h.
Step S123: ginseng extraction mixture is separated, ginseng isolate is obtained.
Wherein, separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
Step S124: ginseng isolate and water being mixed and carry out heating distillation extraction, and ginseng extraction is obtained after condensation Object.
Wherein, the ratio of isolate and water is 1g/L~5g/L, and distillation time is 6h~8h.
The preparation step of ginger-root extract:
(1) race is crushed, sieving, obtains ginger root powder.
Wherein, the aperture of the sieve of sieving is greater than or equal to 300 mesh.
(2) supercritical CO is used2Fluid extracts ginger root powder, obtains race extraction mixture.
Wherein, supercritical CO2Flow velocity is 2kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, extraction temperature 35 DEG C, extraction time 5h.
(3) race extraction mixture is separated, obtains race isolate.
Wherein, separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
(4) race isolate and water are mixed and carries out heating distillation extraction, obtain ginger extract after condensation.
Wherein, the ratio of isolate and water is 1g/L~5g/L, and distillation time is 6h~8h.
The preparation step of Fructus Forsythiae berry extract:
(1) Fructus Forsythiae fruit powder is broken, sieving obtains Fructus Forsythiae fruit powder end.
Wherein, the aperture of the sieve of sieving is greater than or equal to 300 mesh.
(2) supercritical CO is used2Fluid extracts Fructus Forsythiae fruit powder end, obtains Fructus Forsythiae fruit extraction mixture.
Wherein, supercritical CO2Flow velocity is 2kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, extraction temperature 35 DEG C, extraction time 5h.
(3) Fructus Forsythiae fruit extraction mixture is separated, obtains Fructus Forsythiae fruit isolate.
Wherein, separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
(4) Fructus Forsythiae fruit isolate and water are mixed and carries out heating distillation extraction, Fructus Forsythiae fruit is obtained after condensation and takes object.
Wherein, the ratio of isolate and water is 1g/L~5g/L, and distillation time is 6h~8h.
The preparation step of kuh-seng root extract:
(1) radix sophorae is crushed, sieving, obtains radix sophorae powder.
Wherein, the aperture of the sieve of sieving is greater than or equal to 300 mesh.
(2) supercritical CO is used2Fluid extracts radix sophorae powder, obtains radix sophorae extraction mixture.
Wherein, supercritical CO2Flow velocity is 2kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, extraction temperature 35 DEG C, extraction time 5h.
(3) radix sophorae extraction mixture is separated, obtains radix sophorae isolate.
Wherein, separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
(4) radix sophorae isolate and water are mixed and carries out heating distillation extraction, Fructus Forsythiae fruit is obtained after condensation and takes object.
Wherein, the ratio of isolate and water is 1g/L~5g/L, and distillation time is 6h~8h.
It should be noted that the supercritical CO for the above-mentioned plant extracted by supercritical extraction process2Extract, as control The active constituent of oily anti-hair loss composition, effect are more preferable than the effect of traditional boiling type extract.
The oil-control anti-hair loss composition of any of the above-described embodiment is prepared according to the oil-control anti-hair loss composition of any of the above-described The oil-control anti-hair loss composition that method is prepared is preparing the application in hair washing product or hair products.
The hair washing product as made from above-mentioned oil-control anti-hair loss composition or hair products have effects that oil-control anticreep, are suitble to change It is apt to physical, seborrheica, pressure, Nutrition and Metabolism alopecia problem, and it is smaller to human body irritation.
The following are specific embodiment part, (following embodiment unless otherwise specified, does not then contain and removes inevitable impurity Other components not yet explicitly pointed out in addition), table 1 is the percentage composition of Examples 1 to 4 and comparative example each component, and table 2 is each reality Apply technological parameter when prepared plant extracts in example and comparative example.
Embodiment 1
The preparation step of the oil-control anti-hair loss composition of the present embodiment is as follows:
(1) it according to percentage composition listed by table 1, weighs deionized water and butanediol is mixed and heated to 75 DEG C~85 DEG C, stir 25min~35min.
(2) ginseng root extract, ginger-root extract, Fructus Forsythiae berry extract and the hardship of percentage composition listed by table 1 is added Join root extract, stirring to each component is dissolved, and oil-control anti-hair loss composition is obtained.
The percentage composition of 1 Examples 1 to 4 of table and each raw material of comparative example
Wherein, the preparation step of ginseng root extract is as follows:
(1) ginseng crushed, cross 300 mesh screens, obtain ginseng powder.
(2) supercritical CO for being 2kg/h with flow velocity2Fluid extracts ginseng powder, and it is mixed to obtain ginseng extraction Close object.
Wherein, extracting pressure 15MPa, extraction temperature are 35 DEG C, extraction time 5h.
(3) it is 4MPa in separating pressure, under the conditions of separation temperature is 38 DEG C, ginseng extraction mixture is separated 4h obtains ginseng isolate.
(4) ginseng isolate and water are mixed and carries out heating distillation extraction, wherein the solid-liquid ratio of isolate and water is 1g/L, distillation time 6h obtain ginseng root extract.
It is understood that the preparation step and ginseng of ginger-root extract, Fructus Forsythiae berry extract and kuh-seng root extract The preparation step of extract is identical, and only plant material is different, and so it will not be repeated.
2~embodiment of embodiment 4 and comparative example
The preparation step of the oil-control anti-hair loss composition of 2~embodiment of embodiment 4 and comparative example is identical with embodiment 1, Only the percentage composition of each raw material is different, and the percentage composition of each raw material is shown in Table 1.
Each plant extracts (ginseng root extract, ginger-root extract, Fructus Forsythiae in 2~embodiment of embodiment 4 and comparative example Berry extract and kuh-seng root extract) preparation step and plant extracts corresponding in embodiment 1 (ginseng root extract, Ginger-root extract, Fructus Forsythiae berry extract and kuh-seng root extract) preparation step it is identical, only the technological parameter in preparation step is not Together, technological parameter when prepared plant extracts is shown in Table 2.
Technological parameter in each embodiment of table 2 when prepared plant extracts
The measure of merit of oil-control anti-hair loss composition and commercially available anticreep nourishing liquid that embodiment is prepared:
1. oil-control anticreep is tested
Test method: volunteer 180 with alopecia symptom that the age is 40 years old~50 years old are selected, wherein women 37 Volunteer is randomly divided into 6 groups by people, 143 people of male, and every group of 30 people use Examples 1 to 4, the Anti-hair loss group of comparative example respectively Close object and commercially available anticreep nourishing liquid.
Application method are as follows: after hair washing, be applied at scalp, 1 time a day, each 3ml~5ml is for 4 weeks.
Appraisal procedure: by the way of questionnaire survey, understand using after 4 weeks, subject uses rear oil-control anticreep to product Improvement situation evaluation.
Evaluation result is divided into: effect is unobvious, effect is general, more apparent, clearly, wherein significant effective rate=non- Chang Mingxian (example)/tested number (example) × 100%.
Test result is as shown in table 3:
3 Anti-hair loss test result of table
As shown in Table 3: in the volunteer using the Anti-hair loss composition of Examples 1 to 4, there is 50% respectively, 60%, 53.3%, 56.7% volunteer feels there is obviously anticreep effect, and comparative example and commercially available anticreep is used to nourish In the volunteer of liquid, only 20% and 10% volunteer feels there is obviously oil-control anticreep effect respectively, this illustrates this The oil-control anti-hair loss composition oil-control anticreep effect of invention is substantially better than comparative example and commercially available anticreep nourishing liquid.
2. safety evaluation
180 people of subject is selected, wherein male 110 people, 70 people of female, the age 18~40 years old, sensibility skin crowd.It will be tested Person is randomly divided into 6 groups, and every group of 30 people carry out spot examination experiment to every group of subject respectively.
Spot test method: selecting qualified spot tester, with enclosed patch test method, by tested material about 0.02ml~ 0.025ml is applied in spot tester, and external application special adhesive tape is pasted on subject's forearm song side, removes tested material after 24 hours, in going Except 30min after tested material spot tester, dermoreaction is observed after impression disappearance, by " cosmetics health specification " (version in 2007) Dermoreaction grade scale records its result.
4 skin adverse reaction grading standard of table
5 safety evaluation result of table
Evaluation of result: reaction result is recorded by table 4 (skin adverse reaction grading standard), acquired results are as shown in table 5.
Table 5 is as the result is shown: in Examples 1 to 4 and comparative example, each all negative (scoring of subjects skin Grade: 0 grade).According to " cosmetics health specification " (version in 2007) human skin class patch test judgment criteria, sample to human body without Skin adverse reaction.And there are 31 order reactions in commercially available anticreep nourishing liquid.This shows oil-control anti-hair loss composition of the invention Higher safety is shown, even if using the crowd in sensitive skin, also without there is any abnormal response.
In summary known to the test of oil-control anticreep and security test: oil-control anti-hair loss composition of the invention has oil-control The effect of anticreep and smaller to human body irritation.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.

Claims (10)

1. a kind of oil-control anti-hair loss composition, which is characterized in that according to mass percentage meter, prepare the oil-control anti-hair loss composition Raw material include following component:
Ginseng root extract 2%~20%, ginger-root extract 1%~25%, Fructus Forsythiae berry extract 1%~15%, radix sophorae mention Take object 2%~10%, butanediol 20%~70% and deionized water 10%~50%.
2. oil-control anti-hair loss composition according to claim 1, which is characterized in that the ginseng root extract, which is behaved, joins root Supercritical CO2Extract, the ginger-root extract are the supercritical CO of race2Extract, the Fructus Forsythiae berry extract are Fructus Forsythiae fruit Supercritical CO2Extract, the kuh-seng root extract are the supercritical CO of radix sophorae2Extract.
3. oil-control anti-hair loss composition according to claim 1, which is characterized in that according to mass percentage meter, prepare institute The raw material for stating oil-control anti-hair loss composition includes following component:
Ginseng root extract 10%, ginger-root extract 8%, Fructus Forsythiae berry extract 5%, kuh-seng root extract 5%, butanediol 50% And deionized water surplus.
4. the preparation method of the described in any item oil-control anti-hair loss compositions of claims 1 to 3, which is characterized in that including walking as follows It is rapid:
The deionized water and butanediol are mixed and heated to 75 DEG C~85 DEG C, stir 25min~35min；
The ginseng root extract, the ginger-root extract, the Fructus Forsythiae berry extract and the kuh-seng root extract is added, stirs It mixes to each component and dissolves, obtain oil-control anti-hair loss composition.
5. the preparation method of oil-control anti-hair loss composition according to claim 4, which is characterized in that further include the ginseng The preparation step of extract, the preparation step of the ginger-root extract, the preparation step and the hardship of the Fructus Forsythiae berry extract Join the preparation step of root extract:
The preparation step of the ginseng root extract are as follows: ginseng is crushed, sieving, obtain ginseng powder；Use supercritical CO2 Fluid extracts the ginseng powder, obtains ginseng extraction mixture；Ginseng extraction mixture is carried out Separation, obtains ginseng isolate；The ginseng isolate and water are mixed and carry out heating distillation extraction, obtains people after condensation Join root extract；
The preparation step of the ginger-root extract are as follows: race is crushed, sieving, obtain ginger root powder；Use supercritical CO2Fluid pair The ginger root powder is extracted, and race extraction mixture is obtained；Race extraction mixture is separated, race is obtained Isolate；The race isolate and water are mixed and carry out heating distillation extraction, obtains ginger-root extract after condensation；
The preparation step of the Fructus Forsythiae berry extract are as follows: Fructus Forsythiae fruit powder is broken, sieving obtains Fructus Forsythiae fruit powder end；Use supercritical CO2 Fluid extracts Fructus Forsythiae fruit powder end, obtains Fructus Forsythiae fruit extraction mixture；Fructus Forsythiae fruit extraction mixture is carried out Separation, obtains Fructus Forsythiae fruit root isolate；The Fructus Forsythiae fruit isolate and water are mixed and carry out heating distillation extraction, is obtained after condensation Fructus Forsythiae berry extract；And
The preparation step of the kuh-seng root extract are as follows: radix sophorae is crushed, sieving, obtain radix sophorae powder；Use supercritical CO2 Fluid extracts the radix sophorae powder, obtains radix sophorae extraction mixture；Radix sophorae extraction mixture is carried out Separation, obtains radix sophorae isolate；The even radix sophorae and water are mixed and carry out heating distillation extraction, obtains radix sophorae after condensation Extract.
6. the preparation method of oil-control anti-hair loss composition according to claim 5, which is characterized in that in the step of the sieving The aperture of sieve is greater than or equal to 300 mesh.
7. the preparation method of oil-control anti-hair loss composition according to claim 5, which is characterized in that described to use supercritical CO2 CO in the step of extraction2Flow velocity is 2kg/h~8kg/h, and extracting pressure is 15MPa~25MPa, and extraction temperature is 35 DEG C, extraction Time is 5h.
8. the preparation method of oil-control anti-hair loss composition according to claim 5, which is characterized in that in the step of the separation Separating pressure is 4MPa~6MPa, and separation temperature is 38 DEG C~40 DEG C, and disengaging time is 4h~6h.
9. the preparation method of Anti-hair loss composition according to claim 5, which is characterized in that the step of the distillation extraction In, the solid-liquid ratio of the isolate and the water is 1g/L~5g/L, and distillation time is 6h~8h.
10. described in any item oil-control anti-hair loss compositions of Claims 1 to 4 or according to the described in any item controls of claim 5~9 The oil-control anti-hair loss composition that oily anti-hair loss composition preparation method is prepared is preparing the application in hair washing product or hair products.
CN201811199596.7A 2018-10-15 2018-10-15 Oil-control anti-hair loss composition and preparation method thereof and its application Pending CN109157474A (en)

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