JPH0613449B2 - Cosmetics - Google Patents

Description

[Detailed Description of the Invention] The present invention relates to a cosmetic composition containing an extract of cotyledons, stems, roots or whole plants of seedlings of the Cucurbitaceae plant.

It has been conventionally known that a lotion is prepared by using the juice of fruits of a mature plant of the Cucurbitaceae plant or the juice leached from the stem. In particular, the juice leached from the loofah stem was used as loofah water as it was as lotion. In addition, fresh cucumber fruits are sliced or mashed as they are, or added with flour or the like to be used externally for treating facial packs and burns.

Various uses have been made for cosmetics of mature plants of the Cucurbitaceae plant, for example, use of oil from fruits and seeds of the Cucurbitaceae plant (Japanese Patent Publication No. 53-46892), crude bitter extract for fruit extraction. The effect of inhibiting tyrosinase activity is observed (JP-A-57-77610), the use of juice obtained by treating fruits with a pectin-degrading enzyme (JP-A-59-148710), and the like.

As described above, the juice leached from the fruits or stems of mature plants of the Cucurbitaceae plant, which is promising as a cosmetic base, has a short harvest period, is affected by weather conditions, or has a high fruit price such as melon. In some cases, obtaining raw materials was a problem. Furthermore, in the case of melon, the melon juice has a high sugar content such as fructose and is sticky as a feeling of use.
It also had the disadvantage that the water was weaker than the loofah and the melon water leaching from the stem was not available in large quantities.

The present inventors have conducted intensive studies on such problems, and as a result, the cotyledon, cotyledons, stems, roots or whole grass extract components of Cucurbitaceae have excellent moisturizing properties and are excellent for the skin. It was found that it gives a beautiful skin effect. Furthermore, it has been found that when blended in a cosmetic composition, it improves the color and luster of the skin, provides excellent skin conditioning effects such as the prevention and improvement of fine wrinkles, and improves moisturizing properties. In addition, it is a highly safe cosmetic that does not irritate the skin. Furthermore, when considering the acquisition of raw materials for the cotyledons, stems, roots or whole grass extract of the Cucurbitaceae plant of the present invention, it is relatively easy to obtain the raw materials, regardless of the harvest time or weather conditions. It is also a feature of the present invention that it is inexpensive.

The “seedling” in the present invention refers to a larval plant body having cotyledons.

Furthermore, hot water extract components of cotyledons, stems, roots or whole plants of seedlings of the Cucurbitaceae plant of the present invention were collected from the abdominal cavity of rats according to the report of Hirai et al. (Biopharmaceutical Journal, 37 , 374-380 (1983)). The histamine release inhibitory effect on the mast cells was measured. No histamine-releasing action was observed, and concanavalin A (Con A) or compound 4
The effect of suppressing histamine release by 8/80 (Comp48 / 80) (histamine release inhibitory effect) was observed, and it was found that it is also excellent as an anti-inflammatory agent (Tables 1 and 2).

As is clear from Table 1, the cotyledon, stem, root or whole plant water extract component of loofah seedlings of the present invention has the same anti-inflammatory property as the water extract component of loofah water of mature plant and loofah fruit. The action (anti-inflammatory action) was observed.

As is clear from Table 2, the water-extracted components of the cotyledons, stems, roots or whole plants of melon seedlings of the present invention exhibit an anti-inflammatory effect superior to that of melon pericarp or pulp of mature plants.

The Cucurbitaceae plant used in the present invention includes Cucurb.
itales), Cucurbitaceae, Luffa (Luff)
Examples are a) loofa (Luffa cylindrica Roem.) and cucumber genus (Cucumis melo L.). Also, as the above melon, a net melon [Cucu
mis melo L. (reticulatus group)], yellow mask, chrysanthemum mask, etc. [Cucumis melo L. (wakuwa grou
p)], winter melon [Cucumis melo L. (inodorous
group)], Shirouri 〔Cucumis melo L. (conomon grou
p)], and the hybrid prince melon. The classification of the above Cucurbitaceae plants is based on Tomitaro Makino, "Primary Color Makino Botanical Encyclopedia," pages 541-5, 1982, published by Kitatakakan, sequel 190.
-1 page, 1983, published by Kitatakakan, and Shiro Takashima, "Primary Color Japanese Vegetables Book," pages 143-162, 1982, published by a nursery company.

The cotyledon seedlings of the Cucurbitaceae plant used in the present invention, stems, roots or whole grass extract components, cotyledon seedlings, stems, roots or whole plants of the Cucurbitaceae plant, for example, water, methanol, ethanol, propylene glycol and the like. It is extracted with the water-soluble solvent or the mixed solution thereof, and can be used as a raw material for cosmetics after being concentrated or diluted as necessary. Also,
The extract may be used as it is, or after adding dextrin or the like, it is made into a dry powder by a method such as freeze-drying or spray-drying, and used as a raw material for cosmetics. Considering the stability of the extracted component over time, it is better to handle the extracted component in the powder state. The extraction operation is usually hot water, preferably a method of hot water extraction, for example, at a temperature of 120 to 200 ° C. for about 30 to 120 minutes under pressurized conditions. Also, low temperature (5-40 ℃)
Extraction with can also be used. There is no particular restriction on the amount of extraction solvent used, but usually cotyledons of seedlings of Cucurbitaceae,
Extraction can be carried out at a usage amount of about 1 to 100 times (weight) with respect to the weight of the stem, root or whole plant. The extraction can be repeated.

According to the present invention, cotyledon seedlings, stems, roots or whole grass extract components of the Cucurbitaceae plant, together with various cosmetic bases, basic cosmetics such as lotion, milky lotion and cream, make-up such as foundations. It can be used in the form of cosmetics and hair cosmetics such as hair cream. Moreover, these cosmetics can be manufactured by a conventional method.

Extracts of cotyledons, stems, roots or whole plants of Cucurbitaceae used in the present invention are 0.001 to 20.0 based on the cosmetic base.
It is suitable to use weight%. The above-mentioned amount of the extract component of the cotyledon, stem, root or whole plant of the Cucurbitaceae plant is a blending amount when dry powder is used. 10 if the extract
A 0% product is also possible, and the same is true for a dry powder that has been increased with dextrin or the like. If the amount is less than 0.001% by weight, no sufficient effect can be obtained, and if the amount exceeds 20.0% by weight, the effect is not enhanced, which is uneconomical.

Next, the effectiveness of the cosmetic of the present invention will be described with reference to examples. The contents of the present invention are not limited to these. The parts of the blending amounts shown in Examples and Comparative Examples are parts by weight. The components extracted from the whole plants of the seedlings of the Cucurbitaceae plant in the examples are those extracted by the following method.

Extraction component of melon seedling whole plant Melon seedling whole plant (Sakata Seed Co., Ltd., Volga melon, 10 days after germination, washed with water and freeze-dried) Using 500 ml, 95
Extract at ℃ for 3 hours. The residue was filtered off, the filtrate was concentrated, and then freeze-dried to obtain about 4 g of a pale yellow to pale tan powder.

By the same procedure, water extract component of seedling melon cotyledons from seedling melon cotyledons (yield 4.0 g), water extract component of seedling melon stems from seedling melon stems (yield 4.3 g), seedling melon roots to seedlings. Water-extracted components of melon root (yield 3.1
g), water extract component of melon peel from melon peel (yield 5.
9g), melon pulp water extract component from melon pulp (yield 9.5
g) was obtained and used as a measurement sample for histamine release inhibitory effect and the like. The melon fruit used was a commercially available muskmelon sample. (Table 2) Extractive components of whole plant of loofah seedlings Whole plant of loofah seedlings (Takii Seedling Co., Ltd., thick loofah seeds 10 days after germination, washed with water and freeze-dried)
After finely crushing 10 g, use 500 ml of water at 95 ° C,
Extract for 3 hours. After the residue was filtered off, the filtrate was concentrated and then freeze-dried to obtain about 4 g of a pale yellow to pale brown powder.

By the same procedure, water extract component of seedling loofah cotyledons from seedling loofah cotyledons (yield 4.3g), water extract component of seedling loofah stems from seedling loofah stems (yield 3.9g), seedling loofah roots to seedlings Water extract components of loofah root (yield 3.4
g), water extract component of loofah fruit from loofah fruit (yield 2.
6 g) was obtained and used as a sample for measuring the histamine release inhibitory effect. The loofah fruits were dried in the sun as a sample. (Table 1) Loofah water Fresh loofah water 1 was filtered using a membrane filter and then freeze-dried to obtain about 1 g of a white to pale yellow powder.

Example 1 Lotion formulation Amount A) Water extract component of whole melon of seedlings 0.7 parts 1,3-butylene glycol 8.0 glycerin 2.0 purified water 44.6 B) ethanol 5.0 preservative proper amount Polyoxyethylene (40) hydrogenated castor oil 0.1 Perfume proper amount Purified water 10.0 Manufacturing method: Components A and B are uniformly dissolved and then mixed to obtain a product.

Example 2. Lotion To replace the water extract component of whole melon of seedlings with the water extract component of whole loofah of seedlings, Example 1. A lotion was obtained in the same manner as.

Comparative Example 1 Example 1. A lotion was prepared with the formulation excluding the water-extracted components of the whole melon seedling.

Example 3. Skin cream formulation A) Stearic acid 4.0 parts Cetyl alcohol 3.0 Stearyl alcohol 1.0 Liquid paraffin 6.5 Vaseline 10.0 Sorbitan monostearate 1.5 Polyoxyethylene (25) monostearate 3.0 B ) 1,3-Butylene glycol 5.0 Potassium hydroxide 0.1 Water extraction component of seedling loofah whole grass 0.8 Preservative proper amount Purified water 65.1 C) Perfume proper amount Production method: oil phase component A and water phase Component B is 70 ~
After heating and melting at 75 ° C, component B is added to component A to emulsify, component C is added and mixed during cooling, and the product is cooled to 30 ° C.

Example 4. Emulsion formulation A) Stearic acid 5.0 parts Cetyl alcohol 5.0 Liquid paraffin 2.0 Glycerin monostearate 1.3 Sorbitan monostearate 1.5 Polyoxyethylene (10) sorbitan monooleate 0.8 B) Glycerin 6 0.0 Water-extracted component of seedling melon cotyledon 0.5 Preservative Suitable amount Purified water 77.9 C) Perfume Suitable amount Production method: A product is prepared in the same manner as in Example 3.

Example 5. Pack (rinse type) Prescription Glycerin 15.0 1,3-Butylene glycol 10.0 Polyoxyethylene (40) hydrogenated castor oil 0.5 Water extract component of whole melon seedlings 2.0 Citric acid 0.1 Citric acid Sodium 0.3 Preservative Suitable amount Perfume Suitable amount Purified water 72.1 Manufacturing method: Dissolve each component uniformly to obtain a product.

In order to clarify the safety of the extract component of the Cucurbitaceae plant of the present invention, a primary irritation test on a human body was conducted by an occlusive patch test. That is, using a fin chamber (Taisho Pharmaceutical Co., Ltd.), 30 healthy people were stuck on the flexed side of the forearm for 24 hours, and after removing the patch test plaster, 1
It judged using the average value of the judgment after time, 24 hours, and 48 hours. No erythema was observed in any of the components of the Cucurbitaceae plant, confirming that there was no primary irritation. The test was carried out using 10% by weight aqueous solutions as the samples.

Furthermore, in order to clarify the effect of the cosmetics of the present invention, 25 to 5
A use test was conducted on 30 general women aged 0 years, and a questionnaire survey was conducted by the double blind method focusing on the skin conditioning effect. Toner lotion using the water extract component of whole seed melon (lotion lotion of Example 1), water extract component of whole seed loofah plant (lotion lotion of Example 2), and seedling melon or whole plant of methima Table 3 summarizes the results of using the conventional lotion (Comparative Example 1) containing no water-extracted ingredient of Example 1 for one month. In addition, skin trouble during use test period is 1
No incident occurred.

As is clear from Table 4, the addition of an extract component of whole seed loofah or whole extract of melon whole seedlings gave an excellent skin conditioning effect.

Claims (1)

[Claims] 1. A cosmetic comprising a cotyledon, a stem, a root, or an entire plant of a seedling of a Cucurbitaceae plant mixed with an extract component with a hydrophilic solvent.