KR20110118201A - Cosmetic composition for whitening of the skin - Google Patents
Cosmetic composition for whitening of the skin Download PDFInfo
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- KR20110118201A KR20110118201A KR1020100037659A KR20100037659A KR20110118201A KR 20110118201 A KR20110118201 A KR 20110118201A KR 1020100037659 A KR1020100037659 A KR 1020100037659A KR 20100037659 A KR20100037659 A KR 20100037659A KR 20110118201 A KR20110118201 A KR 20110118201A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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Abstract
The present invention is to provide a cosmetic composition for skin whitening that inhibits melanin production and inhibits tyrosinase activity, and also has excellent antioxidant activity, and particularly shows little cytotoxicity. The cosmetic composition for whitening includes the extract of Zizyphus jujube fruit Extract, Castanea sativa (chestnet) bark Extract and Pleuropterus multiflorus extract, the jujube extract, Yulpi extract and sewage extract, respectively, based on the total weight It contains 0.005-50 weight%. The composition for skin whitening of the present invention inhibits melanin production and inhibits tyrosinase activity due to jujube extract, yulpi extract, sewage extract, etc., and also has an excellent antioxidant activity, and in particular, little cytotoxicity can be obtained. .
Description
The present invention relates to a cosmetic composition for skin whitening, and in particular, inhibits melanin production, inhibits tyrosinase activity, has excellent antioxidant activity, and particularly to a cosmetic composition for skin whitening that shows little cytotoxicity. It is about.
The skin of the human body is the first window in the outermost part of our body and accepts and reacts sensitively to external stimuli. Skin is a very important tissue that has direct contact with the external environment, protects the human body and has biochemical and physical functions. The skin is divided into three layers: epidermis, dermis and subcutaneous tissue.
Melanin (Melanin) is a pigment present in the epidermal layer of the skin, made from melanocytes (melanocyte) present in the basal layer of the epidermis and migrates to epidermal cells called keratinocytes. There are no enzymes that break down melanin in vivo, but they are removed by falling off the skin as keratinocytes break off the epidermis.
In the melanin synthesis process, the melanocyte vesicles in melanocytes are first converted into tyrosine through dopa (DOPA) and then dopaquinone (DOPA quinone) by the enzyme tyrosinase. The reaction gives melanin, a blackish brown copolymer, through dopachrome. The melanin thus produced is transferred to keratinocytes through the melanosomes, where it is lost to the surface of the skin along with the keratinization process for about 28 days. Melanin absorbs the light energy of sunlight UV to protect skin organs under the dermis from UV damage, and it protects the skin from external harmful factors such as trapping harmful oxygen and free radicals generated in skin skin. Play a role.
In addition, the skin color of a person is determined by the amount of melanin in the skin cells. People with high melanin pigments have brown or black skin, while those with low melanin pigments have white skin. However, abnormally low production of melanin causes skin lesions such as vitiligo, and on the contrary, if melanin is not synthesized excessively due to daylight, hormonal changes, inflammation, drugs, or keratinization, the melanin is not completely removed. In addition to damage, pigments in the skin are deposited to form blemishes, freckles, and even from these lesions can cause skin cancer.
Therefore, in order to prevent such pigmentation phenomenon, it is necessary to inhibit a part of melanogenesis process to reduce melanin production.
Today, Asian women prefer white and clean skin like white jade and make it an important standard of beauty. Therefore, the development of whitening agent for treatment of abnormal skin pigmentation and satisfying beauty needs is being actively developed.
Currently, a method of reducing and decolorizing melanin pigments produced in the development of a whitening agent for skin beauty and a method of inhibiting the activity of tyrosinase, an enzyme that forms melanin pigments, are known. However, the whitening agent using tocopherol, vitamins, etc. which are used for reducing melanin pigment | dye is known that the decolorization effect of melanin pigment is insignificant. Therefore, attention has been paid to inhibitors that inhibit the production of melanin pigment by inhibiting the activity of tyrosinase.
In the conventional cosmetic field, as a whitening component, for example, substances that inhibit tyrosinase enzyme activity such as kojic acid, arbutin, hydroquinone, vitamin-C (L-Ascorbic acid) and Their derivatives and various plant extracts have been used. However, the stability in the prescription system is poor, the color is degraded, or the use thereof is limited due to the occurrence of off-flavor, efficacy at the biological level, unclear effect and safety problems.
Kojic acid inhibits enzymatic activity by adsorbing copper ions present in the active site of tyrosinase, but has been discontinued as a raw material for cosmetics because of its instability, skin side effects and recent animal experiments.
Vitamin-C and its derivatives are difficult to use as raw materials for cosmetics due to their oxidative instability. Hydroquinone has excellent whitening effect on the skin but causes allergy, toxicity to melanocytes, and permanent depigmentation to the skin. It is highly irritating to the skin and is currently regulated as a carcinogenic substance, so its use is prohibited and only a limited concentration is allowed in each country.
In addition, arbutin is a derivative in which glucopyranoside is combined with hydroquinone, and has little side effects when using hydroquinone and inhibits the synthesis of melanin pigments without toxicity to humans, thereby increasing melanin pigmentation. Applicability has been suggested as a therapeutic agent for skin diseases, but it has a disadvantage of being partially degraded by skin enzymes.
In terms of safety, discoloration, etc., there are many problems in using more than the effective concentration in cosmetics and pharmaceuticals, and it does not yet show excellent effects.
The present invention inhibits melanin production and inhibits tyrosinase activity, also has excellent antioxidant activity, and in particular, provides a cosmetic composition for skin whitening and a method of producing the same, which shows little cytotoxicity. have.
The cosmetic composition for skin whitening of the present invention for achieving the above object is characterized in that it comprises an extract of Zizyphus jujube fruit Extract, Yulepi (Castanea sativa (chestnet) bark Extract) extract and sewage (Pleuropterus multiflorus) extract. The jujube extract, yulpi extract and sewage extract are characterized in that it contains 0.005 to 50% by weight relative to the total weight. The jujube extract and sewage extract are characterized in that the hydrothermal extraction by adding a polar solvent selected from water, lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof. The composition is a lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, soap, shampoo, conditioner, conditioner, skin lotion, skin softener, skin toner, Astringent, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder, eye shadow, characterized in that it takes one of the formulations selected from the group consisting of.
In addition, the method for preparing a cosmetic composition for skin whitening of the present invention comprises the steps of collecting dates, yulpi and sewage, respectively; Immersing the harvested jujube, yulpi and sewage in propylene glycol; Extracting the extract by hot water in a water bath; Cooling the extract to room temperature; Filtering the cooled extract to form a filtrate; And concentrating by evaporating the solvent from the filtrate.
The skin whitening composition according to the present invention inhibits melanin production due to jujube extract, yulpi extract, sewage extract and the like, inhibits tyrosinase activity, and also has excellent antioxidant activity, and in particular, little cytotoxicity. You can get it.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings in order to facilitate a person skilled in the art to easily carry out the technical idea of the present invention. .
In the present invention, the jujube (Zizyphus jujube fruit Extract) extract, Yule (Castanea sativa (chestnet) bark Extract) extract and sewage (Pleuropterus multiflorus) extract to each contain 0.005 to 50% by weight relative to the total weight of the composition, jujube extract, yeast extract , Sewage extract inhibits melanin production, inhibits tyrosinase activity, has an excellent antioxidant activity, can be obtained a cosmetic composition for skin whitening almost no cytotoxicity.
That is, while China is studying the physiological activities of jujube, yulpi and sewage plants, which are native to China but are currently cultivated in Korea, jujube extract, yulpi extract and sewage extract have excellent antioxidant effect and reduce melanin production. It has been confirmed that it can be usefully used as a composition for skin whitening because it has an effect of inhibiting cinaase activity.
Jujube (Jujube) used in the present invention is cultivated nationwide, and as a deciduous shrub, some hairs on the tip of the branches and the back of the leaves and several branches come out from one place and some fall. Leaves are regenerated, ovate, glossy, acute or obtuse, basal, 2-6cm long, 1-2.5cm wide. The surface of the fruit is reddish brown, elliptical, 1.5 ~ 2.5cm long, and ripe when red. Fruits are not only reproductive, but also dried and harvested, and used as sweets, dishes and abuse as dry fruits. Jujube is processed in daily life and used as jujube extract, jujube tea, jujube vinegar, jujube porridge.
Its main ingredients include betulin, betulinic acid, shareholders bosid A, B and ebelinlactone, and 21-33% oil. Flavonoids (3.7%), tannins (9%), and saponins, such as rutin and quercetin, are found in the leaves, and betulin and betulinic acid are also known in roots. The fruit contains many organic acids (1 to 7%).
In oriental medicine, it is used as a diuretic, tonic (완화 和 劑), and has a sedative effect on insomnia and nervousness, antitumor and antiallergic action.
Jujube extract can be prepared as follows.
Wash the jujube with water and dry it in the shade. Dried jujube is placed in the extraction container and extracted for a certain time at a temperature suitable for water or an organic solvent. The organic solvent is selected from the group consisting of alcohol, hexane, ethyl acetate, acetone and mixtures thereof, wherein the alcohol is a composition having 1 to 5 carbon atoms or a dilution solution of 30 to 99% thereof. And after adding the dried jujube in 15 to 20 weight ratio based on 100 weight of water, it may be prepared by boiling for 20 minutes to 1 hour at 100 to 120 ℃ and filtered it.
Chestnut, the raw material of Castanea sativa (chestnet) bark extract, grows in temperate regions such as Asia, Europe, North America, and North Africa, and has 13 varieties. It is native to the south of Manchuria and is located in Sichuan, Hubei, and Yunnan provinces throughout Samsung and Huazhong. Meanwhile, indigenous Korean species have been grown in the southern part of Korea. Fruits are 1 ~ 3 in needle-shaped chestnut-shaped chestnuts, and are ripe when they ripen.
The seeds (chestnut) contain starch (52-56%), sugar (10-17%) and protein (9-12%). 9-10% of the tannins in the bark and leaves, and triterpenoids such as flavonoids such as hyphenin and ursolic acid, betulin, and rufeol.
Chestnuts increase the length, help the large intestine and stomach, show weariness, chew raw food when the waist and legs are not used well, and squeeze the chestnuts into the cut. The muscles are broken and chewing raw chestnuts on boils and blood vessels is effective.It protects the kidneys and helps to endure hunger.Eczema, hives, impetigo, sweat bands, etc. Wet. If the mouth is very dry after vomiting, boil the chestnut and drink it with water so that it is very good, according to the herbaceous tree (本草綱目).
Yulpi extract can be prepared as follows.
Yulpi is washed with clean water, dried and finely powdered. To the dry weight of powdered Yul-Pi powder, 1 to 15 times the weight of water, lower alcohol, mixture of water and lower alcohol, acetone, ethyl acetate, diethyl ether, benzene, and chloroform were respectively added. It can be extracted by heating at 50-95 degreeC for 1 to 20 hours in the state which prevented the evaporation of the active ingredient, and can also extract by depositing for 1 to 15 days at 5-40 degreeC. This extract is obtained by concentrating under reduced pressure while recovering the solvent evaporated using a distillation apparatus equipped with a cooling capacitor.
Sewage (Pleuropterus multiflorus) is known from China and is a long-growing vine medicinal plant. The height is 3 ~ 4m and the roots are extended to the side, often forming tubers. Heart-shaped leaves are about 3-6 cm long and 2.5-4.5 cm wide. Petioles and jaw leaves [
] But no teeth on the edge. Flowers bloom in August-September in conical inflorescences. There are no petals and 5 calyxes. Fruits are triangular ovate, 2.5mm long, glossy.The reddish brown tuber is called Shouo in one shot. Shouo is famous as a herb that strengthens kidney function, enhances energy, darkens hair and makes people live longer without disease. The function of the liver to get rid of tiredness, multiply the skin, strengthen the bones and muscles, and strengthen the heart is also effective in nervous breakdowns and insomnia. Its excellent hematopoietic effect makes it an excellent treatment for anemia and is widely used in women's menstrual disorders, uterus and chronic constipation. Sewage is also a good medicine to boost the energy of the elderly. Improves kidney function so that hair does not whiten, hair does not fall out, and eating longer prevents aging. Chinese people consider HaoSuo to be the three greatest medicines with ginseng and wolfberry.
Resveratrol, a substance found in sewage, is a substance belonging to the polyphenol family, which is an antioxidant found in plants, and is known to be contained in grapes, mulberries, and peanuts, and is particularly contained in red wine. Resveratrol has been known to have anti-cancer and anti-oxidant effects, and has been shown to be effective in reducing blood clotting, a risky phenomenon that reduces cardiac damage and causes heart attacks and strokes.
Sewage extract can be prepared as follows.
The sewage is washed with clean water and then dried in the shade. Dry sewage is placed in an extraction container and extracted for a predetermined time at an appropriate temperature in an appropriate amount of extraction solvent. The extract may be filtered and concentrated using a vacuum rotary evaporator or the like.
As the extraction solvent, a polar solvent selected from water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof may be used, and ethanol is more effective, and the amount of the extraction solvent is 2 to 10 times the dry weight of the crude drug.
The extraction method may be an extraction method such as a bath extraction, reflux cooling extraction, ultrasonic extraction, etc., it is more effective to extract once to 5 times as an extraction method of the bath extraction.
Maintaining the extraction temperature at 30 to 70 ° C., more preferably at 40 to 60 ° C., and most preferably at 50 ° C. is effective in preventing decay, discoloration and deterioration. The extraction time is 5 to 20 hours or most preferably 10 hours. It is effective to do while. After the sewage extract is obtained, the solids are removed using a filter paper or the like, the suspension is centrifuged, and the supernatant can be used by filtration under reduced pressure. The filtered extract may be concentrated under reduced pressure at 20-100 占 폚 or preferably 50-70 占 폚 with a vacuum rotary concentrator.
Jujube extract, yulpi extract, sewage extract of the present invention can be manufactured in the form of a cosmetic composition containing an active ingredient in the form of a general emulsion formulation and solubilized formulation. Cosmetics of the emulsified formulations include nutrient cosmetics, creams, essences, etc., and cosmetics of the solubilized formulations are flexible cosmetics. In addition to the cosmetic containing the jujube extract, yulpi extract, sewage extract of the present invention by containing a dermatologically acceptable medium or base to be prepared in the form of a topical or systemic application commonly used in the field of dermatology It may be.
Suitable cosmetic formulations are in the form of emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes), nonionic vesicle dispersants obtained by dispersing an oil phase in a solution, gel, solid or pasty anhydrous product, aqueous phase. It may be provided in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. It may also be prepared in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.
And the cosmetic composition of the present invention, in addition to jujube extract, yulpi extract, sewage extract, fatty substances, organic solvents, solubilizers, thickening and gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances , Surfactants, water, ionic or nonionic emulsifiers, fillers, metal ion sequestrants and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or cosmetics It may contain adjuvants conventionally used in the cosmetic or dermatological arts, such as any other ingredients commonly used in the art. In addition, the above components may be introduced in an amount generally used in the dermatology field.
Examples of products to which the cosmetic composition of the present invention can be added include cosmetics such as astringent cosmetics, soft cosmetics, nourishing cosmetics, various creams, essences, packs, foundations, and the like, cleansing agents, face washes, soaps, treatments, and essences. Etc.
Specific formulations of the cosmetic composition of the present invention include skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, Formulations such as soaps, shampoos, cleansing foams, cleansing lotions, cleansing creams, body lotions, body cleansers, emulsions, press powders, loose powders, eye shadows and the like.
The following Examples and Experimental Examples illustrate the present invention in more detail, but do not limit the scope of the invention.
Preparation Example 1 Preparation of Jujube Extract, Yulpi Extract, Sewage Extract for Skin Whitening
50 g of the harvested jujube, 50 g of yulpi, and 50 g of sewage were immersed in 400 ml of 100% propylene glycol, and heated in a 50 ° C. water bath for 10 hours. The extract was cooled to room temperature and filtered through a filter paper to obtain a filtrate. Ethanol was evaporated from the filtrate using nitrogen, concentrated and then dissolved in 10% ethanol to prepare a jujube extract, yulpi extract, sewage extract.
Preparation Example 2 Example and Comparative Example
A cosmetic composition containing jujube extract, yulpi extract, and sewage extract of Preparation Example 1 was prepared, and a cosmetic composition lacking jujube extract, yulpi extract, and sewage extract was prepared in the following composition ratio.
Although the technical spirit of the present invention has been specifically recorded in accordance with the above-described preferred embodiments, it should be noted that the above-described embodiment is for the purpose of description and not of limitation. In addition, those skilled in the art will understand that various embodiments are possible within the scope of the technical idea of the present invention.
Claims (5)
Cosmetic composition for skin whitening.
The jujube extract, yulpi extract and sewage extract each contain 0.005 to 50% by weight based on the total weight
Cosmetic composition for skin whitening.
The jujube extract and sewage extract are hydrothermally extracted by adding a polar solvent selected from water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent thereof.
Cosmetic composition for skin whitening.
The composition is a lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, essence, nutrition essence, pack, soap, shampoo, conditioner, conditioner, skin lotion, skin softener, skin toner, Astringent, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, loose powder, eye shadow
Cosmetic composition for skin whitening.
Immersing the harvested jujube, yulpi and sewage in propylene glycol;
Extracting the extract by hot water in a water bath;
Cooling the extract to room temperature;
Filtering the cooled extract to form a filtrate; And
Concentrating by evaporating the solvent in the filtrate
Skin whitening cosmetic composition manufacturing method comprising a.
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KR1020100037659A KR20110118201A (en) | 2010-04-23 | 2010-04-23 | Cosmetic composition for whitening of the skin |
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KR1020100037659A KR20110118201A (en) | 2010-04-23 | 2010-04-23 | Cosmetic composition for whitening of the skin |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101672251B1 (en) * | 2016-04-18 | 2016-11-03 | 씨앤텍 주식회사 | Cosmetic composition comprising an extract of mixed herbs |
KR101881369B1 (en) * | 2017-02-21 | 2018-07-24 | 충남대학교산학협력단 | Anti-oxidant Aged Chestnut Inner Shell and Anti-oxidant Composition Comprising the Aged Chentnut Inner Shell or Its Extract |
-
2010
- 2010-04-23 KR KR1020100037659A patent/KR20110118201A/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101672251B1 (en) * | 2016-04-18 | 2016-11-03 | 씨앤텍 주식회사 | Cosmetic composition comprising an extract of mixed herbs |
KR101881369B1 (en) * | 2017-02-21 | 2018-07-24 | 충남대학교산학협력단 | Anti-oxidant Aged Chestnut Inner Shell and Anti-oxidant Composition Comprising the Aged Chentnut Inner Shell or Its Extract |
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