KR102035590B1 - Cosmetic composition for scalp protection and hair improvement containing ginsenoside F5 derive from aerial part of hydroponic ginseng and gold sericin derive from golden silkworm - Google Patents
Cosmetic composition for scalp protection and hair improvement containing ginsenoside F5 derive from aerial part of hydroponic ginseng and gold sericin derive from golden silkworm Download PDFInfo
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention relates to a cosmetic composition for scalp protection and hair improvement, comprising ginsenoside F5 derived from hydroponically grown ginseng and golden sericin derived from golden cocoon as an active ingredient.
Description
The present invention relates to a cosmetic composition for protecting the scalp and improving hair, and particularly comprising ginsenoside F5 extracted from the ground portion (leaf and stem) of ginseng cultivated for more than 120 days and golden sericin extracted from the golden cocoon as an active ingredient. It relates to a cosmetic composition for scalp protection and hair improvement.
Unlike normal skin, scalp is covered with terminal hair, not vellus hair, and has a specialized structure in which the sebaceous glands are connected to the virgin and distributed much. If the physiological homeostasis balance is broken in general skin, various symptoms may occur in the scalp as well as symptoms such as pigmentation, wrinkles and overgrowth of the epidermis. In particular, the maintenance of clean hair follicles and healthy hair roots through careful management of the scalp is very important for the growth and maintenance of healthy hair. A normal scalp should be open in a clean state with 2-3 hairs in one pore and no impurities in the pores. The color should be milky and transparent, and the entire scalp should be moist and glossy.
However, with the recent increase in interest in hairstyles, frequent dyeing and perm can cause scalp damage, itching, inflammation, etc., and also increase the likelihood of hair loss due to environmental causes.
On the other hand, since the ginsenoside (ginsenoside) is known as the active ingredient of ginseng in 1963, a lot of research has been made on the pharmacological effects of ginsenosides. Ginsenosides analyzed so far are 182 species, but they account for more than 80% of the five major ginsenosides, Rb1, Rb2, Rc, Rd, Re and Rg1 ginseng ginsenosides. The remaining minor ginsenosides are present in trace amounts.
As pharmacological studies are conducted on these minor ginsenosides, more pharmacological effects are found than major ginsenosides. For example, in the case of the scalp or hair, Korean Patent No. 10-1343857 (hereinafter, "
However, since these minor ginsenosides are present in trace amounts or extremely small amounts in red ginseng or raw ginseng, they have not been fully studied for their industrial application and pharmacological efficacy. A method of extracting ginsenoside F5 from ginseng leaves hydropically grown in Korean Patent No. 10-1624640 (hereinafter referred to as "
This rare minor ginsenoside, ginsenoside F5, can be separated in large quantities from hydroponicly grown ginseng, and ginsenoside F5 has been found to be cytotoxic and anti-inflammatory. No further studies have been conducted on the pharmacological effects of F5.
That is, looking at the patent documents related to ginsenoside F5 after the
In addition, the golden cocoon is a yellow cocoon that was produced by the Golden Silk, a breed that was bred between 2005 and 2007 by breeding Japanese breeding Jam 311 (JS169) and Chinese breeding Jam 312 (CS186). It is known to contain more sericin.
The sericin is a protein constituting the cocoon, the amino acid composition of the sericin is similar to the natural moisturizing factor (NMF) of the human body is known as a material having excellent skin moisturizing effect, in addition to the moisturizing effect, sericin has a sulfated effect, And it is known that there is a whitening effect due to lipid peroxidation and inhibiting the activity of tyrosinase, but there is no full-scale study on whether such sericin is effective for volume protection and hair improvement.
Accordingly, the present inventors have studied the volume protection and hair improvement of ginsenoside F5 extracted from hydroponically grown ginseng and sericin extracted from golden cocoon (hereinafter referred to as "golden sericin" as distinguished from sericin extracted from common cocoon). Focusing on the possibility and verifying the effect, it came to this invention.
The present invention has been made in view of the above-described conventional problems, scalp protection and hair improvement comprising ginsenoside F5 extracted from hydroponically grown ginseng (leaf and stem) and golden sericin extracted from golden cocoon as an active ingredient. It is for providing a cosmetic composition.
The cosmetic composition for scalp protection and hair improvement of the present invention comprises ginsenoside F5 derived from hydroponicly grown ginseng and golden sericin derived from golden cocoon as an active ingredient.
In addition, in the cosmetic composition for scalp protection and hair improvement of the present invention, the ginsenoside F5 is extracted from the leaves and stems of ginseng cultivated for more than 120 days, and the ginsenoside F5 and the golden sericin are each added to the total weight. It is characterized in that it comprises 0.001 to 10% by weight.
In addition, the scalp protection and hair improvement cosmetic composition of the present invention is characterized by increasing the moisture content of the scalp and reducing the amount of oil.
According to the present invention, there is an effect of improving or protecting the condition of the scalp and improving the condition of the hair.
1 is a photograph showing changes in erythema symptoms by taking a 60-fold magnification of the location of erythema symptoms in the scalp of the test participants.
Cosmetic composition for scalp protection and hair improvement comprising ginsenoside F5 derived from the hydroponic cultivated ginseng (leaf and stem) of the present invention and golden sericin derived from golden cocoon (hereinafter, "Scalp protection and hair improvement cosmetics") Composition ") includes ginsenoside F5 extracted from hydroponically grown ginseng (leaf and stem) and golden sericin extracted from golden cocoon as active ingredients.
The ginsenoside F5 is named as (3beta, 6alpha, 12beta) -3,6,12-Trihydroxydammar-24-en-20-yl6-O-alpha-L-arabinofuranosyl-beta-D-glucopyranoside. 1] has a structure.
[Formula 1]
The method for preparing ginsenoside F5, extracting ginseng extract from the sample consisting of the ground portion (stem and leaf) of the ginseng cultivated through hydroponic cultivation, and extracting the liquid distribution extract using a concentrated solvent under reduced pressure using an organic solvent Obtaining, and obtaining a fraction through chromatography of the liquid partition extract.
The ginseng extract is not particularly limited as long as it is a method of obtaining an extract from a natural product, and ultrasonic extraction, filtration, reflux extraction and the like may be preferably used. In addition, the extracted ginseng extract is preferably concentrated under reduced pressure by a vacuum pressure concentrator.
Next, the liquid extract is concentrated by extracting the concentrated concentration under reduced pressure using a liquid partition extraction method using an organic solvent.
The organic solvent is not particularly limited as long as it is an organic solvent that is commonly used for extraction of natural products, but C1 to C5 alcohol, water, hexane, methylene chloride or ethyl acetate may be preferably used.
In addition, the liquid partition extraction method is to remove impurities contained in the ginseng extract by using the solubility in the solvent and the mixing of the solvent and the solvent, and is not particularly limited as long as it is a method for preparing a conventional liquid distribution extract. .
Next, fractions are obtained from the liquid partition extract through chromatography. The chromatography is not particularly limited as long as it is a chromatography method commonly used for component separation of ginsenosides. For example, gas chromatography (GC), thin-layer chromatography (TLC), high performance liquid chromatography (HPLC), or the like can be preferably used.
In addition, the production of the golden sericin derived from the golden cocoon, extracting the golden sericin from the golden cocoon, hydrolysis including the extracted golden sericin, ultrafiltration of the hydrolyzed golden sericin (UF, Ultrafiltration) Separating by, and concentrating and powdering the separated golden sericin.
Extraction of golden sericin from the golden cocoon is not particularly limited as long as it is a method of separating and refining sericin from silkworm cocoons, for example, hot water extraction, soap refining, alkali-known as a conventional refining method. A salt refining method or the like can be preferably used, and the case of recovering golden sericin from the wastewater generated in the refining process for obtaining golden silk from the golden cocoon includes the recovery step.
Next, the hydrolysis process for low molecular weight of the golden sericin extracted from the golden cocoon.
Generally, sericin is known as a hydrophilic protein, but since sericin is extracted from silkworm cocoons, it is still a high molecular material, so that it has poor solubility in water even after powdering. As such, when the solubility in water is inferior, there is a problem that it is difficult to use it as a raw material of cosmetics to be mixed with other component substances by water.
In order to solve such a problem of solubility of water in sericin, a hydrolysis process for reducing the molecular weight of sericin is required in the process of recovering sericin from an aqueous solution containing the extracted sericin.
In this case, the hydrolysis method of sericin is not particularly limited as long as it is a method of hydrolysis in order to lower the molecular weight of sericin extracted from silkworm cocoons, for example, a method or an enzyme that hydrolyzes sericin under acid or basic conditions. The method of hydrolyzing sericin using etc. can be used preferably. In particular, in the case of a method using an enzyme, an alcalase enzyme, a flavozyme enzyme or a protamex enzyme may be preferably used.
Next, in order to remove the golden sericin of the insoluble polymer in the hydrolyzed golden sericin, separation is performed by ultrafiltration.
That is, the hydrolysis of the golden sericin to a significant level, but the molecular weight distribution of the golden sericin is still insoluble sericin because the molecular weight of the distribution has a wide distribution. Therefore, it is preferable to separate the low molecular weight gold sericin with a molecular weight below a certain level through a separation process using a tubular ultrafiltration membrane having a molecular weight of 4,000 fractions.
Next, as a method of pulverizing sericin recovered from the aqueous solution of gold sericin which has been separated by ultrafiltration, a freeze-drying method, a spray drying method, and a freeze-thawing method may be preferably used.
However, the freeze-drying method is a method of drying under vacuum after freezing at -40 ° C for a long time, but has a high recovery rate, but has a disadvantage in that it consumes time and energy, and spray-drying method uses a sericin solution at a high temperature of 200 ° C. It is sprayed in the chamber of the method to recover the powder while evaporating the water, a large amount can be recovered in a short time, but due to the high energy and low recovery rate is not suitable for powdering sericin.
On the other hand, the freeze thawing method is a method of thawing after freezing in a freezer at -4 ° C. or less, in that sericin proteins induce a large association behavior during freezing / thawing, so that precipitated sericin can be easily powdered. More preferably.
In addition, the cosmetic composition for protecting the scalp and hair improvement, ginsenoside F5 extracted from the leaves and stems of hydroponicly cultivated ginseng, hydroponicly grown for more than 120 days and golden sericin extracted from the golden cocoon, respectively, 0.001-10 It is preferable to include the weight percent.
In order to obtain a useful effect of the scalp protection and hair improvement cosmetic composition, at least from ginsenoside F5 and golden cocoon extracted from the leaves and stems of hydroponically grown ginseng included in the scalp protection and hair improvement cosmetic composition. Since the amount of the extracted golden sericin needs to be included in an amount of 0.001% by weight or more based on the total weight, it means that it is not preferable to include 10% by weight or more in terms of economic efficiency only.
In addition, the cosmetic composition for scalp protection and hair improvement may be prepared in any formulation commonly prepared in the art, and may be preferably formulated into an emulsion, cream, paste, gel, liquid, powder, and the like.
EXAMPLE
(1) Isolation of Ginsenoside F5
Separation of the ginsenoside F5 was separated from the leaves and stems, which are ground parts of ginseng cultivated for more than 120 days by hydroponic cultivation, according to a known method described in
(2) Preparation of Golden Sericin
Gold silk cocoon, which was purchased from the Rural Development Administration, was mixed with distilled water at a ratio of 1:30 (weight ratio) and refined for 2 hours at 100 ° C. in a state of complete immersion to extract golden sericin from the golden cocoon.
The aqueous solution containing golden sericin was mixed at a rate of 80 mg of flavozyme enzyme per gram of sericin, and then hydrolyzed at 37 ° C. for 6 hours, and the aqueous solution of golden sericin hydrolyzed by the flavozyme enzyme was used. The golden sericin powder was obtained by concentrating through a separation process using a tubular ultrafiltration membrane having a fractional molecular weight of 4,000, and thawing the concentrated golden sericin aqueous solution after freezing in a freezer at −4 ° C. or lower.
Experimental Example
(1) Selection of experiment participants
The subjects were 20 males and females in their 20s and 30s living in Seoul, and three items, including itching, oiliness, and erythema symptoms, were related to scalp condition through visual inspection and consultation by two experts. With regard to the three categories of hair breakage, combing ease (combability is related to hair splitting, puffiness, etc.), and glossiness, as shown in <Table 1>, it is very good, good and normal. Scalp and hair condition were evaluated on a 5-point scale of poor, poor, and very poor.
<Table 1> Scalp and Hair Condition Rating Scale
In addition, the average value of the scalp and hair condition of the experiment participants evaluated by two experts was divided equally, and divided into four groups (one control group and three experimental groups) with 5 persons in each group. The average value of the states is shown in Table 2 below.
<Table 2> Average value of scalp and hair condition for each group
(2) Verification of stability of sample
As a sample, a sample of ginsenoside F5 isolated from the leaves and stems of hydroponically grown ginseng (sample 1), a sample of golden sericin extracted from golden cocoon (sample 2), and the leaves and stems of hydroponically grown ginseng A sample (Sample 3) containing 1: 1 mixture of ginsenoside F5 and golden sericin extracted from golden cocoon was prepared, and 1% concentration (weight ratio), 5% concentration (weight ratio), and 10% concentration (weight ratio) of each sample were prepared. ) Was applied to the scalp and visually observed, and there were no side effects such as blistering, erythema, edema, and allergy.
(3) manufacture of shampoo
As test shampoos to be applied to the
<Table 3> Composition of Shampoo (Unit: wt%)
(4) Experiment Method
Experimental method of the control group and the experimental group is the same, the control group in the control ginsenoside F5 and golden sericin does not contain at all,
Participants were washed with pre-water for 4 weeks, then shampooed and rubbed evenly for 2 minutes, followed by drying for more than 2 minutes.
① Measurement of oil and water content of the scalp
The amount of oil and water in the scalp of each group of participants in the group was measured three times in advance, 2 weeks after treatment, and 4 weeks after treatment using a moisture measuring instrument, and the measured values were 5 points as shown in Table 4 below. Evaluation was made on a scale.
<Table 4> 5-point scale of oil and water
② Measurement of changes in erythema symptoms of the scalp
The scalp diagnostic device (lens magnification: x20 ~ x300) was used three times in advance, two weeks after treatment, and four weeks after treatment. Photographing was performed to measure changes in erythema symptoms.
③ Measurement of tensile strength of hair
Tensile strength was measured twice before and after treatment for the hair of each group of participants.
Tensile strength of hair is a measure of the tensile length of the hair and the force required to cut the hair while increasing the pulling force at both ends of the hair until the hair is cut. The tensile strength (Rheometer, CR-500DX-S) II, Japan).
④ Expert evaluation
Four weeks after the treatment, two experts who participated in the pre-assessment according to the scalp and hair condition evaluation scales of <Table 1> evaluated the scalp and hair condition of the test participants of each group, and evaluated the scalp and hair condition of the test participants. The change was measured.
(5) Changes in oil and moisture content of the scalp
Changes in the amount of moisture and oil in the scalp of each group of participants are shown in Table 5 below.
<Table 5> Changes in Moisture and Oil Contents of Scalp in Each Group
Table 5 above shows that before treatment, the scalp state of the test participants lacked water and a large amount of oil, which is typically dry and oily scalp.
In the control group using the shampoo (control shampoo) containing no ginsenoside F5 and golden sericin, there was a slight decrease (-9.1%) in the oil content, but little change in the water content.
On the other hand, in the case of
Furthermore, in the
(6) changes in erythema of the scalp
1 is a photograph showing changes in erythema symptoms by taking a 60-fold magnification of the location of erythema symptoms in the scalp of the test participants.
As shown in Figure 1, the control group using the shampoo (control shampoo) that does not contain the ginsenoside F5 and golden sericin, it can be seen that the change in the erythema symptoms is not large.
On the other hand, the
In general, the erythema symptom on the scalp is known to be caused by the scalp irritation caused by the use of chemicals such as pumps and hair dyes, and after using such chemicals such as pumps and hair dyes, the leaves of hydroponically grown ginseng of the present invention And a shampoo containing golden sericin extracted from ginsenoside F5 and / or golden silkworm cocoon extracted from the stem, the scalp protection effect can be expected.
(7) change in tensile strength of hair
The tensile strength change of the hair of each group of participants is shown in Table 6 below.
<Table 6> Changes in tensile strength of hair
As can be seen in Table 6, in the case of the control group using the shampoo (control shampoo) containing no ginsenoside F5 and golden sericin, the tensile strength of the hair was 02%, In
Therefore, the use of a shampoo comprising ginsenoside F5 and / or golden sericin extracted from the leaves and stems of hydroponically grown ginseng of the present invention can be expected to improve the tensile strength of the hair.
(7) expert evaluation
The result of comparing the expert evaluation at 4 weeks after the treatment with the pre-treatment before the treatment is shown in Table 7 below.
<Table 7> Expert Evaluation Results
As shown in Table 7, the previously evaluated by the expert scalp and hair condition 5 point scale evaluation value was within the normal range in the range of 2.70 to 2,72.
After 4 weeks of treatment, the control group using the shampoo (control shampoo) without ginsenoside F5 and golden sericin was not significantly different in the expert's pre / post evaluation.
On the other hand. In the case of the
That is, when the ginsenoside F5 extracted from the leaves and stems of hydroponically grown ginseng of the present invention or the golden sericin extracted from the golden cocoon alone, protection and improvement of the scalp and hair state can be expected. When ginsenoside F5 extracted from hydroponic ginseng leaves and stems and golden sericin extracted from golden cocoon can be expected to have a better effect on the protection of the scalp and hair improvement.
Claims (3)
The ginsenoside F5 is extracted from the leaves and stems of ginseng cultivated for more than 120 days,
The ginsenoside F5 and the golden sericin are respectively 0.001 to 10% by weight based on the total weight of the scalp protection and hair improvement cosmetic composition.
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KR20220107654A (en) | 2021-01-26 | 2022-08-02 | 주식회사 우리기술 | Method for cultivating hydroponic-cultured Panax ginseng for increasing ginsenoside content and the use of it |
KR20230009583A (en) | 2021-07-09 | 2023-01-17 | (주)두드림 | Cosmetic Composition Containing Sericin Derive From Silkworm and Aloe Barbadensis Leaf Extract |
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KR102215254B1 (en) | 2019-07-09 | 2021-02-15 | 주식회사 삼인케미칼 | Manufacturing method for cosmetics or improving condition of damaged hair |
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KR101877801B1 (en) * | 2012-07-05 | 2018-07-13 | (주)아모레퍼시픽 | Composition of skin external application containing ginsenoside F2 derive from hydroponic ginseng |
KR101343857B1 (en) | 2012-09-12 | 2013-12-20 | 재단법인 금산국제인삼약초연구소 | A composition comprising ginsenoside f2 for promoting hair growth or inhibiting hair loss |
KR101457372B1 (en) * | 2012-11-28 | 2014-11-03 | (주)에이씨티 | Composition for improving condition of scalp and hair containing the extract of Golden silkworm cocoon |
KR101624640B1 (en) | 2013-09-12 | 2016-05-27 | 대한민국 | External skin preparation comprising ginsenoside F5 |
KR101675919B1 (en) | 2014-08-13 | 2016-11-15 | 주식회사 코리아나화장품 | Cosmetic Composition comprising Ribonucleic acid and Extract of Panax ginseng as active ingredient |
KR101845132B1 (en) | 2015-07-06 | 2018-04-04 | 최덕원 | Apparatus for aeroponic cultivation of crops |
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KR20220107654A (en) | 2021-01-26 | 2022-08-02 | 주식회사 우리기술 | Method for cultivating hydroponic-cultured Panax ginseng for increasing ginsenoside content and the use of it |
KR20230009583A (en) | 2021-07-09 | 2023-01-17 | (주)두드림 | Cosmetic Composition Containing Sericin Derive From Silkworm and Aloe Barbadensis Leaf Extract |
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