CN109260094A - A kind of composition and preparation method thereof containing plant antiallergic ingredient - Google Patents
A kind of composition and preparation method thereof containing plant antiallergic ingredient Download PDFInfo
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- CN109260094A CN109260094A CN201811386919.3A CN201811386919A CN109260094A CN 109260094 A CN109260094 A CN 109260094A CN 201811386919 A CN201811386919 A CN 201811386919A CN 109260094 A CN109260094 A CN 109260094A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a kind of Genes For Plant Tolerance sensitive composition, the component containing following mass parts: 80-90 parts of the rough gentian anti-irritant factor, 5-15 parts of semen sojae atricolor fermentation liquid, 2-5 parts of highland barley glucan aqueous solution.The symptoms such as the allergy of skin are eliminated using the anti-inflammatory anti-irritant effect of the potent antiallergic of the rough gentian anti-irritant factor, nutrition is provided for skin using the Japanese semen sojae atricolor fermentation liquid of Bacillus acidi lactici acid fermentation and promotees growth of probiotics ingredient, adjust the colony balance and pH value of skin, collaboration antiallergic and the immunity for enhancing skin, the filming function of molecule highland barley glucan is sustained the rough gentian anti-irritant factor in utilization, keep antiallergic efficacy lasting, the abnormal sensitivity phenomenon of individual normal individuals can also be reduced, whole be used for a long time can also be such that skin barrier function reinforces.
Description
Technical field
The present invention relates to cosmetic field, it is specifically related to a kind of composition containing plant antiallergic ingredient and its preparation side
Method.
Background technique
Facial mask is one of current maximum kind of skin care market comsupton, opposite with other dosage forms, the skin uptake of facial mask
It is big to absorb fastly, therefore effect is more prominent, is widely used in anti-aging, whitening, anti-acne, reparation and other effects care product, but
Also big, fast and semi-enclosed absorbing state because of its uptake, causing it is to be easiest to cause allergy in all dosage forms, because
This allergic phenomena for how reducing facial mask has the meaning of reality to the development of industry.
It is directed to the allergic phenomena of facial mask at present, conventional thinking is that anti-sensitizer is added by the thinking of common daily chemical products, such as
The synthesis such as bisabolol, dipotassium glycyrrhizinate of early stage or semi-synthetic raw material and currently popular plant extract or fermentation come
The raw material in source, but in mask product, often having added anti-sensitizer, also still allergy rate is very high, the low mistake for also often having anti-sensitizer to add
Quick rate is high, and whole allergy rate reduces after the raising of anti-sensitizer dosage, but the individual allergy instead of individual original not allergy.
The synergistic combination of anti-sensitizer, which becomes, solves the problems, such as direction the most feasible, but often the anti-sensitizer of separate sources has
Compatibility problems, including effect even drops without cooperative effect, it cannot stablize the problems such as coexisting.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of plant composition and its process for refining for facial mask antiallergic,
And determine coefficient optimum proportion.
The specific technical solution for solving above-mentioned technical problem is as follows:
A kind of Genes For Plant Tolerance sensitive composition, the component containing following mass parts: 80-90 parts of the rough gentian anti-irritant factor, semen sojae atricolor fermentation liquid
5-15 parts, 2-5 parts of highland barley glucan aqueous solution.
Entitled rough gentian (GENTIANA SCABRA) root of cosmetics Chinese of the rough gentian anti-irritant factor of the present invention extracts
Object is indicated from Gentianaceae herbaceos perennial rough gentianGentiana scabra BgeRoot obtained in extract, can be with
Contain or including one or more bioactive molecules, including saponin(e, polysaccharide, alkaloid, cupreol.Suitable rough gentian
(GENTIANA SCABRA) root extract may include Gentiana-s EcustTMGseaifs(comes from Guangdong enlightening U.S. new material
Science and Technology Ltd.), the rough gentian anti-irritant factor (come from Lin Xin biotechnology (Shanghai) Co., Ltd.), the rough gentian anti-irritant factor
(coming from Shanghai Jia Yu Biotechnology Co., Ltd).
In wherein some embodiments, gentiopicroside in different morphological >=1200ppm of the rough gentian anti-irritant factor.
Entitled Bacillus acidi lactici/soya-bean milk tunning the filtrate of cosmetics Chinese of semen sojae atricolor fermentation liquid of the present invention, indicates
From using semen sojae atricolor slurry as substrate, the filtrate obtained using lactobacillus fermentation, can contain or including one or more biologies
Bioactive molecule, including polypeptide, phosphoric acid, nucleosides, vitamin, phosphatide, amino acid, flavones, carboxylic acid have and releive, and moisturizing is repaired
Effect.Suitable semen sojae atricolor fermentation liquid may include VEYATECH®(coming from Axialys innovations company of France).
The entitled glucan of cosmetics Chinese of highland barley glucan of the present invention, is from grass family barley platymiscium highland barleyHordeum vulgare L.var.nudum Hook.f.It is middle to extract obtained (1 → 3) (1 → 4)-callose.
In wherein some embodiments, the content of highland barley glucan is greater than in the highland barley glucan aqueous solution
0.9wt%, the molecular weight 300-500kDa of the highland barley glucan.
Genes For Plant Tolerance sensitive composition of the invention can be made by common process, and three kinds of raw materials for being included all are water-soluble
Raw material can be mixed directly, be stirred evenly.
Preferably, the embodiment of the invention also provides a kind of preparation method of above-mentioned Genes For Plant Tolerance sensitive composition, including it is as follows
Step:
(1) each raw material is weighed in proportion, is uniformly mixed；Chitosan aqueous solution is added, stirs evenly, obtains mixed liquor；
(2) mixed liquor is put into high/low temperature incubator and carries out hot and cold alternation aging；
(3) straight tube centrifuge is centrifuged to clarification after aging, takes supernatant ceramic membrane filter, filtrate carries out ultrafiltration, with filter
When film ultrafiltration to trapped fluid residue 30%, 50% butanediol solution of equivalent is added, the quality for continuing ultrafiltration to permeate is equal to
Stock solution quality takes permeate up to Genes For Plant Tolerance sensitive composition.
In wherein some embodiments, the additive amount of chitosan aqueous solution described in step (1) is 0.1 ~ 0.3wt%, described
Chitosan aqueous solution in chitosan net content be 1wt%.
In wherein some embodiments, hot and cold alternation aging condition described in step (2) are as follows: low temperature is arranged -10 ~ -20 DEG C,
High temperature is arranged 50 ~ 60 DEG C, and alternate cycle is 24 ~ 36h/ times, and alternately 3 ~ 5 times.
In wherein some embodiments, centrifuge speed described in step (3) is 18000 turns；The hole of the ceramic membrane
Diameter is 2 μm；The molecular cut off of the filter membrane is 1200 ~ 1500kDa.
Genes For Plant Tolerance sensitive composition of the present invention has enhancing skin barrier function, antianaphylactic effect, and addition skin care item are common
Matrix or carrier, can be made into the cosmetics such as facial mask, facial cleanser, cream, gel.
Technical solution provided in an embodiment of the present invention has the benefit that
(1) Genes For Plant Tolerance sensitive composition of the present invention preferred the rough gentian anti-irritant factor, semen sojae atricolor fermentation liquid, highland barley glucan aqueous solution,
The symptoms such as the allergy of skin are eliminated using the anti-inflammatory anti-irritant effect of the potent antiallergic of the rough gentian anti-irritant factor, utilize lactobacillic acid
The semen sojae atricolor fermentation liquid of fermentation provides nutrition for skin and promotees growth of probiotics ingredient, adjusts the colony balance and pH value of skin, assists
With antiallergic and enhance the immunity of skin, the filming function of molecule highland barley glucan is sustained the rough gentian anti-irritant factor in utilization, makes
Genes For Plant Tolerance sensitive composition antiallergic is efficacy lasting, can also reduce the abnormal sensitivity phenomenon of individual normal individuals, whole to be used for a long time
Skin barrier function can also be made to reinforce.
(2) Genes For Plant Tolerance sensitive composition of the invention has enhancing facial mask antiallergic effect, generates syneryistic effect, and can delay
Antiallergic ingredient is released, the abnormal sensitivity of individual normal individuals is reduced, the resistance that can also enhance skin is used for a long time, passes through coordinated groups
It closes, also reduces usage amount and cost.
(3) the present invention also provides the preparation methods of Genes For Plant Tolerance sensitive composition removes composition by the purification after combination
In partial invalidity impurity, solve the stabilization compatibility problems of the anti-sensitizer of separate sources.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Embodiment 1
A kind of Genes For Plant Tolerance sensitive composition, preparation method are as follows:
(1) following component: rough gentian anti-irritant factor 80kg, semen sojae atricolor fermentation liquid 15kg, highland barley glucan aqueous solution 2kg is weighed, is mixed
It closes uniform;0.3% chitosan solution (1% concentration) is added, after stirring evenly；
(2) it is put into high/low temperature incubator and carries out aging, aging condition is that low temperature is arranged -10 DEG C, and high temperature is arranged 60 DEG C, alternate cycle
For for 24 hours/secondary, alternating 5 times.
(3) 18000 turns of straight tube centrifuges are centrifuged to clarification after aging, take supernatant with 2 μm of ceramic membrane filters, filtrate
When ultrafiltration through membranes to the trapped fluid residue 30% that progress ultrafiltration is 1200kDa with molecular cut off, the fourth two of the 50% of equivalent is added
Alcoholic solution continues ultrafiltration to the quality of permeate and is equal to stock solution quality, takes permeate to obtain the final product.
Embodiment 2
A kind of Genes For Plant Tolerance sensitive composition, preparation method are as follows:
(1) following component: rough gentian anti-irritant factor 90kg, semen sojae atricolor fermentation liquid 5kg, highland barley glucan aqueous solution 5kg is weighed, is mixed
Uniformly;0.1% chitosan solution (1% concentration) is added, after stirring evenly；
(2) it is put into high/low temperature incubator and carries out aging, aging condition is that low temperature is arranged -20 DEG C, and high temperature is arranged 50 DEG C, alternate cycle
It is 36h/ times, alternately 3 times.
(3) 18000 turns of straight tube centrifuges are centrifuged to clarification after aging, take supernatant with 2 μm of ceramic membrane filters, filtrate
When ultrafiltration through membranes to the trapped fluid residue 30% that progress ultrafiltration is 1500kDa with molecular cut off, the fourth two of the 50% of equivalent is added
Alcoholic solution continues ultrafiltration to the quality of permeate and is equal to stock solution quality, takes permeate to obtain the final product.
Embodiment 3
A kind of Genes For Plant Tolerance sensitive composition, preparation method are as follows:
(1) following component: rough gentian anti-irritant factor 85kg, semen sojae atricolor fermentation liquid 10kg, highland barley glucan aqueous solution 2.5kg is weighed,
It is uniformly mixed;0.2% chitosan solution (1% concentration) is added, after stirring evenly；
(2) it is put into high/low temperature incubator and carries out aging, aging condition is that low temperature is arranged -15 DEG C, and high temperature is arranged 55 DEG C, alternate cycle
It is 30h/ times, alternately 4 times.
(3) 18000 turns of straight tube centrifuges are centrifuged to clarification after aging, take supernatant with 2 μm of ceramic membrane filters, filtrate
When ultrafiltration through membranes to the trapped fluid residue 30% that progress ultrafiltration is 1300kDa with molecular cut off, the fourth two of the 50% of equivalent is added
Alcoholic solution continues ultrafiltration to the quality of permeate and is equal to stock solution quality, takes permeate to obtain the final product.
Embodiment 4
Stability test is carried out to Genes For Plant Tolerance sensitive composition obtained by embodiment 1-3, and comparative example 1 is set.The comparative example 1
The preparation method comprises the following steps: weighing following component: rough gentian anti-irritant factor 85kg, semen sojae atricolor fermentation liquid 10kg, highland barley glucan aqueous solution
2.5kg is uniformly mixed.
Stability test method: by Genes For Plant Tolerance sensitive composition obtained by embodiment 1-3 and comparative example 1 be respectively placed in 4 DEG C,
Three months in 48 DEG C and three kinds of environment of high/low temperature incubator, wherein high/low temperature incubator low temperature is arranged -18 DEG C, high temperature setting 48
DEG C, alternate cycle is 48h/ times, then observes stability result, is specifically shown in Table 1.
1 stability test result table of table
The stability that result above can be seen that the composition after embodiment 1-3 purification significantly improves.
The preparation of 5 antiallergic facial mask of embodiment
(1) preparation of facial mask basic components
A kind of basis facial treatment mask, the component including following mass percentage:
The preparing process of the basic facial treatment mask is as follows:
1. the xanthan gum in component A is soaked with butanediol, then it is added in water phase pot, opens stirring, sequentially adds other remaining
Under component A, be warming up to 80 DEG C, 10 minutes kept the temperature, until being completely dissolved.
2. the mixing speed of emulsion pot is maintained at 300 revs/min, by component A by vacuum suck, low speed homogeneous 5 minutes.
Start to cool down.
3. drop to 45 DEG C, the raw material of B component is added in emulsion pot, opens stirring, is uniformly mixed；
4. stirring is cooled to 40 DEG C or less, C, D component is added, stirring 10 minutes until uniformly；Filtering and discharging when being down to 38 DEG C.
(2) preparation of antiallergic facial mask
Genes For Plant Tolerance sensitive composition is added in the basis facial treatment mask made from above-mentioned steps (1), is uniformly mixed, experimental group 1- is made
The antiallergic facial mask of 9 and comparative experiments group 1-11；The wherein component of the Genes For Plant Tolerance sensitive composition and additive amount such as the following table 2.
The component of 2 Genes For Plant Tolerance sensitive composition of table and additive amount in formula
Wherein the corresponding raw material of each code name is as follows:
A: the rough gentian anti-irritant factor；B: semen sojae atricolor fermentation liquid；C1: highland barley glucan aqueous solution, 30 ~ 500,000 dalton, content >=
0.9%；C2: highland barley glucan aqueous solution, 5 ~ 100,000 dalton, content >=0.9%；C3: highland barley glucan aqueous solution, 80 ~ 1,200,000
Dalton, content >=0.9%；
Wherein comparative test group 12 the preparation method comprises the following steps: by tri- kinds of raw materials of A, B, C1, be uniformly mixed.Experimental group 1-9 and comparison are real
The preparation method of group 1-11 is tested with embodiment 3.
(3) human skin patch test
Human body function patch test is carried out to the antiallergic facial mask of experimental group 1-9 obtained above and comparative experiments group 1-11.It is specific to survey
Method for testing are as follows: the volunteer at 90 18 ~ 60 years old health ages, men and women is unlimited, is divided into 3 groups, every group of 30 people, everyone does 8
Sample (4 holes having more are empty).Skin closure type patch test is carried out, area is selected to be no more than 50mm2, depth about 1mm
Qualified patch tries equipment, and the inner forearm of volunteer is used as to test zone, random number, and tested material is put into patch and tries device cell
Interior, test dosage is 20-25mg, is gently pressed with palm and is allowed to equably be pasted on skin, continues 48h, tested respectively at removing
After object spot tester 30min(after impression disappearance after), for 24 hours with 48h by 3 Plays of table observe dermoreaction, record observation result see
Table 4.1 ~ 4.3.
3. skin closure type patch test dermoreaction grade scale of table
4.1 embodiment 1-4 of table is observed and recorded
Table 4.2 embodiment 5-9 and comparative example 1-4 is observed and recorded
4.3 comparative example 5-12 of table is observed and recorded
By table 4.1 ~ 4.3 as it can be seen that under combination matching of the present invention and additive amount, the allergy rate of facial mask can be significantly reduced, there is association
Same synergistic effect weakens beyond proportion synergistic effect.Additive amount crosses major general and effect is not achieved, and adding too much effect does not increase instead
There is the possibility of decline.The proportion can be reduced allergic reaction early period that the rough gentian anti-irritant factor is applied alone simultaneously, prompt have sustained release antiallergic
The effect of ingredient, and small molecule or macromolecular glucan in proportion combines corresponding effect useless.Show process for refining simultaneously
Not the effect of not weakening composition.
(4) resistance to histamine test
Resistance to histamine test is carried out to the antiallergic facial mask of experimental group 1-9 obtained above and comparative experiments group 1-11.Specific test side
Method are as follows: take 420 weight 250-300g albino guinea-pigs, right metapedes is lost hair or feathers and (avoids damage to skin) with depilatory agent, then press property
Not, weight is randomly divided into 42 groups: experimental group, triamcinolone acetonide acetate carbamide ointment group, and every group 10, half male and half female.By right metapedes
Skin fine sandpaper gently rubs and is allowed to rubescent at the depilation of back, but is degree with not bleeding, then again to the reagent of wound surface smearing institute
Object 0.2mL, about 1.0 cm of area2, wherein 21 groups of natural drying (about 40min) medications afterwards, are denoted as 0h group, in addition do naturally for 21 groups
It is wrapped up after dry with gauze, immobilization with adhesive tape, package medication is removed after 4h, is denoted as 4h group.Every 3min successively by low concentration to highly concentrated
It spends to every cavy dorsal portion and smears histamine 0.03mL, Histamine concentrations are respectively 1.0 × 10-4、1.5×10-4、2.0×10-4、
2.5×10-4、3.0×10-4、3.5×10-4、4.0×10-4.When itch reaction occurs in cavy, that is, lick right metapedes wound site
(or be applied to maximum concentration do not occur yet itch reaction until), accumulate every cavy histamine amount to be administered at this time, as should
The amount of cavy tolerance histamine.Specific test result is shown in Table 5.
5 histamine test result of table
By table 5 as it can be seen that under combination matching of the present invention and additive amount, the tolerance of Guinea Pig Histamine can be remarkably reinforced, effect connects
Nearly hormone.Histamine is that mostly important inflammatory factor and inflammation, allergic phenomena are directly related, thus the present invention have to allergy it is bright
It is aobvious to alleviate effect.Show the effect of process for refining does not weaken composition simultaneously.
Above-mentioned histamine test data shows there is apparent histamine tolerance synergistic function in combination matching of the present invention, surpasses
Proportion synergistic effect weakens out.Additive amount crosses major general and effect is not achieved, and adding too much effect increases unobvious.From 0h group and 4h
The comparison of group can find out that this proportion can also have sustained release, extend the effect of histamine tolerance time, and small molecule in proportion or big point
Sub- glucan combination is useless to delay effect accordingly.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (8)
1. a kind of Genes For Plant Tolerance sensitive composition, which is characterized in that the component containing following mass parts: rough gentian anti-irritant factor 80-90
Part, 5-15 parts of semen sojae atricolor fermentation liquid, 2-5 parts of highland barley glucan aqueous solution.
2. Genes For Plant Tolerance sensitive composition according to claim 1, which is characterized in that the rough gentian of the rough gentian anti-irritant factor
Bitter glycosides content >=1200ppm.
3. Genes For Plant Tolerance sensitive composition according to claim 1 or 2, which is characterized in that the highland barley glucan aqueous solution
The content of middle highland barley glucan is greater than 0.9wt%, the molecular weight 300-500kDa of the highland barley glucan.
4. the preparation method of the described in any item Genes For Plant Tolerance sensitive compositions of claim 1-3, includes the following steps:
(1) each raw material is weighed in proportion, is uniformly mixed；Chitosan aqueous solution is added, stirs evenly, obtains mixed liquor；
(2) mixed liquor is put into high/low temperature incubator and carries out hot and cold alternation aging；
(3) straight tube centrifuge is centrifuged to clarification after aging, takes supernatant ceramic membrane filter, filtrate carries out ultrafiltration, with filter
When film ultrafiltration to trapped fluid residue 30%, 50% butanediol solution of equivalent is added, the quality for continuing ultrafiltration to permeate is equal to
Stock solution quality takes permeate up to Genes For Plant Tolerance sensitive composition.
5. the preparation method of Genes For Plant Tolerance sensitive composition according to claim 4, which is characterized in that shell described in step (1)
The additive amount of water solution is 0.1 ~ 0.3wt%, and the net content of chitosan is 1wt% in the chitosan aqueous solution.
6. the preparation method of Genes For Plant Tolerance sensitive composition according to claim 4, which is characterized in that cold described in step (2)
Hot alternately aging condition are as follows: low temperature is arranged -10 ~ -20 DEG C, and high temperature is arranged 50 ~ 60 DEG C, and alternate cycle is 24 ~ 36h/ times, alternating 3 ~
5 times.
7. the preparation method of Genes For Plant Tolerance sensitive composition according to claim 4, which is characterized in that described in step (3) from
Scheming revolving speed is 18000 turns；The aperture of the ceramic membrane is 2 μm；The molecular cut off of the filter membrane is 1200 ~ 1500kDa.
8. application of the described in any item Genes For Plant Tolerance sensitive compositions of claim 1-3 as antiallergic cosmetic additive agent, described anti-
Sensitization cosmetic is facial mask, facial cleanser, cream, gel.
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| CN112438925A (en) * | 2020-12-03 | 2021-03-05 | 澳思美日用化工（广州）有限公司 | Anti-allergy repairing composition and application thereof |
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