CN108883156A - 用干扰素λ治疗丁型肝炎病毒感染 - Google Patents

用干扰素λ治疗丁型肝炎病毒感染 Download PDF

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Publication number
CN108883156A
CN108883156A CN201780020097.4A CN201780020097A CN108883156A CN 108883156 A CN108883156 A CN 108883156A CN 201780020097 A CN201780020097 A CN 201780020097A CN 108883156 A CN108883156 A CN 108883156A
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CN
China
Prior art keywords
hdv
patient
interferon lambda
treatment
serum
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Pending
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CN201780020097.4A
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English (en)
Chinese (zh)
Inventor
爱德华多·布鲁诺·马丁斯
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Aigerfeng Innovative Therapy Co
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Egger Horn Biological Pharmacy Co Ltd
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Publication of CN108883156A publication Critical patent/CN108883156A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201780020097.4A 2016-02-19 2017-02-17 用干扰素λ治疗丁型肝炎病毒感染 Pending CN108883156A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662297759P 2016-02-19 2016-02-19
US62/297,759 2016-02-19
PCT/US2017/018466 WO2017143253A1 (en) 2016-02-19 2017-02-17 Treatment of hepatitis delta virus infection with interferon lambda

Publications (1)

Publication Number Publication Date
CN108883156A true CN108883156A (zh) 2018-11-23

Family

ID=59625481

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780020097.4A Pending CN108883156A (zh) 2016-02-19 2017-02-17 用干扰素λ治疗丁型肝炎病毒感染

Country Status (17)

Country Link
US (2) US10953072B2 (https=)
EP (2) EP3957319B1 (https=)
JP (3) JP7674628B2 (https=)
KR (1) KR20180110127A (https=)
CN (1) CN108883156A (https=)
CY (1) CY1124220T1 (https=)
DK (1) DK3416675T3 (https=)
ES (2) ES2874592T3 (https=)
HR (1) HRP20210862T1 (https=)
HU (1) HUE055343T2 (https=)
LT (1) LT3416675T (https=)
PL (1) PL3416675T3 (https=)
PT (1) PT3416675T (https=)
RS (1) RS61944B1 (https=)
SI (1) SI3416675T1 (https=)
SM (1) SMT202100335T1 (https=)
WO (1) WO2017143253A1 (https=)

Cited By (1)

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CN114555079A (zh) * 2019-10-16 2022-05-27 艾格尔峰生物制药有限公司 治疗丁型肝炎病毒感染的方法

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US11311519B2 (en) 2014-05-01 2022-04-26 Eiger Biopharmaceuticals, Inc. Treatment of hepatitis delta virus infection
WO2016172342A1 (en) 2015-04-21 2016-10-27 Eiger Biopharmaceuticals, Inc. Pharmaceutical compositions comprising lonafarnib and ritonavir
JP7674628B2 (ja) 2016-02-19 2025-05-12 イーアイティー・ファーマ・インコーポレイテッド インターフェロンラムダによるデルタ型肝炎ウイルス感染の処置
GB201621728D0 (en) * 2016-12-20 2017-02-01 Ucb Biopharma Sprl Methods
CN113286605A (zh) * 2018-08-23 2021-08-20 艾格尔峰生物制药有限公司 用干扰素λ治疗丁型肝炎病毒感染
KR20220035365A (ko) 2019-07-18 2022-03-22 엔요 파마 인터페론의 부작용을 감소시키는 방법
US20230070752A1 (en) * 2019-08-21 2023-03-09 Korea Advanced Institute Of Science And Technology Novel interferon lambda variant and method of producing the same
WO2021159027A1 (en) * 2020-02-06 2021-08-12 Eiger Biopharmaceuticals, Inc. Treatment of coronavirus infection with interferon lambda

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JP2014525939A (ja) * 2011-08-25 2014-10-02 ナノジェン・ファーマシューティカル・バイオテクノロジー ペグインターフェロンλ１複合体
JP2015528449A (ja) * 2012-08-30 2015-09-28 レプリコール インコーポレーティッド Ｂ型肝炎感染及びｄ型肝炎感染の治療方法
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EP1575609A4 (en) 2002-10-23 2010-12-15 Zymogenetics L L C METHOD FOR THE TREATMENT OF VIRUS INFECTIONS USING IL-28 AND IL-29
JP2006528679A (ja) 2003-04-01 2006-12-21 インターミューン インコーポレイテッド コロナウイルス感染症及びサースを治療するための組成物及び方法
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WO2006076014A2 (en) 2004-04-30 2006-07-20 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Interferon-alpha constructs for use in the treatment of sars
JP2009502803A (ja) 2005-07-20 2009-01-29 ザイモジェネティクス， インコーポレイテッド Ｉｌ−２８およびｉｌ−２９のシステイン欠失変異体、ならびにそれを用いる抗ウイルス法
CA2616004A1 (en) 2005-07-20 2007-02-01 Zymogenetics, Inc. Use of truncated cysteine il28 and il29 mutants to treat cancers and autoimmune disorders
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JP7674628B2 (ja) 2016-02-19 2025-05-12 イーアイティー・ファーマ・インコーポレイテッド インターフェロンラムダによるデルタ型肝炎ウイルス感染の処置
GB201621728D0 (en) 2016-12-20 2017-02-01 Ucb Biopharma Sprl Methods
CN113286605A (zh) 2018-08-23 2021-08-20 艾格尔峰生物制药有限公司 用干扰素λ治疗丁型肝炎病毒感染
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JP2014525939A (ja) * 2011-08-25 2014-10-02 ナノジェン・ファーマシューティカル・バイオテクノロジー ペグインターフェロンλ１複合体
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Publication number Priority date Publication date Assignee Title
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Also Published As

Publication number Publication date
ES2874592T3 (es) 2021-11-05
EP3416675B1 (en) 2021-03-24
US10953072B2 (en) 2021-03-23
HUE055343T2 (hu) 2022-05-28
EP3957319A1 (en) 2022-02-23
WO2017143253A1 (en) 2017-08-24
JP2024156840A (ja) 2024-11-06
JP7674628B2 (ja) 2025-05-12
US20190111110A1 (en) 2019-04-18
KR20180110127A (ko) 2018-10-08
SMT202100335T1 (it) 2021-07-12
JP2019505553A (ja) 2019-02-28
SI3416675T1 (sl) 2021-09-30
RS61944B1 (sr) 2021-07-30
JP2022172279A (ja) 2022-11-15
LT3416675T (lt) 2021-06-25
EP3416675B9 (en) 2021-07-14
EP3416675A1 (en) 2018-12-26
US12508297B2 (en) 2025-12-30
EP3416675A4 (en) 2020-01-08
EP3957319B1 (en) 2024-12-04
US20210228686A1 (en) 2021-07-29
HRP20210862T1 (hr) 2021-09-17
PT3416675T (pt) 2021-06-14
CY1124220T1 (el) 2022-05-27
ES3008560T3 (en) 2025-03-24
PL3416675T3 (pl) 2021-10-11
DK3416675T3 (da) 2021-06-14

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Country or region after: U.S.A.

Address after: California, USA

Applicant after: EIT Pharmaceutical Co.

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Applicant before: Aigerfeng Innovative Therapy Co.

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Applicant after: Aigerfeng Innovative Therapy Co.

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Address before: California, USA

Applicant before: EIGER BIOPHARMACEUTICALS, Inc.

Country or region before: U.S.A.