CN108822062A - 一种多西他赛的精制方法 - Google Patents
一种多西他赛的精制方法 Download PDFInfo
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- CN108822062A CN108822062A CN201811044896.8A CN201811044896A CN108822062A CN 108822062 A CN108822062 A CN 108822062A CN 201811044896 A CN201811044896 A CN 201811044896A CN 108822062 A CN108822062 A CN 108822062A
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- docetaxel
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
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- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
Description
检测项目 | 精制前 | 精制后 |
多西他赛HPLC纯度 | 96.30% | 98.65% |
单杂(7.94min保留时间) | 1.02% | 0.13% |
单杂(16.32min保留时间) | 0.61% | 0.25% |
单杂(35.59min保留时间) | 0.45% | 0.33% |
单杂(37.88min保留时间) | 0.34% | 0.28% |
7-表多西他赛 | 0.04% | 0.04% |
10-羰基多西他赛 | 0.04% | 0.04% |
其他单杂 | <0.1% |
Claims (7)
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CN201811044896.8A CN108822062B (zh) | 2018-09-07 | 2018-09-07 | 一种多西他赛的精制方法 |
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CN201811044896.8A CN108822062B (zh) | 2018-09-07 | 2018-09-07 | 一种多西他赛的精制方法 |
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CN108822062A true CN108822062A (zh) | 2018-11-16 |
CN108822062B CN108822062B (zh) | 2020-08-28 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110305080A (zh) * | 2019-08-12 | 2019-10-08 | 新乡双鹭药业有限公司 | 一种多西他赛的纯化方法 |
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WO2011081373A2 (en) * | 2009-12-31 | 2011-07-07 | Samyang Genex Corporation | Method for preparing highly pure anhydrous crystalline docetaxel |
CN102838568A (zh) * | 2012-07-26 | 2012-12-26 | 吉林派高生物制药有限公司 | 一种从红豆杉中提取紫杉醇的方法 |
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2018
- 2018-09-07 CN CN201811044896.8A patent/CN108822062B/zh active Active
Patent Citations (8)
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US20080200700A1 (en) * | 2004-10-08 | 2008-08-21 | Indena S.P.A. | Semisynthesis process for the preparation of 10 deacetyl-n-debenzoyl-paclitaxel |
WO2007044950A2 (en) * | 2005-10-12 | 2007-04-19 | Sicor, Inc. | Crystalline forms of docetaxel and processes for their preparation |
CN101648928A (zh) * | 2009-08-20 | 2010-02-17 | 上海北卡医药技术有限公司 | 紫杉烷类化合物的纯化方法 |
WO2011081373A2 (en) * | 2009-12-31 | 2011-07-07 | Samyang Genex Corporation | Method for preparing highly pure anhydrous crystalline docetaxel |
CN102838568A (zh) * | 2012-07-26 | 2012-12-26 | 吉林派高生物制药有限公司 | 一种从红豆杉中提取紫杉醇的方法 |
CN103508984A (zh) * | 2013-10-22 | 2014-01-15 | 北京和谐伟业化学科技有限公司 | 连续浸漉吸附富集法从红豆杉中提取10-dab的方法 |
CN106243066A (zh) * | 2016-08-05 | 2016-12-21 | 上海贝美医药科技有限公司 | 紫杉醇的结晶纯化方法 |
CN107880001A (zh) * | 2017-12-28 | 2018-04-06 | 云南汉德生物技术有限公司 | 一种从红豆杉中提取10‑去乙酰基巴卡亭ⅲ的方法 |
Non-Patent Citations (6)
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ASHOK G. CHAUDHARY 等: "Modified taxols. 10. Preparation of 7-deoxytaxol, a highly bioactive taxol derivative, and interconversion of taxol and 7-epi-taxol", 《THE JOURNAL OF ORGANIC CHEMISTRY》 * |
B. MALLIKARJUNARAO 等: "A stability-indicating HPLC assay method for docetaxel", 《JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS》 * |
JEAN WATCHUENG 等: "Efficient purification of paclitaxel from yews using high-performance displacement chromatography technique", 《JOURNAL OF CHROMATOGRAPHY A》 * |
SUN, HH 等: "A Facile Two‐Column Chromatographic Process for Efficient Purification of Paclitaxel from Crude Extract", 《JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES》 * |
孙婧: "多烯紫杉醇的合成工艺研究", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》 * |
方大树 等: "紫杉烷二萜类化合物10-DABⅢ的分离纯化", 《中国药房》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110305080A (zh) * | 2019-08-12 | 2019-10-08 | 新乡双鹭药业有限公司 | 一种多西他赛的纯化方法 |
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Address after: No. 111, Qin Road, Donggang Town, Xishan District, Wuxi City, Jiangsu Province, 214000 Applicant after: Wuxi Yeshan Pharmaceutical Co.,Ltd. Address before: 214199 red bean Industrial Park, Donggang Town, Xishan District, Jiangsu, Wuxi Applicant before: JIANGSU YEW PHARMACEUTICAL Co.,Ltd. |
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Address after: No. 111, Qin Road, Donggang Town, Xishan District, Wuxi City, Jiangsu Province, 214000 Patentee after: Wuxi yew Pharmaceutical Co.,Ltd. Address before: No. 111, Qin Road, Donggang Town, Xishan District, Wuxi City, Jiangsu Province, 214000 Patentee before: Wuxi Yeshan Pharmaceutical Co.,Ltd. |
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