CN108699589B - 核酸样品的制备方法 - Google Patents

核酸样品的制备方法 Download PDF

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CN108699589B
CN108699589B CN201780012761.0A CN201780012761A CN108699589B CN 108699589 B CN108699589 B CN 108699589B CN 201780012761 A CN201780012761 A CN 201780012761A CN 108699589 B CN108699589 B CN 108699589B
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nucleic acid
skin
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rna
ssl
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CN108699589A (zh
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井上高良
八谷辉
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Kao Corp
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • B32B5/18—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by features of a layer of foamed material
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020091044A1 (ja) 2018-11-01 2020-05-07 花王株式会社 被験体の皮膚細胞に由来する核酸の調製方法
KR102875895B1 (ko) 2020-01-10 2025-10-23 카오카부시키가이샤 핵산 증폭 방법
CN115279901A (zh) * 2020-03-11 2022-11-01 花王株式会社 来自皮肤表面脂质的rna的制备方法
US20230144067A1 (en) * 2020-04-24 2023-05-11 Kao Corporation Method for detecting severity of premenstrual syndrome
JP2021175958A (ja) * 2020-05-01 2021-11-04 花王株式会社 アトピー性皮膚炎検出用タンパク質マーカーの調製方法
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JP2022164646A (ja) * 2021-04-15 2022-10-27 花王株式会社 乳幼児おむつ皮膚炎の症度の検出方法
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JP7851106B2 (ja) * 2021-11-19 2026-04-24 花王株式会社 炭酸ガス製剤の有効性を検出する方法
NL2030378B1 (en) 2021-12-31 2023-07-05 Lumicks Ca Holding B V Selecting forces for means and methods involving cellular avidity
EP4624591A1 (en) 2022-11-24 2025-10-01 Kao Corporation Internal standard gene in skin surface lipid specimen
JP2025071065A (ja) * 2023-10-20 2025-05-02 花王株式会社 肌タイプの分類方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012109157A3 (en) * 2011-02-07 2013-11-14 The Governing Council Of The University Of Toronto Bioprobes and methods of use thereof
CN103782174A (zh) * 2011-06-07 2014-05-07 卡里斯生命科学卢森堡控股有限责任公司 用于癌症的循环生物标志物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5774699A (en) * 1998-08-14 2000-03-06 Johnson & Johnson Consumer Companies, Inc. Human stearoyl-coa desaturase-related compositions and methods for treating skin disorders
JP2003533965A (ja) * 1998-08-14 2003-11-18 ジョンソン・アンド・ジョンソン・コンシューマー・カンパニーズ・インコーポレイテッド 皮膚の異常症状を治療するためのヒト・ステアロイル−ＣｏＡデサチュラーゼ−関連組成物および方法
US6645611B2 (en) * 2001-02-09 2003-11-11 3M Innovative Properties Company Dispensable oil absorbing skin wipes
US6638611B2 (en) * 2001-02-09 2003-10-28 3M Innovative Properties Company Multipurpose cosmetic wipes
US6649181B1 (en) * 2002-05-29 2003-11-18 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic adhesive strip
JP2005192409A (ja) * 2003-12-26 2005-07-21 Shiseido Co Ltd 体毛からｒｎａを抽出するための方法
JP2007529278A (ja) 2004-03-17 2007-10-25 レビビコア， インコーポレイテッド 機能的α１，３ガラクトシルトランスフェラーゼを欠く動物に由来する組織生成物
US7183057B2 (en) * 2004-03-31 2007-02-27 Dermtech International Tape stripping methods for analysis of skin disease and pathological skin state
KR101267430B1 (ko) * 2006-10-04 2013-05-30 문우철 핵산을 안정적으로 보관하는 새로운 피부 유전자 카드와이를 이용한 유전자 분석방법, 그리고 이의 응용 방법
JP2008222876A (ja) * 2007-03-13 2008-09-25 Institute Of Physical & Chemical Research 生分解性吸油用フィルム
US20100285463A1 (en) * 2007-06-29 2010-11-11 Medizinische Univversitat Innsbruck Selecting nucleic acid samples suitable for genotyping
US20110160080A1 (en) 2008-05-14 2011-06-30 Chang Sherman H Diagnosis of Melanoma and Solar Lentigo by Nucleic Acid Analysis
JP2010115178A (ja) * 2008-11-14 2010-05-27 Nippon Menaade Keshohin Kk 皮膚の炎症の予測方法及びその用途
JP2011019505A (ja) * 2009-01-29 2011-02-03 Mukogawa Gakuin 特定遺伝子を検出する方法
WO2013020926A1 (en) * 2011-08-11 2013-02-14 Febit Holding Gmbh Complex sets of mirnas as non-invasive biomarkers for psoriasis
WO2013151664A1 (en) 2012-04-02 2013-10-10 modeRNA Therapeutics Modified polynucleotides for the production of proteins
CN110055320A (zh) 2012-03-17 2019-07-26 加州大学评议会 痤疮的快速诊断和个体化治疗
CN104411338A (zh) 2012-04-02 2015-03-11 现代治疗公司 用于产生与人类疾病相关的生物制剂和蛋白质的修饰多核苷酸
CA2874716A1 (en) 2012-05-31 2013-12-05 Takeda Pharmaceutical Company Limited Method for assessing endometriosis
FR2993282B1 (fr) 2012-07-13 2017-11-10 Expanscience Lab Procede d'identification de marqueurs moleculaires de la peau d'enfant
CA2892490A1 (en) 2012-11-26 2014-05-30 Caris Science, Inc. Biomarker compositions and methods
EP2931356B1 (en) 2012-12-14 2019-03-06 Mindera Corporation Methods and devices for detection and acquisition of biomarkers
JP5895244B2 (ja) 2014-06-27 2016-03-30 株式会社ライラック研究所 機能性化粧水
JP6650240B2 (ja) 2014-11-25 2020-02-19 花王株式会社 メラニン制御剤の探索方法
WO2016172598A1 (en) * 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes and uses thereof
CN107787370A (zh) * 2015-05-28 2018-03-09 卢西根公司 Rna的分子检测

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012109157A3 (en) * 2011-02-07 2013-11-14 The Governing Council Of The University Of Toronto Bioprobes and methods of use thereof
CN103782174A (zh) * 2011-06-07 2014-05-07 卡里斯生命科学卢森堡控股有限责任公司 用于癌症的循环生物标志物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
《DNA fingerprinting secondary transfer from different skin areas：Morphological and genetic studies》;Silvia Zoppis等;《Forensic Science International：Genetics》;20140731;第11卷;参见全文，特别是摘要、第138页、140页、图3、第142页右栏和第143页左栏 *
《Molecular approaches for forensic cell type identification: On mRNA, miRNA, DNA methylation and microbial markers》;Titia Sijen;《Forensic Science International：Genetics》;20150930;第18卷;全文 *
Silvia Zoppis等.《DNA fingerprinting secondary transfer from different skin areas：Morphological and genetic studies》.《Forensic Science International：Genetics》.2014,第11卷第137-143页. *

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WO2018008319A1 (ja) 2018-01-11
JP6231252B1 (ja) 2017-11-15
JP2022097507A (ja) 2022-06-30
CN113481294B (zh) 2024-03-12
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