CN108698992B - 用于治疗癌症的2-氰基异吲哚啉衍生物 - Google Patents

用于治疗癌症的2-氰基异吲哚啉衍生物 Download PDF

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CN108698992B
CN108698992B CN201780009130.3A CN201780009130A CN108698992B CN 108698992 B CN108698992 B CN 108698992B CN 201780009130 A CN201780009130 A CN 201780009130A CN 108698992 B CN108698992 B CN 108698992B
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carbonitrile
cyano
dihydro
pyrrolo
methyl
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CN108698992A (zh
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K·R·吉布森
A·琼斯
M·I·肯普
A·马丁
M·L·施托克利
G·A·惠特洛克
M·D·伍德罗
K·A·米尼尔
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Mission Therapeutics Ltd
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CN201780009130.3A 2016-03-18 2017-03-17 用于治疗癌症的2-氰基异吲哚啉衍生物 Active CN108698992B (zh)

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GB1604647.6 2016-03-18
GBGB1604647.6A GB201604647D0 (en) 2016-03-18 2016-03-18 Novel compounds
PCT/GB2017/050763 WO2017158388A1 (en) 2016-03-18 2017-03-17 2-cyanoisoindoline derivatives for treating cancer

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US (1) US10683269B2 (cg-RX-API-DMAC7.html)
EP (1) EP3429994B1 (cg-RX-API-DMAC7.html)
JP (1) JP6959250B2 (cg-RX-API-DMAC7.html)
CN (1) CN108698992B (cg-RX-API-DMAC7.html)
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MA (1) MA43746A (cg-RX-API-DMAC7.html)
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Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6708661B2 (ja) 2015-03-30 2020-06-10 ミッション セラピューティクス リミティド Usp30阻害剤としての1−シアノ−ピロリジン化合物
EP3800186B1 (en) 2015-07-14 2024-10-02 Mission Therapeutics Limited Cyanopyrrolidines as dub inhibitors for the treatment of cancer
GB201521109D0 (en) 2015-11-30 2016-01-13 Mission Therapeutics Ltd Novel compounds
GB201522267D0 (en) 2015-12-17 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201522768D0 (en) 2015-12-23 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201602854D0 (en) 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds
GB201603779D0 (en) 2016-03-04 2016-04-20 Mission Therapeutics Ltd Novel compounds
GB201604638D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
JP6959252B2 (ja) 2016-03-24 2021-11-02 ミッション セラピューティクス リミティド Dub阻害剤としての1−シアノピロリジン誘導体
US11014912B2 (en) 2016-09-27 2021-05-25 Mission Therapeutics Limited Cyanopyrrolidine derivatives with activity as inhibitors of USP30
GB201616511D0 (en) 2016-09-29 2016-11-16 Mission Therapeutics Limited Novel compounds
GB201616627D0 (en) * 2016-09-30 2016-11-16 Mission Therapeutics Limited Novel compounds
TWI771327B (zh) 2016-10-05 2022-07-21 英商使命醫療公司 新穎化合物
GB201617758D0 (en) 2016-10-20 2016-12-07 Almac Discovery Limited Pharmaceutical compounds
BR112019019555A2 (pt) 2017-03-30 2020-04-22 Hoffmann La Roche composto de fórmula i, composição farmacêutica, método de inibição de hpk1, método para melhorar uma resposta imune, método para tratar um distúrbio e uso do composto
GB201708652D0 (en) 2017-05-31 2017-07-12 Mission Therapeutics Ltd Novel compounds and uses
EP3642196B1 (en) 2017-06-20 2022-08-17 Mission Therapeutics Limited Substituted cyanopyrrolidines with activity as dub inhibitors
KR102717600B1 (ko) 2017-10-06 2024-10-15 포르마 세라퓨틱스 인크. 유비퀴틴 특이적 펩티다제 30의 억제
CA3098628A1 (en) 2018-05-17 2019-11-21 Forma Therapeutics, Inc. Fused bicyclic compounds useful as ubiquitin-specific peptidase 30 inhibitors
CN112601584A (zh) 2018-07-24 2021-04-02 豪夫迈·罗氏有限公司 异喹啉化合物及其用途
WO2020036940A1 (en) 2018-08-14 2020-02-20 Amgen Inc. N-cyano-7-azanorbornane derivatives and uses thereof
TW202024053A (zh) 2018-10-02 2020-07-01 美商建南德克公司 異喹啉化合物及其用途
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof
PT3860989T (pt) 2018-10-05 2023-06-30 Forma Therapeutics Inc Pirrolinas fundidas que atuam como inibidores da protease 30 específica da ubiquitina (usp30)
CN109321940A (zh) * 2018-11-30 2019-02-12 西南大学 一种酰胺的电化学氧化合成方法及其应用
WO2020132561A1 (en) 2018-12-20 2020-06-25 C4 Therapeutics, Inc. Targeted protein degradation
WO2020139916A1 (en) * 2018-12-26 2020-07-02 Forma Therapeutics, Inc. Inhibiting ubiquitin specific peptidase 9x
GB201905371D0 (en) 2019-04-16 2019-05-29 Mission Therapeutics Ltd Novel compounds
GB201905375D0 (en) 2019-04-16 2019-05-29 Mission Therapeutics Ltd Novel compounds
CN114258392A (zh) * 2019-08-21 2022-03-29 卡尔维斯塔制药有限公司 酶抑制剂
GB201912674D0 (en) 2019-09-04 2019-10-16 Mission Therapeutics Ltd Novel compounds
CN112538083B (zh) * 2019-09-23 2023-04-28 华东师范大学 一类靶向bcl6的芳香环并五元芳杂环类小分子有机化合物及其衍生物及其应用
CN110804041B (zh) * 2019-09-25 2023-03-31 香港科技大学深圳研究院 抗肿瘤的吲哚类化合物的制备方法及吲哚类化合物和应用
WO2021058018A1 (en) * 2019-09-29 2021-04-01 Beigene, Ltd. Inhibitors of kras g12c
CN113135924B (zh) * 2020-01-19 2024-04-26 广东东阳光药业股份有限公司 嘧啶衍生物及其在药物中的应用
GB202001980D0 (en) 2020-02-13 2020-04-01 Almac Discovery Ltd Therapeutic mentods
WO2021204856A1 (en) 2020-04-08 2021-10-14 Mission Therapeutics Limited N-cyanopyrrolidines with activity as usp30 inhibitors
MX2022014429A (es) 2020-05-28 2022-12-07 Mission Therapeutics Ltd N-cianopirrolidinas con actividad como inhibidores de usp30.
US20230303547A1 (en) 2020-06-04 2023-09-28 Mission Therapeutics Limited N-cyanopyrrolidines with activity as usp30 inhibitors
SMT202500343T1 (it) 2020-06-08 2025-11-10 Mission Therapeutics Ltd 1-(5-(2-cianopiridin-4-il)ossazol-2-carbonil)-4-metilesaidropirrolo[3,4-b]pirrol-5(1h)-carbonitrile come inibitore di usp30 per l’uso nel trattamento di disfunzione mitocondriale, cancro e fibrosi
CN114053270B (zh) * 2020-08-05 2023-06-13 兰州大学第二医院 泛素结合酶e2t的小分子抑制剂
GB202016800D0 (en) 2020-10-22 2020-12-09 Mission Therapeutics Ltd Novel compounds
EP4271383A4 (en) * 2020-12-29 2024-10-23 Merck Sharp & Dohme LLC Amido-substituted pyridyl compounds and methods of use thereof for the treatment of herpesviruses
US20240409536A1 (en) * 2021-08-30 2024-12-12 Remix Therapeutics Inc. Compounds and methods for modulating splicing
JP2024544660A (ja) 2021-12-01 2024-12-03 ミッション セラピューティクス リミティド Usp30阻害剤としての活性を有する置換n-シアノピロリジン
CA3240377A1 (en) * 2021-12-08 2023-06-15 Gnanasambandam Kumaravel Bicyclic heteroarenes and methods of their use
GB202200753D0 (en) 2022-01-21 2022-03-09 Almac Discovery Ltd Pharmaceutical compounds
AR128432A1 (es) * 2022-02-02 2024-05-08 The Katholieke Univ Leuven Tetrahidropiridopirimidinas y análogos relacionados para la inhibición de yap / taz-tead
WO2025067111A1 (zh) * 2023-09-27 2025-04-03 苏州必扬医药科技有限公司 一种Menin-MLL相互作用抑制剂及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103261169A (zh) * 2010-09-24 2013-08-21 密歇根大学董事会 脱泛素酶抑制剂及其应用方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360569A (en) 1993-11-12 1994-11-01 Lever Brothers Company, Division Of Conopco, Inc. Activation of bleach precursors with catalytic imine quaternary salts
AU2001256981A1 (en) 2000-04-06 2001-10-23 Axys Pharmaceuticals, Inc. Cathepsin cysteine protease inhibitors
CA2422367C (en) * 2000-09-15 2010-05-18 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
WO2002088079A2 (en) 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
US7105667B2 (en) 2001-05-01 2006-09-12 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
US7521557B2 (en) 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
JP2009535393A (ja) 2006-05-01 2009-10-01 ファイザー・プロダクツ・インク 置換2−アミノ縮合複素環式化合物
CA2827072C (en) 2011-02-25 2019-01-08 Yuhan Corporation Diaminopyrimidine derivatives and processes for the preparation thereof
EP2565186A1 (en) 2011-09-02 2013-03-06 Hybrigenics S.A. Selective and reversible inhibitors of ubiquitin specific protease 7
HK1199249A1 (en) 2011-09-30 2015-06-26 山东轩竹医药科技有限公司 Oxazolidinone antibiotics containing fused ring
US9802904B2 (en) * 2012-12-28 2017-10-31 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof
CN106458914B (zh) 2014-03-28 2020-01-14 常州捷凯医药科技有限公司 作为axl抑制剂的杂环化合物
ES2667793T3 (es) 2014-07-08 2018-05-14 Viiv Healthcare Uk Limited Derivados de isoindolina para su uso en el tratamiento de una infección vírica
GB201416754D0 (en) 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
JP6708661B2 (ja) 2015-03-30 2020-06-10 ミッション セラピューティクス リミティド Usp30阻害剤としての1−シアノ−ピロリジン化合物
EP3800186B1 (en) 2015-07-14 2024-10-02 Mission Therapeutics Limited Cyanopyrrolidines as dub inhibitors for the treatment of cancer
GB201521109D0 (en) 2015-11-30 2016-01-13 Mission Therapeutics Ltd Novel compounds
GB201522267D0 (en) 2015-12-17 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201522768D0 (en) 2015-12-23 2016-02-03 Mission Therapeutics Ltd Novel compounds
GB201602854D0 (en) 2016-02-18 2016-04-06 Mission Therapeutics Ltd Novel compounds
GB201603779D0 (en) 2016-03-04 2016-04-20 Mission Therapeutics Ltd Novel compounds
GB201604638D0 (en) 2016-03-18 2016-05-04 Mission Therapeutics Ltd Novel compounds
JP6959252B2 (ja) 2016-03-24 2021-11-02 ミッション セラピューティクス リミティド Dub阻害剤としての1−シアノピロリジン誘導体
US11014912B2 (en) 2016-09-27 2021-05-25 Mission Therapeutics Limited Cyanopyrrolidine derivatives with activity as inhibitors of USP30
GB201616511D0 (en) 2016-09-29 2016-11-16 Mission Therapeutics Limited Novel compounds
GB201616627D0 (en) 2016-09-30 2016-11-16 Mission Therapeutics Limited Novel compounds
TWI771327B (zh) 2016-10-05 2022-07-21 英商使命醫療公司 新穎化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103261169A (zh) * 2010-09-24 2013-08-21 密歇根大学董事会 脱泛素酶抑制剂及其应用方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Ubiquitin-specific proteases as cancer drug targets;Wolfgang Sippl,等;《Future Oncol》;20111231;第7卷(第5期);619-623 *

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