CN1086728C - 含有抗氧剂的泡腾组合物 - Google Patents
含有抗氧剂的泡腾组合物 Download PDFInfo
- Publication number
- CN1086728C CN1086728C CN95190852A CN95190852A CN1086728C CN 1086728 C CN1086728 C CN 1086728C CN 95190852 A CN95190852 A CN 95190852A CN 95190852 A CN95190852 A CN 95190852A CN 1086728 C CN1086728 C CN 1086728C
- Authority
- CN
- China
- Prior art keywords
- oxidation inhibitor
- weight
- powder
- contain
- vehicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000003078 antioxidant effect Effects 0.000 title abstract description 6
- 239000003963 antioxidant agent Substances 0.000 title abstract description 5
- 239000004604 Blowing Agent Substances 0.000 title abstract 2
- 239000000843 powder Substances 0.000 claims abstract description 49
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 36
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 30
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 22
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 18
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 18
- 230000003472 neutralizing effect Effects 0.000 claims abstract description 15
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 15
- 230000003647 oxidation Effects 0.000 claims description 65
- 238000007254 oxidation reaction Methods 0.000 claims description 65
- 239000003112 inhibitor Substances 0.000 claims description 58
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 18
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 15
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 14
- 235000005487 catechin Nutrition 0.000 claims description 14
- 229950001002 cianidanol Drugs 0.000 claims description 14
- 235000017550 sodium carbonate Nutrition 0.000 claims description 14
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 13
- 150000001720 carbohydrates Chemical class 0.000 claims description 13
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims description 12
- 150000001746 carotenes Chemical class 0.000 claims description 12
- 235000005473 carotenes Nutrition 0.000 claims description 12
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 10
- 229930003427 Vitamin E Natural products 0.000 claims description 9
- 235000019165 vitamin E Nutrition 0.000 claims description 9
- 239000011709 vitamin E Substances 0.000 claims description 9
- 229940046009 vitamin E Drugs 0.000 claims description 9
- 239000002075 main ingredient Substances 0.000 claims description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 6
- 239000000600 sorbitol Substances 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- 125000003071 maltose group Chemical group 0.000 claims description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- 229940095064 tartrate Drugs 0.000 claims description 2
- 235000018927 edible plant Nutrition 0.000 claims 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 description 24
- 239000000203 mixture Substances 0.000 description 18
- 235000014633 carbohydrates Nutrition 0.000 description 11
- 239000000463 material Substances 0.000 description 11
- 235000013734 beta-carotene Nutrition 0.000 description 10
- 239000011648 beta-carotene Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 9
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 9
- 239000003921 oil Substances 0.000 description 9
- 235000019198 oils Nutrition 0.000 description 9
- 239000003981 vehicle Substances 0.000 description 9
- 229960002747 betacarotene Drugs 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 7
- 235000021552 granulated sugar Nutrition 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 7
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 239000000654 additive Substances 0.000 description 5
- -1 catechin gallic acid ester Chemical class 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000003925 fat Substances 0.000 description 5
- 244000215068 Acacia senegal Species 0.000 description 4
- 229920000084 Gum arabic Polymers 0.000 description 4
- 235000010489 acacia gum Nutrition 0.000 description 4
- 230000000996 additive effect Effects 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000049 pigment Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229930091371 Fructose Natural products 0.000 description 3
- 239000005715 Fructose Substances 0.000 description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 description 3
- 239000000205 acacia gum Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 2
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- ANVAOWXLWRTKGA-XHGAXZNDSA-N all-trans-alpha-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-XHGAXZNDSA-N 0.000 description 2
- WGVKWNUPNGFDFJ-DQCZWYHMSA-N beta-Tocopherol Natural products OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C WGVKWNUPNGFDFJ-DQCZWYHMSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000008121 dextrose Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000005562 fading Methods 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 235000015320 potassium carbonate Nutrition 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 229960004793 sucrose Drugs 0.000 description 2
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 2
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 1
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- IPDWABJNXLNLRA-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)C(O)C(O)C(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IPDWABJNXLNLRA-UHFFFAOYSA-N 0.000 description 1
- HRQKOYFGHJYEFS-UHFFFAOYSA-N Beta psi-carotene Chemical compound CC(C)=CCCC(C)=CC=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C HRQKOYFGHJYEFS-UHFFFAOYSA-N 0.000 description 1
- 102000004954 Biglycan Human genes 0.000 description 1
- 108090001138 Biglycan Proteins 0.000 description 1
- IPDWABJNXLNLRA-LREBCSMRSA-N C(CC(O)(C(=O)O)CC(=O)O)(=O)O.C([C@H](O)[C@@H](O)C(=O)O)(=O)O Chemical compound C(CC(O)(C(=O)O)CC(=O)O)(=O)O.C([C@H](O)[C@@H](O)C(=O)O)(=O)O IPDWABJNXLNLRA-LREBCSMRSA-N 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 235000003903 alpha-carotene Nutrition 0.000 description 1
- 239000011795 alpha-carotene Substances 0.000 description 1
- ANVAOWXLWRTKGA-HLLMEWEMSA-N alpha-carotene Natural products C(=C\C=C\C=C(/C=C/C=C(\C=C\C=1C(C)(C)CCCC=1C)/C)\C)(\C=C\C=C(/C=C/[C@H]1C(C)=CCCC1(C)C)\C)/C ANVAOWXLWRTKGA-HLLMEWEMSA-N 0.000 description 1
- LNTHITQWFMADLM-UHFFFAOYSA-N anhydrous gallic acid Natural products OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000010389 delta-tocopherol Nutrition 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 235000000633 gamma-carotene Nutrition 0.000 description 1
- 239000011663 gamma-carotene Substances 0.000 description 1
- HRQKOYFGHJYEFS-RZWPOVEWSA-N gamma-carotene Natural products C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C=1C(C)(C)CCCC=1C)\C)/C)\C)(\C=C\C=C(/CC/C=C(\C)/C)\C)/C HRQKOYFGHJYEFS-RZWPOVEWSA-N 0.000 description 1
- 235000010382 gamma-tocopherol Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000010525 oxidative degradation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940059574 pentaerithrityl Drugs 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/02—Anti-oxidant compositions; Compositions inhibiting chemical change containing inorganic compounds
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/34—Anti-oxidant compositions; Compositions inhibiting chemical change containing plant or animal materials of unknown composition
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/42—Preservation of non-alcoholic beverages
- A23L2/44—Preservation of non-alcoholic beverages by adding preservatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/358—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
本发明提供一种含有抗氧剂的泡腾组合物,其主要组分包括:0.05-15%(重量)的含抗氧剂粉末,10-35%(重量)碳酸氢钠和/或碳酸钠,10-70%(重量)中和剂和30-55%(重量)赋形剂。本发明的含有抗氧剂的泡腾组合物能稳定地含有抗氧剂,且其溶解性优异。
Description
技术领域
本发明涉及一种含有抗氧剂的泡腾组合物。
先有技术
现已知道抗氧剂如胡萝卜素、维生素E、儿茶素等,当与体内产生自由基结合时显示出稳定自由基的活性,它能终止体内自由的链锁反应(自由基清除剂活性),并能抑制构成有机体的蛋白质等的分解代谢(抗氧化活性),从而防止致癌作用(抗癌活性)。最近,据报导,抗氧剂还具有防止晒斑由于暴露于紫外光而演变的活性以及免疫增强活性。从目前与保健食品有关的发展趋向来看,现在人们的注意力已集中用于食品和药品的抗氧剂上。
然而,由于其溶解性及对空气(氧)、光和热等的稳定性的原因,很难将抗氧剂配入泡腾制剂中。
本发明的一个目的是提供一种能均匀地、稳定地含有所述抗氧剂、且其溶解性优异的新型制剂、特别是新型泡腾制剂。
发明的公开
本发明的发明人进行广泛的研究,并发现上述目的可以通过一种含有下述特定的含抗氧剂粉末的泡腾组合物来实现。本发明就是根据这一新发现而完成的。
按照本发明,提供了一种含有抗氧剂的泡腾组合物,其主要组分包括:
0.05-15%(重量)(以下简称为%)含有0.2-20%(以含抗氧剂粉末为基准计)抗氧剂(脂溶性物质)的一种含抗氧剂粉末或儿茶素[含有至少10%(以含儿茶素粉末为基准计)水溶性抗氧剂的一种含儿茶素粉末],
10-35% 碳酸氢钠和/或碳酸钠
10-70% 中和剂,和
30-55% 赋形剂。
按照本发明,还提供了如下所述的含有抗氧剂的泡腾组合物,其主要组分包括:0.1-5.0%含有0.5-10%(以含抗氧剂粉末为基准计)抗氧剂(脂溶性物质)的一种含抗氧剂粉末,20-30%碳酸氢钠和/或碳酸钠,10-40%中和剂和30-55%赋形剂;如下所述的含有抗氧剂的泡腾组合物,其中中和剂选自苹果酸、酒石酸、柠檬酸和抗坏血酸;如下所述的含有抗氧剂的泡腾组合物,其中赋形剂是一种选自麦芽糖醇、山梨糖醇和麦芽糖的碳水化合物;以及如下所述的含抗氧剂的泡腾组合物,其中所述抗氧剂是至少一种选自胡萝卜素、维生素E和儿茶素的抗氧剂。
本发明的含有抗氧剂的泡腾组合物的特点是:该组合物能令人满意地防止抗氧剂由于氧化而产生的降解,并显示出甚至在冷水中的高溶解度。
下面将更详细地说明本发明的组合物。作为所述泡腾组合物主要组分之一的含有抗氧剂粉末包括例如含有胡萝卜素、维生素E、儿茶素等作为抗氧剂的粉末。胡萝卜素是维生素A的前体,具有前维生素A活性。可用的胡萝卜素包括α-、β-和γ-胡萝卜素。维生素E可以是α-、β-、γ-和δ-维生素E中任何一种。所述这些胡萝卜素和维生素E的品种,无论是天然的还是合成的,都可以有利地用来实施本发明。儿茶素的典型例子是表格儿茶素棓酸酯(EGCg)、表儿茶素棓酸酯(ECg)、表棓儿茶素(EGC)和表儿茶素(EC),例如茶多酚、苹果多酚等。
在含抗氧剂粉末中,含胡萝卜素、维生素E或类脂溶性物质的粉末包括例如含有包含溶解在适当脂或油中的所述抗氧剂和一种用于形成颗料的适当基料(赋形剂),或用于促进溶解作用的乳化剂等的基体的那些粉末。可用的脂和油的例子包括通常的脂类和油类,例如玉米油、花生油、芳香油及类似的植物脂类和油类。用于形成颗粒的基料(赋形剂)的例子包括常用的材料例如糖类如乳糖、阿拉伯胶、糊精等;也能起乳化剂作用的多糖如阿拉伯胶、酪蛋白等;和蛋白质。可用的乳化剂的例子是卵磷脂、脂肪酸甘油酯、脂肪酸蔗糖酯、硬脂酰乳酸钙、脂肪酸脱水山梨醇酯、脂肪酸丙二醇酯等。用于本发明的含有抗氧剂粉末可以含有用于抑制该粉末中胡萝卜素或类似的抗氧剂氧化的氧化抑制剂,如L-抗坏血酸与棕榈酸形成的酯、维生素C、酶催改性的芸香苷等。粉末中加入这类氧化抑制剂是所希望的。
含抗氧剂粉末的基体可用传统方法来形成,如用喷雾干燥以制得具有任选粒度的所需粉末。
在含抗氧剂粉末中,含儿茶素或类似的水溶性抗氧剂的粉末很容易制备,例如只要用热水或醇来萃取该抗氧剂,并将萃取液浓缩,然后用传统方法,如用喷雾干燥将所得浓缩物制成颗粒即可。
本发明组合物中含抗氧剂粉末的比例范围是0.05-15%,较好是0.1-5.0%。粉末中抗氧剂(脂溶性物质)的比例是0.2-20%,较好是0.5-10%。这就表示,其余的99.8-80%是由脂和油、用于形成颗粒的基料或乳化剂,以及任选地与这些组分一起添加的氧化抑制剂构成的。当粉末中加入氧化抑制剂时,其用量比例较好为该含抗氧剂粉末重量的约0.5-20%。粉末中儿茶素或类似的水溶性抗氧剂的比例是至少10%。
用于本发明的其它主要组分是作为泡腾组分的特定量的碳酸氢钠和/或碳酸钠和中和剂的组合,以及碳水化合物。这里所用的“中和剂”这一术语是指能中和碳酸氢钠和/或碳酸钠,从而产生二氧化碳的一种酸性化合物。这类酸性化合物的典型例子包括L-酒石酸、柠檬酸、乳酸、d1-苹果酸、富马酸、L-抗坏血酸等。其中d1-苹果酸为优选。
本发明组合物中泡腾组分的比例如下:碳酸氢钠和/或碳酸钠的比例选择在10-35%,较好20-30%的范围,中和剂的比例选择在10-70%,较好10-40%的范围。具体说,碳酸氢钠的合适比例是10-35%,优选20-30%,碳酸钠的合适比例是11-31%,优选20-26%。最理想的是单独使用碳酸氢钠,其比例选择在20-25%的范围。中和剂的用量较好至少与碳酸氢钠等当量。由于存在泡腾组分,本发明的预期明显效果是可以达到的。
更具体说,泡腾组分的存在使得本发明的组合物极易溶于水中。一个进一步的优点是该组合物的水溶液显示出良好的味道。但是,如果碳酸氢钠和中和剂的用量的比例超出所规定的范围,则将不利地变得难以制备成形性能及味道都令人满意的最终产品。
呈通常粉末形式的泡腾组分可用于本发明。颗粒的粒子尺寸(粒子直径、尺寸等)没有具体的限制,但较好是,其尺寸范围在制造预期的药片时不会破坏含抗氧剂粉末的基体。换言之,如果使用高结晶度的颗粒,则在制片时含抗氧剂粉末的基体会被破坏,因此当抗氧剂暴露于空气、光、热等时就很可能会分解,从而损失掉。在这种情况下,泡腾组分对所述基体的破坏程度取决于各泡腾组分的固有性质和结晶度。本发明人的研究发现了如下问题。当用有机酸作中和剂时,使用前必须将大晶粒的酸粉碎或磨碎。具体说,当使用苹果酸时,最好是使用平均晶粒尺寸为250-350微米的苹果酸,这种粒度无需粉碎就可使用。当作为赋形剂使用时,大晶粒的砂糖或类似物是不希望的。较好是使用与所述中和剂情况相同的碳水化合物或和类似的粉碎的和小颗粒化物质。
粒度为100-150微米的碳酸氢钠和/或碳酸钠通常是比较好的。对于用作赋形剂,该碳水化合物可以是任何一种常用的糖类,如葡萄糖、果糖和类似的单糖,麦芽糖、蔗糖和类似的二聚糖,木糖醇、山梨糖醇、麦芽糖醇、甘露糖醇、季戊四醇和类似的糖醇等。在这些糖类中,麦芽糖醇、山梨糖醇和麦芽糖是优选的。这些赋形剂的粒度可以和可得到的粉状或颗粒状晶体一样,一般为约180-350微米,但没有具体限制。
这里使用的含抗氧剂粉末、泡腾组分和赋形剂的比例基本上从上面规定的范围选定。这样就可得到能达到本发明预期结果的泡腾组合物。另一方面,含抗氧剂粉末的比例低于所述范围时,将导致所得组合物失去商业价值的缺点,而含抗氧剂粉末的比例高于所述范围时,将导致药片重量增加和溶解性变差的缺点。
主要含有所述预定量特定成分的本发明的泡腾组合物可以含有传统的添加剂。可用的添加剂包括,例如增稠剂、表面活性剂(乳化剂)、渗透压 调节剂、电解质、甜味剂、香味增强剂、颜料、pH调节剂等。添加剂的比例是任选的,其选择范围通常是能产生各添加剂固有效果又不会对本发明的预期结果产生不利影响的范围。
本发明的泡腾组合物可通过传统方法用所述基本组分和任选添加剂制备。一种较好的制备方法是干法低压制片工艺,该工艺包括称取各组分,将这些组分混合物以及在较低的压力下将该混合物成形为片剂。片剂成形压力太高时,将会使含抗氧剂粉末的基体破裂,从而使该抗氧剂容易氧化,而太低的压力则会使片剂的性能变差。因此,可使用的压力选自一个适当的范围。该压力通常选自约0.2-0.35顿/厘米2,较好约0.24-0.31顿/厘米2。值得推荐的是在所述范围内的压力可导致硬度约4.0-6.6KP,较好约4.5-5.9KP的片剂。片剂的硬度用压力表示,即用一台Schleuniger药片硬度仪,型号4M(Schleuniger-4M)以特定的载荷速度(1.0毫米/秒)对药片两边加压,直至药片破裂时的压力。
实施本发明的最佳模式
下面给出更详细说明本发明的实例。实例中的份数和百分数均指重量。
实例1
砂糖 2,000mg
dl-苹果酸(平均粒度为250-350μm) 1,000mg
L-抗坏血酸 500mg
碳酸氢钠 1,000mg
β-胡萝卜素粉末 50mg
(含4%β-胡萝卜素)
甜味剂 适量
香味增强剂 适量
总量 4,800mg
β-胡萝卜素粉末的制备方法如下:从4份溶于32份植物脂肪和油的β-胡萝卜素、2份L-抗坏血酸、2份生育粉提取物、0.9份茶提取物(含茶多酚)、0.1份L-抗坏血酸与棕榈酸形成的酯和58份作为基料的阿拉伯胶(糖类)制成基质。
将上述各成分混合在一起,然后在0.26顿/厘米2的压力下将混合物制成本发明的片剂。
如此制得的药片其硬度为5.1KP,溶解时间为1分钟10秒,稳定性良好(在50℃储存2周后进行加速试验,结果表明残留的β-胡萝卜素的比例为90%或略高些)。
药片硬度按上述方法测定,测定溶解时间时将药片溶解在140毫升冷水(8℃)中。β-胡萝卜素的稳定性用如下方法评估。用环已烷萃取药片中所含的β-胡萝卜素,用吸光计(Hitachi U-3000)测量提取液中胡萝卜素的吸收波长(450nm)。结果用随时间而变化的残留胡萝卜素量与刚生产后马上测定所得到测量值之比表示。该比值越高,说明由于氧化降解而损失的胡萝卜素就越少。也可进行其他稳定性试验项目,这些试验选自包装材料的溶胀试验(用肉眼检查)、药片褪色试验(用Tokyo Denshoku公司生产的色差计,ColorAce型号TC-1)以及味道变化试验(通过功能试验)。
该包装材料在50℃储存2周后未显示出溶胀现象。药片显示出褪色值ΔE<3,味道变化在允许的范围内。
实例2-7
按照本发明由下面表1所列组分制备泡腾药片(表中各数值的单位是毫克)。
表1
实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | |
β-胡萝卜素维生素E茶多酚提取物 | 2 | 5 | 5 | 10 | 10 | 30 |
苹果酸酒石酸柠檬酸L-抗坏血酸 | 800100 | 300300300500 | 1,000100 | 500300200 | 1,000 | 1,000 |
碳酸氢钠碳酸钠 | 900 | 1,000 | 500500 | 1,000 | 1,000 | 700200 |
Frost sugar(霜糖) | 2,000 | 2,300 | 2,000 | 2,500 | 2,000 | 2,200 |
植物脂肪和油 | 10 | 10 | 20 | 15 | 10 | 0 |
阿拉伯胶 | 20 | 25 | 15 | 10 | 10 | 12 |
甜味剂香味增强剂其它成分 | 适量适量适量 | 适量适量适量 | 适量适量适量 | 适量适量适量 | 适量适量适量 | 适量适量适量 |
合计(每片) | 4,500 | 5,200 | 4,600 | 5,500 | 4,600 | 4,800 |
实例8-20
按照本发明由下面表2和表3所列组分制备泡腾药片(表2和表3中各数值为重量%)。
表2
实例号 | |||||||
8 | 9 | 10 | 11 | 12 | 13 | 14 | |
砂糖霜糖(Frost sugar)葡萄糖果糖 | -42-- | -42-- | -42-- | -42-- | -41-- | -41-- | -4 2-- |
L-抗坏血酸L-酒石酸(颗粒)柠檬酸(颗粒)dl-苹果酸 | 10--21 | 10--21 | 10--21 | 10--21 | 1025-- | 10-25- | --30- |
甜味剂 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 |
碳酸氢钠碳酸钠 | 21- | 21- | 21- | 21- | 20- | 20- | 21- |
β-胡萝卜素粉末 | 1.1 | 2.2 | 0.5 | 0.7 | 1.0 | 1.0 | 1.1 |
香味增强剂/颜料 | 微量 | 微量 | 微量 | 微量 | 微量 | 微量 | 微量 |
碳酸钾 | - | - | - | - | - | - | - |
重量(克/片) | 4.8 | 4.8 | 4.8 | 4.8 | 5.1 | 5.1 | 4.8 |
β-胡萝卜素含量(毫克/片) | 2 | 4 | 1 | 3 | 2 | 2 | 2 |
表3
实例号 | ||||||
15 | 16 | 17 | 18 | 19 | 20 | |
砂糖霜糖(Frost sugar)葡萄糖果糖 | -36-- | -42-- | -42-- | 42--- | --42- | ---42 |
L-抗坏血酸L-酒石酸(颗粒)柠檬酸(颗粒)dl-苹果酸 | 8--31 | 10--22 | 10--21 | 10--21 | 10--21 | 10--21 |
甜味剂 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 |
碳酸氢钠碳酸钠 | 21- | 174 | 21- | 21- | 21- | 21- |
β-胡萝卜素粉末 | 0.9 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 |
香味增强剂/颜料 | 微量 | 微量 | 微量 | 微量 | 微量 | 微量 |
碳酸钾 | - | - | - | - | - | - |
重量(克/片) | 5.8 | 5.0 | 5.0 | 4.8 | 4.8 | 4.8 |
β-胡萝卜素含量(毫克/片) | 2 | 2 | 2 | 2 | 2 | 2 |
实例21-26
按照本发明由下面表4所列组分制备泡腾药片(表中数值为重量%)。
表4
实例号 | ||||||
21 | 22 | 23 | 24 | 25 | 26 | |
砂糖麦芽糖醇山梨糖醇麦芽糖 | 2018-- | 2018-- | 316-- | 351-- | 20-18- | 20--18 |
L-抗坏血酸L-酒石酸柠檬酸 | 1020- | 10-20 | 1020- | 1021- | 1020- | 1020- |
甜味剂 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 |
碳酸氢钠碳酸钠 | 20- | 20- | 20- | 182 | 20- | 20- |
β-胡萝卜素粉末 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 | 1.1 |
香味增强剂/颜料 | 微量 | 微量 | 微量 | 微量 | 微量 | 微量 |
重量(克/片) | 5.1 | 5.1 | 5.1 | 5.1 | 5.1 | 5.1 |
β-胡萝卜素含量(毫克/片) | 2 | 2 | 2 | 2 | 2 | 2 |
按照本发明用与实例21相同的方法制备泡腾药片,所不同的是改变作为碳水化合物的砂糖和麦芽糖醇的比例,制片时改变压力直至药片的硬度数值相同为止。
就各种药片而言,测定其制片压力和溶解时间。
测定结果连同所用碳水化合物的用量一起列于下面表5中。
表5
样品序 | 所用碳水化合物 | 制片压力(顿/25毫米φ) | 溶解时间 | |
砂糖 | 麦芽糖醇 | |||
1 | 1,900毫克 | 0 | 3.9 | 2分10秒 |
2 | 1,600毫克 | 300毫克 | 3.0 | 2分0秒 |
3 | 1,300毫克 | 600毫克 | 2.0 | 1分44秒 |
4 | 1,000毫克 | 900毫克 | 1.6 | 1分27秒 |
表5说明,麦芽糖醇的用量越大,制片压力就可越低,而且溶解所需时间也越短。
本发明工业应用的可能性
按照本发明,提供了一种崭新的组合物,这种组合物能稳定地含有抗氧剂、具有高的药片硬度,而且溶解时间短。本发明的组合物可用于食品领域和药物领域。
Claims (6)
1.一种含有抗氧剂的泡腾组合物,其主要组分包括:
0.05-15%重量的一种含抗氧剂粉末,以含抗氧剂粉末为基准计,其含有0.2-20%重量的抗氧剂,其中所述抗氧剂是选自由胡萝卜素、维生素E和儿茶素组成的这一组中的至少一种。
10-35%重量的碳酸氢钠和/或碳酸钠,
10-70%重量的中和剂,和
30-55%重量的赋形剂。
2.按照权利要求1的含抗氧剂泡腾组合物,其主要组分包括:
0.1-5.0%重量的一种含抗氧剂粉末,以含抗氧剂粉末为基准计,其含有0.5-10%重量的抗氧剂,
20-30%重量的碳酸氢钠和/或碳酸钠,
10-40%重量的中和剂,和
30-55%重量的赋形剂。
3.按照权利要求1或2的含抗氧剂泡腾组合物,其中中和剂选自苹果酸、酒石酸、柠檬酸和抗坏血酸。
4.按照权利要求1或2的含抗氧剂泡腾组合物,其中赋形剂是一种选自麦芽糖醇、山梨糖醇和麦芽糖的碳水化合物。
5.一种含有儿荼素的泡腾组合物,其主要组分包括:
0.05-15%重量的含儿茶素粉末,以含儿茶素粉末为基准计,其含至少10%重量的儿茶素,
10-35%重量的碳酸氢钠和/或碳酸钠,
10-70%重量的中和剂,和
30-55%重量的赋形剂。
6.按照权利要求3的含抗氧剂泡腾组合物,其中赋形剂是一种选自麦芽糖醇、山梨糖醇和麦芽糖的碳水化合物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP16378794 | 1994-07-15 | ||
JP163787/94 | 1994-07-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1135232A CN1135232A (zh) | 1996-11-06 |
CN1086728C true CN1086728C (zh) | 2002-06-26 |
Family
ID=15780706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95190852A Expired - Fee Related CN1086728C (zh) | 1994-07-15 | 1995-07-12 | 含有抗氧剂的泡腾组合物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5919483A (zh) |
EP (1) | EP0724004A4 (zh) |
JP (1) | JP3548865B2 (zh) |
KR (1) | KR100361389B1 (zh) |
CN (1) | CN1086728C (zh) |
AU (1) | AU689921B2 (zh) |
CA (1) | CA2171612C (zh) |
TW (1) | TW367357B (zh) |
WO (1) | WO1996002609A1 (zh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2204599A1 (en) * | 1995-09-07 | 1997-03-13 | Otsuka Pharmaceutical Co., Ltd. | Low-pressure tableted effervescent preparation |
US6660049B1 (en) | 1996-07-31 | 2003-12-09 | Natural Soda Aala, Inc. | Process for control of crystallization of inorganics from aqueous solutions |
US6589555B2 (en) | 1999-12-29 | 2003-07-08 | Mahendra Pandya | Effervescent vitaceutical compositions and related methods |
KR100456578B1 (ko) * | 2001-11-30 | 2004-11-10 | 박희재 | 동력조향장치용 입력축 검사기 및 그 검사방법 |
US7125859B2 (en) * | 2003-07-24 | 2006-10-24 | Materials Evolution And Development Usa, Inc. | Nucleic acid antioxidant compositions, methods for obtaining such compositions and formulations thereof |
US7785640B2 (en) * | 2004-01-16 | 2010-08-31 | Amerilab Technologies, Inc. | Effervescent composition including cranberry extract |
US20080044540A1 (en) * | 2004-03-19 | 2008-02-21 | Hirotsugu Kido | Anti-Degradation Agent |
US20060039972A1 (en) * | 2004-08-19 | 2006-02-23 | Mary Aldritt | Effervescent composition including a grape-derived component |
JP2007254339A (ja) * | 2006-03-22 | 2007-10-04 | Takasago Internatl Corp | ロックイン型粉末 |
KR100801891B1 (ko) | 2006-11-02 | 2008-02-12 | 한상진 | 천연물질을 이용한 생식기 염증 예방 또는 치료용 약제학적 조성물 |
EP2213304A1 (en) * | 2007-10-03 | 2010-08-04 | ASAHI BREWERIES, Ltd. | Granule, tablet, and their production methods |
US9474292B1 (en) | 2010-09-16 | 2016-10-25 | EvoSci Biotech LLC | Nutritional powder including brewer's yeast, aronia extract, and cranberry extract for animals |
JP6785083B2 (ja) * | 2016-07-29 | 2020-11-18 | ミヨシ油脂株式会社 | 抗酸化剤、抗酸化剤を含有する油脂組成物およびこれを含有する油性食品 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6051104A (ja) * | 1983-08-30 | 1985-03-22 | Ajinomoto Co Inc | ビタミンe含有水性液剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2083997A (en) * | 1980-09-16 | 1982-04-07 | Bp Nutrition | Animal feed supplement |
JPS59166585A (ja) * | 1983-03-10 | 1984-09-19 | Osaka Chem Lab | 抗酸化剤 |
DE3517916A1 (de) * | 1985-05-18 | 1986-11-20 | Krüger GmbH & Co KG, 5060 Bergisch Gladbach | Vitamin-e-brausetabletten |
-
1995
- 1995-07-12 JP JP50487796A patent/JP3548865B2/ja not_active Expired - Fee Related
- 1995-07-12 KR KR1019960701330A patent/KR100361389B1/ko not_active IP Right Cessation
- 1995-07-12 EP EP95925102A patent/EP0724004A4/en not_active Withdrawn
- 1995-07-12 CA CA002171612A patent/CA2171612C/en not_active Expired - Fee Related
- 1995-07-12 CN CN95190852A patent/CN1086728C/zh not_active Expired - Fee Related
- 1995-07-12 WO PCT/JP1995/001380 patent/WO1996002609A1/ja not_active Application Discontinuation
- 1995-07-12 AU AU29357/95A patent/AU689921B2/en not_active Ceased
- 1995-07-12 US US08/617,841 patent/US5919483A/en not_active Expired - Fee Related
- 1995-07-14 TW TW084107309A patent/TW367357B/zh active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6051104A (ja) * | 1983-08-30 | 1985-03-22 | Ajinomoto Co Inc | ビタミンe含有水性液剤 |
Also Published As
Publication number | Publication date |
---|---|
AU689921B2 (en) | 1998-04-09 |
CA2171612C (en) | 2005-02-01 |
EP0724004A4 (en) | 1996-12-27 |
AU2935795A (en) | 1996-02-16 |
KR960704994A (ko) | 1996-10-09 |
WO1996002609A1 (fr) | 1996-02-01 |
CA2171612A1 (en) | 1996-02-01 |
TW367357B (en) | 1999-08-21 |
EP0724004A1 (en) | 1996-07-31 |
US5919483A (en) | 1999-07-06 |
KR100361389B1 (ko) | 2003-01-24 |
JP3548865B2 (ja) | 2004-07-28 |
CN1135232A (zh) | 1996-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1086728C (zh) | 含有抗氧剂的泡腾组合物 | |
US6814958B1 (en) | Food compositions, compositions for oral cavity and medicinal compositions for preventing or treating periodontosis and method for preventing or treating periodontosis | |
Goulas et al. | Dynamic changes in targeted phenolic compounds and antioxidant potency of carob fruit (Ceratonia siliqua L.) products during in vitro digestion | |
AU677048B2 (en) | Formulations containing carotenoids and procarotenoids combined with polyphenols in the prevention of the damages due to an abnormal production of free radicals | |
CA2628977C (en) | Composition for regulating intestinal disorders comprising selenium, prebiotics, phosphatides and flavonols, and methos of use thereof | |
EP2146708B1 (fr) | Composition a activité lipolytique, son procédé d'obtention et utilisation de la composition. | |
US10213376B2 (en) | Method of suppressing coloration of catechins and a dentifrice composition | |
EP0925068B1 (en) | Use of a pharmaceutical composition containing polyphenols from grapes or from wine, in particular resveratrol, and yeast extracts | |
US20040171694A1 (en) | Dietetic preparation and use of an alpha-hydroxy carboxylic acid(citric acid for the treatment of obesity | |
EP2079460B1 (fr) | Utilisation cosmetique par voie orale de la glucosamine eventuellement associee a au moins un compose polyphenol | |
KR20080052617A (ko) | 폴리페놀을 함유하는 신규 조성물 | |
KR20200034789A (ko) | 수중유형 유화 조성물과, 이것을 포함하는 식품 및 음료 | |
CN1167436A (zh) | 低压泡滕片剂 | |
US10201582B2 (en) | Compositions and methods for alleviating hyposalivation and for providing oral comfort | |
CN111511362A (zh) | 口腔组合物及使用方法 | |
KR20150115448A (ko) | 커큐민을 함유하는 숙취해소용 제제 | |
JP2009050196A (ja) | 食品組成物 | |
CA3164697A1 (en) | A cannaboside composition and method to produce | |
KR100690071B1 (ko) | 숙취 예방 및 개선용 기능성 조성물 | |
US20240058474A1 (en) | Cannabinoid emulsions and complexes and related methods of manufacture | |
JP2008214245A (ja) | アルドース還元酵素阻害剤およびその製造方法 | |
JP5725663B2 (ja) | 酵素阻害剤 | |
KR102401997B1 (ko) | 아로니아 주스의 제조방법 | |
KR100504021B1 (ko) | 난용성 약물의 고체분산체 및 이를 함유하는 경구용 항진균제 조성물 | |
CA3236483A1 (en) | Water dispersible botanical compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20020626 Termination date: 20110712 |