CN108653422A - A kind of Chinese herbal and crude drugs preparations and preparation method thereof for treating grice diarrhoea - Google Patents
A kind of Chinese herbal and crude drugs preparations and preparation method thereof for treating grice diarrhoea Download PDFInfo
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- CN108653422A CN108653422A CN201810425463.0A CN201810425463A CN108653422A CN 108653422 A CN108653422 A CN 108653422A CN 201810425463 A CN201810425463 A CN 201810425463A CN 108653422 A CN108653422 A CN 108653422A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
The present invention discloses a kind of Chinese herbal and crude drugs preparations and preparation method thereof for treating grice diarrhoea, belongs to field of animal.The Chinese herbal and crude drugs preparations are made of 15 30 parts of 25 40 parts of garden burnet root, 20 35 parts of puberulous glochidion branchlet and leaf, 0.5 2.0 parts of shikimic acid powder and table sugar.Preparation method is to mix decocting liquid by garden burnet root and Glochidion puberum after decocting twice, after adding shikimic acid powder and table sugar mixing, is fully dissolved to obtain the final product.Inventive formulation is reasonable, and preparation method is simple, safe without toxic side effect, and drug residue free has no drug resistance, and bioavilability is high, has notable curative effect to viral and bacteroidal piglet diarrhoea.
Description
Technical field
The present invention relates to field of animal, and in particular to a kind of Chinese herbal and crude drugs preparations that treating grice diarrhoea and its preparation side
Method.
Background technology
Grice diarrhoea have become influence piglet survival ratio a key factor, the piglet being especially just born, once
Diarrhea occurs, the death rate is up to 60-90%, seriously affects the economic benefit of China's pig breeding industry.Grice diarrhoea mainly has viral
Diarrhea and bacterial diarrhea, virus diarrhea are mainly that the absorption of cell death influence intestines is caused with virus attack intestinal villus cell
Function and generate diarrhea.Currently, having been proven to cause the virus of grice diarrhoea to have：Infectious gastroenteritis virus, colyliform disease
Poison, Porcine epidemic diarrhea virus, pig circular ring virus, pig enterovirus, library cloth virus, bocavirus etc..Transmissible gastroenteritis disease
Poison and epidemic diarrhea virus are to pig all easy infections at various ages and kind, wherein the lethality of piglet below 2 week old is reachable
100%；Rotavirus is to 10-60 age in days piglet easy infections, using apocleisis, diarrhea, vomiting, water sample or paste excrement as main feature,
Severe patient's dehydration is even dead；Bocavirus is newfound virus in 2009, can cause host's abdomen through studying bocavirus
It rushes down, has correlation with the diarrhea epidemic situation of pig in 2010.After bacterial diarrhea is primarily due to pathogen contamination, natural environment and climate changes
Change causes, harm it is serious have Escherichia coli, salmonella, clostridieum welchii, Shigella etc., especially Escherichia coli caused by
Piglet yellow-white dysentery influences pig farm very big, death rate height.Single virus, bacterium or mixed infection can be directly or indirectly
Cause grice diarrhoea, once diarrhea occurs for piglet, growth retardation or even downgrowth, severe patient can be caused to cause death, to supporting
Pig industry can cause heavy economic losses.
Virus diarrhea almost has generation in global pig-raising countries.Currently, there is no effectively treatment piglet virus diarrhea
Drug, the effective ways for preventing the disease be reinforce feeding management and effective vaccine inoculation.However, at present to the viral abdomen of piglet
Rush down vaccine control measure that there is no special efficacy, ideal.The antigenicity of inactivated vaccine is not high, needs additionally to add adjuvant.And Li Bawei
The various antiviral drugs such as woods, amantadine are forbidden to use by Ministry of Agriculture's explicit order.The treatment of bacterial diarrhea is due to pathogen
Drug resistance easily is generated to antibiotic, therapeutic effect is not notable, and the yellowish-white dysentery on pig farm is difficult to control.
Chinese herbal medicine is China's tradition the most and naturally occurring medicinal material, and source resource is extremely abundant, price is relatively low
It is honest and clean, containing there are many natural chemical compositions and nutritional ingredient, such as tannin, saponin, alkaloid, organic acid, vitamin, mineral
Matter, trace element etc., these ingredients are in addition to antibacterial, antiviral, anti-inflammatory, convergent effect, additionally it is possible to improve immunity function,
The drawbacks of improving production performance, extra-nutrition etc., but also drug resistance generated without western medicine antibiotics, therefore, in livestock and poultry disease
It is with a wide range of applications in the prevention and treatment of disease.In the case where current swinery epidemic disease is mostly that mixed infection is multiple, make
With the invasion and sprawling of the Chinese medicine treatment, control cause of disease that have no adverse reaction, there is certain advantage, and Chinese herbal and crude drugs preparations are in swinery
In be rarely reported for treating or preventing diarrhea.
Invention content
Present invention aim to address problems of the prior art, provide a kind of formula rationally, curative effect is apparent, prepares
Method is simple, each grass-roots unit can be used, operate, have no drug resistance and medicament residue, and can effectively treat grice diarrhoea
Chinese herbal and crude drugs preparations.
The raw material of the present invention is all from Chinese herbal medicine, and science is configured to a kind of Chinese medicine preparation for treating grice diarrhoea, this medium-height grass
Medicine preparation has antibacterial, antiviral, anti-inflammatory, convergence, invigorating the spleen, warm stomach and raising immunity and other effects, is suitable for viral and thin
Piglet diarrhoea caused by bacterium sexual factor, has no toxic side effect, drug residue free, moreover it is possible to improve immunity of organisms.
Purpose to realize the present invention, used technical solution are as follows：
A kind of Chinese herbal and crude drugs preparations for treating grice diarrhoea, are grouped as by the group of following parts by weight：25-40 parts of garden burnet root, abacus
15-30 parts of 20-35 parts of cotyledon, 0.5-2.0 parts of shikimic acid powder and table sugar.
Preferably, the table sugar is the one or two of brown sugar, brown sugar.
Preferably, it is grouped as by the group of following parts by weight：25-35 parts of garden burnet root, 25-30 parts of puberulous glochidion branchlet and leaf, shikimic acid
20-25 parts of 1.0-2.0 parts of powder and brown sugar.
Preferably, it is grouped as by the group of following parts by weight：30-40 parts of garden burnet root, 20-25 parts of puberulous glochidion branchlet and leaf, shikimic acid
15-25 parts of 1.0-1.5 parts of powder and brown sugar.
Preferably, it is grouped as by the group of following parts by weight：30 parts of garden burnet root, 25 parts of puberulous glochidion branchlet and leaf, 1 part of shikimic acid powder and
20 parts of brown sugar.
Preferably, it is grouped as by the group of following parts by weight：25 parts of garden burnet root, 30 parts of puberulous glochidion branchlet and leaf, 1.5 parts of shikimic acid powder and
25 parts of brown sugar.
Preferably, the Chinese herbal and crude drugs preparations are aqua.
It is including following the present invention also provides a kind of preparation method of the Chinese herbal and crude drugs preparations for the treatment of grice diarrhoea as previously discussed
Step：
（1）Each component is weighed according to each raw material weight number；
（2）Garden burnet root, puberulous glochidion branchlet and leaf are put into marmite, drinking water is added, after impregnating 20-30 minutes, adds water and does not cross drug, it will
Marmite is placed on stove fire and decocts, and after boiling 20-25 minutes, liquid is poured out, and obtains first time liquid；
（3）Warm water is added in marmite, is carried out second and is decocted, after boiling 15-20 minutes, liquid is poured out, with first time medicine
Liquid mixes, and after natural cooling, shikimic acid powder and brown sugar is added and as treats the Chinese herbal and crude drugs preparations of grice diarrhoea fully after dissolving.
The present invention also provides it is a kind of it is as previously discussed treatment grice diarrhoea Chinese herbal and crude drugs preparations application method, each taking
40 mL continuously take 3 days 2 times a day.
The present invention also provides a kind of Chinese herbal and crude drugs preparations for treating grice diarrhoea to prepare the medicine for treating or preventing grice diarrhoea
It is applied in object.
（1）Garden burnet root.Garden burnet alias is garden burnet, mountainous region melon, pig ginseng, blood arrow grass；For the dry of rosaceous plant garden burnet
Dry root and rhizome.The ground such as numerous mountains slope, border, grassland, grassy marshland, shrubbery and field side are born in, North China, northeast, East China, west are distributed in
The ground such as southern, northwest and Henan, Hubei, Hunan, Guangxi.Main ingredient：Containing tannin, sanguisorbin and retinoid substance.Property
Taste：Hardship, is slightly cold at acid.Return liver, stomach, large intestine channel.Pharmacological action：1. restraining.It can stop blooding in gastrointestinal tract, antidiarrheal can subtract for burning
Light exudation；2. antibacterial.It is mainly false to shigella dysenteriae, proteus, typhoid bacillus, paratyphosum Bacterium, verdigris in Escherichia coli, beam
Monad, comma bacillus, tubercle bacillus, diplococcus meningitidis etc. have antibacterial action；3. nourishing qi and blood, strengthening spleen, tonifying kidney.It can improve
The immunity of body can be used for the leukopenia caused by many reasons such as virus, cell infection and some unknown causes,
It can also be used for the treatment of decrease of platelet, immunologic hypofunction, alpastic anemia；4. anti-inflammatory effect.Aqueous extract rat
Intraperitoneal injection, can obviously inhibit inflammatory seep caused by prostaglandin E1, have certain anti-inflammatory effect.There is antiphagin work
With can inactivate bacteriophage and bacteriophage is inhibited to be bred in thalline, but not prevent bacteriophage and bacterial adsorption.
（2）Glochidion puberum.Glochidion puberum is euphorbia plant.Upright racemosus shrub, high l-3m.Sprig taupe, it is close by rust
Or yellowish-brown pubescence.Leaf alternate；The long 1-3mm of petiole, by pubescence；Stipule triangle is to narrow triangle, long 1-2mm, by pubescence；
Leaf oblong is to long round shape is oval or lanceolar, dilute oval or obovate, long 3-9cm, wide 1.2-3.5cm, blunt to the anxious point of apex,
Dilute subcircular, often with small cusp, base portion wedge shape to obtuse, only for middle arteries by thin pubescence or there are few hair, lower flour green is close above
By pubescence, 5-8 pairs of lateral vein, below it is apparent.Flower unisexuality homophyletic or different strain, spend small, and 2-5 fasciating in axil；Without petal；Sepal
6,2 wheels；Male flower bennet is thin, long l-8mm, and usually by pubescence, sepal matter is thicker, and oblong to long and narrow round or long round shape falls ovum
Shape, it is outer by thin pubescence；3 pieces of stamen, symphysis is at column, no degeneration ovary；Female flower bennet long l-3mm, it is close by pubescence, calyx with
The nearly similar shape of male flower, but slightly shorter and thick, the equal hair in two sides；Ovary is close by villus, the rooms 8-10, style symphysis circlewise, length and width with
Ovary is several equal, and apex does not expand, and hangs contracting with ovary junction.Capsule oblate spheroid, diameter 8-15mm are obviously indulged often with 8-10 items
Ditch, the cyclic annular Su Huazhu slightly extended of apex tool, close by pubescence, band is red when ripe, the nearly kidney shape of seed, has trigone, is about
4mm, bronzing.The month at florescence 6-10, the fruiting period 8-12 months.It is born in the shrubbery of hillside.Be distributed Fujian, Guangdong, Guangxi, Guizhou, Sichuan,
The ground such as Hubei, Jiangxi, Zhejiang, Jiangsu, Anhui, Shaanxi.It is used as medicine with root and leaf.It is slight bitter, puckery, it is cool；It is slightly poisonous, return kidney channel.Root is complete
Year can adopt, and slice dries；Leaf summer and autumn acquire, and dry.Root, stem, leaf, fruit are used as medicine, and energy subdhing swelling and detoxicating controls dysentery antidiarrheal.Pharmacological action.
Antibacterial action：Leaf decoction has inhibition to make 9 kinds of enterobacteriaceaes such as shigella, paratyphoid bacillus A and Salmonella typhi
With wherein most sensitive to congratulating shigella dysenteriae, potency in vitro is 1：1280；Root decoction is without antibacterial action.
（3）Shikimic acid.Shikimic acid is a kind of monomeric compound extracted from Chinese medicine Chinese anise, is present in Magnoliaceae plant
In the dry mature fruit of object illiciumverum, character is white fine powder, soluble easily in water.Shikimic acid has anti-inflammatory, analgesic activity, big
Oxalic acid is alternatively arranged as antiviral and Anti-cancer medicament intermediate.It is mainly used for preventing Bird Flu, infective bronchitis, biography
The viral diseases such as metachromia laryngotracheitis, newcastle disease, infectious bursa of Fabricius.Chinese anise belongs to integration of drinking and medicinal herbs as defined in the Ministry of Public Health
Kind, be both food and drug, without any toxicity and side effects.
（4）Brown sugar.Brown sugar typically refers to, with the sugarcane commerieal sugar of honey, generally refer to sugarcane through squeezing the juice, by simply and easy treat,
The band honey of concentrated formation.It remains the nutritional ingredient of more sugarcane, it is easier to be digested, can quickly supplement
Muscle power enhances vigour, so be otherwise known as " chocolate in east ", wherein not only contain the carbohydrate that thermal energy can be provided,
Also contain growth in humans and develops the various elements such as indispensable riboflavin, carrotene, niacin and trace element manganese, zinc, chromium.
In addition, the calcium content of brown sugar is 10 times of white sugar, iron-holder is 3.6 times of white sugar.Brown sugar has tonifying middle-Jiao and Qi, strengthening the spleen and stomach, warms up
The effect of stomach.
(5) brown sugar.The raw material that brown sugar uses is sugarcane, and containing 95% or so sucrose, traditional method is will to gather in
Sugarcane rolled by chopping, the juice pressed out first removes the impurity such as soil, bacterium, fiber, then with small fire infusion 5~6
Hour, it is stirred continuously and allows moisture evaporating slowly, so that the concentration of sugar is gradually increased, the syrup of high concentration can solidify after the cooling period
As the raw sugar of solid block, that is, brown sugar brick.Brown sugar sugariness is very high, and the ingredient contained substance of brown sugar is abundant, has and enriches blood
The effect of nourishing the liver, slow middle analgesic, invigorating the spleen warm stomach and dispelling cold and absorbing clot.
Beneficial effects of the present invention：
1, raw material of the present invention is the Chinese herbal medicine of " medicine food in source ", safe without toxic side effect, pollution-free, drug residue free, without drug resistance
Property, bioavilability is high, significant in efficacy.It overcomes and treats Chinese herbal medicine used in grice diarrhoea currently on the market since prescription is unreasonable
Or it is only simple crush, the shortcomings of grain size is excessive, and drug release is slow, and bioavilability is low, and clinical effectiveness is not fine.
2, formula is reasonable, and preparation method is simple, and product quality is more stable, and not only antiviral and antibacterial actions are strong, and
And have the function of anti-inflammatory, convergence and improve immunity of organisms, treatment grice diarrhoea is with obvious effects.Palatability is good simultaneously, uses
When it is easy to operate.
3, clinical application proves, has notable curative effect to treatment grice diarrhoea, and it is malicious to substantially reduce virus, the band of bacterium
Amount, and drug residue free, make pork product reach nuisanceless requirement, the health of people have been effectively ensured.
Description of the drawings
Fig. 1 is the epidemic diarrhea virus PCR testing results of 6 pig farm pathological material of disease of embodiment；Wherein 1：Positive control, 2 ~ 8 points
It is not different pig farm pathological material of diseases, 9：Negative control, M：DNA standards DL2000.
Fig. 2 is the transmissible gastroenteritis PCR testing results of 6 pig farm pathological material of disease of embodiment；Wherein 1：Positive control, 2 ~ 4 difference
For pig farm pathological material of disease, 5：Negative control, M：Maker.
Specific implementation mode
The present invention program is described in further detail with reference to embodiment, following the description is merely to explain this hair
It is bright, its content is not defined.Experimental method used in following embodiments is conventional side unless otherwise specified
Method, material, reagent etc. used in following embodiments, is commercially available unless otherwise specified.
Embodiment 1 prepares the Chinese herbal and crude drugs preparations for the treatment of grice diarrhoea
A kind of Chinese herbal and crude drugs preparations for treating grice diarrhoea, preparation include the following steps：
（1）Component is weighed according to following parts by weight：300 g of garden burnet root, 250 g of puberulous glochidion branchlet and leaf, 10 g of shikimic acid powder and brown sugar 200
g；
（2）300 g of garden burnet root, 250 g of puberulous glochidion branchlet and leaf are put into marmite, 500 cool mL drinking water are added, impregnates 20 ~ 30 points
Clock adds water and does not cross drug, medicine marmite is placed on stove fire and is decocted with moderate heat, boils after twenty minutes, and liquid is poured out 300 millis
It rises, then, then heats appropriate amount of water, carry out second and decoct, boil 15 minutes, pour out liquid, mixed with first time, after cooling, added
Enter 200 g of 10 g of shikimic acid powder and brown sugar, fully dissolving can gavage.
Embodiment 2
A kind of Chinese herbal and crude drugs preparations for treating grice diarrhoea, preparation include the following steps：
（1）Component is weighed according to following parts by weight：250 g of garden burnet root, 300 g of puberulous glochidion branchlet and leaf, 15 g of shikimic acid powder and brown sugar 250
g；
（2）250 g of garden burnet root, 300 g of puberulous glochidion branchlet and leaf are put into marmite, 500 cool mL drinking water are added, impregnates 20 ~ 30 points
Clock adds water and does not cross drug, medicine marmite is placed on stove fire and is decocted with moderate heat, boils after twenty minutes, and liquid is poured out 300 millis
It rises, then, then heats appropriate amount of water, carry out second and decoct, boil 15 minutes, pour out liquid, mixed with first time, after cooling, added
Enter 250 g of 15 g of shikimic acid powder and brown sugar, fully dissolving can gavage.
Embodiment 3
A kind of Chinese herbal and crude drugs preparations for treating grice diarrhoea, preparation include the following steps：
（1）Component is weighed according to following parts by weight：350 g of garden burnet root, 300 g of puberulous glochidion branchlet and leaf, 20 g of shikimic acid powder and brown sugar 150
g；
（2）350 g of garden burnet root, 300 g of puberulous glochidion branchlet and leaf are put into marmite, 600 cool mL drinking water are added, impregnates 20 ~ 30 points
Clock adds water and does not cross drug, medicine marmite is placed on stove fire and is decocted with moderate heat, boils after twenty minutes, and liquid is poured out 300 millis
It rises, then, then heats appropriate amount of water, carry out second and decoct, boil 15 minutes, pour out liquid, mixed with first time, after cooling, added
Enter 100 g of 20 g of shikimic acid powder and brown sugar, fully dissolving can gavage.
Embodiment 4
A kind of Chinese herbal and crude drugs preparations for treating grice diarrhoea, preparation include the following steps：
（1）Component is weighed according to following parts by weight：300 g of garden burnet root, 200 g of puberulous glochidion branchlet and leaf, 15 g of shikimic acid powder and brown sugar 250
g；
（2）300 g of garden burnet root, 200 g of puberulous glochidion branchlet and leaf are put into marmite, 500 cool mL drinking water are added, impregnates 20 ~ 30 points
Clock adds water and does not cross drug, medicine marmite is placed on stove fire and is decocted with moderate heat, boils after twenty minutes, and liquid is poured out 300 millis
It rises, then, then heats appropriate amount of water, carry out second and decoct, boil 15 minutes, pour out liquid, mixed with first time, after cooling, added
Enter 250 g of 15 g of shikimic acid powder and brown sugar, fully dissolving can gavage.
Application example
Embodiment 5
Chinese herbal and crude drugs preparations prepared by embodiment 1 are applied with diarrhea piglet, it is as follows using step and effect：
1. case selection standard
（1）The piglet of 0-60 ages in days
（2）Symptoms are depressed spirit, apocleisis, the sleeping ground of happiness, vomiting, row's symptoms such as yellow-white or paste excrement, dehydration.
（3）Grice diarrhoea caused by bacterium sexual factor is diagnosed as by bacterium separation through veterinary laboratories.It is sterile to take disease
The lymphonodi mesenterici of pig, is inoculated on nutrient agar panel, takes colony inoculation to maconkey agar tablet, from maconkey agar
The red colonies of the median size, smooth bumps, rounding chosen on tablet, serum factor experiment, 0 antigen-reactive of Escherichia coli are
The positive is accredited as Escherichia coli.Median size, smooth bumps, the colourless bacterium colony of rounding chosen from maconkey agar tablet,
Serum factor is tested, and 0 antigen-reactive of Sharpe door rod bacterium is the positive, is accredited as Salmonella.Meanwhile lymphonodi mesenterici sample
PCR detection viruses are carried out, virus is feminine gender.
2. curative effect determinate standard
It cures：Substantially without symptoms such as vomiting, diarrhea, dehydrations, enteron aisle digestion is normal, and the state of mind is good.
Effectively：Vomiting, diarrhea number are reduced, and dewatering symptom mitigates, and the state of mind improves.
In vain：Clinical symptoms aggravate, or even dead.
3. therapeutic scheme
8 different pig farms of above-mentioned case standard will be met（Raiser）Totally 502 pigs wherein have 6 caused by Escherichia coli
（Family）, have 2 fields caused by Salmonella（Family）.Application method is to gavage, each taking 40 mL/ heads, 2 times a day, even
It is continuous to take 3 days.
4. treatment results
After medication 3 days, clinical examination is carried out to illness piglet, the results are shown in Table 1.
1 bacterial diarrhea clinical treatment outcome of table
| Group | Recovery from illness | In vain |
| Salmonellosis | 91.8（56/61） | 8.2%(5/61) |
| Colibacillosis | 95.9%(423/441) | 4.1%(18/441) |
By table 1 as it can be seen that being treated to diarrhea piglet using 1 Chinese herbal and crude drugs preparations of the embodiment of the present invention, the treatment of illness piglet is cured
Rate is high, significant effect, illustrates that Chinese herbal and crude drugs preparations of the present invention are directed to the hair that can effectively control grice diarrhoea of piglet bacillary diarrhea
Disease, piglet controls favourable prognosis, without side-effects.
Embodiment 6
Chinese herbal and crude drugs preparations prepared by embodiment 1 are applied with diarrhea piglet, it is as follows using step and effect：
1. case selection standard
（1）The piglet of 0-60 ages in days
（2）Symptoms are depressed spirit, apocleisis, the sleeping ground of happiness, vomiting, row's symptoms such as yellow-white or paste excrement, dehydration.
（3）Grice diarrhoea (Fig. 1, Fig. 2 caused by viral element is diagnosed as by RT-PCR method through veterinary laboratories）.
Diagnosis reference Guangxi Local standard：《The detection RT-PCR methods of Porcine epidemic diarrhea virus (PEDV)》（DB45/T 1012-2014）
With《The detection RT-PCR methods of transmissible gastro-enteritis virus》（DB45/T 1007-2014）.
2. curative effect determinate standard
It cures：Substantially without symptoms such as vomiting, diarrhea, dehydrations, enteron aisle digestion is normal, and the state of mind is good.
Effectively：Vomiting, diarrhea number are reduced, and dewatering symptom mitigates, and the state of mind improves.
In vain：Clinical symptoms aggravate, or even dead.
3. therapeutic scheme
14 different pig farms of above-mentioned case standard will be met（Raiser）Totally 986 pigs, wherein epidemic diarrhea virus cause
Have 12（Family）, 2 fields of transmissible gastroenteric（Family）.Application method is to gavage, each taking 40 mL/ heads, 2 times a day, even
It is continuous to take 4 days.
4. treatment results
After medication 4 days, clinical examination and viral diagnosis are carried out to illness piglet.It the results are shown in Table 2.
The clinical treatment outcome of 2 virus diarrhea of table
| Group | Recovery from illness | In vain | Excrement PCR testing results |
| Transmissible gastroenteritis | 91.1%（112/123） | 8.9%(11/123) | It is negative |
| Epidemic diarrhea virus disease | 88.9%(767/863) | 11.1%(96/863) | It is negative |
As can be seen from Table 2, being treated to diarrhea piglet using 1 Chinese herbal and crude drugs preparations of the embodiment of the present invention, the treatment of illness piglet is cured
Rate is high, significant effect, illustrates that Chinese herbal and crude drugs preparations of the present invention are directed to the hair that can effectively control grice diarrhoea of piglet virus diarrhea
Disease, piglet controls favourable prognosis, without side-effects.
7 safety testing of embodiment：
20 age in days sodium selenite 50 is chosen, is divided into 5 groups, every group 10, Chinese herbal and crude drugs preparations is made using the embodiment of the present invention 1
1-4 times gavages 7 days, and one group of blank control group is arranged（Non-administration sodium selenite）.During medication, observe 5 groups of piglets the case where.Knot
Fruit shows that medication group and control group piglet do not have any bad or Novel presentation, and feeding and drinking-water are normal, weight gain and sky
White control group no significant difference.Illustrate Chinese medicine composition safe without toxic side effect of the present invention, has no adverse effects to piglet growth.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
The change or replacement expected without creative work, should be covered by the protection scope of the present invention.Therefore, of the invention
Protection domain should be determined by the scope of protection defined in the claims.
Claims (10)
1. a kind of Chinese herbal and crude drugs preparations for treating grice diarrhoea, which is characterized in that be grouped as by the group of following parts by weight：Garden burnet root
15-30 parts of 25-40 parts, 20-35 parts of puberulous glochidion branchlet and leaf, 0.5-2.0 parts of shikimic acid powder and table sugar.
2. treating the Chinese herbal and crude drugs preparations of grice diarrhoea according to claim 1, which is characterized in that the table sugar is red
The one or two of sugar, brown sugar.
3. treating the Chinese herbal and crude drugs preparations of grice diarrhoea according to claim 2, which is characterized in that by the group of following parts by weight
It is grouped as：20-25 parts of 25-35 parts of garden burnet root, 25-30 parts of puberulous glochidion branchlet and leaf, 1.0-2.0 parts of shikimic acid powder and brown sugar.
4. treating the Chinese herbal and crude drugs preparations of grice diarrhoea according to claim 2, which is characterized in that by the group of following parts by weight
It is grouped as：15-25 parts of 30-40 parts of garden burnet root, 20-25 parts of puberulous glochidion branchlet and leaf, 1.0-1.5 parts of shikimic acid powder and brown sugar.
5. treating the Chinese herbal and crude drugs preparations of grice diarrhoea according to claim 2, which is characterized in that by the component of following parts by weight
Composition：20 parts of 30 parts of garden burnet root, 25 parts of puberulous glochidion branchlet and leaf, 1 part of shikimic acid powder and brown sugar.
6. treating the Chinese herbal and crude drugs preparations of grice diarrhoea according to claim 2, which is characterized in that by the component of following parts by weight
Composition：25 parts of 25 parts of garden burnet root, 30 parts of puberulous glochidion branchlet and leaf, 1.5 parts of shikimic acid powder and brown sugar.
7. according to the Chinese herbal and crude drugs preparations for treating grice diarrhoea described in claim 1-6 any one, which is characterized in that the medium-height grass
Medicine preparation is aqua.
8. it is a kind of it is as claimed in claim 7 treatment grice diarrhoea Chinese herbal and crude drugs preparations preparation method, which is characterized in that including with
Lower step：
（1）Each component is weighed according to each raw material weight number；
（2）Garden burnet root, puberulous glochidion branchlet and leaf are put into marmite, drinking water is added, after impregnating 20-30 minutes, adds water and does not cross drug, it will
Marmite is placed on stove fire and decocts, and after boiling 20-25 minutes, liquid is poured out, and obtains first time liquid；
（3）Warm water is added in marmite, is carried out second and is decocted, after boiling 15-20 minutes, liquid is poured out, with first time medicine
Liquid mixes, and after natural cooling, shikimic acid powder and brown sugar is added and as treats the Chinese herbal and crude drugs preparations of grice diarrhoea fully after dissolving.
9. a kind of application method of Chinese herbal and crude drugs preparations that treating grice diarrhoea as described in claim 1-7 any one, feature
It is, each taking 40 mL, 2 times a day, continuously takes 3 days.
10. preparing treatment or prevention son according to the Chinese herbal and crude drugs preparations for treating grice diarrhoea described in claim 1-7 any one
It is applied in the drug of diarrhea of pigs.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098307A (en) * | 1993-12-02 | 1995-02-08 | 袁称发 | Glochidion puberum extract |
| WO2014175509A1 (en) * | 2013-04-26 | 2014-10-30 | Han Myung Soon | Composition for preventing and relieving calf diarrhea and manufacturing method therefor |
| CN105535173A (en) * | 2014-10-28 | 2016-05-04 | 潘旭丽 | Hematochezia treating drug |
| CN106491664A (en) * | 2016-11-30 | 2017-03-15 | 广西壮族自治区动物疫病预防控制中心 | A kind of Chinese medicine composition for treating pig virus diarrhoea |
-
2018
- 2018-05-07 CN CN201810425463.0A patent/CN108653422B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098307A (en) * | 1993-12-02 | 1995-02-08 | 袁称发 | Glochidion puberum extract |
| WO2014175509A1 (en) * | 2013-04-26 | 2014-10-30 | Han Myung Soon | Composition for preventing and relieving calf diarrhea and manufacturing method therefor |
| CN105535173A (en) * | 2014-10-28 | 2016-05-04 | 潘旭丽 | Hematochezia treating drug |
| CN106491664A (en) * | 2016-11-30 | 2017-03-15 | 广西壮族自治区动物疫病预防控制中心 | A kind of Chinese medicine composition for treating pig virus diarrhoea |
Non-Patent Citations (2)
| Title |
|---|
| 冉先德主编: "《中华药海 下》", 31 August 1993, 哈尔滨出版社 * |
| 黄燮才主编: "《实用中草药原色图谱》", 31 July 1993, 广西科学技术出版社 * |
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