WO2014175509A1 - Composition for preventing and relieving calf diarrhea and manufacturing method therefor - Google Patents
Composition for preventing and relieving calf diarrhea and manufacturing method therefor Download PDFInfo
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- WO2014175509A1 WO2014175509A1 PCT/KR2013/005300 KR2013005300W WO2014175509A1 WO 2014175509 A1 WO2014175509 A1 WO 2014175509A1 KR 2013005300 W KR2013005300 W KR 2013005300W WO 2014175509 A1 WO2014175509 A1 WO 2014175509A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
Definitions
- the present invention relates to a composition for preventing and improving calf diarrhea and a method for manufacturing the same, and more particularly, a composition for preventing and improving calf diarrhea, which has a diarrhea improvement effect in calf, not only in spring, summer and autumn but also in winter when the temperature is lowered below freezing. And to a method for producing the same.
- Calf diarrhea which is one of the major causes of calf mortality, is one of the most economically damaging livestock diseases in livestock farms.
- Calf diarrhea is a clinical syndrome in which three factors are linked, including pathogenic microorganisms, the breeding environment, and cattle themselves. Above all, young calves are known to be highly susceptible to various pathogens. Within six months of age, calves are infected with pathogens from a variety of environments and headstocks, resulting in a variety of diseases caused by these pathogens.
- the pathogen-inducing pathogens of calf known to date in Korea include bovine viral diarrhea virus (BVD), bovine rotavirus (BRV) and bovine coronavirus (BCV), and bacterial strains such as E. coil and Salmonella spp. , Clostridium spp., Campylobacter . Parasites also include Eimeria spp., Isospora spp., Cryptosporidium spp. Etc. are known.
- E. coil The following is a bacterial enterotoxins septic E. coil was detected 26.1% to 34.8%, from 8 to 14 days of age prior to 7 days of age, in the report of the Acres, such as 34.8% are detected in more than 22 days of age detection rate of E. coil and rotavirus is Diarrhea of calves within 5 days was 62% and 10%, respectively.
- bacterial enterotoxins septic E. coil was detected 26.1% to 34.8%, from 8 to 14 days of age prior to 7 days of age, in the report of the Acres, such as 34.8% are detected in more than 22 days of age detection rate of E. coil and rotavirus is Diarrhea of calves within 5 days was 62% and 10%, respectively.
- Korean Patent Publication No. 10-1067536 (2011.09.27.) Discloses a composition for treating diarrhea of calves formed by mixing natural herbal materials such as ginseng, wormwood, sesame and carrot, which are good for antibiotic effects and gastrointestinal diseases.
- composition for treating diarrhea of calves using natural herbal materials such as ginseng or wormwood has some effects of treating diarrhea of calves in the spring and autumn, but there is a slight problem of diarrhea treatment effect in winter when the temperature goes below freezing.
- the present inventors have developed a composition for preventing and improving calf diarrhea having a diarrhea improvement effect of calf in spring, summer, and autumn, as well as winter, when the temperature drops below freezing.
- the present invention provides the following means.
- the present invention provides a composition for preventing and improving calf diarrhea comprising Agaricus blazei Murill as an active ingredient.
- the composition is added Agaricus mushrooms (Agaricus blazei Murill), based on 100 parts by weight of water and the powder 3 to 5 parts by weight, and the Agaricus mushroom (Agaricus blazei Murill) powder heat produced by heating for 1 to 5 minutes at a temperature of 90 to 100 °C Extract may be included as an active ingredient.
- Agaricus mushrooms Agaricus blazei Murill
- the Agaricus mushroom Agaricus blazei Murill powder heat produced by heating for 1 to 5 minutes at a temperature of 90 to 100 °C Extract
- composition is Agaricus mushroom ( Agaricus blazei Murill) 100 to 100 parts by weight of ginseng may additionally include as an active ingredient.
- composition is agaricus mushrooms ( Agaricus blazei Murill) 3 to 5 parts by weight of powder and 3 to 5 parts by weight of ginseng powder, and Agaricus mushroom prepared by heating for 1 to 5 minutes at a temperature of 90 to 100 °C ( Agaricus blazei Murill) powder and ginseng powder heating extract may be included as an active ingredient.
- agaricus mushrooms Agaricus blazei Murill
- ginseng powder heating extract may be included as an active ingredient.
- the present invention is agaricus mushroom ( Agaricus blazei Murill) 3 to 5 parts by weight and provides a method for producing a composition for preventing and improving calf diarrhea, characterized in that for heating for 1 to 5 minutes at a temperature of 90 to 100 °C.
- Ginseng 3 to 5 parts by weight based on 100 parts by weight of water is characterized in that it further comprises.
- composition for preventing and improving calf diarrhea according to the present invention is effective to prevent diarrhea of the calf by feeding the newborn calf before feeding colostrum, not only in spring, summer and autumn but also in winter when the temperature drops below freezing. There is an effect to improve, there is an advantage to solve the problem of the emergence of resistant bacteria and the stability of livestock products by the use of drugs such as antibiotics or antibacterial agents.
- the present invention is agaricus mushroom ( Agaricus blazei Murill) 3 to 5 parts by weight of powder and 3 to 5 parts by weight of ginseng powder, and Agaricus mushroom prepared by heating for 1 to 5 minutes at a temperature of 90 to 100 °C ( Agaricus blazei Murill) provides a calf diarrhea example and improvement composition comprising a powder and ginseng powder heated extract as an active ingredient.
- Calf's diarrheal disease is the most frequent among cattle diseases, and the economic damage of livestock farms is also the greatest.
- newborn calves are characterized by unstable intestinal infections and incomplete intestinal infection of normal bacteria, and their ability to absorb digestion is also poor.
- unabsorbed moisture and harmful bacteria toxins remain in the intestine, the calf will suffer severe cramps in the intestine. In this way, the calf that suffers from convulsions is deprived of moisture in the body by osmotic pressure, leading to dehydration.
- Calf born in winter is very likely to die if diarrhea occurs due to the rapid drop in immunity.
- a feature of the present invention is to provide a composition for preventing and improving diarrhea of calves, which can improve calves' diarrhea not only in spring, summer and autumn but also in winter when temperatures drop below freezing.
- composition for preventing and improving calf diarrhea according to the present invention will be described.
- the calf diarrhea prevention and improvement composition according to the present invention is characterized in that it comprises Agaricus blazei (Agricus blazei Murill) as an active ingredient.
- Agaricus blazei Agricus blazei Murill
- Agaricus blazei Murill Agaricus mushroom
- Agaricus mushroom is also known as white mushrooms, spiritual mushrooms, folds of mushrooms, folds of mushrooms, and fungi belonging to the genus of fungi, but the appearance is similar to the mushrooms of Agaricus bisporus , but the mushroom stand is thick, long, and strong in smell. Is characteristic.
- Representative pharmacological action of Agaricus mushrooms include hypoglycemic action, lowering blood pressure, lowering cholesterol, antithrombosis, and immunoreactive activity.
- Agaricus mushrooms are known to contain a number of medicinal ingredients, which are physiologically active and contain lectins with hemagglutination. The important physiological activity in Agaricus mushrooms is ⁇ -glucan, which has been reported to have the function of immunoactivator, antioxidant activity, biological tissue regeneration and healing, antibiotics, antibacterial and antiviral activity.
- the Agaricus blazei Murill was first discovered in Florida in the United States in 1944, and became widely known when it was discovered that it was edible by the indigenous people of Piadade, a mountainous region of Brazil in the mid-1960s, and in parts of North and Latin America. It is known to grow wild and has not been reported elsewhere. Research on artificial cultivation began around the 1990s when it became known that it is rich in various nutrients such as protein, fat, fiber, vitamins, inorganic salts, amino acids, essential fatty acids and nucleic acids, and is good for various adult diseases including cancer. As a result, it was the first successful cultivation in Japan in 1992, and is now artificially cultivated in Korea and China.
- Agaricus blazei Murill ( Agaricus blazei Murill) has a high anti-tumor effect, such as anti-cancer effect, tumor suppression, blood sugar and blood pressure lowering, and many studies have been conducted to identify a variety of physiological activities such as enhancing the body's immunity.
- composition for preventing and improving calf diarrhea according to the present invention is Agaricus mushroom ( Agaricus blazei Murill) may additionally include ginseng to increase the activity of the useful ingredient.
- the ginseng (Panax ginseng) can be said to be the highest healing plants, the main ingredient is at least 13 kinds of ginsenosides (saponins) classified into the protoparnasadiol and the protoparnasatriol according to the ratio of aglycone (aglycone) ), Diacid oil such as panaxinol, organic acids and esters, sterols, nitrogen compounds, vitamins such as folic acid, enzymes, etc., and is known to have a wide variety of effects other than the central nervous system.
- the ginseng (Panax ginseng) is a plant that has been widely used as a representative nourishment tonic since ancient times, and is commonly used in the form of red ginseng, which is manufactured by heating white ginseng as dried and dried at room temperature, or red ginseng.
- Known medicinal effects of ginseng to date include anti-aging, anti-arteriosclerosis, hyperlipidemia, liver function enhancement, radiation disorders elimination, immunity enhancement, antithrombotic, antihypertensive antistress, blood sugar drop, blood pressure drop, anticancer effect.
- composition for preventing and improving calf diarrhea of the present invention is Agaricus mushroom ( Agaricus blazei It is preferable to include 90 to 100 parts by weight of ginseng based on 100 parts by weight of Murill, and if less than 90 parts by weight of ginseng is used, the agaricus mushroom ( Agaricus blazei Murill) may not sufficiently increase the activity of the useful ingredient, including more than 100 parts by weight can cause excessive calf body temperature.
- the Agaricus blazei Murill is used by drying, and the ginseng is preferably rooted.
- Agaricus blazei Murill and ginseng are powdered in order to increase the extraction efficiency of the active ingredient and shorten the extraction time, and have an average particle size of 1 to 1000 ⁇ m, preferably 10 to 500 ⁇ m. While extracting hot water, a heated extract may be prepared in the form of a suspension containing Agaricus blazei Murill and ginseng powder as it is.
- composition for preventing and improving calf diarrhea according to the present invention is effective to prevent diarrhea of the calf by feeding the newborn calf before feeding colostrum, not only in spring, summer and autumn but also in winter when the temperature drops below freezing. There is an effect to improve, there is an advantage to solve the problem of the emergence of resistant bacteria and the stability of livestock products by the use of drugs such as antibiotics or antibacterial agents.
- the method for producing a composition for preventing and improving calf diarrhea according to the present invention based on 100 parts by weight of water Agaricus mushroom ( Agaricus blazei Murill) powder is added 3 to 5 parts by weight and is characterized by heating for 1 to 5 minutes, preferably 2 to 3 minutes at a temperature of 90 to 100 °C.
- composition of the present invention When the composition of the present invention is mixed with less than 3 parts by weight of the Agaricus blazei Murill based on 100 parts by weight of water, the effect of improving diarrhea of the calf may be insufficient. It can be inconvenient to eat.
- the composition of the present invention may additionally include 3 to 5 parts by weight of ginseng with respect to 100 parts by weight of water, and containing less than 3 parts by weight of ginseng sufficiently increases the activity of the useful ingredient Agaricus blazei Murill It may not be possible, including more than 5 parts by weight can cause excessive calf body temperature. It is preferable to include the ginseng in the form of a powder.
- Calf diarrhea prevention and improvement composition according to the present invention at a temperature of 35 to 40 °C, one time is fed before feeding colostrum, two and three times are fed at intervals of 3 to 4 hours, 50 ml per oral Administration can prevent diarrhea in newborn calves.
- the calf diarrhea prevention and improvement composition according to the present invention 2 to 5 times a day, preferably about 3 times a day 10 to 200 ml, preferably 50 ml
- the diarrhea of the calf can be improved by oral administration for 1 to 4 days, preferably 2 days.
- ginseng powder heated extract 4 parts by weight of ginseng powder having an average particle size of 300 ⁇ m was mixed with 100 parts by weight of water, and then heated at 100 ° C. for 2 minutes to prepare a ginseng powder heated extract as a composition for preventing and improving calf diarrhea.
- Example 1 Table 1 division Head total Incidence (two) Diarrhea onset Comparative Example 1 20 25.0 (5) 23.5 Example 1 20 10.0 (2) 28 Example 2 20 5.0 (1) 29 * Incidence: Diarrhea incidence up to 45 days of age
- Example 1 and Example 2 In winter, when the temperature fell below freezing, in order to determine whether the calf diarrhea of the composition for preventing and improving calf diarrhea prepared in Comparative Example 1, Example 1 and Example 2 is improved, diarrhea symptoms in newborn calf of 10-45 days old
- the calf diarrhea prevention and improvement composition prepared in Comparative Example 1, Example 1 and Example 2 for the calf was administered orally three times a day, 50ml per time for 2 days, the results are shown in Table 2 below. Indicated.
- Example 1 the composition for the prevention and improvement of calf diarrhea of Example 1 and Example 2 is excellent in improving the diarrhea of the newborn calf compared to the composition of Comparative Example 1.
- composition for preventing and improving calf diarrhea according to the present invention has an advantage of effectively improving diarrhea even when the calves have weakened immunity in winter when the temperature falls below freezing.
Abstract
The present invention relates to: a composition for preventing and relieving calf diarrhea, containing extracts of Agaricus blazei Murill; and a manufacturing method therefor, wherein the composition can prevent diarrhea in calves by feeding the composition to neonatal calves before feeding them colostrum, and relieving calf diarrhea in the spring, summer and autumn, and in the winter during which the temperature falls below zero, and has advantages of solving a problem of the appearance of resistant bacteria according to the use of antibiotics or antimicrobial agents and a livestock product stability problem.
Description
본 발명은 송아지 설사 예방 및 개선용 조성물 및 그 제조방법에 관한 것으로, 보다 상세하게는 봄, 여름, 가을뿐만 아니라 기온이 영하로 내려가는 겨울에도 송아지의 설사 개선 효과가 있는 송아지 설사 예방 및 개선용 조성물 및 그 제조방법에 관한 것이다.The present invention relates to a composition for preventing and improving calf diarrhea and a method for manufacturing the same, and more particularly, a composition for preventing and improving calf diarrhea, which has a diarrhea improvement effect in calf, not only in spring, summer and autumn but also in winter when the temperature is lowered below freezing. And to a method for producing the same.
송아지 폐사의 중요 원인으로 손꼽히는 송아지 설사증, 특히 신생 송아지의 설사증은 축산농가에 가장 큰 경제적 손실을 입히는 가축 질병 중 하나로서, 미국에서 송아지 설사증에 의한 피해액은 연간 12조 내지 24조원 이상이라고 알려져 있다.Calf diarrhea, which is one of the major causes of calf mortality, is one of the most economically damaging livestock diseases in livestock farms.
신생 송아지 설사의 원인은 복합적이고 다양한 전염성, 영양적, 면역학적 그리고 환경적인 요인이 관련되어 있다. 송아지 설사증은 병원성 미생물, 사육환경 및 소 자체 등 세 요소의 상호연계성 및 다양한 원인이 관여하여 나타나는 임상 증후군이다. 무엇보다 어린 송아지는 각종 병원체에 대한 감수성이 높다고 알려져 있다. 생후 6개월 이내 송아지는 다양한 환경 및 모축에서 나오는 병원체들에 감염됨으로써 이들 병원체들이 일으키는 다양한 질병이 발생되고 있다.The causes of newborn calf diarrhea are associated with a variety of infectious, nutritional, immunological and environmental factors. Calf diarrhea is a clinical syndrome in which three factors are linked, including pathogenic microorganisms, the breeding environment, and cattle themselves. Above all, young calves are known to be highly susceptible to various pathogens. Within six months of age, calves are infected with pathogens from a variety of environments and headstocks, resulting in a variety of diseases caused by these pathogens.
국내에서 지금까지 알려진 송아지의 소화기질병 유발 병원체들은, 바이러스성으로는 bovine viral diarrhea virus (BVD), bovine rotavirus (BRV), bovine coronavirus (BCV) 등이 있으며, 세균성으로는 E. coil, Salmonella spp., Clostridium spp., Campylobacter 등이 있다. 또한, 기생충으로는 Eimeria spp., Isospora spp., Cryptosporidium spp. 등이 알려져 있다.The pathogen-inducing pathogens of calf known to date in Korea include bovine viral diarrhea virus (BVD), bovine rotavirus (BRV) and bovine coronavirus (BCV), and bacterial strains such as E. coil and Salmonella spp. , Clostridium spp., Campylobacter . Parasites also include Eimeria spp., Isospora spp., Cryptosporidium spp. Etc. are known.
신생 송아지의 설사 원인체로 로타바이러스(rotavirus)의 검출률은 69.2%로 장독혈성 E. coil의 14.7% 보다 현저히 높은 검출률을 나타내고 있다. 설사 발생 일령에서 바이러스성인 로타바이러스는 7일령 이전에 41.7%, 8 내지 14일령에 48.1%가 검출되어 약 90%가 생후 2주일 이내에 검출되었다고 하였다.The rate of detection of rotavirus as a cause of diarrhea in newborn calves was 69.2%, which was significantly higher than that of enterotoxic E. coil . Viral rotavirus at the age of diarrhea occurred at 41.7% before 7 days of age and 48.1% at 8 to 14 days of age, with approximately 90% detected within 2 weeks of age.
다음은 세균성으로 장독혈성 E. coil는 7일령 이전에 34.8%, 8 내지 14일령에 26.1% 검출되었고, 22일령 이상에서도 34.8%가 검출된 Acres 등의 보고에서는 E. coil와 로타바이러스의 검출률은 5일 이내에 설사한 송아지에서 각각 62%, 10%로 나타나고 있다. 송아지 설사병을 치료하기 위해서는 여러 가지 방법이 있을 수 있지만, 현재 시중에서 판매 및 유통되고 있는 약물들은 일시적인 효과를 나타낼 뿐 치료를 중단하게 되면 병원균이 잠복하였다가 재발하거나 만성화될 우려가 있으며, 장기간 반복치료시 내성문제가 심각하게 대두될 수 있다.The following is a bacterial enterotoxins septic E. coil was detected 26.1% to 34.8%, from 8 to 14 days of age prior to 7 days of age, in the report of the Acres, such as 34.8% are detected in more than 22 days of age detection rate of E. coil and rotavirus is Diarrhea of calves within 5 days was 62% and 10%, respectively. There are many ways to treat calves and diarrheal diseases. However, currently available drugs on the market have only temporary effects. If the treatment is discontinued, pathogens may be latent and relapse or become chronic. Resistance problems can be serious.
최근 한우 및 젖소사육의 대형화로 살모넬라 등 병원균에 의한 송아지 설사병이 증가하고 있고, 그로 인한 약물 사용도 증가하고 있는 실정이다. 화학적 약물의 사용은 감염증에 일시적인 효과는 있으나, 투약을 중지하면 재감염의 문제가 있으며, 장기사용에 따른 내성균의 출현 증가뿐만 아니라 약물의 잔류로 안전한 축산물 생산에 걸림돌이 된다.Recently, calf diarrheal diseases caused by pathogens such as Salmonella are increasing due to the enlargement of cattle and cow breeding, and the use of drugs is also increasing. Although the use of chemical drugs has a temporary effect on infectious diseases, discontinuation of the medications has the problem of re-infection, and the increase in the appearance of resistant bacteria with long-term use, as well as the retention of drugs, is an obstacle to the safe production of livestock products.
상기와 같은 문제를 해결하기 위해 천연약용식물을 이용한 송아지의 설사 치료용 조성물에 대한 연구가 활발히 이루어지고 있다.In order to solve the above problems, studies on the composition for treating diarrhea of calves using natural medicinal plants are being actively conducted.
대한민국등록특허공보 제10-1067536호(2011.09.27.)에는 항생효과와 위장병에 좋은 인삼, 쑥, 칡즙 및 당근과 같은 천연한방재료를 혼합하여 조성된 송아지의 설사치료용 조성물이 개시되어 있다.Korean Patent Publication No. 10-1067536 (2011.09.27.) Discloses a composition for treating diarrhea of calves formed by mixing natural herbal materials such as ginseng, wormwood, sesame and carrot, which are good for antibiotic effects and gastrointestinal diseases.
상기 인삼이나 쑥과 같은 천연한방재료를 이용한 송아지의 설사 치료용 조성물은 봄과 가을에 송아지의 설사를 치료하는 효과가 일부 있지만, 기온이 영하로 내려가는 겨울에는 설사 치료 효과가 미미한 문제가 있다.The composition for treating diarrhea of calves using natural herbal materials such as ginseng or wormwood has some effects of treating diarrhea of calves in the spring and autumn, but there is a slight problem of diarrhea treatment effect in winter when the temperature goes below freezing.
이에, 본 발명자는 봄, 여름, 가을뿐만 아니라 기온이 영하로 내려가는 겨울에도 송아지의 설사 개선 효과가 있는 송아지 설사 예방 및 개선용 조성물 및 그 제조방법을 개발하였다. Accordingly, the present inventors have developed a composition for preventing and improving calf diarrhea having a diarrhea improvement effect of calf in spring, summer, and autumn, as well as winter, when the temperature drops below freezing.
본 발명의 목적은 봄, 여름, 가을뿐만 아니라 기온이 영하로 내려가는 겨울에도 송아지의 설사 개선 효과가 있는 송아지 설사 예방 및 개선용 조성물 및 그 제조방법을 제공하는 것이다.It is an object of the present invention to provide a composition for preventing and improving calf diarrhea having a diarrhea improvement effect of calves in spring, summer, autumn as well as winter temperatures drop below zero.
상기 목적을 달성하기 위하여 본 발명은 다음과 같은 수단을 제공한다.In order to achieve the above object, the present invention provides the following means.
본 발명은 아가리쿠스버섯(Agaricus blazei Murill)을 유효성분으로 포함하는 송아지 설사 예방 및 개선용 조성물을 제공한다.The present invention provides a composition for preventing and improving calf diarrhea comprising Agaricus blazei Murill as an active ingredient.
상기 조성물은 물 100 중량부에 대하여 아가리쿠스버섯(Agaricus blazei Murill) 분말 3 내지 5 중량부를 첨가하고, 90 내지 100 ℃의 온도에서 1 내지 5 분 동안 가열하여 제조한 아가리쿠스버섯(Agaricus blazei Murill) 분말 가열 추출액을 유효성분으로 포함할 수 있다.The composition is added Agaricus mushrooms (Agaricus blazei Murill), based on 100 parts by weight of water and the powder 3 to 5 parts by weight, and the Agaricus mushroom (Agaricus blazei Murill) powder heat produced by heating for 1 to 5 minutes at a temperature of 90 to 100 ℃ Extract may be included as an active ingredient.
상기 조성물은 아가리쿠스버섯(Agaricus
blazei Murill) 100 중량부에 대하여 인삼 90 내지 100 중량부를 추가적으로 유효성분으로 포함할 수 있다.The composition is Agaricus mushroom (Agaricus
blazei Murill) 100 to 100 parts by weight of ginseng may additionally include as an active ingredient.
상기 조성물은 물 100 중량부에 대하여 아가리쿠스버섯(Agaricus
blazei Murill) 분말 3 내지 5 중량부 및 인삼 분말 3 내지 5 중량부를 첨가하고, 90 내지 100 ℃의 온도에서 1 내지 5 분 동안 가열하여 제조한 아가리쿠스버섯(Agaricus
blazei Murill) 분말 및 인삼 분말 가열 추출액을 유효성분으로 포함할 수 있다.The composition is agaricus mushrooms (Agaricus
blazei Murill) 3 to 5 parts by weight of powder and 3 to 5 parts by weight of ginseng powder, and Agaricus mushroom prepared by heating for 1 to 5 minutes at a temperature of 90 to 100 ℃ (Agaricus
blazei Murill) powder and ginseng powder heating extract may be included as an active ingredient.
또한, 본 발명은 물 100 중량부에 대하여 아가리쿠스버섯(Agaricus
blazei Murill) 3 내지 5중량부를 첨가하고 90 내지 100 ℃의 온도에서 1 내지 5 분 동안 가열하는 것을 특징으로 하는 송아지 설사 예방 및 개선용 조성물의 제조방법을 제공한다.In addition, the present invention is agaricus mushroom (Agaricus
blazei Murill) 3 to 5 parts by weight and provides a method for producing a composition for preventing and improving calf diarrhea, characterized in that for heating for 1 to 5 minutes at a temperature of 90 to 100 ℃.
상기 물 100 중량부에 대하여 인삼 3 내지 5 중량부를 추가적으로 포함하는 것을 특징으로 한다.Ginseng 3 to 5 parts by weight based on 100 parts by weight of water is characterized in that it further comprises.
본 발명에 따른 송아지 설사 예방 및 개선용 조성물은 갓 태어난 송아지에게 초유를 먹이기 전에 급여하여 송아지의 설사를 예방하는 효과가 있고, 봄, 여름, 가을뿐만 아니라 기온이 영하로 내려가는 겨울에도 송아지의 설사를 개선하는 효과가 있으며, 항생물질이나 항균제 등의 약제의 사용에 따른 내성균의 출현 문제와 축산물의 안정성 문제를 해결하는 장점이 있다.The composition for preventing and improving calf diarrhea according to the present invention is effective to prevent diarrhea of the calf by feeding the newborn calf before feeding colostrum, not only in spring, summer and autumn but also in winter when the temperature drops below freezing. There is an effect to improve, there is an advantage to solve the problem of the emergence of resistant bacteria and the stability of livestock products by the use of drugs such as antibiotics or antibacterial agents.
본 발명은 물 100 중량부에 대하여 아가리쿠스버섯(Agaricus
blazei Murill) 분말 3 내지 5 중량부 및 인삼 분말 3 내지 5 중량부를 첨가하고, 90 내지 100 ℃의 온도에서 1 내지 5 분 동안 가열하여 제조한 아가리쿠스버섯(Agaricus
blazei Murill) 분말 및 인삼 분말 가열 추출액을 유효성분으로 포함하는 것을 특징으로 하는 송아지 설사 예장 및 개선용 조성물을 제공한다.The present invention is agaricus mushroom (Agaricus
blazei Murill) 3 to 5 parts by weight of powder and 3 to 5 parts by weight of ginseng powder, and Agaricus mushroom prepared by heating for 1 to 5 minutes at a temperature of 90 to 100 ℃ (Agaricus
blazei Murill) provides a calf diarrhea example and improvement composition comprising a powder and ginseng powder heated extract as an active ingredient.
이하, 본 발명을 상세히 설명하면 다음과 같다.Hereinafter, the present invention will be described in detail.
송아지의 설사병은 소 질병 중 가장 많은 발생율을 보이며 이에 의한 축산농가의 경제적 피해 또한 가장 크다. 특히 갓 태어난 송아지는 유해균의 감염이나 정상세균총의 미완성시 장이 불안정해지고, 소화흡수능력 역시 떨어지는 특성이 있다. 그리하여 흡수되지 않는 수분과 유해균의 독소가 장내에 머물면 송아지는 장에 심한 잔경련으로 고통을 받게 된다. 이와 같이 잔경련을 앓는 송아지는 삼투압작용으로 체내수분마저 빼앗기게 되어 탈수 상태까지 이르게 된다. 이러한 증상은 설사 단독 증세나 설사 증세가 포함된 합병증의 전체 질병 중 60% 이상을 차지한다.Calf's diarrheal disease is the most frequent among cattle diseases, and the economic damage of livestock farms is also the greatest. In particular, newborn calves are characterized by unstable intestinal infections and incomplete intestinal infection of normal bacteria, and their ability to absorb digestion is also poor. Thus, if unabsorbed moisture and harmful bacteria toxins remain in the intestine, the calf will suffer severe cramps in the intestine. In this way, the calf that suffers from convulsions is deprived of moisture in the body by osmotic pressure, leading to dehydration. These symptoms account for more than 60% of all diseases of diarrhea alone or complications involving diarrhea.
겨울에 태어나는 송아지는 면역력이 급격히 떨어져 설사가 발생할 경우 폐사할 확률이 매우 높다.Calf born in winter is very likely to die if diarrhea occurs due to the rapid drop in immunity.
본 발명의 특징은 봄, 여름, 가을뿐만 아니라 기온이 영하로 내려가는 겨울에도 송아지의 설사를 개선할 수 있는 송아지의 설사 예방 및 개선용 조성물을 제공하는 것이다.A feature of the present invention is to provide a composition for preventing and improving diarrhea of calves, which can improve calves' diarrhea not only in spring, summer and autumn but also in winter when temperatures drop below freezing.
먼저, 본 발명에 따른 송아지 설사 예방 및 개선용 조성물을 설명한다.First, the composition for preventing and improving calf diarrhea according to the present invention will be described.
본 발명에 따른 송아지 설사 예방 및 개선용 조성물은 아가리쿠스버섯(Agaricus blazei Murill)을 유효성분으로 포함하는 것을 특징으로 한다.The calf diarrhea prevention and improvement composition according to the present invention is characterized in that it comprises Agaricus blazei (Agricus blazei Murill) as an active ingredient.
상기 아가리쿠스버섯(Agaricus blazei Murill)은 흰들버섯, 신령버섯이라고도 하며 주름버섯목, 주름버섯과, 주름버섯속에 속하는 버섯으로 겉모양은 양송이버섯(Agaricus bisporus)과 유사하지만, 버섯 대가 두껍고 길며 향기가 강력한 것이 특징이다. 아가리쿠스버섯의 대표적인 약리작용으로는 혈당강하 작용, 혈압강하, 콜레스테롤 저하, 항혈전, 면역부활활성 등이 있다. 아가리쿠스 버섯은 많은 약효성분을 함유하고 있는 것으로 알려져 있는데, 생리활성을 갖는 물질로서, 혈구응집작용을 갖는 렉틴(lectin)을 함유하고 있다. 아가리쿠스 버섯에서 중요한 생리활성을 나타내는 물질은 β-글루칸으로서, β-글루칸은 면역활성체의 기능, 항산화능, 생체조직 재생과 치유기능, 항생제, 항균 및 항바이러스 활성을 가지고 있다고 보고되고 있다. Agaricus blazei Murill ( Agaricus mushroom) is also known as white mushrooms, spiritual mushrooms, folds of mushrooms, folds of mushrooms, and fungi belonging to the genus of fungi, but the appearance is similar to the mushrooms of Agaricus bisporus , but the mushroom stand is thick, long, and strong in smell. Is characteristic. Representative pharmacological action of Agaricus mushrooms include hypoglycemic action, lowering blood pressure, lowering cholesterol, antithrombosis, and immunoreactive activity. Agaricus mushrooms are known to contain a number of medicinal ingredients, which are physiologically active and contain lectins with hemagglutination. The important physiological activity in Agaricus mushrooms is β-glucan, which has been reported to have the function of immunoactivator, antioxidant activity, biological tissue regeneration and healing, antibiotics, antibacterial and antiviral activity.
상기 아가리쿠스버섯(Agaricus blazei Murill)은 1944년 미국 플로리다주에서 처음 발견된 뒤, 1960년대 중반 브라질의 산악지대인 피아다데의 원주민들이 식용한다는 사실이 밝혀지면서 널리 알려지기 시작하였으며, 북아메리카와 중남미 일부 지역에서 자생하는 것으로 알려져 있을 뿐 다른 지역에서는 보고된 적이 없다. 단백질, 지방, 섬유질, 비타민, 무기염류, 아미노산, 필수지방산, 핵산 등 각종 영양소가 풍부하고, 암을 비롯한 각종 성인병에 좋다는 사실이 알려지면서 1990년대를 전후해 인공재배 연구가 이루어지기 시작하였다. 그 결과 1992년 일본에서 처음으로 인공재배에 성공하였고, 현재는 한국 및 중국에서도 인공적으로 재배되고 있다. The Agaricus blazei Murill was first discovered in Florida in the United States in 1944, and became widely known when it was discovered that it was edible by the indigenous people of Piadade, a mountainous region of Brazil in the mid-1960s, and in parts of North and Latin America. It is known to grow wild and has not been reported elsewhere. Research on artificial cultivation began around the 1990s when it became known that it is rich in various nutrients such as protein, fat, fiber, vitamins, inorganic salts, amino acids, essential fatty acids and nucleic acids, and is good for various adult diseases including cancer. As a result, it was the first successful cultivation in Japan in 1992, and is now artificially cultivated in Korea and China.
상기 아가리쿠스버섯(Agaricus blazei Murill)은 항암작용, 종양발생 억제,혈당 및 혈압강하 등 성인병 예방효과가 높고, 인체의 면역력을 증강시키는 등 다양한 생리활성을 규명한 연구는 많이 수행되고 있다. Agaricus blazei Murill ( Agaricus blazei Murill) has a high anti-tumor effect, such as anti-cancer effect, tumor suppression, blood sugar and blood pressure lowering, and many studies have been conducted to identify a variety of physiological activities such as enhancing the body's immunity.
본 발명에 따른 송아지 설사 예방 및 개선용 조성물은 아가리쿠스버섯(Agaricus
blazei Murill) 유용성분의 활성을 증가시키기 위해 인삼을 추가적으로 포함할 수 있다.The composition for preventing and improving calf diarrhea according to the present invention is Agaricus mushroom (Agaricus
blazei Murill) may additionally include ginseng to increase the activity of the useful ingredient.
상기 인삼(Panax ginseng)은 치유력이 가장 높은 식물이라 할 수 있으며, 주요 성분은 아글리콘(aglycone) 비율에 따라 프로토파낙사디올과 프로토파낙사트리올로 분류되는 적어도 13종 이상의 진세노사이드(사포닌), 파낙시놀 등의 증류오일, 유기산 및 에스테르, 스테롤, 질소화합물, 엽산 등의 비타민, 효소 등을 함유하고 있으며, 중추신경조정 외에 매우 다양한 효능을 지니고 있는 것으로 알려져 있다.The ginseng (Panax ginseng) can be said to be the highest healing plants, the main ingredient is at least 13 kinds of ginsenosides (saponins) classified into the protoparnasadiol and the protoparnasatriol according to the ratio of aglycone (aglycone) ), Diacid oil such as panaxinol, organic acids and esters, sterols, nitrogen compounds, vitamins such as folic acid, enzymes, etc., and is known to have a wide variety of effects other than the central nervous system.
상기 인삼(Panax ginseng)은 예로부터 대표적인 자양강장제로 널리 사용되어온 식물로서 일반적으로 재배하여 채취한 그대로의 수삼을 상온에서 건조시킨 백삼, 또는 수삼을 가열처리하여 제조되는 홍삼의 형태로 주로 사용되고 있다.The ginseng (Panax ginseng) is a plant that has been widely used as a representative nourishment tonic since ancient times, and is commonly used in the form of red ginseng, which is manufactured by heating white ginseng as dried and dried at room temperature, or red ginseng.
현재까지 알려진 인삼의 약효로는 노화억제, 항동맥경화, 고지혈증 개선, 간기능항진, 방사선장애제거, 면역증강, 항혈전, 뇌기능항진 항스트레스, 혈당강하, 혈압강하, 항암효과 등이 있다.Known medicinal effects of ginseng to date include anti-aging, anti-arteriosclerosis, hyperlipidemia, liver function enhancement, radiation disorders elimination, immunity enhancement, antithrombotic, antihypertensive antistress, blood sugar drop, blood pressure drop, anticancer effect.
이들의 효과를 나타내는 주요 성분은 사포닌 계통의 물질들에 의하여 주로 이루어지고 있는 것으로 알려지고 있으며 주로 인삼의 뿌리에 함유된 산성 다당체의 추출 및 분리를 통하여 이들의 효능에 관한 연구들이 최근 활발하게 진행되는 것으로 알려져 있다.It is known that the main ingredient showing their effect is mainly made by saponin-based substances, and researches on their efficacy through extraction and separation of acidic polysaccharides contained in the root of ginseng have been actively conducted recently. It is known.
본 발명의 송아지 설사 예방 및 개선용 조성물은 아가리쿠스버섯(Agaricus blazei Murill) 100 중량부에 대하여 인삼 90 내지 100 중량부를 포함하는 것이 바람직하며, 인삼을 90 중량부 미만 포함하면 아가리쿠스버섯(Agaricus
blazei Murill) 유용성분의 활성을 충분히 증가시키지 못할 수 있으며, 100 중량부 초과 포함하면 송아지의 체온이 과도하게 상승할 수 있다.The composition for preventing and improving calf diarrhea of the present invention is Agaricus mushroom (Agaricus blazei It is preferable to include 90 to 100 parts by weight of ginseng based on 100 parts by weight of Murill, and if less than 90 parts by weight of ginseng is used, the agaricus mushroom (Agaricus
blazei Murill) may not sufficiently increase the activity of the useful ingredient, including more than 100 parts by weight can cause excessive calf body temperature.
상기 아가리쿠스버섯(Agaricus blazei Murill)은 건조하여 사용하며, 상기 인삼은 뿌리를 사용하는 것이 바람직하다. The Agaricus blazei Murill is used by drying, and the ginseng is preferably rooted.
상기 아가리쿠스버섯(Agaricus blazei Murill)과 인삼은 유효성분의 추출 효율을 높이는 동시에 추출을 위한 시간을 단축하기 위해서 분말화시켜서 사용하고, 평균입자크기 1 내지 1000 ㎛, 바람직하게는 10 내지 500 ㎛인 분말을 열수 추출하되, 상기 아가리쿠스버섯(Agaricus blazei Murill)과 인삼 분말을 그대로 포함하는 현탁액 형태로 가열 추출물을 제조하여 이용할 수 있다. Agaricus blazei Murill and ginseng are powdered in order to increase the extraction efficiency of the active ingredient and shorten the extraction time, and have an average particle size of 1 to 1000 μm, preferably 10 to 500 μm. While extracting hot water, a heated extract may be prepared in the form of a suspension containing Agaricus blazei Murill and ginseng powder as it is.
본 발명에 따른 송아지 설사 예방 및 개선용 조성물은 갓 태어난 송아지에게 초유를 먹이기 전에 급여하여 송아지의 설사를 예방하는 효과가 있고, 봄, 여름, 가을뿐만 아니라 기온이 영하로 내려가는 겨울에도 송아지의 설사를 개선하는 효과가 있으며, 항생물질이나 항균제 등의 약제의 사용에 따른 내성균의 출현 문제와 축산물의 안정성 문제를 해결하는 장점이 있다.The composition for preventing and improving calf diarrhea according to the present invention is effective to prevent diarrhea of the calf by feeding the newborn calf before feeding colostrum, not only in spring, summer and autumn but also in winter when the temperature drops below freezing. There is an effect to improve, there is an advantage to solve the problem of the emergence of resistant bacteria and the stability of livestock products by the use of drugs such as antibiotics or antibacterial agents.
다음은, 본 발명에 따른 송아지 설사 예방 및 개선용 조성물의 제조방법을 설명한다.Next, a method for preparing a composition for preventing and improving calf diarrhea according to the present invention will be described.
본 발명에 따른 송아지 설사 예방 및 개선용 조성물의 제조방법은, 물 100 중량부에 대하여 아가리쿠스버섯(Agaricus
blazei Murill) 분말 3 내지 5 중량부를 첨가하고 90 내지 100 ℃의 온도에서 1 내지 5 분, 바람직하게는 2 내지 3 분 동안 가열하는 것을 특징으로 한다.The method for producing a composition for preventing and improving calf diarrhea according to the present invention, based on 100 parts by weight of water Agaricus mushroom (Agaricus
blazei Murill) powder is added 3 to 5 parts by weight and is characterized by heating for 1 to 5 minutes, preferably 2 to 3 minutes at a temperature of 90 to 100 ℃.
본 발명의 조성물은 물 100 중량부에 대하여 상기 아가리쿠스버섯(Agaricus
blazei Murill)을 3 중량부 미만 혼합하면 송아지의 설사를 개선하는 효능이 미흡할 수 있으며, 5 중량부 초과 혼합하면 특유의 맛과 향 때문에 섭취하기 불편할 수 있다.When the composition of the present invention is mixed with less than 3 parts by weight of the Agaricus blazei Murill based on 100 parts by weight of water, the effect of improving diarrhea of the calf may be insufficient. It can be inconvenient to eat.
본 발명은, 본 발명의 조성물은 상기 물 100 중량부에 대하여 인삼 3 내지 5중량부를 추가적으로 포함할 수 있으며, 인삼을 3 중량부 미만 포함하면 아가리쿠스버섯(Agaricus blazei Murill) 유용성분의 활성을 충분히 증가시키지 못할 수 있으며, 5 중량부 초과 포함하면 송아지의 체온이 과도하게 상승할 수 있다. 상기 인삼도 분말 형태로 포함하는 것이 바람직하다.The present invention, the composition of the present invention may additionally include 3 to 5 parts by weight of ginseng with respect to 100 parts by weight of water, and containing less than 3 parts by weight of ginseng sufficiently increases the activity of the useful ingredient Agaricus blazei Murill It may not be possible, including more than 5 parts by weight can cause excessive calf body temperature. It is preferable to include the ginseng in the form of a powder.
본 발명에 따른 송아지 설사 예방 및 개선용 조성물은 35 내지 40 ℃의 온도로, 1회는 초유를 먹이기 전에 급여하고, 2회 및 3회는 3 내지 4 시간 간격으로 급여하되, 회당 50 ㎖씩 경구투여함으로써 갓 태어난 송아지의 설사를 예방할 수 있다.Calf diarrhea prevention and improvement composition according to the present invention at a temperature of 35 to 40 ℃, one time is fed before feeding colostrum, two and three times are fed at intervals of 3 to 4 hours, 50 ml per oral Administration can prevent diarrhea in newborn calves.
송아지가 자라면서 면역력이 약해져 설사하는 경우에는, 본 발명에 따른 송아지 설사 예방 및 개선용 조성물을 1일 2 내지 5 회, 바람직하게는 3회 정도를, 회당 10 내지 200 ㎖, 바람직하게는 50 ㎖씩, 1 내지 4 일, 바람직하게는 2일 동안 경구투여함으로써 송아지의 설사를 개선할 수 있다.When the calf grows and the immunity is weakened and diarrhea, the calf diarrhea prevention and improvement composition according to the present invention 2 to 5 times a day, preferably about 3 times a day 10 to 200 ml, preferably 50 ml The diarrhea of the calf can be improved by oral administration for 1 to 4 days, preferably 2 days.
이하, 실시예를 통하여 본 발명의 구성 및 효과를 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것일 뿐 본 발명의 범위가 이들 실시예에 의해 제한되는 것은 아니다. Hereinafter, the configuration and effects of the present invention through the embodiments will be described in more detail. These examples are only for illustrating the present invention, but the scope of the present invention is not limited by these examples.
[비교예 1]Comparative Example 1
물 100 중량부에 평균입자크기 300 ㎛인 인삼 분말 4 중량부를 혼합한 후 100 ℃의 온도에서 2분 동안 가열하여 인삼 분말 가열 추출액을 송아지 설사 예방 및 개선용 조성물로 제조하였다.4 parts by weight of ginseng powder having an average particle size of 300 μm was mixed with 100 parts by weight of water, and then heated at 100 ° C. for 2 minutes to prepare a ginseng powder heated extract as a composition for preventing and improving calf diarrhea.
[실시예 1]Example 1
물 100중량부에 건조한 평균입자크기 300 ㎛인 아가리쿠스버섯(Agaricus
blazei Murill) 분말 4 중량부를 혼합한 후 100 ℃의 온도에서 2분 동안 가열하여 아가리쿠스버섯 분말 가열 추출액을 송아지 설사 예방 및 개선용 조성물로 제조하였다.4 parts by weight of Agaricus blazei Murill powder having an average particle size of 300 μm dried to 100 parts by weight of water, and then heated at 100 ° C. for 2 minutes to heat Agaricus mushroom powder extract to prevent and improve calf diarrhea. Prepared.
[실시예 2]Example 2
물 100중량부에 건조한 평균입자크기 300 ㎛인 아가리쿠스버섯(Agaricus
blazei Murill) 분말 4 중량부 및 평균입자크기 300 ㎛인 인삼 분말 4 중량부를 투입한 후, 100 ℃의 온도에서 2분 동안 가열하여 아가리쿠스버섯 분말 및 인삼 분말 가열 추출액을 송아지 설사 예방 및 개선용 조성물로 제조하였다.4 parts by weight of Agaricus blazei Murill powder having an average particle size of 300 μm and 4 parts by weight of ginseng powder having an average particle size of 300 μm were added to 100 parts by weight of water, followed by heating at a temperature of 100 ° C. for 2 minutes. Mushroom powder and ginseng powder heated extract was prepared as a composition for preventing and improving calf diarrhea.
[실험예 1]Experimental Example 1
총 60두수의 송아지를 대상으로 각 20두수의 송아지에게 비교예 1, 실시예 1 및 실시예 2에서 제조한 설사 예방 및 개선용 조성물을 투여하되, 1회는 초유를 먹이기 전에 경구투여하고, 2회 및 3회는 3시간 간격으로 경구투여하되, 회당 50 ㎖씩 급여한 후, 설사발병여부 및 설사가 발병하는 경우의 설사발병일수를 조사하였고, 그 결과를 하기 표 1에 나타내었다.A total of 60 heads of calves were administered to each of 20 heads of calves, the composition for preventing and improving diarrhea prepared in Comparative Example 1, Example 1 and Example 2, once orally administered before feeding colostrum, 2 Once and three times orally administered at 3 hour intervals, 50 ml per dose was administered, and whether diarrhea occurred or diarrheal days when diarrhea was investigated, the results are shown in Table 1 below.
표 1
Table 1
| 구분 | 총두수 | * 발병율 (두) | 설사발병일령 |
| 비교예 1 | 20 | 25.0 (5) | 23.5 |
| 실시예 1 | 20 | 10.0 (2) | 28 |
| 실시예 2 | 20 | 5.0 (1) | 29 |
| * 발병율 : 생후 45일령까지의 설사 발병율 | |||
| division | Head total | Incidence (two) | Diarrhea onset |
| Comparative Example 1 | 20 | 25.0 (5) | 23.5 |
| Example 1 | 20 | 10.0 (2) | 28 |
| Example 2 | 20 | 5.0 (1) | 29 |
| * Incidence: Diarrhea incidence up to 45 days of age | |||
상기 표 1을 보면, 비교예 1의 조성물을 급여한 경우보다 실시예 1 및 실시예 2의 조성물을 급여한 경우에 송아지 설사 발병율이 매우 낮아지는 것을 확인할 수 있다. 또한, 비교예 1의 조성물을 급여한 경우보다 실시예 1 및 실시예 2의 조성물을 급여한 경우에 설사발병일이 늦춰지는 것은 확인할 수 있다. Looking at Table 1, it can be confirmed that the calf diarrhea incidence is very low when the composition of Example 1 and Example 2 is fed than when the composition of Comparative Example 1 is fed. Moreover, when feeding the composition of Example 1 and Example 2 than when feeding the composition of Comparative Example 1, it can be confirmed that the day of diarrhea onset is delayed.
[실험예 2]Experimental Example 2
기온이 영하로 내려간 겨울에, 비교예 1, 실시예 1 및 실시예 2에서 제조한 송아지 설사 예방 및 개선용 조성물의 송아지 설사 개선 여부를 확인하기 위하여, 10~45일령의 신생 송아지 중 설사증상이 있는 송아지를 대상으로 비교예 1, 실시예 1 및 실시예 2에서 제조한 송아지 설사 예방 및 개선용 조성물을 1일 3회, 회당 50㎖씩 2일 동안 경구투여하였으며, 그 결과를 하기 표 2에 나타내었다. In winter, when the temperature fell below freezing, in order to determine whether the calf diarrhea of the composition for preventing and improving calf diarrhea prepared in Comparative Example 1, Example 1 and Example 2 is improved, diarrhea symptoms in newborn calf of 10-45 days old The calf diarrhea prevention and improvement composition prepared in Comparative Example 1, Example 1 and Example 2 for the calf was administered orally three times a day, 50ml per time for 2 days, the results are shown in Table 2 below. Indicated.
표 2
TABLE 2
| 구분 | 치료율 (치료된 송아지 두수/설사증상 있는 송아지 두수) |
| 비교예 1 | 20% (2/10) |
| 실시예 1 | 70% (7/10) |
| 실시예 2 | 90% (9/10) |
| division | Treatment rate (treated calves / diarrhea) |
| Comparative Example 1 | 20% (2/10) |
| Example 1 | 70% (7/10) |
| Example 2 | 90% (9/10) |
상기 표 2를 보면, 실시예 1과 실시예 2의 송아지 설사 예방 및 개선용 조성물은 비교예 1의 조성물에 비해 신생 송아지의 설사를 개선하는 정도가 우수함을 알 수 있다.Looking at the Table 2, it can be seen that the composition for the prevention and improvement of calf diarrhea of Example 1 and Example 2 is excellent in improving the diarrhea of the newborn calf compared to the composition of Comparative Example 1.
본 발명에 따른 송아지 설사 예방 및 개선용 조성물은 기온이 영하로 내려간 겨울에 면역력이 약해진 송아지가 설사를 하는 경우에도 효과적으로 설사를 개선할 수 있는 장점이 있다.The composition for preventing and improving calf diarrhea according to the present invention has an advantage of effectively improving diarrhea even when the calves have weakened immunity in winter when the temperature falls below freezing.
Claims (6)
- 아가리쿠스버섯(Agaricus blazei Murill)을 유효성분으로 포함하는 것을 특징으로 하는 송아지 설사 예방 및 개선용 조성물.Calf diarrhea prevention and improvement composition comprising agaricus mushroom ( Agaricus blazei Murill) as an active ingredient.
- 제 1항에 있어서, 물 100 중량부에 대하여 아가리쿠스버섯(Agaricus blazei Murill) 분말 3 내지 5 중량부를 첨가하고, 90 내지 100 ℃의 온도에서 1 내지 5 분 동안 가열하여 제조한 아가리쿠스버섯(Agaricus blazei Murill) 분말 가열 추출액을 유효성분으로 포함하는 것을 특징으로 하는 송아지 설사 예방 및 개선용 조성물.According to claim 1, Agaricus mushrooms (Agaricus blazei Murill) Agaricus mushroom prepared by adding 3 to 5 parts by weight of powder, and heated for 1 to 5 minutes at a temperature of 90 to 100 ℃ (Agaricus blazei Murill) calf diarrhea prevention and improvement composition comprising the powdered heating extract as an active ingredient.
- 제 1항에 있어서,The method of claim 1,상기 아가리쿠스버섯(Agaricus blazei Murill) 100 중량부에 대하여 인삼 90 내지 100 중량부 더 포함하는 혼합물을 유효성분으로 포함하는 것을 특징으로 하는 송아지 설사 예방 및 개선용 조성물.Agaricus mushrooms (Agaricus blazei Murill) calf diarrhea prevention and improvement composition comprising a mixture containing 90 to 100 parts by weight of ginseng with respect to 100 parts by weight as an active ingredient.
- 제 3항에 있어서,The method of claim 3, wherein물 100 중량부에 대하여 아가리쿠스버섯(Agaricus blazei Murill) 분말 3 내지 5 중량부 및 인삼 분말 3 내지 5 중량부를 첨가하고, 90 내지 100 ℃의 온도에서 1 내지 5 분 동안 가열하여 제조한 아가리쿠스버섯(Agaricus blazei Murill) 분말 및 인삼 분말 가열 추출액을 유효성분으로 포함하는 것을 특징으로 하는 송아지 설사 예방 및 개선용 조성물.Agaricus mushrooms per 100 parts by weight of water (Agaricus blazei Murill) 3 to 5 parts by weight of powder and 3 to 5 parts by weight of ginseng powder, and Agaricus mushroom prepared by heating for 1 to 5 minutes at a temperature of 90 to 100 ℃ (Agaricus blazei Murill) calf diarrhea prevention and improvement composition comprising the powder and ginseng powder heating extract as an active ingredient.
- 물 100 중량부에 대하여, 아가리쿠스버섯(Agaricus blazei Murill) 분말 3 내지 5 중량부를 첨가하고, 90 내지 100 ℃의 온도에서 1 내지 5 분 동안 가열하는 것을 특징으로 하는 송아지 설사 예방 및 개선용 조성물의 제조방법.With respect to 100 parts by weight of water, Agaricus mushrooms (Agaricus blazei Murill) 3 to 5 parts by weight of powder is added, the method for producing a calf diarrhea prevention and improvement composition, characterized in that the heating for 1 to 5 minutes at a temperature of 90 to 100 ℃.
- 제 5항에 있어서,The method of claim 5,상기 물 100 중량부에 대하여, 인삼 분말 3 내지 5 중량부를 추가적으로 포함하는 것을 특징으로 하는 송아지 설사 예방 및 개선용 조성물의 제조방법.About 100 parts by weight of water, ginseng powder 3 to 5 parts by weight additionally characterized in that the calf diarrhea prevention and method for producing a composition for improvement.
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| CN104998053A (en) * | 2015-08-21 | 2015-10-28 | 王璐 | Traditional Chinese medicine for treating infantile diarrhea |
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| KR101864761B1 (en) * | 2016-01-27 | 2018-06-05 | 이문연 | Composition for preventing and improving of ruminants |
| KR20230120943A (en) | 2022-02-10 | 2023-08-17 | 류형준 | Treatment for calf diarrhea |
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- 2013-04-26 KR KR1020130046560A patent/KR20140128004A/en not_active Application Discontinuation
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| EP1389466A1 (en) * | 2001-04-27 | 2004-02-18 | Ajinomoto Co., Inc. | Immunopotentiators |
| US20080031892A1 (en) * | 2004-07-16 | 2008-02-07 | Medimush A/S | Immune modulating compounds from fungi |
| KR20100025958A (en) * | 2008-08-28 | 2010-03-10 | 장홍길 | Medical's a composite of the calf |
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| CN107260754A (en) * | 2017-07-03 | 2017-10-20 | 天津农学院 | A kind of method that Agaricus Blazei Murrill polysaccharide resisting eimeria coccidium is used in livestock and poultry cultivation |
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