CN108619255A - Rheum officinale is fresh to carry spray-dried powders medicine materical crude slice - Google Patents
Rheum officinale is fresh to carry spray-dried powders medicine materical crude slice Download PDFInfo
- Publication number
- CN108619255A CN108619255A CN201810733340.3A CN201810733340A CN108619255A CN 108619255 A CN108619255 A CN 108619255A CN 201810733340 A CN201810733340 A CN 201810733340A CN 108619255 A CN108619255 A CN 108619255A
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- CN
- China
- Prior art keywords
- fresh
- medicine materical
- materical crude
- decoction
- crude slice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of " rheum officinale is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：Rhubarb medicinal material harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, crush, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.Such prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule etc., is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of rhubarb decoction pieces.
Background technology
Chinese herb rhubarb is polygonum rheum palmatumRheum palmatumL., Rheum tanguticum MaximRheum tanguticumMaxim.ex Balf. or Rheum officinaleRheum officinale Baill. dry root and rhizome, have
The effect of heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, removing dampness through diuresis and removing jaundice.It is mainly used for the stagnant constipation of real heat, blood-head
Hematemesis, hot eyes pharynx swelling, carbuncle swells furunculosis, abdominalgia with intestinal abscess, blood stasis closed, postpartum stasis, traumatic injury, damp-heat dysentery, jaundice,
The treatment of stranguria, oedema and externally treating burns and scalds etc. is a herb common on tcm clinical practice.The processing method of traditional rheum officinale
For：Autumn end cauline leaf is withered or the preceding excavation of secondary spring germination, removes radicula, scrapes off crust, valve cutting or section, and restricting, it is dry or direct to wear bunchiness
It is dry, it is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Such medicine materical crude slice volume is big, hygiene mark
It is accurate poor, it is easy to make moist, mildew, is unfavorable for taking care of, storage and transportation cost height.In addition, such prepared slice quality stability is poor, face
Bed curative effect is difficult to ensure, patient takes inconvenience, works slow.Therefore, develop that a kind of stable quality is reliable, storage/transportation cost
It is low, conducive to keeping, carry and easy to use, rapid-action novel rhubarb decoction pieces, it is imperative.Existing market rhubarb decoction pieces, are removed
Except traditional medicine materical crude slice, also Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice two kinds of forms, but be both original with traditional medicine materical crude slice
Material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes；Concentrated granular can only carry
Water soluble ingredient is taken out to fall.
Invention content
The invention discloses a kind of " rheum officinale is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：In rhubarb medicinal material
After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~
The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering,
Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.The concentrate of gained is spray-dried, control dried object water content is to be crushed within 10%, crosses 60
Mesh sieves, and is vacuum-packed to get finished product.Finished product is containing general anthraquinone with aloe-emodin（C15H10O5）, Rhein（C15H8O6）, rheum emodin
（C15H10O5）, Chrysophanol（C15H10O4）And Physcion（C16H12O5）Total amount meter, no less than 3.0%.This powder decoction pieces faces
The general usage amount of bed is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet, from
And the convenience and compliance of Clinical practice are substantially increased, be conducive to the treatment of clinical acute disease.
The present invention solve traditional rhubarb decoction pieces are bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after rhubarb medicinal material is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained is spray-dried, until water content is 10%, is crushed, and is crossed 60 mesh sieve, is vacuum-packed to get finished product.Finished product contains total anthracene
Quinone is with aloe-emodin（C15H10O5）, Rhein（C15H8O6）, rheum emodin（C15H10O5）, Chrysophanol（C15H10O4）And rheum emodin
Methyl ether（C16H12O5）Total amount meter, be 3.5%.
Claims (2)
1. a kind of rheum officinale is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：After rhubarb medicinal material harvesting, clean in time,
Impurity and the dis-medicinal part such as silt are removed, in the piece for taking advantage of using fresh herb tap water in 12 hours and cleaning and being cut into 2 ~ 5mm thickness, addition 1 ~
The water of 5 times of 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice；5 are added in the gained dregs of a decoction
The water of ~ 10 times of weight is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned concoction, cross 60 ~
100 mesh sieve, and are concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；Gained concentrate is spray-dried,
It is to be crushed within 10% to control dried object water content, crosses 60 mesh sieve, is vacuum-packed to get finished product；Finished product is containing general anthraquinone with aloe
Rheum emodin（C15H10O5）, Rhein（C15H8O6）, rheum emodin（C15H10O5）, Chrysophanol（C15H10O4）And Physcion
（C16H12O5）Total amount meter, no less than 3.0%.
2. rheum officinale according to claim 1 is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, and such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733340.3A CN108619255A (en) | 2018-07-06 | 2018-07-06 | Rheum officinale is fresh to carry spray-dried powders medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733340.3A CN108619255A (en) | 2018-07-06 | 2018-07-06 | Rheum officinale is fresh to carry spray-dried powders medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108619255A true CN108619255A (en) | 2018-10-09 |
Family
ID=63689704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733340.3A Pending CN108619255A (en) | 2018-07-06 | 2018-07-06 | Rheum officinale is fresh to carry spray-dried powders medicine materical crude slice |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362182A (en) * | 2017-08-25 | 2017-11-21 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of phoenix-tail fern |
| CN107412303A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eupatorium |
| CN107432883A (en) * | 2017-08-25 | 2017-12-05 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of lopseed |
| CN107582624A (en) * | 2017-08-25 | 2018-01-16 | 徐自升 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Pogostemon cablin |
| CN108186690A (en) * | 2018-03-21 | 2018-06-22 | 山西省医药与生命科学研究院 | A kind of Chinese medicine processing method |
-
2018
- 2018-07-06 CN CN201810733340.3A patent/CN108619255A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107362182A (en) * | 2017-08-25 | 2017-11-21 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of phoenix-tail fern |
| CN107412303A (en) * | 2017-08-25 | 2017-12-01 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of eupatorium |
| CN107432883A (en) * | 2017-08-25 | 2017-12-05 | 徐漫 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of lopseed |
| CN107582624A (en) * | 2017-08-25 | 2018-01-16 | 徐自升 | A kind of fresh preparation technology for squeezing vacuum drying powder decoction pieces of Pogostemon cablin |
| CN108186690A (en) * | 2018-03-21 | 2018-06-22 | 山西省医药与生命科学研究院 | A kind of Chinese medicine processing method |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181009 |
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| WD01 | Invention patent application deemed withdrawn after publication |