CN108635387A - Rhizoma Chuanxiong is fresh to carry spray-dried powders medicine materical crude slice - Google Patents
Rhizoma Chuanxiong is fresh to carry spray-dried powders medicine materical crude slice Download PDFInfo
- Publication number
- CN108635387A CN108635387A CN201810733351.1A CN201810733351A CN108635387A CN 108635387 A CN108635387 A CN 108635387A CN 201810733351 A CN201810733351 A CN 201810733351A CN 108635387 A CN108635387 A CN 108635387A
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- China
- Prior art keywords
- medicine materical
- materical crude
- crude slice
- fresh
- decoction
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- 239000003814 drug Substances 0.000 title claims abstract description 18
- 239000000843 powder Substances 0.000 title claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000012141 concentrate Substances 0.000 claims abstract description 5
- 241000244365 Ligusticum sinense Species 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract description 3
- 239000006187 pill Substances 0.000 claims abstract description 3
- 239000003826 tablet Substances 0.000 claims abstract description 3
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 claims description 3
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 claims description 3
- 229940114124 ferulic acid Drugs 0.000 claims description 3
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 claims description 3
- 235000001785 ferulic acid Nutrition 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 241000112528 Ligusticum striatum Species 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 238000003860 storage Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000125183 Crithmum maritimum Species 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of " Rhizoma Chuanxiong is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：Ligusticum chuanxiong Hort harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, crush, be sieved after be vacuum-packed.The water content of powder decoction pieces is less than 10%.Such prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule etc., is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of ligusticum wallichii decoction piece.
Background technology
Chuanxiong is samphire Rhizoma ChuanxiongLigusticum chuanxiongHort. dry rhizome has and lives
The effect of blood gas, wind-expelling pain-stopping.This product is mainly used for chest impediment and cardialgia, chest side of body shouting pain, tumbling and swelling, irregular menstruation, Amenorrhea pain
Jing , Disorder lump in the abdomen is suffered from abdominal pain, headache, the treatment of arthralgia pain due to rheumatism etc. is most common a herb on tcm clinical practice.The processing of traditional Rhizoma Chuanxiong
Method is：Summer is significantly prominent when the section disk on stem, and is excavated when purplish, removes silt, drying after sun drying, then remove fibrous root,
It is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Thus obtained ligusticum wallichii decoction piece volume is big, health
Standard deviation is learned, is easy to make moist, go rancid, be unfavorable for taking care of, storage and transportation cost are high.In addition, such prepared slice quality stability
Difference, clinical efficacy be difficult to ensure, patient takes inconvenience, works slow.Therefore, develop that a kind of stable quality is reliable, storage/transportation
It is at low cost, conducive to keeping, carry and easy to use, rapid-action novel ligusticum wallichii decoction piece, it is imperative.Existing market Rhizoma Chuanxiong is drunk
Piece, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both with traditional medicine materical crude slice
For raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes；Concentrated granular is only
Water soluble ingredient can be extracted.
Invention content
The invention discloses a kind of " Rhizoma Chuanxiong is fresh to carry spray-dried powders medicine materical crude slice ", are primarily characterized in that：In Ligusticum chuanxiong Hort
After harvesting, clean in time, removal impurity and the dis-medicinal part such as silt, in taken advantage of in 24 hours using fresh herb tap water clean and be cut into 2 ~
The piece of 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering,
Dregs pressing takes juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, the dregs of a decoction squeeze again
Juice collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is
1.02 ~ 1.10 concentrate.The concentrate of gained is spray-dried, control dried object water content is to be crushed within 10%, crosses 60
Mesh sieves, and is vacuum-packed to get finished product.Ferulic acid in finished product medicine materical crude slice（C10H10O4）Content is no less than 0.20%.
The clinical general usage amount of this powder decoction pieces is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter pill, dissipate
In agent, capsule and tablet, to substantially increase the convenience and compliance of Clinical practice, be conducive to controlling for clinical acute disease
It treats.
The present invention solve traditional ligusticum wallichii decoction piece is bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after Ligusticum chuanxiong Hort is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, dregs of a decoction pressure
Extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again
It squeezes the juice, collects concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.05 to be concentrated into relative density.It will
The concentrate of gained is spray-dried, until water content is 10%, is crushed, and is crossed 60 mesh sieve, is vacuum-packed to get finished product.In finished product medicine materical crude slice
Ferulic acid（C10H10O4）Content is 0.25%.
Claims (2)
1. a kind of Rhizoma Chuanxiong is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：After Ligusticum chuanxiong Hort harvesting, clean in time,
Impurity and the dis-medicinal part such as silt are removed, in the piece for taking advantage of using fresh herb tap water in 12 hours and cleaning and being cut into 2 ~ 5mm thickness, addition 1 ~
The water of 5 times of 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice；5 are added in the gained dregs of a decoction
The water of ~ 10 times of weight is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned concoction, cross 60 ~
100 mesh sieve, and are concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；Gained concentrate is spray-dried,
It is to be crushed within 10% to control dried object water content, crosses 60 mesh sieve, is vacuum-packed to get finished product；Ferulic acid in finished product medicine materical crude slice
（C10H10O4）Content is no less than 0.20%.
2. Rhizoma Chuanxiong according to claim 1 is fresh to carry spray-dried powders medicine materical crude slice, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, and such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733351.1A CN108635387A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Chuanxiong is fresh to carry spray-dried powders medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733351.1A CN108635387A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Chuanxiong is fresh to carry spray-dried powders medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108635387A true CN108635387A (en) | 2018-10-12 |
Family
ID=63750402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733351.1A Withdrawn CN108635387A (en) | 2018-07-06 | 2018-07-06 | Rhizoma Chuanxiong is fresh to carry spray-dried powders medicine materical crude slice |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108635387A (en) |
-
2018
- 2018-07-06 CN CN201810733351.1A patent/CN108635387A/en not_active Withdrawn
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20181012 |